Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells

European Spine Journal

Volumn 21, Issue SUPPL. 6, 2012, Pages

  Klawitter, M ^a   Quero, L ^a   Klasen, J ^b   Liebscher, T ^c,d   Nerlich, A ^e   Boos, N ^a,b,f   Wuertz, K ^a,f  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^c Klinikum Karlsbad Langensteinbach   (Germany)

^d Department of Spinal Cord Injury Unfallkrankenhaus Berlin ^*  (Germany)

^e KLINIKUM BOGENHAUSEN   (Germany)

^f AOSpine Research Network   (Switzerland)

Author keywords

Gene expression; Immunoblotting; Intervertebral disc; Signaling pathway; Triptolide

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; RNA POLYMERASE II; STROMELYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; ANABOLIC AGENT; ANTIINFLAMMATORY AGENT; COLLAGEN; CYTOKINE; DITERPENE; EPOXIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHENANTHRENE DERIVATIVE; TOLL LIKE RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRIPTERYGIUM WILFORDII; UPREGULATION; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; INTERVERTEBRAL DISK; METABOLISM; MIDDLE AGED; TIME;

ADULT; AGGRECANS; ANABOLIC AGENTS; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; CYTOKINES; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; MALE; METABOLISM; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHENANTHRENES; TIME FACTORS; TOLL-LIKE RECEPTORS;

EID: 84875810226     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-011-1919-y     Document Type: Article

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