-
1
-
-
84883391069
-
The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention
-
Villamil MA, Liang Q and Zhuang Z. The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention. Cell biochemistry and biophysics. 2013; 67:111-126.
-
(2013)
Cell biochemistry and biophysics.
, vol.67
, pp. 111-126
-
-
Villamil, M.A.1
Liang, Q.2
Zhuang, Z.3
-
2
-
-
0028233372
-
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"Nend rule" protein substrates
-
Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL and Ciechanover A. Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"Nend rule" protein substrates. The Journal of biological chemistry. 1994; 269:9574-9581.
-
(1994)
The Journal of biological chemistry.
, vol.269
, pp. 9574-9581
-
-
Blumenfeld, N.1
Gonen, H.2
Mayer, A.3
Smith, C.E.4
Siegel, N.R.5
Schwartz, A.L.6
Ciechanover, A.7
-
3
-
-
0018992813
-
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation
-
Ciechanover A, Heller H, Elias S, Haas AL and Hershko A. ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proceedings of the National Academy of Sciences of the United States of America. 1980; 77:1365-1368.
-
(1980)
Proceedings of the National Academy of Sciences of the United States of America.
, vol.77
, pp. 1365-1368
-
-
Ciechanover, A.1
Heller, H.2
Elias, S.3
Haas, A.L.4
Hershko, A.5
-
4
-
-
70350150000
-
The emerging complexity of protein ubiquitination
-
Komander D. The emerging complexity of protein ubiquitination. Biochemical Society transactions. 2009; 37:937-953.
-
(2009)
Biochemical Society transactions.
, vol.37
, pp. 937-953
-
-
Komander, D.1
-
5
-
-
72549108632
-
Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation
-
Martinez-Forero I, Rouzaut A, Palazon A, Dubrot J and Melero I. Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15:6751-6757.
-
(2009)
Clinical cancer research : an official journal of the American Association for Cancer Research.
, vol.15
, pp. 6751-6757
-
-
Martinez-Forero, I.1
Rouzaut, A.2
Palazon, A.3
Dubrot, J.4
Melero, I.5
-
6
-
-
84864222562
-
Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
-
Kulathu Y and Komander D. Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nature reviews Molecular cell biology. 2012; 13:508-523.
-
(2012)
Nature reviews Molecular cell biology.
, vol.13
, pp. 508-523
-
-
Kulathu, Y.1
Komander, D.2
-
7
-
-
67649634849
-
Defining the Human Deubiquitinating Enzyme Interaction Landscape
-
Sowa ME, Bennett EJ, Gygi SP and Harper JW. Defining the Human Deubiquitinating Enzyme Interaction Landscape. Cell. 2009; 138:389-403.
-
(2009)
Cell.
, vol.138
, pp. 389-403
-
-
Sowa, M.E.1
Bennett, E.J.2
Gygi, S.P.3
Harper, J.W.4
-
8
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J and Gu W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002; 416:648-653.
-
(2002)
Nature.
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
Gu, W.7
-
9
-
-
83555162507
-
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
-
Hock AK, Vigneron Am Fau - Carter S, Carter S Fau -Ludwig RL, Ludwig Rl Fau - Vousden KH and Vousden KH. Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J. 2011; 30:4921-4930.
-
(2011)
EMBO J.
, vol.30
, pp. 4921-4930
-
-
Hock, A.K.1
Vigneron, A.M.2
Fau-Carter, S.3
Carter, S.4
Fau-Ludwig, R.L.5
Ludwig, R.L.6
Fau-Vousden, K.H.7
Vousden, K.H.8
-
10
-
-
1842421376
-
A dynamic role of HAUSP in the p53-Mdm2 pathway
-
Li M, Brooks CL, Kon N and Gu W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Molecular cell. 2004; 13:879-886.
-
(2004)
Molecular cell.
, vol.13
, pp. 879-886
-
-
Li, M.1
Brooks, C.L.2
Kon, N.3
Gu, W.4
-
11
-
-
77953777868
-
The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling
-
Dirac AM and Bernards R. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. Molecular cancer research : MCR. 2010; 8:844-854.
-
(2010)
Molecular cancer research : MCR.
, vol.8
, pp. 844-854
-
-
Dirac, A.M.1
Bernards, R.2
-
12
-
-
84887487541
-
Deubiquitinating enzyme Usp12 is a novel co-activator of the Androgen Receptor
-
Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L and Robson CN. Deubiquitinating enzyme Usp12 is a novel co-activator of the Androgen Receptor. The Journal of biological chemistry. 2013; 288:32641-32650.
-
(2013)
The Journal of biological chemistry.
, vol.288
, pp. 32641-32650
-
-
Burska, U.L.1
Harle, V.J.2
Coffey, K.3
Darby, S.4
Ramsey, H.5
O'Neill, D.6
Logan, I.R.7
Gaughan, L.8
Robson, C.N.9
-
13
-
-
79953185042
-
Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46
-
Joo HY, Jones A, Yang C, Zhai L, Smith ADt, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C and Wang H. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. The Journal of biological chemistry. 2011; 286:7190-7201.
-
(2011)
The Journal of biological chemistry.
, vol.286
, pp. 7190-7201
-
-
Joo, H.Y.1
Jones, A.2
Yang, C.3
Zhai, L.4
Smith, A.D.5
Zhang, Z.6
Chandrasekharan, M.B.7
Sun, Z.W.8
Renfrow, M.B.9
Wang, Y.10
Chang, C.11
Wang, H.12
-
14
-
-
79955985329
-
USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
-
Draker R, Sarcinella E and Cheung P. USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation. Nucleic acids research. 2011; 39:3529-3542.
