DNA damage as a molecular link in the pathogenesis of COPD in smokers

European Respiratory Journal

Volumn 39, Issue 6, 2012, Pages 1368-1376

  Aoshiba, Kazutetsu ^a,b   Zhou, Fang ^a   Tsuji, Takao ^b   Nagai, Atsushi ^b  

^a Graduate School of Medical Science   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell senescence; Chronic obstructive pulmonary disease; DNA damage; Interleukin 6; Nuclear factor B

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ATM PROTEIN; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DOUBLE STRANDED DNA; HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; P53 BINDING PROTEIN 1; PROTEIN GAMMA H2AX; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENDOTHELIUM CELL; FEMALE; GUINEA PIG; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; INFLAMMATION; LUNG ALVEOLUS CELL TYPE 1; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS WALL; LUNG ENDOTHELIUM; MALE; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AGED; APOPTOSIS; CASPASE 3; CELL AGING; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DEOXYGUANOSINE; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; FEMALE; HISTONES; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; NF-KAPPA B; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; TUMOR SUPPRESSOR PROTEINS;

EID: 84861865579     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00050211     Document Type: Article

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