24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup

Toxicology and Applied Pharmacology

Volumn 288, Issue 2, 2015, Pages 131-142

  Teeguarden, Justin G ^a,b   Twaddle, Nathan C ^c   Churchwell, Mona I ^c   Yang, Xiaoxia ^c   Fisher, Jeffrey W ^c   Seryak, Liesel M ^d   Doerge, Daniel R ^c  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Bisphenol A; Endocrine disruptors; Exposure; Oral; Pharmacokinetics; Sublingual

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; GLUCURONIDE; SULFATE; BENZHYDRYL DERIVATIVE; BISPHENOL A GLUCURONIDE; ENDOCRINE DISRUPTOR; PHENOL DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL MONITORING; BODY WEIGHT; CONJUGATE; CONTAMINATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG GLUCURONIDATION; DRUG URINE LEVEL; ELIMINATION HALF-LIFE; EXPOSURE; FOOD; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MOUTH MUCOSA; NORMAL HUMAN; SIMULATION; SOUP; TIME TO MAXIMUM PLASMA CONCENTRATION; BIOLOGICAL MODEL; BIOTRANSFORMATION; BLOOD; FOOD CONTAMINATION; GASTROINTESTINAL ABSORPTION; HALF LIFE TIME; METABOLIC CLEARANCE RATE; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION; URINARY EXCRETION; URINE; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; BENZHYDRYL COMPOUNDS; BIOTRANSFORMATION; ENDOCRINE DISRUPTORS; FOOD CONTAMINATION; GLUCURONIDES; HALF-LIFE; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL; MOUTH MUCOSA; ORAL MUCOSAL ABSORPTION; PHENOLS; RENAL ELIMINATION; SULFATES; YOUNG ADULT;

EID: 84929595201     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.01.009     Document Type: Article

References (65)

