Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA)

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Hormann, Annette M ^a   Vom Saal, Frederick S ^a   Nagel, Susan C ^b   Stahlhut, Richard W ^a   Moyer, Carol L ^a   Ellersieck, Mark R ^a   Welshons, Wade V ^a   Toutain, Pierre Louis ^c,d   Taylor, Julia A ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CREATININE; HAND SANITIZER; BENZHYDRYL DERIVATIVE; ENDOCRINE DISRUPTOR; PHENOL DERIVATIVE;

ABSORPTION; ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE URINE LEVEL; EATING; EXPOSURE; FEMALE; FOOD CONTAMINATION; FOOD INTAKE; HAND WASHING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; MALE; MASS SPECTROMETRY; ORAL EXPOSURE; PAPER; RISK FACTOR; SKIN ABSORPTION; SKIN PENETRATION; THERMAL RECEIPT PAPER; TRANSDERMAL EXPOSURE; URINALYSIS; BLOOD; CHEMISTRY; ENVIRONMENTAL EXPOSURE; URINE; YOUNG ADULT;

ADULT; BENZHYDRYL COMPOUNDS; EATING; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; FEMALE; HAND DISINFECTION; HAND SANITIZERS; HUMANS; MALE; PAPER; PHENOLS; SKIN ABSORPTION; YOUNG ADULT;

EID: 84908520960     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110509     Document Type: Article

References (49)

