-
1
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
D. E. Kleiner et al., Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 2005 41 6 1313 1321
-
(2005)
Hepatology
, vol.41
, Issue.6
, pp. 1313-1321
-
-
Kleiner, D.E.1
-
2
-
-
34547491854
-
Obesity and nonalcoholic fatty liver disease
-
P. Angulo Obesity and nonalcoholic fatty liver disease Nutr. Rev. 2007 65 6 Pt 2 S57 S63
-
(2007)
Nutr. Rev.
, vol.65
, Issue.6
, pp. S57-S63
-
-
Angulo, P.1
-
3
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
M. Ekstedt et al., Long-term follow-up of patients with NAFLD and elevated liver enzymes Hepatology 2006 44 4 865 873
-
(2006)
Hepatology
, vol.44
, Issue.4
, pp. 865-873
-
-
Ekstedt, M.1
-
4
-
-
29144492553
-
Pathology of nonalcoholic steatohepatitis
-
E. M. Brunt Pathology of nonalcoholic steatohepatitis Hepatol. Res. 2005 33 2 68 71
-
(2005)
Hepatol. Res.
, vol.33
, Issue.2
, pp. 68-71
-
-
Brunt, E.M.1
-
5
-
-
38449085703
-
Nonalcoholic fatty liver disease as a feature of the metabolic syndrome
-
P. Socha et al., Nonalcoholic fatty liver disease as a feature of the metabolic syndrome Rocz. Panstw. Zakl. Hig. 2007 58 1 129 137
-
(2007)
Rocz. Panstw. Zakl. Hig.
, vol.58
, Issue.1
, pp. 129-137
-
-
Socha, P.1
-
6
-
-
84876154662
-
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
-
H. Jo et al., Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor Hepatology 2013 57 4 1366 1377
-
(2013)
Hepatology
, vol.57
, Issue.4
, pp. 1366-1377
-
-
Jo, H.1
-
7
-
-
84860483727
-
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
-
S. Fu S. M. Watkins G. S. Hotamisligil The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling Cell Metab. 2012 15 5 623 634
-
(2012)
Cell Metab.
, vol.15
, Issue.5
, pp. 623-634
-
-
Fu, S.1
Watkins, S.M.2
Hotamisligil, G.S.3
-
8
-
-
82255173966
-
The unfolded protein response: from stress pathway to homeostatic regulation
-
P. Walter D. Ron The unfolded protein response: from stress pathway to homeostatic regulation Science 2011 334 6059 1081 1086
-
(2011)
Science
, vol.334
, Issue.6059
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
9
-
-
84856111924
-
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
-
C. Hetz The unfolded protein response: controlling cell fate decisions under ER stress and beyond Nat. Rev. Mol. Cell Biol. 2012 13 2 89 102
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, Issue.2
, pp. 89-102
-
-
Hetz, C.1
-
10
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
D. L. Eizirik A. K. Cardozo M. Cnop The role for endoplasmic reticulum stress in diabetes mellitus Endocr. Rev. 2008 29 1 42 61
-
(2008)
Endocr. Rev.
, vol.29
, Issue.1
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
11
-
-
84862776863
-
Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets
-
J. Li et al., Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets J. Hepatol. 2012 56 4 900 907
-
(2012)
J. Hepatol.
, vol.56
, Issue.4
, pp. 900-907
-
-
Li, J.1
-
12
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
J. Hirosumi et al., A central role for JNK in obesity and insulin resistance Nature 2002 420 6913 333 336
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 333-336
-
-
Hirosumi, J.1
-
13
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
H. L. Kammoun et al., GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 2009 119 5 1201 1215
-
(2009)
J. Clin. Invest.
, vol.119
, Issue.5
, pp. 1201-1215
-
-
Kammoun, H.L.1
-
14
-
-
84886558949
-
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
-
Y. Kawano D. E. Cohen Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease J. Gastroenterol. 2013 48 4 434 441
-
(2013)
J. Gastroenterol.
, vol.48
, Issue.4
, pp. 434-441
-
-
Kawano, Y.1
Cohen, D.E.2
-
15
-
-
84891702448
-
PPAR-alpha as a key nutritional and environmental sensor for metabolic adaptation
-
A. V. Contreras N. Torres A. R. Tovar PPAR-alpha as a key nutritional and environmental sensor for metabolic adaptation Adv. Nutr. 2013 4 4 439 452
-
(2013)
Adv. Nutr.
