Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist

Spine

Volumn 36, Issue 15, 2011, Pages 1190-1196

  Sinclair, S Michael ^a   Shamji, Mohammed F ^b   Chen, Jun ^a   Jing, Liufang ^a   Richardson, William J ^c   Brown, Christopher R ^c   Fitch, Robert D ^c   Setton, Lori A ^c,d  

^a Duke University   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

cytokine; infl ammation; intervertebral; soluble TNF receptor; TNF antagonism; tumor necrosis factor

Indexed keywords

INTERLEUKIN 6; NITRIC OXIDE; PROSTAGLANDIN E2; RECOMBINANT TUMOR NECROSIS FACTOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT TUMOR NECROSIS FACTOR RECEPTOR 2; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ANTAGONISM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFLAMMATION; INTERVERTEBRAL DISK; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-6; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MIDDLE AGED; NITRIC OXIDE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 79959855332     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181ebdb43     Document Type: Article

References (52)

1. Le Maitre C , Hoyland J , Freemont A Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 and TNF expression profi le Arthritis Res Ther 2007 ; 9 : R77
2. Séguin CA , Pilliar RM , Roughley PJ , et al. Tumor necrosis factor alpha modulates matrix production and catabolism in nucleus pulposus tissue Spine 2005 ; 30 : 1940
3. Olmarker K , Rydevik B Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: Possible implications for future pharmacologic treatment strategies of sciatica Spine 2001 ; 26 : 863
4. Peng B , Hao J , Hou S , et al. Possible pathogenesis of painful intervertebral disc degeneration Spine 2006 ; 31 : 560
5. Kang JD , Georgescu HI , McIntyre-Larkin L , et al. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 Spine 1996 ; 21 : 271
6. Olmarker K , Larsson K Tumor necrosis factor alpha and nucleuspulposus- induced nerve root injury Spine 1998 ; 23 : 2538
7. Weiler C , Nerlich AG , Bachmeier BE , et al. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls Spine 2005 ; 30 : 44
8. Nygaard OP , Mellgren SI , Osterud B The infl ammatory properties of contained and noncontained lumbar disc herniation Spine 1997 ; 22 : 2484
9. Haro H , Shinomiya K , Komori H , et al. Upregulated expression of chemokines in herniated nucleus pulposus resorption Spine 1996 ; 21 : 1647
10. Matsui Y , Maeda M , Nakagami W , et al. The involvement of matrix metalloproteinases and infl ammation in lumbar disc herniation Spine 1998 ; 23 : 863
11. Burke JG , Watson RWG , McCormack D , et al. Intervertebral discs which cause low back pain secrete high levels of proinfl ammatory mediators J Bone Joint Surg 2002 ; 84 : 196-201 (Pubitemid 34257682)
12. Demircan MN , Asir A , Cetinkal A , et al. Is there any relationship between proinfl ammatory mediator levels in disc material and myelopathy with cervical disc herniation and spondylosis? A nonrandomized, prospective clinical study Eur Spine J 2007 ; 16 : 983-6 (Pubitemid 47064381)
13. Burke JG , Watson RWG , Conhyea D , et al. Human nucleus pulposis can respond to a pro-infl ammatory stimulus Spine 2003 ; 28 : 2685
14. Studer RK , Aboka AM , Gilbertson LG , et al. p38 MAPK inhibition in nucleus pulposus cells: A potential target for treating intervertebral disc degeneration Spine 2007 ; 32 : 2827
15. Séguin CA , Bojarski M , Pilliar RM , et al. Differential regulation of matrix degrading enzymes in a TNF-induced model of nucleus pulposus tissue degeneration Matrix Biol 2006 ; 25 : 409-18 (Pubitemid 44512122)
16. Séguin CA , Pilliar RM , Madri JA , et al. TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration Spine 2008 ; 33 : 356
17. Abe Y , Akeda K , An HS , et al. Proinfl ammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells Spine 2007 ; 32 : 635
18. Aoki Y , Rydevik B , Kikuchi S , et al. Local application of discrelated cytokines on spinal nerve roots Spine 2002 ; 27 : 1614
19. Igarashi T , Kikuchi S , Shubayev V , et al. Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology: Molecular, histologic, and behavioral comparisons in rats Spine 2000 ; 25 : 2975
20. Goupille P , Mulleman D , Chevalier X Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: Lessons from the osteoarthritic experience Arthritis Res Ther 2007 ; 9 : 110
21. Korhonen T , Karppinen J , Paimela L , et al. The treatment of disc herniation-induced sciatica with infl iximab: One-year follow-up results of FIRST II, a randomized controlled trial Spine 2006 ; 31 : 2759
22. Genevay S , Stingelin S , Gabay C Effi cacy of etanercept in the treatment of acute, severe sciatica: A pilot study Ann Rheum Dis 2004 ; 63 : 1120-3 (Pubitemid 39120364)
