Signaling organelles of the innate immune system

Cell

Volumn 151, Issue 6, 2012, Pages 1168-1178

  Kagan, Jonathan C ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN;

BINDING SITE; CELL ORGANELLE; CELL STRUCTURE; EUKARYOTE; GENETIC SCREENING; INNATE IMMUNITY; LIGAND BINDING; MAMMAL CELL; MICROORGANISM DETECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84870910920     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.11.011     Document Type: Review

References (109)

1. S. Akira, S. Uematsu, and O. Takeuchi Pathogen recognition and innate immunity Cell 124 2006 783 801
2. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 2001 732 738
3. N. Barnich, J.E. Aguirre, H.C. Reinecker, R. Xavier, and D.K. Podolsky Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-kappaB activation in muramyl dipeptide recognition J. Cell Biol. 170 2005 21 26
4. G.M. Barton, and J.C. Kagan A cell biological view of Toll-like receptor function: regulation through compartmentalization Nat. Rev. Immunol. 9 2009 535 542
5. A.M. Blanco, A. Perez-Arago, S. Fernandez-Lizarbe, and C. Guerri Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells J. Neurochem. 106 2008 625 639
6. C. Brikos, R. Wait, S. Begum, L.A. O'Neill, and J. Saklatvala Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components Mol. Cell. Proteomics 6 2007 1551 1559
7. M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh, and Y.M. Kim The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling J. Cell Biol. 177 2007 265 275
8. G.D. Brown, and S. Gordon Immune recognition. A new receptor for beta-glucans Nature 413 2001 36 37
9. G.D. Brown, J. Herre, D.L. Williams, J.A. Willment, A.S. Marshall, and S. Gordon Dectin-1 mediates the biological effects of beta-glucans J. Exp. Med. 197 2003 1119 1124
10. D.L. Burdette, K.M. Monroe, K. Sotelo-Troha, J.S. Iwig, B. Eckert, M. Hyodo, Y. Hayakawa, and R.E. Vance STING is a direct innate immune sensor of cyclic di-GMP Nature 478 2011 515 518
11. E.D. Cambronne, and C.R. Roy Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems Traffic 7 2006 929 939
12. C.Y. Chiang, V. Veckman, K. Limmer, and M. David Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation J. Biol. Chem. 287 2012 3704 3709
13. P. Cossart Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes Proc. Natl. Acad. Sci. USA 108 2011 19484 19491
14. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
15. E. Dixit, S. Boulant, Y. Zhang, A.S. Lee, C. Odendall, B. Shum, N. Hacohen, Z.J. Chen, S.P. Whelan, and M. Fransen Peroxisomes are signaling platforms for antiviral innate immunity Cell 141 2010 668 681
16. S.L. Doyle, H. Husebye, D.J. Connolly, T. Espevik, L.A. O'Neill, and A.F. McGettrick The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation Nat. Commun. 3 2012 707
17. X. Du, A. Poltorak, M. Silva, and B. Beutler Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Blood Cells Mol. Dis. 25 1999 328 338
18. S.E. Ewald, B.L. Lee, L. Lau, K.E. Wickliffe, G.P. Shi, H.A. Chapman, and G.M. Barton The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor Nature 456 2008 658 662
19. S.E. Ewald, A. Engel, J. Lee, M. Wang, M. Bogyo, and G.M. Barton Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase J. Exp. Med. 208 2011 643 651
20. M.U. Gack, Y.C. Shin, C.H. Joo, T. Urano, C. Liang, L. Sun, O. Takeuchi, S. Akira, Z. Chen, S. Inoue, and J.U. Jung TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity Nature 446 2007 916 920
21. J.E. Galán, and H. Wolf-Watz Protein delivery into eukaryotic cells by type III secretion machines Nature 444 2006 567 573
22. A.T. Gewirtz, T.A. Navas, S. Lyons, P.J. Godowski, and J.L. Madara Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression J. Immunol. 167 2001 1882 1885
23. T.L. Gioannini, and J.P. Weiss Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells Immunol. Res. 39 2007 249 260
24. T.L. Gioannini, A. Teghanemt, D. Zhang, N.P. Coussens, W. Dockstader, S. Ramaswamy, and J.P. Weiss Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations Proc. Natl. Acad. Sci. USA 101 2004 4186 4191
25. T.L. Gioannini, A. Teghanemt, D. Zhang, E.N. Levis, and J.P. Weiss Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation J. Endotoxin Res. 11 2005 117 123
26. S.E. Girardin, I.G. Boneca, L.A. Carneiro, A. Antignac, M. Jéhanno, J. Viala, K. Tedin, M.K. Taha, A. Labigne, and U. Zähringer Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan Science 300 2003 1584 1587
