Human exposures to bisphenol A: Mismatches between data and assumptions

Reviews on Environmental Health

Volumn 28, Issue 1, 2013, Pages 37-58

  Vandenberg, Laura N ^a   Hunt, Patricia A ^b   Myers, John Peterson ^c   Vom Saal, Frederick S ^d  

^a TUFTS UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c Environmental Health Sciences   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Contamination; Endocrine disruptor; Metabolism; Urine; Xenoestrogen

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; PHENOL DERIVATIVE;

ANIMAL; DIET; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMAN; METABOLISM; POLLUTANT; REVIEW; RISK ASSESSMENT;

ANIMALS; BENZHYDRYL COMPOUNDS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HUMANS; PHENOLS; RISK ASSESSMENT;

ANIMALIA;

EID: 84879058255     PISSN: 00487554     EISSN: None     Source Type: Journal    
DOI: 10.1515/reveh-2012-0034     Document Type: Review

References (247)

1. Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, vom Saal FS. Components of plastic: Experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B Biol Sci 2009;364:2079-96.
2. Vandenberg LN, Chahoud I, Padmanabhan V, Paumgartten FJR, Schoenfelder G. Biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol A. Environ Health Perspect 2010;118:1051-4.
3. Groff T. Bisphenol A: Invisible pollution. Curr Opin Pediatr 2010;22:524-9.
4. Dodds EC, Lawson W. Synthetic estrogenic agents without the phenanthrene nucleus. Nature 1936;137:996.
5. Gould JC, Leonard LS, Maness SC, Wagner BL, Conner K, et al. Bisphenol A interacts with the estrogen receptor a in a distinct manner from estradiol. Mol Cell Endocrinol 1998;142:203-14.
6. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252-63.
7. Markey CM, Michaelson CL, Veson EC, Sonnenschein C, Soto AM. The mouse uterotrophic assay: A reevaluation of its validity in assessing the estrogenicity of bisphenol A. Environ Health Perspect 2001;109:55-60.
8. Bailin PS, Byrne M, Lewis S, Liroff R. Public awareness drives market for safer alternatives, 2008. Available at: Http://www. iehn.org/documents/ BPA%20market%20report%20Final.pdf. Accessed on April 20, 2011.
9. Guerrero PF. Toxic substances control act: EPA's limited progress in regulating toxic chemicals. T-RCED-94-212. Washington, DC: General Accounting Office, 1994.
10. Schug TT, Janesick A, Blumberg B, Heindel JJ. Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 2011;127:204-15.
11. Rubin BS. Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol 2011;127:27-34.
12. Richter C, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 2007;24:199-224.
13. Wetherill YB, Akingbemi BT, Kanno J, McLachlan JA, Nadal A, et al. In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol 2007;24:178-98.
14. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol 2007;24:139-77.
15. Braun JM, Hauser R. Bisphenol A and children's health. Curr Opin Pediatr 2011;23:233-9.
16. Hauser R, Sokol R. Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult male. Fertil Steril 2008;89:e59-65.
17. Meeker JD, Sathyanarayana S, Swan SH. Phthalates and other additives in plastics: Human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci 2009;364:2097-113.
18. Stillerman KP, Mattison DR, Giudice LC, Woodruff TJ. Environmental exposures and adverse pregnancy outcomes: A review of the science. Reprod Sci 2008;15:631-50.
19. Ranjit N, Siefert K, Padmanabhan V. Bisphenol-A and disparities in birth outcomes: A review and directions for future research. J Perinatol 2009;30:2-9.
20. Bondesson M, Jonsson J, Pongratz I, Olea N, Cravedi JP, et al. A CASCADE of effects of bisphenol A. Reprod Toxicol 2009;28:563-7.
21. Burridge E. Chemical profile: Bisphenol A. ICIS Chem Bus 2008;274:48.
22. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006;147:S56-69.
23. Vandenberg LN. Exposure to bisphenol A in Canada: Invoking the precautionary principle. Can Med Assoc J 2011;183:1265-70.
24. Woodruff TJ, Axelrad DA, Kyle AD, Nweke O, Miller GG, et al. Trends in environmentally related childhood illnesses. Pediatrics 2004;113:1133-40.
25. Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, et al. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 2009;117:1945-52.
26. Braun JM, Kalkbrenner AE, Calafat AM, Yolton K, Ye X, et al. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics 2011;128:873-82.
27. Perera F, Vishnevetsky J, Herbstman JB, Calafat AM, Xiong W, et al. Prenatal bisphenol A exposure and child behavior in an inner-city cohort. Environ Health Perspect 2012;120:1190-4.
28. Sathyanarayana S, Braun JM, Yolton K, Liddy S, Lanphear BP. Case report: High prenatal bisphenol A exposure and infant neonatal neurobehavior. Environ Health Perspect 2011;119:1170-5.
29. Maserejian NN, Trachtenberg FL, Hauser R, McKinlay S, Shrader P, et al. Dental composite restorations and psychosocial function in children. Pediatrics 2012;130:e328-38.
30. Bellinger DC, Trachtenberg F, Zhang A, Tavares M, Daniel D, et al. Dental amalgam and psychosocial status: The New England Children's Amalgam Trial. J Dent Res 2008;87:470-4.
31. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. J Am Med Assoc 2008;300:1303-10.
32. Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS. Association of urinary bisphenol A concentration with heart disease: Evidence from NHANES 2003/06. PLoS One 2010;5:e8673.
33. Carwile JL, Michels KB. Urinary bisphenol A and obesity: NHANES 2003-2006. Environ Res 2011;111:825-30.
34. Wang T, Li M, Chen B, Xu M, Xu Y, et al. Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 2011;97:E223-7.
35. Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, et al. Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 2012;125:1482-90.
36. Trasande L, Attina TM, Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. J Am Med Assoc 2012;308:1113-21.
37. Shankar A, Teppala S. Relationship between urinary bisphenol A levels and diabetes mellitus. J Clin Endocrinol Metab 2011;96:3822-6.
38. Shankar A, Teppala S. Urinary bisphenol A and hypertension in a multiethnic sample of US adults. J Environ Public Health 2012;2012:481641.
39. Shankar A, Teppala S, Sabanayagam C. Urinary bisphenol A levels and measures of obesity: Results from the national health and nutrition examination survey 2003-2008. ISRN Endocrinol 2012;2012:965243.
40. Shankar A, Teppala S, Sabanayagam C. Bisphenol A and peripheral arterial disease: Results from the NHANES. Environ Health Perspect 2012;120:1297-300.
41. Wang HX, Zhou Y, Tang CX, Wu JG, Chen Y, et al. Association between bisphenol A exposure and body mass index in Chinese school children: A cross-sectional study. Environ Health 2012;11:79.
42. Li DK, Zhou Z, Miao M, He Y, Wang J, et al. Urine bisphenol-A (BPA) level in relation to semen quality. Fertil Steril 2010;95:625-30 e1-4.
43. Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, et al. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol 2010;30:532-9.
44. Li D, Zhou Z, Qing D, He Y, Wu T, et al. Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod 2010;25:519-27.
45. Li DK, Zhou Z, Miao M, He Y, Qing D, et al. Relationship between urine bisphenol-A (BPA) level and declining male sexual function. J Androl 2010;31:500-6.
46. Yamada H, Furuta I, Kato EH, Kataoka S, Usuki Y, et al. Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reprod Toxicol 2002;16:735-9.
47. Sugiura-Ogaswara M, Ozaki Y, Sonta S-I, Makino T, Suzumori K. Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod 2005;20:2325-9.
48. Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, et al. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl 2009;33:385-93.
49. Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, et al. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect 2012;120:978-83.
50. Bloom MS, Kim D, Vom Saal FS, Taylor JA, Cheng G, et al. Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization. Fertil Steril 2011;96:672-7 e2.
51. Fujimoto VY, Kim D, vom Saal FS, Lamb JD, Taylor JA, et al. Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization. Fertil Steril 2011;95:1816-9.
52. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 2008;116:39-44.
53. Dekant W, Volkel W. Human exposure to bisphenol A by biomonitoring: Methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol 2008;228:114-34.
54. Mahalingaiah S, Meeker JD, Pearson KR, Calafat AM, Ye X, et al. Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environ Health Perspect 2008;116:173-8.
55. Nepomnaschy PA, Baird DD, Weinberg CR, Hoppin JA, Longnecker MP, et al. Within-person variability in urinary bisphenol A concentrations: Measurements from specimens after long-term frozen storage. Environ Res 2009;109: 734-7.
56. Ye X, Wong LY, Bishop AM, Calafat AM. Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections. Environ Health Perspect 2011;119:983-8.
57. Woodruff TJ, Zota AR, Schwartz JM. Environmental chemicals in pregnant women in the US: NHANES 2003-2004. Environ Health Perspect 2011;119:878-85.
58. Kortenkamp A. Low dose mixture effects of endocrine disrupters: Implications for risk assessment and epidemiology. Int J Androl 2008;31:233-40.
59. Rajapakse N, Silva E, Kortenkamp A. Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone activity. Environ Health Perspect 2002;110:917-21.
60. Rajapakse N, Silva E, Scholze M, Kortenkamp A. Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay. Environ Sci Technol 2004;38:6343-52.
61. Silva E, Rajapakse N, Kortenkamp A. Something from " nothing "-eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 2002;36:1751-6.
62. Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJR, et al. Urine, serum and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 2010;118:1055-70.
63. Heindel JJ. Animal models for probing the developmental basis of disease and dysfunction paradigm. Basic Clin Pharmacol Toxicol 2008;102:76-81.
64. Palmer JR, Wise LA, Hatch EE, Troisi R, Titus-Ernstoff L, et al. Prenatal diethylstilbestrol exposure and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2006;15:1509-14.
65. McLachlan JA. Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 2001;22:319-41.
66. McLachlan JA. Commentary: Prenatal exposure to diethylstilbestrol (DES): A continuing story. Int J Epidemiol 2006;35:868-70.
67. Tominaga T, Negishi T, Hirooka H, Miyachi A, Inoue A, et al. Toxicokinetics of bisphenol A in rats, monkeys and chimpanzees by the LC-MS/MS method. Toxicology 2006;226:208-17.
68. Zalko D, Soto AM, Dolo L, Dorio C, Ratahao E, et al. Biotransformations of bisphenol A in a mammalian model: Answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. Environ Health Perspect 2003;111:309-19.
