Metabolism and kinetics of bisphenol a in humans at low doses following oral administration

Chemical Research in Toxicology

Volumn 15, Issue 10, 2002, Pages 1281-1287

  Völkel, Wolfgang ^a   Colnot, Thomas ^a,b   Csanády, György A ^c   Filser, Johannes G ^c   Dekant, Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MERCK KGAA   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL GLUCURONIDE; DRUG METABOLITE; GLUCURONIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; ENTEROHEPATIC CIRCULATION; ESTROGEN ACTIVITY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INFERTILITY; INGESTION; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SPECIES DIFFERENCE; TOXICOKINETICS; TOXIN ANALYSIS;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; BODY BURDEN; ESTROGENS, NON-STEROIDAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOLS;

EID: 0036802304     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025548t     Document Type: Article

References (31)

1. Bitman, J., and Cecil, H. (1970) Estrogenic activity of DDT analogs and polychlorinated biphenyls. J. Agric. Food Chem. 18, 1108.
2. Dodds, E. C., and Lawson, W. (1936) Synthetic estrogenic agents without the phenanthrene nucleus. Nature 137, 996.
3. Colborn, T., vom Saal, F. S., and Soto, A. M. (1993) Developmental effects of endocrine-disrupting chemicals in wildlife and humans [see comments]. Environ. Health Perspect. 101, 378-384.
4. Kavlock, R. J., Daston, G. P., DeRosa, C., Fenner-Crisp, P., Gray, L. E., Kaattari, S., Lucier,G., Luster, M., Mac, M. J., Maczka, C., Miller, R., Moore, J., Rolland, R., Scott, G., Sheehan, M., Sinks, T., and Tilson, H. A. (1996) Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop. Environ. Health Perspect. 104 (Suppl. 4), 715-740.
5. Safe, H. S. (2000) Endocrine disruptors and human health - Is there a problem? An update. Environ. Health Perspect. 108, 487-493.
6. Sharpe, R. M., and Skakkebaek, N. E. (1993) Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392-1395.
7. Fenner-Crisp, P. A. (1997) Endocrine disruptor risk characterization: An EPA perspective. Reg. Toxicol. Pharmacol. 26, 70-73.
8. Gaido, K. W., Leonard, L. S., Lovell, S., Gould, J. C., Babai, D., Portier, C. J., and McDonnell, D. P. (1997) Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143, 205-212.
9. Kuiper, G. G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustafsson, J. A. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863-870.
10. Morrissey, R. E., George, J. D., Price, C. J., Tyl, R. W., Marr, M. C., and Kimmel, C. A. (1987) The developmental toxicity of bisphenol A in rats and mice. Fundam. Appl. Toxicol. 8, 571-582.
11. Laws, S. C., Carey, S. A., Ferrell, J. M., Bodman, G. J., and Cooper, R. L. (2000) Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol. Sci. 54, 154-167.
12. Yoo, S. D., Shin, B. S., Kwack, S. J., Lee, B. M., Park, K. L., Han, S. Y., and Kim, H. S. (2000) Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administration. J. Toxicol. Environ. Health 61, 131-139.
13. Yoo, S. D., Shin, B. S., Lee, B. M., Lee, K. C., Han, S. Y., Kim, H. S., Kwack, S. J., and Park, K. L. (2001) Bioavailability and mammary excretion of bisphenol A in Sprague-Dawley rats. J. Toxicol. Environ. Health A 64, 417-426.
14. Pottenger, L. H., Domoradzki, J. Y., Markham, D. A., Hansen, S. C., Cagen, S. Z., and Waechter, J. M., Jr. (2000) The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol. Sci. 54, 3-18.
15. Snyder, R. W., Maness, S. C., Gaido, K. W., Welsch, F., Sumner, S. C., and Fennell, T. R. (2000) Metabolism and disposition of bisphenol A in female rats. Toxicol. Appl. Pharmacol. 168, 225-234.
16. Matthews, J. B., Twomey, K., and Zacharewski, T. R. (2001) In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors α and β. Chem. Res. Toxicol. 14, 149-157.
17. Kawamura, Y., Sano, H., and Yamada, T. (1999) Migration of bisphenol-A from can coatings to drinks. J. Food Hygienic Soc. Jpn. 40, 158-165.
18. Inoue, K., Kato, K., Yoshimura, Y., Makino, T., and Nakazawa, H. (2000) Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection. J. Chromatogr. B, Biomed. Sci. Appl. 749, 17-23.
19. Brotons, J. A., Olea-Serrano, M. F., Villalobos, M., Pedraza, V., and Olea, N. (1995) Xenoestrogens released from lacquer coatings in food cans. Environ. Health Perspect. 103, 608-612.
20. Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L., and Feldman, D. (1993) Bisphenol A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132, 2279-2286.
21. Elsby, R., Maggs, J. L., Ashby, J., and Park, B. K. (2001) Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: Implications for extrapolation to humans. J. Pharmacol. Exp. Ther. 297, 103-113.
22. Howe, S. R., and Borodinsky, L. (1998) Potential exposure to bisphenol A from food-contact use of polycarbonate resins. Food Addit. Contam. 15, 370-375.
23. Knaak, J. B., and Sullivan, L. J. (1966) Metabolism of bisphenol A in the rat. Toxicol. Appl. Pharmacol. 8, 175-184.
24. Dobrinska, M. R. (1989) Enterohepatic circulation of drugs. J. Clin. Pharmacol. 29, 577-580.
25. Colburn, W. A. (1982) Pharmacokinetic and biopharmaceutic parameters during enterohepatic circulation of drugs. J. Pharm. Sci. 71, 131-133.
26. Koch, H. P., and Ritschel, W. A. (1986) Synopsis der Biopharmazie und Pharmakokinetik, pp 232-240, ecomed, München.
27. Filser, J. G. (1996) Toxikokinetik. In Toxikologie (Greim, H., and Deml, E., Eds.) pp 13-40, VCH, Weinheim.
28. Ohkuma, H., Abe, K., Ito, M., Kokado, A., Kambegawa, A., and Maeda, M. (2002) Development of a highly sensitive enzyme-linked immunosorbent assay for bisphenol A in serum. Analyst 127, 93-97.
29. Watanabe, T., Yamamoto, H., Inoue, K., Yamaguchi, A., Yoshimura, Y., Kato, K., Nakazawa, H., Kuroda, N., and Nakashima, K. (2001) Development of sensitive high-performance liquid chromatography with fluorescence detection using 4-(4,5-diphenyl-1H-imidazol-2-yl)-benzoyl chloride as a labeling reagent for determination of bisphenol A in plasma samples. J. Chromatogr. B, Biomed. Sci. Appl. 762, 1-7.
30. Fung, E. Y., Ewoldsen, N. O., St Germain, H. A., Jr., Marx, D. B., Miaw, C. L., Siew, C., Chou, H. N., Gruninger, S. E., and Meyer, D. M. (2000) Pharmacokinetics of bisphenol A released from a dental sealant. J. Am. Dent. Assoc. 131, 51-58.
31. EU-Report (2002) Draft Risk Assessment of Bisphenol A (Carried Out in Accordance with the Council Regulation (EEC) 793/93 on the Evaluation and Control of the Risks of "Existing" Substances), Rapporteur, United Kingdom (Contact: Environment Agency, Chemicals Assessment Section, Oxfordshire, U.K.).