1. GrandViewResearch (2014) Global bisphenol A (BPA) market by appliation (appliances, automotive, consumer, construction, electrical & electronics) expected to reach USD 20.03 billion by 2020. http://www.digitaljournal.com/pr/2009287, Accessed June 24, 2014. http://www.digitaljournal.com/pr/2009287, Accessed June 24, 2014.
2. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008) Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 116: 39-44.
3. Liao C, Kannan K (2012a) Determination of free and conjugated forms of bisphenol a in human urine and serum by liquid chromatography-tandem mass spectrometry. Environ Sci Technol 46: 5003-5009.
4. Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM, et al. (2003) Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ Health Perspect 111: 994-1006.
5. Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, et al. (2013a) Low Dose Effects of Bisphenol A: An Integrated Review of In Vitro, Laboratory Animal and Epidemiology Studies. Endocrine Disruption 1: E1-E20.
6. Mendum T, Stoler E, VanBenschoten H, Warner JC (2011) Concentration of bisphenol A in thermal paper. Green Chemistry Letters and Reviews 4: 81-86.
7. Liao C, Kannan K (2011) Widespread Occurrence of Bisphenol A in Paper and Paper Products: Implications for Human Exposure. Environ Sci Technol 45: 9372-9739.
8. Funke AP, Schiller R, Motzkus HW, Gunther C, Muller RH, et al. (2002) Transdermal delivery of highly lipophilic drugs: in vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations. Pharm Res 19: 661-668.
9. Karande P, Mitragotri S (2009) Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim Biophys Acta 1788: 2362-2373.
10. EFSA (2013) Draft scientific opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs - exposure assessment; EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids; European Food Safety Authority (EFSA), Parma, Italy, July 1.
11. Xue J, Zartarian V, Moya J, Freeman N, Beamer P, et al. (2007) A meta-analysis of children's hand-to-mouth frequency data for estimating nondietary ingestion exposure. Risk Anal 27: 411-420.
12. Heffernan AL, Aylward LL, Samidurai AJ, Davies PS, Toms LM, et al. (2014) Short term variability in urinary bisphenol A in Australian children. Environ Int 68C: 139-143.
13. Singh I, Morris AP (2011) Performance of transdermal therapeutic systems: Effects of biological factors. Int J Pharm Investig 1: 4-9.
14. IBISWorld (2012) Hand sanitizer manufacturing in the US: Market research report. Feb 2012. http://www.ibisworld.com/industry/hand-sanitizer-manufacturing.html.
15. Brand RM, Charron AR, Sandler VL, Jendrzejewski JL (2007) Moisturizing lotions can increase transdermal absorption of the herbicide 2,4-dichlorophenoxacetic acid across hairless mouse skin. Cutan Ocul Toxicol 26: 15-23.
16. StatisticsBrain (2014) Fast food statistics, http://www.statisticbrain.com/fast-food-statistics/, Accessed March 26.Statistic Brain.
17. Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, et al. (2014a) A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environ Health 13: 25.
18. EPA (2014) Bisphenol A alternatives in thermal paper. United States Environmental Protection Agency, Final document, January 2014. http://www.epa.gov/dfe/pubs/projects/bpa/bpa-report-complete.pdf. Accessed 9/9/14.
19. Gayrard V, Lacroix MZ, Collet SH, Viguie C, Bousquet-Melou A, et al. (2013) High bioavailability of bisphenol a from sublingual exposure. Environ Health Perspect 121: 951-956.
20. vom Saal FS, Vandevoort CA, Taylor JA, Welshons WV, Toutain PL, et al. (2014) Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures. Reprod Toxicol 45: 105-116.
21. Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJ, et al. (2010a) Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 118: 1055-1070.
22. Fitzmaurice S, Maibach HI (2010) Gender differences in skin. In: M.A F, Miller KM, Maibach HI, editors. Textbook of Aging Skin. New York: Springer. 999-1017.
23. Polak S, Ghobadi C, Mishra H, Ahamadi M, Patel N, et al. (2012) Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption. J Pharm Sci 101: 2584-2595.
24. Levitt DG (2004) Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference. BMC Clin Pharmacol 4: 2-7.
25. Goldzieher JW, Stanczyk FZ (2008) Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins. Contraception 78: 4-9.
26. You L, Zhu X, Shrubsole MJ, Fan H, Chen J, et al. (2011) Renal function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006). Environ Health Perspect 119: 527-533.
27. Krieter DH, Canaud B, Lemke HD, Rodriguez A, Morgenroth A, et al. (2013) Bisphenol A in chronic kidney disease. Artif Organs 37: 283-290.
28. Vandenberg LN, Welshons WV, Vom Saal FS, Toutain PL, Myers JP (2014b) Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environ Health 13: 46.
29. EFSA (2008) Toxicokinetics of Bisphenol A - Scientific Opinion of the Panel on Food additives, Flavourings, Processing aids and Materials in Contact with Food (AFC). European Food Safety Authority July, 2008. http://www.efsa.europa.eu/EFSA/efsa-locale-1178620753812-1211902017492.htm. Accessed September 2, 2014.
30. FDA (2008a) Food and Drug Administration draft assessment of bisphenol A for use in Food contact applications, August 14, 2008. http://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm166145.htm. watAccessed August 6, 2014.
31. Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, et al. (2013) Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Toxicol Appl Pharmacol 267: 41-48.
32. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV (2007) Human exposure to bisphenol A (BPA). Reproductive Toxicology 24: 139-177.
33. Gayrard V, Lacroix MA, Collet SH, Viguié C, Bousquet-Melou A, et al. (2013) Interpreting Bbsphenol A absorption in the canine oral cavity. Environ Health Perspect 121: A323-A324.
34. Rochester JR (2013) Bisphenol A and human health: A review of the literature. Reprod Toxicol 42: 132-155.
35. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, et al. (2008) Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300: 1303-1310.
36. Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, et al. (2012) Urinary bisphenol a concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 125: 1482-1490.
37. Trasande L (2014) Further limiting bisphenol a in food uses could provide health and economic benefits. Health Aff (Millwood) 33: 316-323.
38. Ehrlich S, Calafat AM, Humblet O, Smith T, Hauser R (2014) Handling of thermal receipts as a source of exposure to bisphenol A. JAMA 311: 859-860.
39. Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, et al. (2011) Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ Health Perspect 119: 131-137.
40. Zalko D, Jacques C, Duplan H, Bruel S, Perdu E (2011) Viable skin efficiently absorbs and metabolizes bisphenol A. Chemosphere 82: 424-430.
41. Vanderford BJ, Drewes JE, Eaton A, Guo YC, Haghani A, et al. (2014) Results of an Interlaboratory Comparison of Analytical Methods for Contaminants of Emerging Concern in Water. Anal Chem 86: 774-782.
42. Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W (2002) Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol 15: 1281-1287.
43. Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, et al. (2014) Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Toxicol Sci 139: 4-20.
44. Ye X, Zhou X, Hennings R, Kramer J, Calafat AM (2013) Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ Health Perspect 121: 283-286.
45. Vinas R, Watson CS (2013) Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions. Environ Health Perspect 121: 352-358.
46. Welshons WV, Nagel SC, vom Saal FS (2006) Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinol 147: S56-S69.
47. Liao C, Liu F, Alomirah H, Loi VD, Mohd MA, et al. (2012) Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures. Environ Sci Technol 46: 6860-6866.
48. Environment Canada (2008) Screening Assessment for The Challenge Phenol, 4,4′ -(1-methylethylidene) bis- (Bisphenol A) Chemical Abstracts Service Registry Number 80-05-7. Environment Canada and Health Canada, Ottawa, October 2008.
49. Liao C, Kannan K (2012b) High levels of bisphenol a in paper currencies from several countries, and implications for dermal exposure. Environ Sci Technol 45: 6761-6768.