1. ANSES Risk Assessment of Bisphenol A (BPA) on Human Health ANSES 2013.
2. Arakawa C., Fujimaki K., Yoshinaga J., Imai H., Serizawa S., Shiraishi H. Daily urinary excretion of bisphenol A. Environ. Health Prev. Med. 2004, 9:22-26.
3. Arbuckle T.E., Davis K., Marro L., Fisher M., Legrand M., LeBlanc A., Gaudreau E., Foster W.G., Choeurng V., Fraser W.D., Group M.S. Phthalate and bisphenol A exposure among pregnant women in Canada-results from the MIREC study. Environ. Int. 2014, 68:55-65.
4. Becker K., Goen T., Seiwert M., Conrad A., Pick-Fuss H., Muller J., Wittassek M., Schulz C., Kolossa-Gehring M. GerES IV: phthalate metabolites and bisphenol A in urine of German children. Int. J. Hyg. Environ. Health 2009, 212:685-692.
5. Benowitz N.L., Hukkanen J., Jacob P. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb. Exp. Pharmacol. 2009, 29-60.
6. Birnbaum L.S., Bucher J.R., Collman G.W., Zeldin D.C., Johnson A.F., Schug T.T., Heindel J.J. Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A. Environ. Health Perspect. 2012, 120(12):1640-1644.
7. Calafat A.M., Ye X., Wong L.Y., Reidy J.A., Needham L.L. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ. Health Perspect. 2008, 116:39-44.
8. Calafat A.M., Koch H.M., Swan S.H., Hauser R., Goldman L.R., Lanphear B.P., Longnecker M.P., Rudel R.A., Teitelbaum S.L., Whyatt R.M., Wolff M.S. Misuse of blood serum to assess exposure to bisphenol A and phthalates. Breast Cancer Res. 2013, 15:403.
9. Carwile J.L., Luu H.T., Bassett L.S., Driscoll D.A., Yuan C., Chang J.Y., Ye X., Calafat A.M., Michels K.B. Polycarbonate bottle use and urinary bisphenol A concentrations. Environ. Health Perspect. 2009, 117:1368-1372.
10. Chapin R.E., Adams J., Boekelheide K., Gray L.E., Hayward S.W., Lees P.S., McIntyre B.S., Portier K.M., Schnorr T.M., Selevan S.G., Vandenbergh J.G., Woskie S.R. NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res. B Dev. Reprod. Toxicol. 2008, 83:157-395.
11. Christensen K.L., Lorber M., Koslitz S., Bruning T., Koch H.M. The contribution of diet to total bisphenol A body burden in humans: results of a 48hour fasting study. Environ. Int. 2012, 50:7-14.
12. Churchwell M.I., Camacho L., Vanlandingham M.M., Twaddle N.C., Sepehr E., Delclos K.B., Fisher J.W., Doerge D.R. Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Toxicol. Sci. 2014, 139:4-20.
13. Dekant W., Völkel W. Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol. Appl. Pharmacol. 2008, 228:114-134.
14. Doerge D.R., Twaddle N.C., Vanlandingham M., Fisher J.W. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 2010, 247:158-165.
15. Doerge D.R., Twaddle N.C., Woodling K.A., Fisher J.W. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Toxicol. Appl. Pharmacol. 2010, 248:1-11.
16. Doerge D.R., Twaddle N.C., Vanlandingham M., Fisher J.W. Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. Toxicol. Lett. 2012, 211(2):114-119.
17. European Food Safety Authority Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request from the commission related to 2,2-bis(4-hydroxyphenyl)propane (bisphenol A). EFSA J. 2007, 428:1-75.
18. European Food Safety Authority DRAFT Scientific Opinion on the Risks to Public Health Related to the Presence of Bisphenol A (BPA) in Foodstuffs - Part A: Exposure Assessment 2013, 314. European Food Safety Authority, Parma, Italy.
19. Fisher J.W., Twaddle N.C., Vanlandingham M., Doerge D.R. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Toxicol. Appl. Pharmacol. 2011, 257:122-136.
20. Food and Drug Administration Exposure to Bisphenol A (BPA) for Infants, Toddlers and Adults From the Consumption of Infant Formula, Toddler Food and Adult (Canned) Food 2009, Food and Drug Administration, Washington D.C. C. T. Division of Biotechnology, GRAS Notice Review (Eds.).
21. Fujimaki K., Arakawa C., Yoshinaga J., Watanabe C., Serizawa S., Imai H., Shiraishi H., Mizumoto Y. Estimation of intake level of bisphenol A in Japanese pregnant women based on measurement of urinary excretion level of the metabolite. Nippon Eiseigaku Zashi 2004, 59.
22. Gayrard V., Lacroix M.Z., Collet S.H., Viguie C., Bousquet-Melou A., Toutain P.L., Picard-Hagen N. High bioavailability of bisphenol A from sublingual exposure. Environ. Health Perspect. 2013, 121(8):951-956.