27. H.S. Goodridge, D.M. Underhill, and N. Touret Mechanisms of Fc receptor and dectin-1 activation for phagocytosis Traffic 13 2012 1062 1071
28. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira A Toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
29. A. Hidmark, A. von Saint Paul, and A.H. Dalpke Cutting Edge: TLR13 Is a Receptor for Bacterial RNA J. Immunol. 6 2012 2717 2721
30. J.A. Hoffmann The immune response of Drosophila Nature 426 2003 33 38
31. K. Honda, Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction Nature 434 2005 1035 1040
32. S.M. Horner, H.M. Liu, H.S. Park, J. Briley, and M. Gale Jr. Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus Proc. Natl. Acad. Sci. USA 108 2011 14590 14595
33. T. Horng, and R. Medzhitov Drosophila MyD88 is an adapter in the Toll signaling pathway Proc. Natl. Acad. Sci. USA 98 2001 12654 12658
34. T. Horng, G.M. Barton, R.A. Flavell, and R. Medzhitov The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Nature 420 2002 329 333
35. F. Hou, L. Sun, H. Zheng, B. Skaug, Q.X. Jiang, and Z.J. Chen MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response Cell 146 2011 448 461
36. H. Husebye, M.H. Aune, J. Stenvik, E. Samstad, F. Skjeldal, O. Halaas, N.J. Nilsen, H. Stenmark, E. Latz, and E. Lien The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes Immunity 33 2010 583 596
37. N. Inohara, T. Koseki, L. del Peso, Y. Hu, C. Yee, S. Chen, R. Carrio, J. Merino, D. Liu, J. Ni, and G. Núñez Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB J. Biol. Chem. 274 1999 14560 14567
38. H. Ishikawa, and G.N. Barber STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling Nature 455 2008 674 678
39. H. Ishikawa, Z. Ma, and G.N. Barber STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity Nature 461 2009 788 792
40. C.A. Janeway Jr. Approaching the asymptote? Evolution and revolution in immunology Cold Spring Harb. Symp. Quant. Biol. 54 1989 1 13
41. C.A. Janeway Jr.; and R. Medzhitov Innate immune recognition Annu. Rev. Immunol. 20 2002 197 216
42. X. Jiang, L.N. Kinch, C.A. Brautigam, X. Chen, F. Du, N.V. Grishin, and Z.J. Chen Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response Immunity 36 2012 959 973
43. M.S. Jin, and J.O. Lee Structures of the toll-like receptor family and its ligand complexes Immunity 29 2008 182 191
44. J.C. Kagan, and R. Medzhitov Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling Cell 125 2006 943 955
45. J.C. Kagan, T. Su, T. Horng, A. Chow, S. Akira, and R. Medzhitov TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta Nat. Immunol. 9 2008 361 368
46. J.Y. Kang, and J.O. Lee Structural biology of the Toll-like receptor family Annu. Rev. Biochem. 80 2011 917 941
47. T.D. Kanneganti, M. Lamkanfi, and G. Núñez Intracellular NOD-like receptors in host defense and disease Immunity 27 2007 549 559
48. H. Kato, O. Takeuchi, E. Mikamo-Satoh, R. Hirai, T. Kawai, K. Matsushita, A. Hiiragi, T.S. Dermody, T. Fujita, and S. Akira Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 J. Exp. Med. 205 2008 1601 1610
49. T. Kawai, O. Adachi, T. Ogawa, K. Takeda, and S. Akira Unresponsiveness of MyD88-deficient mice to endotoxin Immunity 11 1999 115 122
50. Y.M. Kim, M.M. Brinkmann, M.E. Paquet, and H.L. Ploegh UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes Nature 452 2008 234 238
51. C. Korherr, R. Hofmeister, H. Wesche, and W. Falk A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling Eur. J. Immunol. 27 1997 262 267
52. J.J. Kovacs, M.R. Hara, C.L. Davenport, J. Kim, and R.J. Lefkowitz Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways Dev. Cell 17 2009 443 458
53. E. Kowalinski, T. Lunardi, A.A. McCarthy, J. Louber, J. Brunel, B. Grigorov, D. Gerlier, and S. Cusack Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA Cell 147 2011 423 435
54. H. Kumar, T. Kawai, H. Kato, S. Sato, K. Takahashi, C. Coban, M. Yamamoto, S. Uematsu, K.J. Ishii, O. Takeuchi, and S. Akira Essential role of IPS-1 in innate immune responses against RNA viruses J. Exp. Med. 203 2006 1795 1803
55. H. Kumar, T. Kawai, and S. Akira Pathogen recognition by the innate immune system Int. Rev. Immunol. 30 2011 16 34
56. M. Lamkanfi, and V.M. Dixit Inflammasomes: guardians of cytosolic sanctity Immunol. Rev. 227 2009 95 105