-
(2011)
Nucleic acids research.
, vol.39
, pp. 3529-3542
-
-
Draker, R.1
Sarcinella, E.2
Cheung, P.3
-
15
-
-
84873055250
-
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer
-
Li X, Stevens PD, Yang H, Gulhati P, Wang W, Evers BM and Gao T. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene. 2013; 32:471-478.
-
(2013)
Oncogene.
, vol.32
, pp. 471-478
-
-
Li, X.1
Stevens, P.D.2
Yang, H.3
Gulhati, P.4
Wang, W.5
Evers, B.M.6
Gao, T.7
-
16
-
-
84907069900
-
Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
-
McClurg UL, Summerscales EE, Harle VJ, Gaughan L and Robson CN. Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway. Oncotarget. 2014; 5:7081-7092.
-
(2014)
Oncotarget.
, vol.5
, pp. 7081-7092
-
-
McClurg, U.L.1
Summerscales, E.E.2
Harle, V.J.3
Gaughan, L.4
Robson, C.N.5
-
17
-
-
84864355390
-
USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells
-
Zhiqiang Z, Qinghui Y, Yongqiang Z, Jian Z, Xin Z, Haiying M and Yuepeng G. USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. Journal of cancer research and clinical oncology. 2012; 138:1231-1238.
-
(2012)
Journal of cancer research and clinical oncology.
, vol.138
, pp. 1231-1238
-
-
Zhiqiang, Z.1
Qinghui, Y.2
Yongqiang, Z.3
Jian, Z.4
Xin, Z.5
Haiying, M.6
Yuepeng, G.7
-
18
-
-
84865455417
-
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation
-
Moretti J, Chastagner P, Liang CC, Cohn MA, Israel A and Brou C. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. The Journal of biological chemistry. 2012; 287:29429-29441.
-
(2012)
The Journal of biological chemistry.
, vol.287
, pp. 29429-29441
-
-
Moretti, J.1
Chastagner, P.2
Liang, C.C.3
Cohn, M.A.4
Israel, A.5
Brou, C.6
-
19
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D and Courtois G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature. 2003; 424:801-805.
-
(2003)
Nature.
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israel, A.4
Wallach, D.5
Courtois, G.6
-
20
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
-
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A and Mosialos G. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature. 2003; 424:793-796.
-
(2003)
Nature.
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
Farmer, H.4
Ashworth, A.5
Mosialos, G.6
-
21
-
-
0033392501
-
The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin
-
Taya S, Yamamoto T, Kanai-Azuma M, Wood SA and Kaibuchi K. The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes to cells : devoted to molecular & cellular mechanisms. 1999; 4:757-767.
-
(1999)
Genes to cells : devoted to molecular & cellular mechanisms.
, vol.4
, pp. 757-767
-
-
Taya, S.1
Yamamoto, T.2
Kanai-Azuma, M.3
Wood, S.A.4
Kaibuchi, K.5
-
23
-
-
36549056015
-
Epigenetic changes in cancer
-
Gronbaek K, Hother C and Jones PA. Epigenetic changes in cancer. APMIS. 2007; 115:1039-1059.
-
(2007)
APMIS.
, vol.115
, pp. 1039-1059
-
-
Gronbaek, K.1
Hother, C.2
Jones, P.A.3
-
24
-
-
67650215581
-
OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity
-
Stanisic V, Malovannaya A, Qin J, Lonard DM and O'Malley BW. OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. The Journal of biological chemistry. 2009; 284:16135-16145.
-
(2009)
The Journal of biological chemistry.
, vol.284
, pp. 16135-16145
-
-
Stanisic, V.1
Malovannaya, A.2
Qin, J.3
Lonard, D.M.4
O'Malley, B.W.5
-
25
-
-
30044437463
-
The ubiquitin-specific protease USP10 modulates androgen receptor function
-
Faus H, Meyer HA, Huber M, Bahr I and Haendler B. The ubiquitin-specific protease USP10 modulates androgen receptor function. Molecular and cellular endocrinology. 2005; 245:138-146.
-
(2005)
Molecular and cellular endocrinology.
, vol.245
, pp. 138-146
-
-
Faus, H.1
Meyer, H.A.2
Huber, M.3
Bahr, I.4
Haendler, B.5
-
26
-
-
34547730282
-
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
-
Zhu P, Zhou W, Wang J, Puc J, Ohgi KA, Erdjument-Bromage H, Tempst P, Glass CK and Rosenfeld MG. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Molecular cell. 2007; 27:609-621.
-
(2007)
Molecular cell.
, vol.27
, pp. 609-621
-
-
Zhu, P.1
Zhou, W.2
Wang, J.3
Puc, J.4
Ohgi, K.A.5
Erdjument-Bromage, H.6
Tempst, P.7
Glass, C.K.8
Rosenfeld, M.G.9
-
27
-
-
85039883383
-
p53 as an intervention target for cancer and aging. Pathobiology of aging & age related diseases
-
Oct
-
Hasty P and Christy BA. p53 as an intervention target for cancer and aging. Pathobiology of aging & age related diseases. 2013; Oct 8(3).
-
(2013)
, vol.8
, Issue.3
-
-
Hasty, P.1
Christy, B.A.2
-
28
-
-
84863799882
-
Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor
-
Guseva NV, Rokhlin OW, Bair TB, Glover RB and Cohen MB. Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012; 3:183-194.
-
(2012)
Oncotarget.
, vol.3
, pp. 183-194
-
-
Guseva, N.V.1
Rokhlin, O.W.2
Bair, T.B.3
Glover, R.B.4
Cohen, M.B.5
-
29
-
-
84886743570
-
Lysine-specific modifications of p53: a matter of life and death?