69. Taylor JA, vom Saal FS, Welshons WV, Drury B, Rottinghaus G, et al. Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: Relevance for human exposure. Environ Health Perspect 2011;119:422-30.
70. Miyakoda H, Tabata M, Onodera S, Takeda K. Comparison of conjugative activity, conversion of bisphenol A to bisphenol A glucuronide, in fetal and mature male rat. J Health Sci 2000;46:269-74.
71. Pottenger LH, Domoradzki JY, Markham DA, Hansen SC, Cagen SZ, et al. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicol Sci 2000;54:3-18.
72. Takahashi O, Oishi S. Disposition of orally administered 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in pregnant rats and placental transfer to fetuses. Environ Health Perspect 2000;108:931-5.
73. Upmeier A, Degen GH, Diel P, Michna H, Bolt HM. Toxicokinetics of bisphenol A in female DA/Han rats after a single i.v. and oral administration. Arch Toxicol 2000;74:431-6.
74. Domoradzki JY, Thornton CM, Pottenger LH, Hansen SC, Card TL, et al. Age and dose dependency of the pharmacokinetics and metabolism of bisphenol A in neonatal sprague-dawley rats following oral administration. Toxicol Sci 2004;77:230-42.
75. Yoo SD, Shin BS, Lee BM, Lee KC, Han SY, et al. Bioavailability and mammary excretion of bisphenol A in Sprague-Dawley rats. J Toxicol Environ Health A 2001;64:417-26.
76. Negishi T, Tominaga T, Ishii Y, Kyuwa S, Hayasaka I, et al. Comparative study on toxicokinetics of bisphenol A in F344 rats, monkeys (Macaca fascicularis), and chimpanzees (Pan troglodytes). Exp Anim 2004;53:391-4.
77. Xiao Q, Li Y, Ouyang H, Xu P, Wu D. High-performance liquid chromatographic analysis of bisphenol A and 4-nonylphenol in serum, liver and testis tissues after oral administration to rats and its application to toxicokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 2006;830:322-9.
78. Prins GS, Ye SH, Birch L, Ho SM, Kannan K. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reprod Toxicol 2011;31:1-9.
79. Taylor JA, Welshons WV, vom Saal FS. No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice. Reprod Toxicol 2008;25:169-76.
80. Kim Y-H, Kim C-S, Park S, Han SY, Pyo M-Y, et al. Gender differences in the levels of bisphenol A metabolites in urine. Biochem Biophys Res Commun 2003;312:441-8.
81. Mykkanen H, Tikka J, Pitkanen T, Hanninen O. Fecal bacterial enzyme activities in infants increase with age and adoption of adult-type diet. J Pediatr Gastroenterol Nutr 1997;25:312-6.
82. Liao C, Kannan K. Determination of free and conjugated forms of bisphenol A in human urine and serum by liquid chromatographytandem mass spectrometry. Environ Sci Technol 2012;46:5003-9.
83. Ye X, Zhou X, Wong LY, Calafat AM. Concentrations of bisphenol A and seven other phenols in pooled sera from 3-11 year old children: 2001-2002 National Health and Nutrition Examination Survey. Environ Sci Technol 2012;46:12664-71.
84. Nishikawa M, Iwano H, Yanagisawa R, Koike N, Inoue H, et al. Placental transfer of conjugated bisphenol A and subsequent reactivation in the rat fetus. Environ Health Perspect 2010;118:1196-203.
85. Stowell CL, Barvian KK, Young PCM, Bigsby RM, Verdugo DE, et al. A role for sulfation-desulfation in the uptake of bisphenol A into breast tumor cells. Chem Biol 2006;13:891-7.
86. Sakamoto H, Yokota H, Kibe R, Sayama Y, Yuasa A. Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat. Biochim Biophys Acta 2002;1573:171-6.
87. Collier AC, Ganley NA, Tingle MD, Blumenstein M, Marvin KW, et al. UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Biochem Pharmacol 2002;63:409-19.
88. Ye X, Kuklenyik Z, Needham LL, Calafat AM. Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4- methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 2005;383:638-44.
89. Calafat AM, Weuve J, Ye X, Jia LT, Hu H, et al. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect 2009;117: 639-44.
90. Becker K, Guen T, Seiwert M, Conrad A, Pick-Fuss H, et al. GerES IV: Phthalate metabolites and bisphenol A in urine of German children. Int J Hyg Environ Health 2009;212:685-92.
91. He Y, Miao M, Herrinton LJ, Wu C, Yuan W, et al. Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Environ Res 2009;109:629-33.
92. Bushnik T, Haines D, Levallois P, Levesque J, Van Oostdam J, et al. Lead and bisphenol A concentrations in the Canadian population. Health Rep 2010;21:7-18.
93. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, et al. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect 2005;113:391-5.
94. EFSA. Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-bis(4-hydroxyphenyl)propane. EFSA J 2006;428:1-75.
95. EFSA. Toxicokinetics of bisphenol A: Scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food (AFC). EFSA J 2008;759:1-10.
96. Kosarac I, Kubwabo C, Lalonde K, Foster W. A novel method for the quantitative determination of free and conjugated bisphenol A in human maternal and umbilical cord blood serum using a two-step solid phase extraction and gas chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2012;898:90-4.