23. Geens T., Apelbaum T.Z., Goeyens L., Neels H., Covaci A. Intake of bisphenol A from canned beverages and foods on the Belgian market. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 2010, 27:1627-1637.
24. Geens T., Aerts D., Berthot C., Bourguignon J.P., Goeyens L., Lecomte P., Maghuin-Rogister G., Pironnet A.M., Pussemier L., Scippo M.L., Van Loco J., Covaci A. A review of dietary and non-dietary exposure to bisphenol-A. Food Chem. Toxicol. 2012, 50:3725-3740.
25. Gyllenhammar I., Glynn A., Darnerud P.O., Lignell S., van Delft R., Aune M. 4-Nonylphenol and bisphenol A in Swedish food and exposure in Swedish nursing women. Environ. Int. 2012, 43C:21-28.
26. Health Canada Health Canada's Updated Assessment of Bisphenol A (BPA) Exposure From Food Sources 2012, F. D. Bureau of Chemical Safety, Health Products, Food Branch (Eds.).
27. Hormann A.M., Vom Saal F.S., Nagal S.C., Stalhut R.W., Moyer C.L., Ellersieck M.R., Welshons W.V., Toutain P.L., Taylor J.A. Holding thermal paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA). PLoS One 2014, 9:1-12.
28. Japanese National Institute of Advanced Industrial Science and Technology, R. I. o. S. f. S. a. S. R. (2011). Bisphenol A (BPA) Risk Assessment Report.
29. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2009, 364:2063-2078.
30. Koch H.M., Kolossa-Gehring M., Schroter-Kermani C., Angerer J., Bruning T. Bisphenol A in 24 h urine and plasma samples of the German Environmental Specimen Bank from 1995 to 2009: a retrospective exposure evaluation. J. Expo. Sci. Environ. Epidemiol. 2012, 22:610-616.
31. Lakind J.S., Naiman D.Q. Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA data. J. Expo. Sci. Environ. Epidemiol. 2008, 18:608-615.
32. Lakind J.S., Naiman D.Q. Daily intake of bisphenol A and potential sources of exposure: 2005-2006 National Health and Nutrition Examination Survey. J. Expo. Sci. Environ. Epidemiol. 2010, 1-8.
33. Lakind J.S., Levesque J., Dumas P., Bryan S., Clarke J., Naiman D.Q. Comparing United States and Canadian population exposures from National Biomonitoring Surveys: bisphenol A intake as a case study. J. Expo. Sci. Environ. Epidemiol. 2012, 22:219-226.
34. Markham D.A., Waechter J.M., Wimber M., Rao N., Connolly P., Chuang J.C., Hentges S., Shiotsuka R.N., Dimond S., Chappelle A.H. Development of a method for the determination of bisphenol a at trace concentrations in human blood and urine and elucidation of factors influencing method accuracy and sensitivity. J. Anal. Toxicol. 2010, 34:293-303.
35. Mishina E.V., Hoffman A.C. Clinical pharmacology research strategy for dissolvable tobacco products. Nicotine Tob. Res. 2014, 16:253-262.
36. Moors S., Blaszkewicz M., Bolt H.M., Degen G.H. Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS. Mol. Nutr. Food Res. 2007, 51:787-798.
37. Morgan M.K., Jones P.A., Calafat A.M., Ye X., Croghan C.W., Chuang J.C., Wilson N.K., Clifton M.S., Figueroa Z., Sheldon L.S. Assessing the quantitative relationships between preschool children's exposures to bisphenol A by route and urinary biomonitoring. Environ. Sci. Technol. 2011, 45:5309-5316.
38. Ouchi K., Watanabe S. Measurement of bisphenol A in human urine using liquid chromatography with multi-channel coulometric electrochemical detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 780:365-370.
39. Patterson T.A., Twaddle N.C., Roegge C.S., Callicott R.J., Fisher J.W., Doerge D.R. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Toxicol. Appl. Pharmacol. 2013, 267:41-48.
40. Rudel R.A., Gray J.M., Engel C.L., Rawsthorne T.W., Dodson R.E., Ackerman J.M., Rizzo J., Nudelman J.L., Brody J.G. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ. Health Perspect. 2011, 119:914-920.
41. Schecter A., Malik N., Haffner D., Smith S., Harris T.R., Paepke O., Birnbaum L. Bisphenol A (BPA) in U.S. food. Environ. Sci. Technol. 2010, 44:9425-9430.
42. Sohlberg E., Halldin M.M., Annas A., Konigsson K., Jansson B., Pehrson R., Borg N. The impact of the site of blood sampling on pharmacokinetic parameters following sublingual dosing to dogs. J. Pharmacol. Toxicol. Methods 2013, 67:1-4.