-
Marouco D, Garabadgiu AV, Melino G and Barlev NA. Lysine-specific modifications of p53: a matter of life and death? Oncotarget. 2013; 4:1556-1571.
-
(2013)
Oncotarget
, vol.4
, pp. 1556-1571
-
-
Marouco, D.1
Garabadgiu, A.V.2
Melino, G.3
Barlev, N.A.4
-
30
-
-
79959469514
-
The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination
-
Thalappilly S, Feng X, Pastyryeva S, Suzuki K, Muruve D, Larocque D, Richard S, Truss M, von Deimling A, Riabowol K and Tallen G. The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination. PloS one. 2011; 6:e21065.
-
(2011)
PloS one.
, vol.6
, pp. e21065
-
-
Thalappilly, S.1
Feng, X.2
Pastyryeva, S.3
Suzuki, K.4
Muruve, D.5
Larocque, D.6
Richard, S.7
Truss, M.8
von Deimling, A.9
Riabowol, K.10
Tallen, G.11
-
31
-
-
77958566202
-
USP7/HAUSP promotes the sequence-specific DNA binding activity of p53
-
Sarkari F, Sheng Y and Frappier L. USP7/HAUSP promotes the sequence-specific DNA binding activity of p53. PloS one. 2010; 5:e13040.
-
(2010)
PloS one.
, vol.5
, pp. e13040
-
-
Sarkari, F.1
Sheng, Y.2
Frappier, L.3
-
32
-
-
84856415004
-
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
-
Sun XX, Challagundla KB and Dai MS. Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J. 2012; 31:576-592.
-
(2012)
EMBO J.
, vol.31
, pp. 576-592
-
-
Sun, X.X.1
Challagundla, K.B.2
Dai, M.S.3
-
33
-
-
84894462315
-
Monoubiquitination is critical for ovarian tumor domaincontaining ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein
-
Li Y, Sun XX, Elferich J, Shinde U, David LL and Dai MS. Monoubiquitination is critical for ovarian tumor domaincontaining ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein. The Journal of biological chemistry. 2014; 289:5097-5108.
-
(2014)
The Journal of biological chemistry.
, vol.289
, pp. 5097-5108
-
-
Li, Y.1
Sun, X.X.2
Elferich, J.3
Shinde, U.4
David, L.L.5
Dai, M.S.6
-
34
-
-
84864386119
-
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitinconjugating enzyme UBC13
-
Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S and Fukai S. Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitinconjugating enzyme UBC13. The Journal of biological chemistry. 2012; 287:25860-25868.
-
(2012)
The Journal of biological chemistry.
, vol.287
, pp. 25860-25868
-
-
Sato, Y.1
Yamagata, A.2
Goto-Ito, S.3
Kubota, K.4
Miyamoto, R.5
Nakada, S.6
Fukai, S.7
-
35
-
-
79960035010
-
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation
-
Yagi R, Zhu J and Paul WE. An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. International immunology. 2011; 23:415-420.
-
(2011)
International immunology.
, vol.23
, pp. 415-420
-
-
Yagi, R.1
Zhu, J.2
Paul, W.E.3
-
36
-
-
73949087506
-
GATA3 in development and cancer differentiation: cells GATA have it
-
Chou J, Provot S and Werb Z. GATA3 in development and cancer differentiation: cells GATA have it! Journal of cellular physiology. 2010; 222:42-49.
-
(2010)
Journal of cellular physiology
, vol.222
, pp. 42-49
-
-
Chou, J.1
Provot, S.2
Werb, Z.3
-
37
-
-
84875979211
-
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3
-
Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G and Li B. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. The Journal of biological chemistry. 2013; 288:9373-9382.
-
(2013)
The Journal of biological chemistry.
, vol.288
, pp. 9373-9382
-
-
Zhang, J.1
Chen, C.2
Hou, X.3
Gao, Y.4
Lin, F.5
Yang, J.6
Gao, Z.7
Pan, L.8
Tao, L.9
Wen, C.10
Yao, Z.11
Tsun, A.12
Shi, G.13
Li, B.14
-
38
-
-
84883185607
-
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling
-
Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Han JK, Lee MJ, Finley D and Jho EH. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis. 2013; 2:e64.
-
(2013)
Oncogenesis.
, vol.2
, pp. e64
-
-
Jung, H.1
Kim, B.G.2
Han, W.H.3
Lee, J.H.4
Cho, J.Y.5
Park, W.S.6
Maurice, M.M.7
Han, J.K.8
Lee, M.J.9
Finley, D.10
Jho, E.H.11
-
39
-
-
84878208622
-
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of beta-Catenin
-
Wu N, Liu C, Bai C, Han YP, Cho WC and Li Q. Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of beta-Catenin. International journal of molecular sciences. 2013; 14:10749-10760.
-
(2013)
International journal of molecular sciences.
, vol.14
, pp. 10749-10760
-
-
Wu, N.1
Liu, C.2
Bai, C.3
Han, Y.P.4
Cho, W.C.5
Li, Q.6
-
40
-
-
38149078715
-
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
-
Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL and McMahon SB. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Molecular cell. 2008; 29:102-111.
-
(2008)
Molecular cell.
, vol.29
, pp. 102-111
-
-
Zhang, X.Y.1
Varthi, M.2
Sykes, S.M.3
Phillips, C.4
Warzecha, C.5
Zhu, W.6
Wyce, A.7
Thorne, A.W.8
Berger, S.L.9
McMahon, S.B.10
-
41
-
-
33744906046
-
Genomic models of metastatic cancer:functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencing pathway
-
Glinsky GV. Genomic models of metastatic cancer:functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencing pathway. Cell cycle (Georgetown, Tex). 2006; 5:1208-1216.