97. Padmanabhan V, Siefert K, Ransom S, Johnson T, Pinkerton J, et al. Maternal bisphenol-A levels at delivery: A looming problem? J Perinatol 2008;28:258-63.
98. Lee YJ, Ryu H-Y, Kim H-K, Min CS, Lee JH, et al. Maternal and fetal exposure to bisphenol A in Korea. Reprod Toxicol 2008;25:413-9.
99. Ye X, Zhou X, Hennings R, Kramer J, Calafat AM. Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: An elusive laboratory challenge. Environ Health Perspect 2013;121:283-6.
100. Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. Toxicol Appl Pharmacol 2010;247: 158-65.
101. Volkel W, Colnot T, Csanady GA, Filsner JG, Dekant W. Metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem Res Toxicol 2002;15:1281-7.
102. Birnbaum LS, Bucher JR, Collman GW, Zeldin DC, Johnson AF, et al. Consortium-based science: The NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A. Environ Health Perspect 2012;120:1640-4.
103. Kang J-H, Kito K, Kondo F. Factors influencing the migration of bisphenol A from cans. J Food Protect 2003;66:1444-7.
104. Takao Y, Lee HC, Kohra S, Arizono K. Release of bisphenol from food can lining upon heating. J Health Sci 2002;48:331-4.
105. Cao XL, Corriveau J, Popovic S. Bisphenol A in canned food products from Canadian markets. J Food Prot 2010;73: 1085-9.
106. Schecter A, Malik N, Haffner D, Smith S, Harris TR, et al. Bisphenol A (BPA) in U.S. food. Environ Sci Technol 2010;44:9425-30.
107. US PIRG. No silver lining: An investigation into bisphenol A in canned foods. Washington, DC: PIRG, updated 2010. Available at: Http://www.uspirg.org/ home/reports/report-archives/healthy-communities/healthy-communities/ no-silver-liningan-investigation-into-bisphenol-a-in-canned-foods. Accessed 20 Sep 2010.
108. Oldring PKT, Nehring U. Packing materials. 7. Metal packaging for foodstuffs, ILSI Europe Report Series, 2007.
109. Vivacqua A, Recchia AG, Fasanella G, Gabriele S, Carpino A, et al. The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. Endocrine 2003;22:275-84.
110. Quitmeyer A, Roberts R. Babies, bottles, and bisphenol A: The story of a scientist-mother. PLoS Biol 2007;5:e200.
111. Brede C, Fjeldal P, Skjevrak I, Herikstad H. Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling, and brushing. Food Addit Contam 2003;20:684-9.
112. Geens T, Aerts D, Berthot C, Bourguignon JP, Goeyens L, et al. A review of dietary and non-dietary exposure to bisphenol-A. Food Chem Toxicol 2012;50:3725-40.
113. Heindel JJ. Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction. Semin Reprod Med 2006;24:168-77.
114. Myers JP, Zoeller RT, vom Saal FS. A clash of old and new scientific concepts in toxicity, with important implications for public health. Environ Health Perspect 2009;117:1652-5.
115. Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, et al. Endocrine-disrupting chemicals and public health protection: A statement of principles from the Endocrine Society. Endocrinology 2012;153:4097-110.
116. Balakrishnan B, Henare K, Thorstensen EB, Ponnampalam AP, Mitchell MD. Transfer of bisphenol A across the human placenta. Am J Obstet Gynecol 2010;202:e1-7.
117. Schoenfelder G, Wittfoht W, Hopp H, Talsness CE, Paul M, et al. Parent bisphenol A accumulation in the human maternal-fetalplacental unit. Environ Health Perspect 2002;110:A703-7.
118. Cooper JE, Kendig EL, Belcher SM. Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles. Chemosphere 2011;85:943-7.
119. Cao XL, Corriveau J. Migration of bisphenol A from polycarbonate baby and water bottles into water under severe conditions. J Agric Food Chem 2008;56:6478-81.
120. Cao XL, Corriveau J. Survey of bisphenol A in bottled water products in Canada. Food Addit Contam B 2008;1:161-4.
121. Belfroid A, van Velzen M, van der Horst B, Vethaak D. Occurrence of bisphenol A in surface water and uptake in fish: Evaluation of field measurements. Chemosphere 2002;49: 97-103.
122. Barnes KK, Kolpin DW, Furlong ET, Zaugg SD, Meyer MT, et al. A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States-I) Groundwater. Sci Total Environ 2008;402:192-200.
123. Rudel RA, Melly SJ, Geno PW, Sun G, Brody JG. Identification of alkylphenols and other estrogenic phenolic compounds in wastewater, septage, and groundwater on Cape Cod, Massachusetts. Environ Sci Technol 1998;32:861-9.
124. Focazio MJ, Kolpin DW, Barnes KK, Furlong ET, Meyer MT, et al. A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States-II) untreated drinking water sources. Sci Total Environ 2008;402:201-16.
125. Li X, Ying GG, Su HC, Yang XB, Wang L. Simultaneous determination and assessment of 4-nonylphenol, bisphenol A and triclosan in tap water, bottled water and baby bottles. Environ Int 2010;36:557-62.
126. Maggioni S, Balaguer P, Chiozzotto C, Benfenati E. Screening of endocrine-disrupting phenols, herbicides, steroid estrogens, and estrogenicity in drinking water from the waterworks of 35 Italian cities and from PET-bottled mineral water. Environ Sci Pollut Res Int 2012;20:1649-60.