, vol.4
, Issue.4
, pp. 439-452
-
-
Contreras, A.V.1
Torres, N.2
Tovar, A.R.3
-
16
-
-
1542283630
-
Peroxisome proliferator-activated receptor alpha target genes
-
S. Mandard M. Muller S. Kersten Peroxisome proliferator-activated receptor alpha target genes Cell Mol. Life Sci. 2004 61 4 393 416
-
(2004)
Cell Mol. Life Sci.
, vol.61
, Issue.4
, pp. 393-416
-
-
Mandard, S.1
Muller, M.2
Kersten, S.3
-
17
-
-
34548094132
-
The role of PPAR alpha in the pathogenesis of fatty liver disease
-
L. Xu Y. M. Li The role of PPAR alpha in the pathogenesis of fatty liver disease Zhonghua Ganzangbing Zazhi 2005 13 9 715 717
-
(2005)
Zhonghua Ganzangbing Zazhi
, vol.13
, Issue.9
, pp. 715-717
-
-
Xu, L.1
Li, Y.M.2
-
18
-
-
69449086702
-
Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human
-
M. Rakhshandehroo et al., Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human PLoS One 2009 4 8 e6796
-
(2009)
PLoS One
, vol.4
, Issue.8
-
-
Rakhshandehroo, M.1
-
19
-
-
77956868119
-
The Role of PPAR Activation in Liver and Muscle
-
L. Burri G. H. Thoresen R. K. Berge The Role of PPAR Activation in Liver and Muscle PPAR Res. 2010 2010 11
-
(2010)
PPAR Res.
, vol.2010
, pp. 11
-
-
Burri, L.1
Thoresen, G.H.2
Berge, R.K.3
-
20
-
-
38949149637
-
Ursolic acid: an anti- and pro-inflammatory triterpenoid
-
Y. Ikeda A. Murakami H. Ohigashi Ursolic acid: an anti- and pro-inflammatory triterpenoid Mol. Nutr. Food Res. 2008 52 1 26 42
-
(2008)
Mol. Nutr. Food Res.
, vol.52
, Issue.1
, pp. 26-42
-
-
Ikeda, Y.1
Murakami, A.2
Ohigashi, H.3
-
21
-
-
77953884960
-
Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3
-
M. F. Azevedo et al., Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3 Phytother. Res. 2010 24 Suppl 2 S220 S224
-
(2010)
Phytother. Res.
, vol.24
, pp. S220-S224
-
-
Azevedo, M.F.1
-
22
-
-
34247115917
-
Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator
-
S. H. Jung et al., Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator Biochem. J. 2007 403 2 243 250
-
(2007)
Biochem. J.
, vol.403
, Issue.2
, pp. 243-250
-
-
Jung, S.H.1
-
23
-
-
84864234886
-
Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors alpha and gamma
-
L. Wang et al., Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors alpha and gamma Zhongxiyi Jiehe Xuebao 2012 10 7 793 799
-
(2012)
Zhongxiyi Jiehe Xuebao
, vol.10
, Issue.7
, pp. 793-799
-
-
Wang, L.1
-
24
-
-
84862665187
-
Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease
-
S. D. Kunkel et al., Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease PLoS One 2012 7 6 e39332
-
(2012)
PLoS One
, vol.7
, Issue.6
-
-
Kunkel, S.D.1
-
25
-
-
84897382346
-
Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats
-
S. Li et al., Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats PLoS One 2014 9 1 e86724
-
(2014)
PLoS One
, vol.9
, Issue.1
-
-
Li, S.1
-
26
-
-
84929466333
-
-
Science, John Wiley & Sons, 1st edn
-
M. H. de Angelis, P. Chambon and S. Brown, Standards of Mouse Model Phenotyping, Science, John Wiley & Sons, 1st edn, 2009, vol. 1, pp. 113-114
-
(2009)
Standards of Mouse Model Phenotyping
, vol.1
, pp. 113-114
-
-
De Angelis, M.H.1
Chambon, P.2
Brown, S.3
-
27
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
E. G. Bligh W. J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 1959 37 8 911 917
-
(1959)
Can. J. Biochem. Physiol.