-
(2006)
Cell cycle (Georgetown, Tex).
, vol.5
, pp. 1208-1216
-
-
Glinsky, G.V.1
-
42
-
-
79952030196
-
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer
-
Liu YL, Yang YM, Xu H and Dong XS. Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer. Journal of surgical oncology. 2011; 103:283-289.
-
(2011)
Journal of surgical oncology.
, vol.103
, pp. 283-289
-
-
Liu, Y.L.1
Yang, Y.M.2
Xu, H.3
Dong, X.S.4
-
43
-
-
35548986309
-
Regulation of cell cycle progression and gene expression by H2A deubiquitination
-
Joo HY, Zhai L, Yang C, Nie S, Erdjument-Bromage H, Tempst P, Chang C and Wang H. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 2007; 449:1068-1072.
-
(2007)
Nature.
, vol.449
, pp. 1068-1072
-
-
Joo, H.Y.1
Zhai, L.2
Yang, C.3
Nie, S.4
Erdjument-Bromage, H.5
Tempst, P.6
Chang, C.7
Wang, H.8
-
44
-
-
84886667168
-
Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression
-
Xu Y, Yang H, Joo HY, Yu JH, Smith ADt, Schneider D, Chow LT, Renfrow M and Wang H. Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression. Cell cycle (Georgetown, Tex). 2013; 12:3219-3227.
-
(2013)
Cell cycle (Georgetown, Tex).
, vol.12
, pp. 3219-3227
-
-
Xu, Y.1
Yang, H.2
Joo, H.Y.3
Yu, J.H.4
Smith, A.D.5
Schneider, D.6
Chow, L.T.7
Renfrow, M.8
Wang, H.9
-
45
-
-
84899820221
-
The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment
-
Yang W, Lee YH, Jones AE, Woolnough JL, Zhou D, Dai Q, Wu Q, Giles KE, Townes TM and Wang H. The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nature communications. 2014; 5:3818.
-
(2014)
Nature communications.
, vol.5
, pp. 3818
-
-
Yang, W.1
Lee, Y.H.2
Jones, A.E.3
Woolnough, J.L.4
Zhou, D.5
Dai, Q.6
Wu, Q.7
Giles, K.E.8
Townes, T.M.9
Wang, H.10
-
46
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma S, Chen BP, Murphy M, Kurimasa A and Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. The Journal of biological chemistry. 2001; 276(45):462-467.
-
(2001)
The Journal of biological chemistry
, vol.276
, Issue.45
, pp. 462-467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
47
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M and Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer research. 2004; 64:2390-2396.
-
(2004)
Cancer research.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
O'Driscoll, M.2
Rief, N.3
Iwabuchi, K.4
Lobrich, M.5
Jeggo, P.A.6
-
48
-
-
84900790137
-
RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair
-
Li T, Guan J, Huang Z, Hu X and Zheng X. RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair. Journal of cell science. 2014; 127:2238-2248.
-
(2014)
Journal of cell science.
, vol.127
, pp. 2238-2248
-
-
Li, T.1
Guan, J.2
Huang, Z.3
Hu, X.4
Zheng, X.5
-
49
-
-
84892562030
-
USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15
-
Sharma N, Zhu Q, Wani G, He J, Wang QE and Wani AA. USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15. Cell cycle (Georgetown, Tex). 2014; 13:106-114.
-
(2014)
Cell cycle (Georgetown, Tex).
, vol.13
, pp. 106-114
-
-
Sharma, N.1
Zhu, Q.2
Wani, G.3
He, J.4
Wang, Q.E.5
Wani, A.A.6
-
50
-
-
38149081168
-
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di-and trimethylation
-
Nakagawa T, Kajitani T, Togo S, Masuko N, Ohdan H, Hishikawa Y, Koji T, Matsuyama T, Ikura T, Muramatsu M and Ito T. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di-and trimethylation. Genes & development. 2008; 22:37-49.
-
(2008)
Genes & development.
, vol.22
, pp. 37-49
-
-
Nakagawa, T.1
Kajitani, T.2
Togo, S.3
Masuko, N.4
Ohdan, H.5
Hishikawa, Y.6
Koji, T.7
Matsuyama, T.8
Ikura, T.9
Muramatsu, M.10
Ito, T.11
-
51
-
-
84878758649
-
The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
-
Mosbech A, Lukas C, Bekker-Jensen S and Mailand N. The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. The Journal of biological chemistry. 2013; 288:16579-16587.
-
(2013)
The Journal of biological chemistry.
, vol.288
, pp. 16579-16587
-
-
Mosbech, A.1
Lukas, C.2
Bekker-Jensen, S.3
Mailand, N.4
-
52
-
-
84880424207
-
USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing
-
Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Tempst P, Townes TM, Giles KE, Ma L and Wang H. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes & development. 2013; 27:1581-1595.
-
(2013)
Genes & development.
, vol.27
, pp. 1581-1595
-
-
Zhang, Z.1
Jones, A.2
Joo, H.Y.3
Zhou, D.4
Cao, Y.5
Chen, S.6
Erdjument-Bromage, H.7
Renfrow, M.8
He, H.9
Tempst, P.10
Townes, T.M.11
Giles, K.E.12
Ma, L.13
Wang, H.14
-
53
-
-
84918540501
-
Ubiquitinspecific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity
-
Hock AK, Vigneron AM and Vousden KH. Ubiquitinspecific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. The Journal of biological chemistry. 2014; 289:34862-34870.
-
(2014)
The Journal of biological chemistry.