127. Dupuis A, Migeot V, Cariot A, Albouy-Llaty M, Legube B, et al. Quantification of bisphenol A, 353-nonylphenol and their chlorinated derivatives in drinking water treatment plants. Environ Sci Pollut Res Int 2012;19:4193-205.
128. Santhi VA, Sakai N, Ahmad ED, Mustafa AM. Occurrence of bisphenol A in surface water, drinking water and plasma from Malaysia with exposure assessment from consumption of drinking water. Sci Total Environ 2012;427-428:332-8.
129. Bae B, Jeong JH, Lee SJ. The quantification and characterization of endocrine disruptor bisphenol-A leaching from epoxy resins. Water Sci Technol 2002;46:381-7.
130. Carwile JL, Luu HT, Bassett LS, Driscoll DA, Yuan C, et al. Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect 2009;117:1368-72.
131. Amiridou D, Voutsa D. Alkylphenols and phthalates in bottled waters. J Hazard Mater 2011;185:281-6.
132. Matsumoto A, Kunugita N, Kitagawa K, Isse T, Oyama T, et al. Bisphenol A levels in human urine. Environ Health Perspect 2003;111:101-4.
133. Yamano Y, Miyakawa S, Iizumi K, Itoh H, Iwasaki M, et al. Long-term study of urinary bisphenol A in elementary school children. Environ Health Prev Med 2008;13:332-7.
134. Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB. Canned soup consumption and urinary bisphenol A: A randomized crossover trial. J Am Med Assoc 2011;306:2218-20.
135. Rudel RA, Gray JM, Engel CL, Rawsthorne TW, Dodson RE, et al. Food packaging and bisphenol A and bis(2-ethylhexyl) phthalate exposure: Findings from a dietary intervention. Environ Health Perspect 2011;119:914-20.
136. Sathyanarayana S, Alcedo G, Saelens BE, Zhou C, Dills RL, et al. Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures. J Expo Sci Environ Epidemiol 2013 Feb 27. DOI: 10.1038/jes.2013.9 [Epub ahead of print].
137. Willhite CC, Ball GL, McLellan CJ. Derivation of a Bisphenol A organ reference dose (RfD) and drinking-water equivalent concentration. J Toxicol Environ Health B 2008;11:69-146.
138. Goodman JE, Witorsch RJ, McConnell EE, Sipes IG, Slayton TM, et al. Weight-of-evidence evaluation of reproductive and developmental effects of low doses of bisphenol A. Crit Rev Toxicol 2009;39:1-75.
139. Arnold SM, Clark KE, Staples CA, Klecka GM, Dimond SS, et al. Relevance of drinking water as a source of human exposure to bisphenol A. J Expo Sci Environ Epidemiol 2013;23:137-44.
140. World Health Organization. Joint FAO/WHO expert meeting to review toxicological and health aspects of bisphenol A 2010, updated 2010. Available at: Http://www.who.int/foodsafety/chem/chemicals/bisphenol-release/en/index. html. Accessed 1 Dec 2010.
141. Stahlhut RW, Welshons WV, Swan SH. Bisphenol A data in NHANES suggest longer than expected half-life, substantial non-food exposure, or both. Environ Health Perspect 2009;117:784-9.
142. Teeguarden JG, Calafat AM, Ye X, Doerge DR, Churchwell MI, et al. Twenty-four hour human urine and serum profiles of bisphenol A during high-dietary exposure. Toxicol Sci 2011;123:48-57.
143. Teeguarden JG, Calafat AM, Doerge DR. Adhering to fundamental principles of biomonitoring, BPA pharmacokinetics, and mass balance is no " flaw " . Toxicol Sci 2012;125:321-5.
144. Lakind JS, Naiman DQ. Daily intake of bisphenol A and potential sources of exposure: 2005-2006 National Health and Nutrition Examination Survey. J Expo Sci Environ Epidemiol 2011;21:272-9.
145. Vom Saal FS, Prins GS, Welshons WV. Report of very low real-world exposure to bisphenol A is unwarranted based on a lack of data and flawed assumptions. Toxicol Sci 2012;125:318-20; author reply 21-5.
146. Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, et al. Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ Health Perspect 2011;119:131-7.
147. Tharp AP, Maffini MV, Hunt PA, Vandevoort CA, Sonnenschein C, et al. Bisphenol A alters the development of the rhesus monkey mammary gland. Proc Natl Acad Sci USA 2012;109:8190-5.
148. Liao C, Kannan K. Widespread occurrence of bisphenol A in paper and paper products: Implications for human exposure. Environ Sci Technol 2011;45:9372-9.
149. Vinas P, Lopez-Garcia I, Campillo N, Rivas RE, Hernandez-Cordoba M. Ultrasound-assisted emulsification microextraction coupled with gas chromatography-mass spectrometry using the Taguchi design method for bisphenol migration studies from thermal printer paper, toys and baby utensils. Anal Bioanal Chem 2012;404:671-8.
150. Mendum T, Stoler E, VanBenschoten H, Warner JC. Concentration of bisphenol A in thermal paper. Green Chem Lett Rev 2011;4:81-6.
