Current trends in biologics delivery to restore intervertebral disc anabolism

Advanced Drug Delivery Reviews

Volumn 84, Issue , 2015, Pages 146-158

  Fontana, Gianluca ^a   See, Eugene ^a   Pandit, Abhay ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Annulus fibrosus; Biomaterials; Cell therapy; Gene therapy; Growth factors; Inflammation; Intervertebral disc; Nucleus pulposus

Indexed keywords

BIOMATERIALS; BIOSYNTHESIS; GENE THERAPY; PATHOLOGY;

ANNULUS FIBROSUS; CELL THERAPY; GROWTH FACTOR; INFLAMMATION; INTERVERTEBRAL DISCS; NUCLEUS PULPOSUS;

METABOLISM;

ADENOVIRUS VECTOR; ANALGESIC AGENT; ASIALO ERYTHROPOIETIN; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CALCITONIN GENE RELATED PEPTIDE; DEXAMETHASONE; ETANERCEPT; GREEN FLUORESCENT PROTEIN; IMD 0560; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 1BETA; NUCLEAR FACTOR KAPPA B DECOY; OLIGONUCLEOTIDE; OSTEOGENIC PROTEIN 1; PARVOVIRUS VECTOR; RECOMBINANT ERYTHROPOIETIN; RESVERATROL; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ANALGESIC ACTIVITY; ANNULUS FIBROSUS; ANTIINFLAMMATORY ACTIVITY; BIOSYNTHESIS; BMP 2 GENE; BMP GENE; BONE REGENERATION; CARTILAGE CELL; CATABOLISM; CELL COMPOSITION; CELL THERAPY; DISCOGENIC PAIN; DORSAL ROOT; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG SAFETY; DRUG TARGETING; GENE EXPRESSION REGULATION; GFP GENE; HUMAN; HYPERALGESIA; IGF 1 GENE; INTERVERTEBRAL DISK DEGENERATION; LUMBAR DISK HERNIA; MESENCHYMAL STEM CELL; MICROBUBBLE; NOCICEPTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEUS PULPOSUS; OP 1 GENE; PRIORITY JOURNAL; REVIEW; SOX 9 GENE; TGF BETA1 GENE; TGF BETA3 GENE; VASCULARIZATION; VIRAL GENE DELIVERY SYSTEM; BIOLOGICAL THERAPY; GENE THERAPY; INTERVERTEBRAL DISC DEGENERATION; METABOLISM; PHYSIOLOGY; PROCEDURES; REGENERATION; TRENDS;

BIOCOMPATIBLE MATERIALS; BIOLOGICAL PRODUCTS; CELL- AND TISSUE-BASED THERAPY; GENETIC THERAPY; HUMANS; INTERVERTEBRAL DISC DEGENERATION; REGENERATION;

EID: 84929133429     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2014.08.008     Document Type: Review

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