, vol.289
, pp. 34862-34870
-
-
Hock, A.K.1
Vigneron, A.M.2
Vousden, K.H.3
-
54
-
-
14644406268
-
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
-
van der Knaap JA, Kumar BR, Moshkin YM, Langenberg K, Krijgsveld J, Heck AJ, Karch F and Verrijzer CP. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Molecular cell. 2005; 17:695-707.
-
(2005)
Molecular cell.
, vol.17
, pp. 695-707
-
-
van der Knaap, J.A.1
Kumar, B.R.2
Moshkin, Y.M.3
Langenberg, K.4
Krijgsveld, J.5
Heck, A.J.6
Karch, F.7
Verrijzer, C.P.8
-
55
-
-
64149129169
-
UAF1 is a subunit of multiple deubiquitinating enzyme complexes
-
Cohn MA, Kee Y, Haas W, Gygi SP and D'Andrea AD. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. The Journal of biological chemistry. 2009; 284:5343-5351.
-
(2009)
The Journal of biological chemistry.
, vol.284
, pp. 5343-5351
-
-
Cohn, M.A.1
Kee, Y.2
Haas, W.3
Gygi, S.P.4
D'Andrea, A.D.5
-
56
-
-
77951247308
-
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex
-
Kee Y, Yang K, Cohn MA, Haas W, Gygi SP and D'Andrea AD. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. The Journal of biological chemistry. 2010; 285:11252-11257.
-
(2010)
The Journal of biological chemistry.
, vol.285
, pp. 11252-11257
-
-
Kee, Y.1
Yang, K.2
Cohn, M.A.3
Haas, W.4
Gygi, S.P.5
D'Andrea, A.D.6
-
57
-
-
45849133054
-
USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A
-
Zhang XY, Pfeiffer HK, Thorne AW and McMahon SB. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Cell cycle (Georgetown, Tex). 2008; 7:1522-1524.
-
(2008)
Cell cycle (Georgetown, Tex).
, vol.7
, pp. 1522-1524
-
-
Zhang, X.Y.1
Pfeiffer, H.K.2
Thorne, A.W.3
McMahon, S.B.4
-
58
-
-
84923573977
-
Ubiquitination and cancer: Histone H2B monoubiquitination - roles to play in human malignancy
-
Cole AJ, Clifton-Bligh RJ and Marsh DJ. Ubiquitination and cancer: Histone H2B monoubiquitination - roles to play in human malignancy. Endocrine-related cancer. 2014; 22:19-33.
-
(2014)
Endocrine-related cancer.
, vol.22
, pp. 19-33
-
-
Cole, A.J.1
Clifton-Bligh, R.J.2
Marsh, D.J.3
-
59
-
-
77957002197
-
A screen for deubiquitinating enzymes involved in the G(2)/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability
-
Aressy B, Jullien D, Cazales M, Marcellin M, Bugler B, Burlet-Schiltz O and Ducommun B. A screen for deubiquitinating enzymes involved in the G(2)/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. Cell cycle (Georgetown, Tex). 2010; 9:3815-3822.
-
(2010)
Cell cycle (Georgetown, Tex).
, vol.9
, pp. 3815-3822
-
-
Aressy, B.1
Jullien, D.2
Cazales, M.3
Marcellin, M.4
Bugler, B.5
Burlet-Schiltz, O.6
Ducommun, B.7
-
60
-
-
68349133311
-
Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance
-
Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S and Dent SY. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Molecular cell. 2009; 35:352-364.
-
(2009)
Molecular cell.
, vol.35
, pp. 352-364
-
-
Atanassov, B.S.1
Evrard, Y.A.2
Multani, A.S.3
Zhang, Z.4
Tora, L.5
Devys, D.6
Chang, S.7
Dent, S.Y.8
-
61
-
-
84861461517
-
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development
-
Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD and Fang D. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. 2012; 46:484-494.
-
(2012)
Molecular cell.
, vol.46
, pp. 484-494
-
-
Lin, Z.1
Yang, H.2
Kong, Q.3
Li, J.4
Lee, S.M.5
Gao, B.6
Dong, H.7
Wei, J.8
Song, J.9
Zhang, D.D.10
Fang, D.11
-
62
-
-
84919783983
-
USP22 Promotes NSCLC Tumorigenesis via MDMX Up-Regulation and Subsequent p53 Inhibition
-
Ding F, Bao C, Tian Y, Xiao H, Wang M, Xie X, Hu F and Mei J. USP22 Promotes NSCLC Tumorigenesis via MDMX Up-Regulation and Subsequent p53 Inhibition. International journal of molecular sciences. 2014; 16:307-320.
-
(2014)
International journal of molecular sciences.
, vol.16
, pp. 307-320
-
-
Ding, F.1
Bao, C.2
Tian, Y.3
Xiao, H.4
Wang, M.5
Xie, X.6
Hu, F.7
Mei, J.8
-
63
-
-
33645708319
-
Regulation of monoubiquitinated PCNA by DUB autocleavage
-
Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R and D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature cell biology. 2006; 8:339-347.
-
(2006)
Nature cell biology.
, vol.8
, pp. 339-347
-
-
Huang, T.T.1
Nijman, S.M.2
Mirchandani, K.D.3
Galardy, P.J.4
Cohn, M.A.5
Haas, W.6
Gygi, S.P.7
Ploegh, H.L.8
Bernards, R.9
D'Andrea, A.D.10
-
64
-
-
80052919716
-
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma
-
Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RA and Dixit VM. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell. 2011; 146:918-930.
-
(2011)
Cell.