151. Geens T, Goeyens L, Kannan K, Neels H, Covaci A. Levels of bisphenol-A in thermal paper receipts from Belgium and estimation of human exposure. Sci Total Environ 2012;435-436:30-3.
152. Biedermann S, Tschudin P, Grob K. Transfer of bisphenol A from thermal printer paper to the skin. Anal Bioanal Chem 2010;398:571-6.
153. Liao C, Kannan K. High levels of bisphenol A in paper currencies from several countries, and implications for dermal exposure. Environ Sci Technol 2011;45:6761-8.
154. Terasaki M, Shiraishi F, Fukazawa H, Makino M. Occurrence and estrogenicity of phenolics in paper-recycling process water: Pollutants originating from thermal paper in waste paper. Environ Toxicol Chem 2007;26:2356-66.
155. Schwartz AW, Landrigan PJ. Bisphenol A in thermal paper receipts: An opportunity for evidence-based prevention. Environ Health Perspect 2012;120:A14-5; author reply A5.
156. Zalko D, Jacques C, Duplan H, Bruel S, Perdu E. Viable skin efficiently absorbs and metabolizes bisphenol A. Chemosphere 2011;82:424-30.
157. Jackson WHJ, Darnell WR, inventors. Process for foaming cellulose acetate rod, 1985. US Patent 4,507,256.
158. Dalhamn T, Edfors ML, Rylander R. Mouth absorption of various compounds in cigarette smoke. Arch Environ Health 1968;16:831-5.
159. Inoue K, Yoshida S, Nakayama S, Ito R, Okanouchi N, et al. Development of stable isotope dilution quantification liquid chromatography-mass spectrometry method for estimation of exposure levels of bisphenol A, 4-tert-octylphenol, 4-nonylphenol, tetrabromobisphenol A, and pentachlorophenol in indoor air. Arch Environ Contam Toxicol 2006;51:503-8.
160. Loganathan SN, Kannan K. Occurrence of bisphenol A in indoor dust from two locations in the eastern United States and implications for human exposures. Arch Environ Contam Toxicol 2011;61:68-73.
161. Geens T, Roosens L, Neels H, Covaci A. Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium. Chemosphere 2009;76:755-60.
162. Rudel RA, Camann DE, Spengler JD, Korn LR, Brody JG. Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Environ Sci Technol 2003;37:4343-55.
163. Volkel W, Kiranoglu M, Fromme H. Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment. Toxicol Lett 2008;179: 155-62.
164. Wilson NK, Chuang JC, Lyu C, Menton R, Morgan MK. Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. J Expo Anal Environ Epidemiol 2003;13:187-202.
165. Wilson NK, Chuang JC, Morgan MK, Lordo RA, Sheldon LS. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare. Environ Res 2007;103:9-20.
166. Matsumoto H, Adachi S, Suzuki Y. Bisphenol A in ambient air particulates responsible for the proliferation of MCF-7 human breast cancer cells and its concentration changes over 6 months. Arch Environ Contam Toxicol 2005;48:459-66.
167. Fu P, Kawamura K. Ubiquity of bisphenol A in the atmosphere. Environ Pollut 2010;158:3138-43.
168. Jones-Otazo HA, Clarke JP, Diamond ML, Archbold JA, Ferguson G, et al. Is house dust the missing exposure pathway for PBDEs ? An analysis of the urban fate and human exposure to PBDEs. Environ Sci Technol 2005;39:5121-30.
169. Sajiki J, Yanagibori R, Kobayashi Y. Study of experiment on leaching of bisphenol A from infant books to artificial saliva. Nihon Eiseigaku Zasshi 2010;65:467-70.
170. Dodson RE, Nishioka M, Standley LJ, Perovich LJ, Brody JG, et al. Endocrine disruptors and asthma-associated chemicals in consumer products. Environ Health Perspect 2012;120: 935-43.
171. Schoringhumer K, Cichna-Markl M. Sample clean-up with sol-gel enzyme and immunoaffinity columns for the determination of bisphenol A in urine. J Chromatogr B 2007;850:361-9.
172. Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, et al. Bisphenol A and other compounds in human saliva and urine associated with the placement of
173. Romero J, Ventura F, Gomez M. Characterization of paint samples used in drinking water reservoirs: Identification of endocrine disruptor compounds. J Chromatogr Sci 2002;40:191-7.
174. Olea N, Pulgar R, Perez P, Olea-Serrano F, Rivas A, et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996;104:298-305.
175. Chapin RE, Adams J, Boekelheide K, Gray LEJ, Hayward SW, et al. NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res B Dev Reprod Toxicol 2008;83:157-395.
176. Duty SM, Mendonca K, Hauser R, Calafat AM, Ye X, et al. Potential sources of bisphenol A in the neonatal intensive care unit. Pediatrics 2013;131:483-9.
177. Ash M, Ash I. Handbook of food packaging chemicals and materials, 2nd ed. Endicott, NY: Synapse Information Resources, 2008.
178. Mathias NR, Hussain MA. Non-invasive systemic drug delivery: Developability considerations for alternate routes of administration. J Pharm Sci 2010;99:1-20.
179. Price TM, Blauer KL, Hansen M, Stanczyk F, Lobo R, et al. Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol. Obstet Gynecol 1997;89:340-5.
180. Kuhl H. Pharmacology of estrogens and progestogens: Influence of different routes of administration. Climacteric 2005;8(Suppl 1):3-63.