, vol.37
, Issue.8
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
28
-
-
34548746833
-
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
-
S. Joshi-Barve et al., Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes Hepatology 2007 46 3 823 830
-
(2007)
Hepatology
, vol.46
, Issue.3
, pp. 823-830
-
-
Joshi-Barve, S.1
-
29
-
-
21244474062
-
Oil red-O stains non-adipogenic cells: a precautionary note
-
A. D. Kinkel et al., Oil red-O stains non-adipogenic cells: a precautionary note Cytotechnology 2004 46 1 49 56
-
(2004)
Cytotechnology
, vol.46
, Issue.1
, pp. 49-56
-
-
Kinkel, A.D.1
-
30
-
-
84862853852
-
Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol
-
C. Li et al., Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol Invest. Ophthalmol. Vis. Sci. 2012 53 6 3241 3249
-
(2012)
Invest. Ophthalmol. Vis. Sci.
, vol.53
, Issue.6
, pp. 3241-3249
-
-
Li, C.1
-
31
-
-
84862842660
-
Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress
-
C. Li et al., Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress Biochem. Biophys. Res. Commun. 2012 423 2 276 281
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.423
, Issue.2
, pp. 276-281
-
-
Li, C.1
-
32
-
-
84924422444
-
Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury
-
J. Huang et al., Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury Epigenetics 2015 10 1 62 72
-
(2015)
Epigenetics
, vol.10
, Issue.1
, pp. 62-72
-
-
Huang, J.1
-
33
-
-
57049146350
-
ER stress and lipogenesis: a slippery slope toward hepatic steatosis
-
S. Basseri R. C. Austin ER stress and lipogenesis: a slippery slope toward hepatic steatosis Dev. Cell 2008 15 6 795 796
-
(2008)
Dev. Cell
, vol.15
, Issue.6
, pp. 795-796
-
-
Basseri, S.1
Austin, R.C.2
-
34
-
-
70350132628
-
Nutritional related liver disease: targeting the endoplasmic reticulum stress
-
H. L. Kammoun et al., Nutritional related liver disease: targeting the endoplasmic reticulum stress Curr. Opin. Clin. Nutr. Metab. Care 2009 12 6 575 582
-
(2009)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.12
, Issue.6
, pp. 575-582
-
-
Kammoun, H.L.1
-
35
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
F. Urano et al., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 Science 2000 287 5453 664 666
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 664-666
-
-
Urano, F.1
-
36
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
S. Oyadomari M. Mori Roles of CHOP/GADD153 in endoplasmic reticulum stress Cell Death Differ. 2004 11 4 381 389
-
(2004)
Cell Death Differ.
, vol.11
, Issue.4
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
37
-
-
84872492049
-
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
-
A. K. Leamy R. A. Egnatchik J. D. Young Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease Prog. Lipid Res. 2013 52 1 165 174
-
(2013)
Prog. Lipid Res.
, vol.52
, Issue.1
, pp. 165-174
-
-
Leamy, A.K.1
Egnatchik, R.A.2
Young, J.D.3
-
38
-
-
84877984694
-
The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications
-
A. Alqahtani et al., The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications Curr. Med. Chem. 2013 20 7 908 931
-
(2013)
Curr. Med. Chem.
, vol.20
, Issue.7
, pp. 908-931
-
-
Alqahtani, A.1
-
39
-
-
77957863271
-
Ursolic acid inhibits early lesions of diabetic nephropathy
-
Y. Zhou et al., Ursolic acid inhibits early lesions of diabetic nephropathy Int. J. Mol. Med. 2010 26 4 565 570
-
(2010)
Int. J. Mol. Med.