, vol.146
, pp. 918-930
-
-
Williams, S.A.1
Maecker, H.L.2
French, D.M.3
Liu, J.4
Gregg, A.5
Silverstein, L.B.6
Cao, T.C.7
Carano, R.A.8
Dixit, V.M.9
-
65
-
-
59649114341
-
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype
-
Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL and D'Andrea AD. Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Developmental cell. 2009; 16:314-320.
-
(2009)
Developmental cell.
, vol.16
, pp. 314-320
-
-
Kim, J.M.1
Parmar, K.2
Huang, M.3
Weinstock, D.M.4
Ruit, C.A.5
Kutok, J.L.6
D'Andrea, A.D.7
-
66
-
-
84886997828
-
Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice
-
Park E, Kim JM, Primack B, Weinstock DM, Moreau LA, Parmar K and D'Andrea AD. Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Molecular and cellular biology. 2013; 33:4360-4370.
-
(2013)
Molecular and cellular biology.
, vol.33
, pp. 4360-4370
-
-
Park, E.1
Kim, J.M.2
Primack, B.3
Weinstock, D.M.4
Moreau, L.A.5
Parmar, K.6
D'Andrea, A.D.7
-
67
-
-
75749132016
-
USP10 regulates p53 localization and stability by deubiquitinating p53
-
Yuan J, Luo K, Zhang L, Cheville JC and Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010; 140:384-396.
-
(2010)
Cell.
, vol.140
, pp. 384-396
-
-
Yuan, J.1
Luo, K.2
Zhang, L.3
Cheville, J.C.4
Lou, Z.5
-
68
-
-
33746766974
-
A role for the deubiquitinating enzyme USP28 in control of the DNAdamage response
-
Zhang D, Zaugg K, Mak TW and Elledge SJ. A role for the deubiquitinating enzyme USP28 in control of the DNAdamage response. Cell. 2006; 126:529-542.
-
(2006)
Cell.
, vol.126
, pp. 529-542
-
-
Zhang, D.1
Zaugg, K.2
Mak, T.W.3
Elledge, S.J.4
-
69
-
-
84873862712
-
Stress granules inhibit apoptosis by reducing reactive oxygen species production
-
Takahashi M, Higuchi M, Matsuki H, Yoshita M, Ohsawa T, Oie M and Fujii M. Stress granules inhibit apoptosis by reducing reactive oxygen species production. Molecular and cellular biology. 2013; 33:815-829.
-
(2013)
Molecular and cellular biology.
, vol.33
, pp. 815-829
-
-
Takahashi, M.1
Higuchi, M.2
Matsuki, H.3
Yoshita, M.4
Ohsawa, T.5
Oie, M.6
Fujii, M.7
-
70
-
-
84859111172
-
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
-
Khoronenkova SV, Dianova, II, Ternette N, Kessler BM, Parsons JL and Dianov GL. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Molecular cell. 2012; 45:801-813.
-
(2012)
Molecular cell.
, vol.45
, pp. 801-813
-
-
Khoronenkova, S.V.1
Dianova, I.I.2
Ternette, N.3
Kessler, B.M.4
Parsons, J.L.5
Dianov, G.L.6
-
71
-
-
77952715402
-
Posttranslational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
-
Edelmann MJ, Kramer HB, Altun M and Kessler BM. Posttranslational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion. The FEBS journal. 2010; 277:2515-2530.
-
(2010)
The FEBS journal.
, vol.277
, pp. 2515-2530
-
-
Edelmann, M.J.1
Kramer, H.B.2
Altun, M.3
Kessler, B.M.4
-
72
-
-
77957893483
-
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity
-
Kouranti I, McLean JR, Feoktistova A, Liang P, Johnson AE, Roberts-Galbraith RH and Gould KL. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol. 2010; 8:e1000471.
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000471
-
-
Kouranti, I.1
McLean, J.R.2
Feoktistova, A.3
Liang, P.4
Johnson, A.E.5
Roberts-Galbraith, R.H.6
Gould, K.L.7
-
73
-
-
84869068767
-
Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1
-
Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH and Zhuang Z. Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. Biochemistry. 2012; 51:9112-9123.
-
(2012)
Biochemistry.
, vol.51
, pp. 9112-9123
-
-
Villamil, M.A.1
Liang, Q.2
Chen, J.3
Choi, Y.S.4
Hou, S.5
Lee, K.H.6
Zhuang, Z.7
-
74
-
-
82855170868
-
Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle
-
Cotto-Rios XM, Jones MJ and Huang TT. Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell cycle (Georgetown, Tex). 2011; 10:4009-4016.
-
(2011)
Cell cycle (Georgetown, Tex).
, vol.10
, pp. 4009-4016
-
-
Cotto-Rios, X.M.1
Jones, M.J.2
Huang, T.T.3
-
75
-
-
84878966189
-
CAPNS1 regulates USP1 stability and maintenance of genome integrity
-
Cataldo F, Peche LY, Klaric E, Brancolini C, Myers MP, Demarchi F and Schneider C. CAPNS1 regulates USP1 stability and maintenance of genome integrity. Molecular and cellular biology. 2013; 33:2485-2496.
-
(2013)
Molecular and cellular biology.
, vol.33
, pp. 2485-2496
-
-
Cataldo, F.1
Peche, L.Y.2
Klaric, E.3
Brancolini, C.4
Myers, M.P.5
Demarchi, F.6
Schneider, C.7
-
76
-
-
84862291218
-
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1
-
Mahul-Mellier AL, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G and Grimm S. De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochimica et biophysica acta. 2012; 1823:1353-1365.
-
(2012)
Biochimica et biophysica acta.