57. E. Latz, A. Visintin, E. Lien, K.A. Fitzgerald, B.G. Monks, E.A. Kurt-Jones, D.T. Golenbock, and T. Espevik Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction J. Biol. Chem. 277 2002 47834 47843
58. E. Latz, A. Schoenemeyer, A. Visintin, K.A. Fitzgerald, B.G. Monks, C.F. Knetter, E. Lien, N.J. Nilsen, T. Espevik, and D.T. Golenbock TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat. Immunol. 5 2004 190 198
59. T. Li, B.A. Diner, J. Chen, and I.M. Cristea Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16 Proc. Natl. Acad. Sci. USA 109 2012 10558 10563
60. P. Liu, and R.G. Anderson Compartmentalized production of ceramide at the cell surface J. Biol. Chem. 270 1995 27179 27185
61. H.M. Liu, Y.M. Loo, S.M. Horner, G.A. Zornetzer, M.G. Katze, and M. Gale Jr. The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity Cell Host Microbe 11 2012 528 537
62. L.R. Marek, and J.C. Kagan Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila Immunity 36 2012 612 622
63. R.L. McCaffrey, P. Fawcett, M. O'Riordan, K.D. Lee, E.A. Havell, P.O. Brown, and D.A. Portnoy A specific gene expression program triggered by Gram-positive bacteria in the cytosol Proc. Natl. Acad. Sci. USA 101 2004 11386 11391
64. R. Medzhitov Approaching the asymptote: 20 years later Immunity 30 2009 766 775
65. R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397
66. P. Nakhaei, P. Genin, A. Civas, and J. Hiscott RIG-I-like receptors: sensing and responding to RNA virus infection Semin. Immunol. 21 2009 215 222
67. H. Ohnishi, H. Tochio, Z. Kato, N. Kawamoto, T. Kimura, K. Kubota, T. Yamamoto, T. Funasaka, H. Nakano, and R.W. Wong TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88 PLoS ONE 7 2012 e38423
68. M. Oldenburg, A. Krüger, R. Ferstl, A. Kaufmann, G. Nees, A. Sigmund, B. Bathke, H. Lauterbach, M. Suter, and S. Dreher TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification Science 337 2012 1111 1115
69. M.H. Orzalli, N.A. Deluca, and D.M. Knipe Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein Proc. Natl. Acad. Sci. USA 109 2012 E3008 E3017
70. A. Ozinsky, D.M. Underhill, J.D. Fontenot, A.M. Hajjar, K.D. Smith, C.B. Wilson, L. Schroeder, and A. Aderem The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors Proc. Natl. Acad. Sci. USA 97 2000 13766 13771
71. E.M. Palsson-McDermott, S.L. Doyle, A.F. McGettrick, M. Hardy, H. Husebye, K. Banahan, M. Gong, D. Golenbock, T. Espevik, and L.A. O'Neill TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway Nat. Immunol. 10 2009 579 586
72. B. Park, M.M. Brinkmann, E. Spooner, C.C. Lee, Y.M. Kim, and H.L. Ploegh Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 Nat. Immunol. 9 2008 1407 1414
73. B.S. Park, D.H. Song, H.M. Kim, B.S. Choi, H. Lee, and J.O. Lee The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex Nature 458 2009 1191 1195
74. A. Pichlmair, O. Schulz, C.P. Tan, T.I. Näslund, P. Liljeström, F. Weber, and C. Reis e Sousa RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates Science 314 2006 997 1001
75. A. Pichlmair, O. Schulz, C.P. Tan, J. Rehwinkel, H. Kato, O. Takeuchi, S. Akira, M. Way, G. Schiavo, and C. Reis e Sousa Activation of MDA5 requires higher-order RNA structures generated during virus infection J. Virol. 83 2009 10761 10769
76. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, and C. Galanos Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
77. J. Radons, S. Gabler, H. Wesche, C. Korherr, R. Hofmeister, and W. Falk Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling J. Biol. Chem. 277 2002 16456 16463
78. V.A. Rathinam, Z. Jiang, S.N. Waggoner, S. Sharma, L.E. Cole, L. Waggoner, S.K. Vanaja, B.G. Monks, S. Ganesan, and E. Latz The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses Nat. Immunol. 11 2010 395 402
79. I. Rhee, and A. Veillette Protein tyrosine phosphatases in lymphocyte activation and autoimmunity Nat. Immunol. 13 2012 439 447
80. D.C. Rowe, A.F. McGettrick, E. Latz, B.G. Monks, N.J. Gay, M. Yamamoto, S. Akira, L.A. O'Neill, K.A. Fitzgerald, and D.T. Golenbock The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction Proc. Natl. Acad. Sci. USA 103 2006 6299 6304
81. T. Saito, D.M. Owen, F. Jiang, J. Marcotrigiano, and M. Gale Jr. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA Nature 454 2008 523 527
82. T. Saitoh, N. Fujita, T. Hayashi, K. Takahara, T. Satoh, H. Lee, K. Matsunaga, S. Kageyama, H. Omori, and T. Noda Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response Proc. Natl. Acad. Sci. USA 106 2009 20842 20846