43. Teeguarden J.G., Calafat A.M., Ye X., Doerge D.R., Churchwell M.I., Gunawan R., Graham M.K. Twenty-four hour human urine and serum profiles of bisphenol A during high-dietary exposure. Toxicol. Sci. 2011, 123:48-57.
44. Teeguarden J., Hanson-Drury S., Fisher J.W., Doerge D.R. Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population?. Food Chem. Toxicol. 2013, 62:949-963.
45. Teeguarden J.G., Fisher J.W., Doerge D.R. Exposure conditions and pharmacokinetic principles: interpreting bisphenol a absorption in the canine oral cavity. Environ. Health Perspect. 2013, 121:A323.
46. Teeguarden J.G., Twaddle N.C., Churchwell M.I., Yang X., Fisher J.W., Seryak L.M., Doerge D.R. Supplemental data for: 24-hour human urine and serum profiles of bisphenol A: evidence against sublingual absorption following ingestion in soup 2015, Data in Brief, (submitted for publication).
47. Thayer, K. A., and Birnbaum, L. S. (Submitted for publication).
48. Tsukioka T., Terasawa J., Sato S., Hatayama Y., Makino K., Nakazawa H. Development of a analytical method of determining trace amount of BPA in ruine samples and estimation of exposure to BPA. J. Environ. Chem. 2004, 14:57-63.
49. Twaddle N.C., Churchwell M.I., Vanlandingham M., Doerge D.R. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24:3011-3020.
50. U.S.Food and Administration Draft Assessment of Bisphenol A for use in Food Contact Applications 2008, 105.
51. United States Environmental Protection Agency Integrated Risk Information System: Bisphenol A 1993, (CASRN 80-05-7), United States Environmental Protection Agency.
52. Vandenberg L.N., Chahoud I., Heindel J.J., Padmanabhan V., Paumgartten F.J., Schoenfelder G. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ. Health Perspect. 2010, 118:1055-1070.
53. Vandenberg L.N., Hunt P.A., Myers J.P., Frederick S.v.S. Human expsoures to bisphenol A: mismatches between data and assumptions. Rev. Environ. Health 2013, 28:37-58.
54. Vandenberg L.N., Gerona R.R., Kannan K., Taylor J.A., van Breemen R.B., Dickenson C.A., Liao C., Yuan Y., Newbold R.R., Padmanabhan V., Vom Saal F.S., Woodruff T.J. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ. Heal. 2014, 13:25.
55. Völkel W., Colnot T., Csanady G.A., Filser J.G., Dekant W. Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem. Res. Toxicol. 2002, 15:1281-1287.
56. Völkel W., Bittner N., Dekant W. Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab. Dispos. 2005, 33:1748-1757.
57. Völkel W., Kiranoglu M., Fromme H. Determination of free and total bisphenol A in urine of infants. Environ. Res. 2011, 111:143-148.
58. Vom Saal F.S., Welshons W.V. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine and that BPA causes numerous hazards from multiple routes of exposure. Mol. Cell. Endocrinol. 2014, 398:105-113.
59. Wilson N.K., Chuang J.C., Morgan M.K., Lordo R.A., Sheldon L.S. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare. Environ. Res. 2007, 103:9-20.
60. Wolff M.S., Teitelbaum S.L., Windham G., Pinney S.M., Britton J.A., Chelimo C., Godbold J., Biro F., Kushi L.H., Pfeiffer C.M., Calafat A.M. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ. Health Perspect. 2007, 115:116-121.
61. World Health Organization Toxicological and Health Aspects of Bisphenol A: Report of Joint FAO/WHO Expert Meeting 2-5 November 2010 and Report of Stakeholder Meeting on Bisphenol A 2011, 60. World Health Organization, Ottawa, CA.
62. World Health Organization Food and Agriculture Organization of the United Nations Toxicological and Health Aspects of Bisphenol A: Report of Joint FAO/WHO Expert Meeting 2-5 November 2010 and Report of Stakeholder Meeting on Bisphenol A 1 November 2010 2011, World Health Organization Press, Geneva.
63. Yang X., Doerge D.R., Fisher J.W. Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. Toxicol. Appl. Pharmacol. 2013, 270:45-59.
64. Ye X., Wong L.Y., Bishop A.M., Calafat A.M. Variability of urinary concentrations of bisphenol A in spot samples, first-morning voids, and 24-hour collections. Environ. Health Perspect. 2011, 119:983-988.
65. Ye X., Zhou X., Hennings R., Kramer J., Calafat A.M. Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ. Health Perspect. 2013, 121:283-286.