, vol.1823
, pp. 1353-1365
-
-
Mahul-Mellier, A.L.1
Datler, C.2
Pazarentzos, E.3
Lin, B.4
Chaisaklert, W.5
Abuali, G.6
Grimm, S.7
-
77
-
-
80053501671
-
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
-
Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 2011; 147:223-234.
-
(2011)
Cell.
, vol.147
, pp. 223-234
-
-
Liu, J.1
Xia, H.2
Kim, M.3
Xu, L.4
Li, Y.5
Zhang, L.6
Cai, Y.7
Norberg, H.V.8
Zhang, T.9
Furuya, T.10
Jin, M.11
Zhu, Z.12
Wang, H.13
Yu, J.14
Li, Y.15
Hao, Y.16
-
78
-
-
84914165998
-
USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A
-
Xiong J, Xu X, Zhou X, Liu J, Gong Z, Wu P and Li W. USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. Molecular medicine reports. 2014; 10:3343-3347.
-
(2014)
Molecular medicine reports.
, vol.10
, pp. 3343-3347
-
-
Xiong, J.1
Xu, X.2
Zhou, X.3
Liu, J.4
Gong, Z.5
Wu, P.6
Li, W.7
-
79
-
-
80053594090
-
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
-
Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A and Sixma TK. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular cell. 2011; 44:147-159.
-
(2011)
Molecular cell.
, vol.44
, pp. 147-159
-
-
Faesen, A.C.1
Dirac, A.M.2
Shanmugham, A.3
Ovaa, H.4
Perrakis, A.5
Sixma, T.K.6
-
80
-
-
84871675699
-
The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway
-
Piatkov KI, Colnaghi L, Bekes M, Varshavsky A and Huang TT. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Molecular cell. 2012; 48:926-933.
-
(2012)
Molecular cell.
, vol.48
, pp. 926-933
-
-
Piatkov, K.I.1
Colnaghi, L.2
Bekes, M.3
Varshavsky, A.4
Huang, T.T.5
-
81
-
-
84883740585
-
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1
-
Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ and Wolberger C. E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nature structural & molecular biology. 2013; 20:1033-1039.
-
(2013)
Nature structural & molecular biology.
, vol.20
, pp. 1033-1039
-
-
Wiener, R.1
DiBello, A.T.2
Lombardi, P.M.3
Guzzo, C.M.4
Zhang, X.5
Matunis, M.J.6
Wolberger, C.7
-
83
-
-
84896731040
-
The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro
-
Okuda H, Ohdan H, Nakayama M, Koseki H, Nakagawa T and Ito T. The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro. PloS one. 2013; 8:e79813.
-
(2013)
PloS one.
, vol.8
, pp. e79813
-
-
Okuda, H.1
Ohdan, H.2
Nakayama, M.3
Koseki, H.4
Nakagawa, T.5
Ito, T.6
-
84
-
-
41549134048
-
Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity
-
Ke Q, Ellen TP and Costa M. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicology and applied pharmacology. 2008; 228:190-199.
-
(2008)
Toxicology and applied pharmacology.
, vol.228
, pp. 190-199
-
-
Ke, Q.1
Ellen, T.P.2
Costa, M.3
-
86
-
-
84555218153
-
The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
-
Faesen Alex C, Luna-Vargas Mark PA, Geurink Paul P, Clerici M, Merkx R, van Dijk Willem J, Hameed Dharjath S, El Oualid F, Ovaa H and Sixma Titia K. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chemistry & biology. 2011; 18:1550-1561.
-
(2011)
Chemistry & biology.
, vol.18
, pp. 1550-1561
-
-
Faesen Alex, C.1
Luna-Vargas Mark, P.A.2
Geurink Paul, P.3
Clerici, M.4
Merkx, R.5
van Dijk Willem, J.6
Hameed Dharjath, S.7
El Oualid, F.8
Ovaa, H.9
Sixma Titia, K.10
-
87
-
-
82255194029
-
Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in nonsmall cell lung cancer cells
-
Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A and Zhuang Z. Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in nonsmall cell lung cancer cells. Chemistry & biology. 2011; 18:1390-1400.
-
(2011)
Chemistry & biology.
, vol.18
, pp. 1390-1400
-
-
Chen, J.1
Dexheimer, T.S.2
Ai, Y.3
Liang, Q.4
Villamil, M.A.5
Inglese, J.6
Maloney, D.J.7
Jadhav, A.8
Simeonov, A.9
Zhuang, Z.10
-
88
-
-
84896603075
-
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
-
Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nature chemical biology. 2014; 10:298-304.
-
(2014)
Nature chemical biology.
, vol.10
, pp. 298-304
-
-
Liang, Q.1
Dexheimer, T.S.2
Zhang, P.3
Rosenthal, A.S.4
Villamil, M.A.5
You, C.6
Zhang, Q.7
Chen, J.8
Ott, C.A.9
Sun, H.10
Luci, D.K.11
Yuan, B.12
Simeonov, A.13
Jadhav, A.14
Xiao, H.15
Wang, Y.16
-
89
-
-
84907886762
-
Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer
-
Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A, Zhuang Z and Maloney DJ. Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. Journal of medicinal chemistry. 2014; 57:8099-8110.
-
(2014)
Journal of medicinal chemistry.
, vol.57
, pp. 8099-8110
-
-
Dexheimer, T.S.1
Rosenthal, A.S.2
Luci, D.K.3
Liang, Q.4
Villamil, M.A.5
Chen, J.6
Sun, H.7
Kerns, E.H.8
Simeonov, A.9
Jadhav, A.10
Zhuang, Z.11
Maloney, D.J.12
-
90
-
-
84929596526
-
Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex
-
(Bethesda MD: NIH Molecular Libraries Programme
-
Dexheimer TS, Rosenthal AS, Liang Q, Chen J, Villamil MA, Kerns EH, Simeonov A, Jadhav A, Zhuang Z and Maloney DJ. (2010). Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. Probe Reports from the NIH Molecular Libraries Program. (Bethesda MD: NIH Molecular Libraries Programme).