23. Cohen SP , Bogduk N , Dragovich A , et al. Randomized, doubleblind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica Anesthesiology 2009 ; 110 : 1116
24. Tobinick E , Davoodifar S Effi cacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: A study of clinical observations in 143 patients Curr Med Res Opin 2004 ; 20 : 1075-85 (Pubitemid 38954470)
25. Chen G , Goeddel DV TNF-R1 signaling: A beautiful pathway Science 2002 ; 296 : 1634-35 (Pubitemid 34579145)
26. Liu Z , Han J Cellular responses to tumor necrosis factor Curr Issues Mol Biol 2001 ; 3 : 79-90 (Pubitemid 33061771)
27. Akeda K , An HS , Gemba T , et al. P89. The intra-discal injection of naked NF kappa B decoy oligonucleotide is effective in restoring disc degeneration in the rabbit annular needle puncture model Spine J 2005 ; 5 : S152-3
28. Raghavendra V , Tanga F , DeLeo JA Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy J Pharmacol Exp Ther 2003 ; 306 : 624
29. Ledeboer A , Sloane EM , Milligan ED , et al. Minocycline attenuates mechanical allodynia and proinfl ammatory cytokine expression in rat models of pain facilitation Pain 2005 ; 115 : 71-83
30. Hoyland JA , Le Maitre C , Freemont AJ Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc Rheumatology 2008 ; 47 : 809
31. Olmarker K , Nutu M , Størkson R Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition Spine 2003 ; 28 : 1635-42
32. Onda A , Yabuki S , Kikuchi S Effects of neutralizing antibodies to tumor necrosis factor-alpha on nucleus pulposus-induced abnormal nociresponses in rat dorsal horn neurons Spine 2003 ; 28 : 967
33. Chen PCH, DuBois GC , Chen MJ Mapping the domain(s) critical for the binding of human tumor necrosis factor-alpha to its two receptors J Biol Chem 1995 ; 270 : 2874
34. Engelmann H , Novick D , Wallach D Two tumor necrosis factorbinding proteins purifi ed from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors J Biol Chem 1990 ; 265 : 1531-6
35. Hale KK , Smith CG , Baker SL , et al. Multifunctional regulation of the biological effects of TNF- by the soluble type I and type II TNF receptors Cytokine 1995 ; 7 : 26-38
36. Edwards CK PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): Novel high affi nity TNF receptor designed for chronic infl ammatory diseases BMJ 1999 ; 58 : 73-81
37. Abraham E , Laterre PF , Garbino J , et al. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients Crit Care Med 2001 ; 29 : 503-10 (Pubitemid 32225290)
38. Peppel K , Crawford D , Beutler B A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity J Exp Med 1991 ; 174 : 1483-9
39. Baer AE , Wang JY , Kraus VB , et al. Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures J Orthop Res 2001 ; 19 : 2-10 (Pubitemid 32288631)
40. Miles AM , Wink DA , Cook JC , et al. Determination of nitric oxide using fl uorescence spectroscopy Methods Enzymol 1996 ; 268 : 105-20 (Pubitemid 26286353)
41. Tomkins P , Cooper K , Webber D , et al. The L929 cell bioassay for murine tumour necrosis factor is not infl uenced by other murine cytokines J Immunol Methods 1992 ; 151 : 313-5
42. Shamji MF , Chen J , Friedman AH , et al. Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist J Controlled Release 2008 ; 129 : 179-86
43. Shamji MF , Whitlatch L , Friedman AH , et al. An injectable and in situ -gelling biopolymer for sustained drug release following perineural administration Spine 2008 ; 33 : 748
44. Loeser RF Molecular mechanisms of cartilage destruction: Mechanics, infl ammatory mediators, and aging collide Arthritis Rheum 2006 ; 54 : 1357
45. Kang JD , Stefanovic-Racic M , McIntyre LA , et al. Toward a biochemical understanding of human intervertebral disc degeneration and herniation: Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases Spine 1997 ; 22 : 1065
46. Liu GZ , Ishihara H , Osada R , et al. Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure Spine 2001 ; 26 : 134
47. Kawakami M , Tamaki T , Hashizume H , et al. The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat Spine 1997 ; 22 : 1074
48. Miyamoto H , Saura R , Harada T , et al. The role of cyclooxygenase-2 and infl ammatory cytokines in pain induction of herniated lumbar intervertebral disc Kobe J Med Sci 2000 ; 46 : 13-28
49. Miyamoto H , Saura R , Doita M , et al. The role of cyclooxygenase- 2 in lumbar disc herniation Spine 2002 ; 27 : 2477
50. Kawakami M , Matsumoto T , Hashizume H , et al. Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat J Orthop Res 2002 ; 20 : 376-81 (Pubitemid 34218286)
51. Winkelstein BA , Rutkowski MD , Sweitzer SM , et al. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment J Comp Neurol 2001 ; 439 : 127-39 (Pubitemid 32906017)
52. Colburn RW , Rickman AJ , DeLeo JA The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior Exp Neurol 1999 ; 157 : 289-304 (Pubitemid 29260737)