Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model

Spine Journal

Volumn 12, Issue 1, 2012, Pages 7-20

  Leckie, Steven K ^a   Bechara, Bernard P ^a   Hartman, Robert A ^a   Sowa, Gwendolyn A ^a   Woods, Barrett I ^a   Coelho, Joao P ^a   Witt, William T ^a   Dong, Qing D ^a   Bowman, Brent W ^a   Bell, Kevin M ^a   Vo, Nam V ^a   Wang, Bing ^a   Kang, James D ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

BMP; Gene therapy; Intervertebral disc degeneration; TIMP

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CARBOXY TERMINAL TELOPEPTIDE; PARVOVIRUS VECTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL RABBIT; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; LOADING TEST; LUMBAR PUNCTURE; LUMBAR SPINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; VIRAL GENE THERAPY; VISCOELASTICITY;

ANIMALS; BIOMECHANICS; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE II; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTERVERTEBRAL DISC DEGENERATION; MAGNETIC RESONANCE IMAGING; RABBITS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84856502135     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2011.09.011     Document Type: Article

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