-
(2010)
Probe Reports from the NIH Molecular Libraries Program
-
-
Dexheimer, T.S.1
Rosenthal, A.S.2
Liang, Q.3
Chen, J.4
Villamil, M.A.5
Kerns, E.H.6
Simeonov, A.7
Jadhav, A.8
Zhuang, Z.9
Maloney, D.J.10
-
91
-
-
84890525480
-
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells
-
Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD and Parmar K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Molecular cancer therapeutics. 2013; 12:2651-2662.
-
(2013)
Molecular cancer therapeutics.
, vol.12
, pp. 2651-2662
-
-
Mistry, H.1
Hsieh, G.2
Buhrlage, S.J.3
Huang, M.4
Park, E.5
Cuny, G.D.6
Galinsky, I.7
Stone, R.M.8
Gray, N.S.9
D'Andrea, A.D.10
Parmar, K.11
-
93
-
-
84860112066
-
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
-
Reverdy C, Conrath S, Lopez R, Planquette C, Atmanene C, Collura V, Harpon J, Battaglia V, Vivat V, Sippl W and Colland F. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chemistry & biology. 2012; 19:467-477.
-
(2012)
Chemistry & biology.
, vol.19
, pp. 467-477
-
-
Reverdy, C.1
Conrath, S.2
Lopez, R.3
Planquette, C.4
Atmanene, C.5
Collura, V.6
Harpon, J.7
Battaglia, V.8
Vivat, V.9
Sippl, W.10
Colland, F.11
-
94
-
-
84898802930
-
Toward understanding ubiquitinmodifying enzymes: from pharmacological targeting to proteomics
-
Lill JR and Wertz IE. Toward understanding ubiquitinmodifying enzymes: from pharmacological targeting to proteomics. Trends in pharmacological sciences. 2014; 35:187-207.
-
(2014)
Trends in pharmacological sciences.
, vol.35
, pp. 187-207
-
-
Lill, J.R.1
Wertz, I.E.2
-
95
-
-
84866021069
-
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
-
Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, McDermott JL, Leach CA, Fulcinniti M, Kodrasov MP, Weinstock J, Kingsbury WD, Hideshima T, Shah PK, Minvielle S, Altun M, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer cell. 2012; 22:345-358.
-
(2012)
Cancer cell.
, vol.22
, pp. 345-358
-
-
Chauhan, D.1
Tian, Z.2
Nicholson, B.3
Kumar, K.G.4
Zhou, B.5
Carrasco, R.6
McDermott, J.L.7
Leach, C.A.8
Fulcinniti, M.9
Kodrasov, M.P.10
Weinstock, J.11
Kingsbury, W.D.12
Hideshima, T.13
Shah, P.K.14
Minvielle, S.15
Altun, M.16
-
96
-
-
84887471999
-
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
-
Fan YH, Cheng J, Vasudevan SA, Dou J, Zhang H, Patel RH, Ma IT, Rojas Y, Zhao Y, Yu Y, Zhang H, Shohet JM, Nuchtern JG, Kim ES and Yang J. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell death & disease. 2013; 4:e867.
-
(2013)
Cell death & disease.
, vol.4
, pp. e867
-
-
Fan, Y.H.1
Cheng, J.2
Vasudevan, S.A.3
Dou, J.4
Zhang, H.5
Patel, R.H.6
Ma, I.T.7
Rojas, Y.8
Zhao, Y.9
Yu, Y.10
Zhang, H.11
Shohet, J.M.12
Nuchtern, J.G.13
Kim, E.S.14
Yang, J.15
-
97
-
-
82255181181
-
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes
-
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chemistry & biology. 2011; 18:1401-1412.
-
(2011)
Chemistry & biology.
, vol.18
, pp. 1401-1412
-
-
Altun, M.1
Kramer, H.B.2
Willems, L.I.3
McDermott, J.L.4
Leach, C.A.5
Goldenberg, S.J.6
Kumar, K.G.7
Konietzny, R.8
Fischer, R.9
Kogan, E.10
Mackeen, M.M.11
McGouran, J.12
Khoronenkova, S.V.13
Parsons, J.L.14
Dianov, G.L.15
Nicholson, B.16
-
98
-
-
84856085129
-
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
-
D'Arcy P, Brnjic S, Olofsson MH, Fryknas M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R and Linder S. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011; 17:1636-1640.
-
(2011)
Nat Med.
, vol.17
, pp. 1636-1640
-
-
D'Arcy, P.1
Brnjic, S.2
Olofsson, M.H.3
Fryknas, M.4
Lindsten, K.5
De Cesare, M.6
Perego, P.7
Sadeghi, B.8
Hassan, M.9
Larsson, R.10
Linder, S.11
-
99
-
-
84882265186
-
Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-kappaB inhibition and p53 reactivation in human lung cancer cells
-
Zhou B, Zuo Y, Li B, Wang H, Liu H, Wang X, Qiu X, Hu Y, Wen S, Du J and Bu X. Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-kappaB inhibition and p53 reactivation in human lung cancer cells. Molecular cancer therapeutics. 2013; 12:1381-1392.
-
(2013)
Molecular cancer therapeutics.
, vol.12
, pp. 1381-1392
-
-
Zhou, B.1
Zuo, Y.2
Li, B.3
Wang, H.4
Liu, H.5
Wang, X.6
Qiu, X.7
Hu, Y.8
Wen, S.9
Du, J.10
Bu, X.11
|