83. M. Sasai, M.M. Linehan, and A. Iwasaki Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3 Science 329 2010 1530 1534
84. R.B. Seth, L. Sun, C.K. Ea, and Z.J. Chen Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3 Cell 122 2005 669 682
85. H. Sun, B.N. Bristow, G. Qu, and S.A. Wasserman A heterotrimeric death domain complex in Toll signaling Proc. Natl. Acad. Sci. USA 99 2002 12871 12876
86. Q. Sun, L. Sun, H.H. Liu, X. Chen, R.B. Seth, J. Forman, and Z.J. Chen The specific and essential role of MAVS in antiviral innate immune responses Immunity 24 2006 633 642
87. K. Tabeta, K. Hoebe, E.M. Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, and J. Goode The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 Nat. Immunol. 7 2006 156 164
88. K. Takahashi, T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, and T. Kouro A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses J. Exp. Med. 204 2007 2963 2976
89. Y. Tanaka, and Z.J. Chen STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway Sci. Signal. 5 2012 ra20
90. S. Tauszig-Delamasure, H. Bilak, M. Capovilla, J.A. Hoffmann, and J.L. Imler Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Nat. Immunol. 3 2002 91 97
91. D. Teis, W. Wunderlich, and L.A. Huber Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction Dev. Cell 3 2002 803 814
92. D. Teis, N. Taub, R. Kurzbauer, D. Hilber, M.E. de Araujo, M. Erlacher, M. Offterdinger, A. Villunger, S. Geley, and G. Bohn p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis J. Cell Biol. 175 2006 861 868
93. P. Tissières, I. Dunn-Siegrist, M. Schäppi, G. Elson, R. Comte, V. Nobre, and J. Pugin Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria Blood 111 2008 2122 2131
94. L.H. Travassos, L.A. Carneiro, M. Ramjeet, S. Hussey, Y.G. Kim, J.G. Magalhães, L. Yuan, F. Soares, E. Chea, and L. Le Bourhis Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry Nat. Immunol. 11 2010 55 62
95. M. Triantafilou, K. Miyake, D.T. Golenbock, and K. Triantafilou Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation J. Cell Sci. 115 2002 2603 2611
96. M. Triantafilou, F.G. Gamper, R.M. Haston, M.A. Mouratis, S. Morath, T. Hartung, and K. Triantafilou Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting J. Biol. Chem. 281 2006 31002 31011
97. P.H. Tseng, A. Matsuzawa, W. Zhang, T. Mino, D.A. Vignali, and M. Karin Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Nat. Immunol. 11 2010 70 75
98. D.M. Underhill, A. Ozinsky, A.M. Hajjar, A. Stevens, C.B. Wilson, M. Bassetti, and A. Aderem The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature 401 1999 811 815
99. L. Unterholzner, S.E. Keating, M. Baran, K.A. Horan, S.B. Jensen, S. Sharma, C.M. Sirois, T. Jin, E. Latz, and T.S. Xiao IFI16 is an innate immune sensor for intracellular DNA Nat. Immunol. 11 2010 997 1004
100. D. Uzri, and L. Gehrke Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities J. Virol. 83 2009 4174 4184
101. R.E. Vance, R.R. Isberg, and D.A. Portnoy Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system Cell Host Microbe 6 2009 10 21
102. S.A. Watt, G. Kular, I.N. Fleming, C.P. Downes, and J.M. Lucocq Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1 Biochem. J. 363 2002 657 666
103. S.D. Wright, R.A. Ramos, P.S. Tobias, R.J. Ulevitch, and J.C. Mathison CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1990 1431 1433
104. M. Yamamoto, S. Sato, H. Hemmi, H. Sanjo, S. Uematsu, T. Kaisho, K. Hoshino, O. Takeuchi, M. Kobayashi, and T. Fujita Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Nature 420 2002 324 329
105. M. Yamamoto, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, and S. Akira Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Science 301 2003 640 643
106. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nat. Immunol. 4 2003 1144 1150
107. Y. Yang, B. Liu, J. Dai, P.K. Srivastava, D.J. Zammit, L. Lefrançois, and Z. Li Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages Immunity 26 2007 215 226
108. M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, M. Miyagishi, K. Taira, S. Akira, and T. Fujita The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Nat. Immunol. 5 2004 730 737
109. I. Zanoni, R. Ostuni, L.R. Marek, S. Barresi, R. Barbalat, G.M. Barton, F. Granucci, and J.C. Kagan CD14 controls the LPS-induced endocytosis of Toll-like receptor 4 Cell 147 2011 868 880