181. Schonfelder G, Flick B, Mayr E, Talsness C, Paul M, et al. In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina. Neoplasia 2002; 4:98-102.
182. US FDA. Draft assessment of bisphenol A for use in food contact applications, updated 2008. Available at: Http://www. fda.gov/ohrms/dockets/ac/ 08/briefing/2008-0038b1-01-02-FDA%20BPA%20Draft%20Assessment.pdf. Accessed 8 Jan 2011.
183. Howdeshell KL, Furr J, Lambright CR, Wilson VS, Ryan BC, et al. Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male Long Evans hooded rat. Toxicol Sci 2008;102:371-82.
184. EFSA. Scientific opinion on bisphenol A: Evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of bisphenol A. EFSA J 2010;8:1829.
185. Gies A, Heinzow B, Heindel JJ, Dieter HH. Bisphenol A workshop of the German Federal Government Agency-March 30-31, 2009. Work group report: Public health issues of bisphenol A. Int J Hyg Environ Health 2009;212:693-6.
186. CERHR. Draft NTP brief on bisphenol A, updated 2008. Available at: Http://cerhr.niehs.nih.gov/chemicals/bisphenol/BPADraftBriefVF-04-14-08.pdf. Accessed on Feb 3, 2009.
187. US FDA. Redbook 2000. Rockville, MD: FDA, 2007.
188. US FDA. FDA science board subcommittee on bisphenol A: Scientific peer-review of the draft assessment of bisphenol A for use in food contact applications. Rockville, MD: FDA, 2008.
189. Volkel W, Bittner N, Dekant W. Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab Dispos 2005;33:1748-57.
190. Mielke H, Partosch F, Gundert-Remy U. The contribution of dermal exposure to the internal exposure of bisphenol A in man. Toxicol Lett 2011;204:190-8.
191. Mielke H, Gundert-Remy U. Physiologically based toxicokinetic modelling as a tool to support risk assessment: Three case studies. J Toxicol 2012;2012:359471.
192. Jakubowski M. Low-level environmental lead exposure and intellectual impairment in children-the current concepts of risk assessment. Int J Occup Med Environ Health 2011;24:1-7.
193. Doerge DR, Twaddle NC, Woodling KA, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Toxicol Appl Pharmacol 2010;248:1-11.
194. Crain DA, Eriksen M, Iguchi T, Jobling S, Laufer H, et al. An ecological assessment of bisphenol-A: Evidence from comparative biology. Reprod Toxicol 2007;24:225-39.
195. Hunt PA, Susiarjo M, Rubio C, Hassold TJ. The bisphenol A experience: A primer for the analysis of environmental effects on mammalian reproduction. Biol Reprod 2009;81:807-13.
196. Maffini MV, Rubin BS, Sonnenschein C, Soto AM. Endocrine disruptors and reproductive health: The case of bisphenol-A. Mol Cell Endocrinol 2006;254-255:179-86.
197. Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: A review of controversies in the field of endocrine disruption. Endocr Rev 2009;30:75-95.
198. Palanza P, Gioiosa L, vom Saal FS, Parmigiani S. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 2008;108:150-7.
199. Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr., et al. Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr Rev 2012;33:378-455.
200. vom Saal FS, Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect 2005;113:926-33.
201. Vandenberg LN. Bisphenol A and aging. In: Weiss B, editor. Aging and vulnerability to environmental chemicals: Age-related disorders and their origins in environmental exposures. London: Royal Society of Chemistry, 2013: 241-66.
202. Shelby MD. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. NTP CERHR MON 2008;(22):v, vii-ix, 1-64 passim. http://www. ncbi.nlm.nih.gov/pubmed/19407859.
203. Colerangle JB, Roy D. Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of Noble rats. J Steroid Biochem Mol Biol 1997;60:153-60.
204. Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, et al. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 2007;148:116-27.
205. Markey CM, Coombs MA, Sonnenschein C, Soto AM. Mammalian development in a changing environment: Exposure to endocrine disruptors reveals the developmental plasticity of steroid-hormone target organs. Evol Dev 2003;5:67-75.
206. Markey CM, Luque EH, Munoz-de-Toro M, Sonnenschein C, Soto AM. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod 2001;65:1215-23.
207. Munoz-de-Toro M, Markey CM, Wadia PR, Luque EH, Rubin BS, et al. Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice. Endocrinology 2005;146:4138-47.
208. Vandenberg LN, Maffini MV, Schaeberle CM, Ucci AA, Sonnenschein C, et al. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reprod Toxicol 2008;26:210-9.
209. Moral R, Wang R, Russo IH, Lamartiniere CA, Pereira J, et al. Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature. J Endocrinol 2008;196:101-12.
210. Ayyanan A, Laribi O, Schuepbach-Mallepell S, Schrick C, Gutierrez M, et al. Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number. Mol Endocrinol 2011;25:1915-23.
211. Wadia PR, Vandenberg LN, Schaeberle CM, Rubin BS, Sonnenschein C, et al. Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains. Environ Health Perspect 2007;115:592-8.
212. Murray TJ, Maffini MV, Ucci AA, Sonnenschein C, Soto AM. Induction of mammary gland ductal hyperplasias and carcinomas in situ following fetal bisphenol A exposure. Reprod Toxicol 2007;23:383-90.