, vol.26
, Issue.4
, pp. 565-570
-
-
Zhou, Y.1
-
40
-
-
33644955272
-
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
-
Q. M. Anstee R. D. Goldin Mouse models in non-alcoholic fatty liver disease and steatohepatitis research Int. J. Exp. Pathol. 2006 87 1 1 16
-
(2006)
Int. J. Exp. Pathol.
, vol.87
, Issue.1
, pp. 1-16
-
-
Anstee, Q.M.1
Goldin, R.D.2
-
41
-
-
77957302090
-
Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c
-
P. Ferre F. Foufelle Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes, Obes. Metab. 2010 12 Suppl 2 83 92
-
(2010)
Diabetes, Obes. Metab.
, vol.12
, pp. 83-92
-
-
Ferre, P.1
Foufelle, F.2
-
42
-
-
0035658444
-
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis
-
J. K. Reddy Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis Am. J. Physiol.: Gastrointest. Liver Physiol. 2001 281 6 G1333 G1339
-
(2001)
Am. J. Physiol.: Gastrointest. Liver Physiol.
, vol.281
, Issue.6
, pp. G1333-G1339
-
-
Reddy, J.K.1
-
43
-
-
79955504163
-
PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver
-
M. A. Abdelmegeed et al., PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver J. Nutr. 2011 141 4 603 610
-
(2011)
J. Nutr.
, vol.141
, Issue.4
, pp. 603-610
-
-
Abdelmegeed, M.A.1
-
44
-
-
33645891166
-
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet
-
T. Nagasawa et al., Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet Eur. J. Pharmacol. 2006 536 1-2 182 191
-
(2006)
Eur. J. Pharmacol.
, vol.536
, Issue.1-2
, pp. 182-191
-
-
Nagasawa, T.1
-
45
-
-
57049111040
-
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
-
D. T. Rutkowski et al., UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators Dev. Cell 2008 15 6 829 840
-
(2008)
Dev. Cell
, vol.15
, Issue.6
, pp. 829-840
-
-
Rutkowski, D.T.1
-
46
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
A. H. Lee et al., Regulation of hepatic lipogenesis by the transcription factor XBP1 Science 2008 320 5882 1492 1496
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1492-1496
-
-
Lee, A.H.1
-
47
-
-
55849112292
-
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
-
E. Bobrovnikova-Marjon et al., PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation Proc. Natl. Acad. Sci. U. S. A. 2008 105 42 16314 16319
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.42
, pp. 16314-16319
-
-
Bobrovnikova-Marjon, E.1
-
48
-
-
39149109306
-
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury
-
N. Tamaki et al., CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury Am. J. Physiol.: Gastrointest. Liver Physiol. 2008 294 2 G498 G505
-
(2008)
Am. J. Physiol.: Gastrointest. Liver Physiol.
, vol.294
, Issue.2
, pp. G498-G505
-
-
Tamaki, N.1
-
49
-
-
84892854446
-
Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes
-
Y. Yang et al., Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes J. Mol. Cell Cardiol. 2014 67 103 111
-
(2014)
J. Mol. Cell Cardiol.
, vol.67
, pp. 103-111
-
-
Yang, Y.1
-
50
-
-
80053897594
-
Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice
-
J. Lu et al., Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice Brain Behav. Immun. 2011 25 8 1658 1667
-
(2011)
Brain Behav. Immun.
, vol.25
, Issue.8
, pp. 1658-1667
-
-
Lu, J.1
-
51
-
-
84901062374
-
Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress
-
S. Shen et al., Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress Chem. Biol. Interact. 2014 218 28 41
-
(2014)
Chem. Biol. Interact.
, vol.218
, pp. 28-41
-
-
Shen, S.1
-
52
-
-
84867605425
-
Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells
-
Q. Y. Zheng et al., Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells Cell Signalling 2013 25 1 206 213
-
(2013)
Cell Signalling
, vol.25
, Issue.1
, pp. 206-213
-
-
Zheng, Q.Y.1
|