213. Durando M, Kass L, Piva J, Sonnenschein C, Soto AM, et al. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ Health Perspect 2007;115:80-6.
214. Jenkins S, Raghuraman N, Eltoum I, Carpenter M, Russo J, et al. Oral exposure to bisphenol A increases dimethylbenzanthracene-induced mammary cancer in rats. Environ Health Perspect 2009;117:910-5.
215. Betancourt AM, Eltoum IA, Desmond RA, Russo J, Lamartiniere CA. In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat. Environ Health Perspect 2010;118:1614-9.
216. Weber Lozada K, Keri RA. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 2011;85:490-7.
217. Lamartiniere CA, Jenkins S, Betancourt AM, Wang J, Russo J. Exposure to the endocrine disruptor bisphenol A alters susceptibility for mammary cancer. Horm Mol Biol Clin Investig 2011;5:45-52.
218. Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 2006;66:5624-32.
219. Prins GS, Birch L, Tang WY, Ho SM. Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod Toxicol 2007;23:374-82.
220. Chao HH, Zhang XF, Chen B, Pan B, Zhang LJ, et al. Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway. Histochem Cell Biol 2012;137:249-59.
221. Zhang HQ, Zhang XF, Zhang LJ, Chao HH, Pan B, et al. Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Mol Biol Rep 2012;39:5651-7.
222. Hunt PA, Lawson C, Gieske M, Murdoch B, Smith H, et al. Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc Natl Acad Sci USA 2012;109:17525-30.
223. Susiarjo M, Hassold TJ, Freeman E, Hunt PA. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet 2007;3:e5.
224. Lawson C, Gieske M, Murdoch B, Ye P, Li Y, et al. Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A. Biol Reprod 2011;84:79-86.
225. US FDA. Update on bisphenol A for use in food contact applications. Rockville, MD: FDA, 2010.
226. Bisphenol A: How much concern is'some' concern?, updated 2008. Available at: Http://prospect.rsc.org/blogs/cw/2008/09/04/bisphenol-a-how-much-concern-is- someconcern/. Accessed 11 Feb 2013.
227. McCarver G, Bhatia J, Chambers C, Clarke R, Etzel R, et al. NTP-CERHR expert panel report on the developmental toxicity of soy infant formula. Birth Defects Res B Dev Reprod Toxicol 2011;92:421-68.
228. NTP-CERHR monograph on the potential human reproductive and developmental effects of hydroxyurea. NTP CERHR MON 2008;(21):vii-viii, v, ix-III1.
229. NTP-CERHR monograph on the potential human reproductive and developmental effects of styrene. NTP CERHR MON 2006;(17):vii-viii, 1-5, I1-2 passim.
230. NTP-CERHR monograph on the potential human reproductive and developmental effects of methylphenidate. NTP CERHR MON 2005;(15):v, vii-I-2, II-xi-147.
231. Shelby MD. NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). NTP CERHR MON 2006;(18):v, vii-7, II-iii-xiii passim. http://www.ncbi.nlm.nih.gov/pubmed/ 19407857.
232. NTP-CERHR monograph on the potential human reproductive and developmental effects of amphetamines. NTP CERHR MON 2005;(16):vii-III1.
233. NTP-CERHR monograph on the potential human reproductive and developmental effects of ethylene glycol. NTP CERHR MON 2004;(11):1-III36.
234. NTP-CERHR monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate (BBP). NTP CERHR MON 2003;(5):i-III90.
235. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). NTP CERHR MON 2003;(4):i-III90.
236. NTP-CERHR monograph on the potential human reproductive and developmental effects of propylene glycol (PG). NTP CERHR MON 2004;(12):i-III6.
237. NTP-CERHR monograph on the potential human reproductive and developmental effects of fluoxetine. NTP CERHR MON 2004;(13):i-III24.
238. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-octyl phthalate (DnOP). NTP CERHR MON 2003;(6):i-III90.
239. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isodecyl phthalate (DIDP). NTP CERHR MON 2003;(3):i-III90.
240. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). NTP CERHR MON 2003;(2):i-III90.
241. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, et al. Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 2007;24:131-8.
242. von Eschenbach AC. Andy's take: Bisphenol A, updated 2008. Available at: Http://www.fda.gov/oc/vonEschenbach/andys-take/andys-take-103108.pdf.
243. Health Canada. Order adding a toxic substance to Schedule 1 to the Canadian Environmental Protection Act, 1999. Canada Gazette 2010;144:2010-10-13.
244. Health Canada. Food and Nutrition: Bisphenol A 2010 [updated 2010; cited September 22, 2010. Available at: Http://www. hc-sc.gc.ca/fn-an/securit/packag- emball/bpa/index-eng.php. Accessed.
245. Diamanti-Kandarakis E, Bourguignon JP, Guidice LC, Hauser R, Prins GS, et al. Endocrine-disrupting chemical: An Endocrine Society scientific statement. Endocr Rev 2009;30: 293-342.
246. Crain DA, Janssen SJ, Edwards TM, Heindel JJ, Ho SM, et al. Female reproductive disorders: The roles of endocrinedisrupting compounds and developmental timing. Fertil Steril 2008;90:911-40.
247. Meeker JD. Exposure to environmental endocrine disrupting compounds and men's health. Maturitas 2010;66: 236-41.