Synergistic effect of combined growth factors in porcine intervertebral disc degeneration

Connective Tissue Research

Volumn 54, Issue 3, 2013, Pages 181-186

  Cho, Hongsik ^a,b,c   Lee, Sangmin ^a   Park, Sang Hyug ^d   Huang, Jinsong ^a   Hasty, Karen A ^a,b,c   Kim, Song Ja ^e  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Campbell Clinic Memphis   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Jungwon University   (South Korea)

^e Kongju National University   (South Korea)

Author keywords

Annulus fibrosus (AF); Bone morphogenetic protein (BMP); Interleukin 1 (IL 1 ); Intervertebral disc (IVD); Matrix metalloproteinase (MMP); Transforming growth factor (TGF ); Tumor necrosis factor (TNF )

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; INTERVERTEBRAL DISK DEGENERATION; NONHUMAN; NUCLEUS PULPOSUS; PROTEIN ANALYSIS; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CYTOKINES; DRUG SYNERGISM; FEMALE; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC DEGENERATION; MATRIX METALLOPROTEINASE 1; SUS SCROFA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84877255209     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2013.775258     Document Type: Article

References (37)

1. Luoma, K., Riihimaki, H., Luukkonen, R., Raininko, R., Viikari-Juntura, E., and Lamminen, A. (2000). Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976). 25: 487-492.
2. Hoy, D.G., Protani, M., De, R., and Buchbinder, R. (2010). The epidemiology of neck pain. Best Pract. Res. Clin. Rheumatol. 24: 783-792.
3. Banes, A.J., Link, G.W., Gilbert, J.W., Tran Son Tay, R., and Monbureau, O. (1990). Culturing cells in a mechanically active environment. Am. Biotechnol. Lab. 8: 12-22.
4. Cs-Szabo, G., Ragasa-San Juan, D., Turumella, V., Masuda, K., Thonar, E., and An, H.S. (2002). Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine (Phila Pa 1976). 27: 2212-2219.
5. Ganey, T., Libera, J., Moos, V., Alasevic, O., Fritsch, K.G., Meisel, H.J., and Hutton, W.C. (2003). Disc chondrocyte transplantation in a canine model: A treatment for degenerated or damaged intervertebral disc. Spine (Phila Pa 1976). 28: 2609-2620.
6. Kang, J.D., Georgescu, H.I., McIntyre-Larkin, L., Stefanovic-Racic, M., Donaldson, W.F. 3rd, and Evans, C.H. (1996). Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine (Phila Pa 1976). 21: 271-277.
7. Le Maitre, C.L., Freemont, A.J., and Hoyland, J.A. (2004). Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J. Pathol. 204: 47-54.
8. Boos, N., Nerlich, A.G., Wiest, I., von der Mark, K., and Aebi, M. (1997). Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration. Histochem. Cell Biol. 108: 471-480.
9. Sive, J.I., Baird, P., Jeziorsk, M., Watkins, A., Hoyland, J.A., and Freemont, A.J. (2002). Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol. Pathol. 55: 91-97.
10. Fujisawa, T., Hattori, T., Takahashi, K., Kuboki, T., Yamashita, A., and Takigawa, M. (1999). Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1. J. Biochem. 125: 966-975.
11. Sandy, J.D., Thompson, V., Doege, K., and Verscharen, C. (2000). The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1. Biochem. J. 351: 161-166.
12. Le Maitre, C.L., Freemont, A.J., and Hoyland, J.A. (2005). The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res. Ther. 7: 732-745.
13. Igarashi, T., Kikuchi, S., Shubayev, V., and Myers, R. (2000). 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine (Phila Pa 1976). 25: 2975-2980.
14. Taylor, T.K., Melrose, J., Burkhardt, D., Ghosh, P., Claes, L.E., Kettler, A., and Wilke, H.J. (2000). Spinal biomechanics and aging are major determinants of the proteoglycan metabolismof intervertebral disc cells. Spine (Phila Pa 1976). 25: 3014-3020.
15. Fukui, N., Zhu, Y., Maloney, W.J., Clohisy, J., and Sandell, L.J. (2003). Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J. Bone Joint Surg. Am. 85-A(Suppl. 3): 59-66.
16. Walsh, A.J., Bradford, D.S., and Lotz, J.C. (2004). In vivo growth factor treatment of degenerated intervertebral discs. Spine (Phila Pa 1976). 29: 156-163.
17. LeMaitre, L., Hoyland, J.A., and Freemont, A.J. (2007). Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res. Ther. 9: R77.
18. Shamji, M.F., Setton, L.A., Jarvis, W., So, S., Chen, J., Jing, L., Bullock, R., Isaacs, R.E., Brown, C., and Richardson, W.J. (2010). Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum. 62: 1974-1982.
19. Lee, J.Y., Hall, R., Pelinkovic, D., Cassinelli, E., Usas, A., Gilbertson, L., Huard, J., and Kang, J. (2001). New use of a three-dimensional pellet culture system for human intervertebral disc cells: Initial characterization and potential use for tissue engineering. Spine (Phila Pa 1976). 26: 2316-2322.
20. Moon, S.H., Nishida, K., Gilbertson, L.G., Lee, H.M., Kim, H., Hall, R.A., Robbins, P.D., and Kang, J.D. (2008). Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976). 33: 1850-1855.
21. Kim, D.J., Moon, S.H., Kim, H., Kwon, U.H., Park, M.S., Han, K.J., Hahn, S.B., and Lee, H.M. (2003). Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine (Phila Pa 1976). 28: 2679-2684.
22. Li, J., Yoon, S.T., and Hutton, W.C. (2004). Effect of bone morphogenetic protein-2 (BMP-2) onmatrix production, other BMPs, andBMP receptors in rat intervertebral disc cells. J. Spinal Disord. Tech. 17: 423-428.
23. Kim, H., Lee, J.U., Moon, S.H., Kim, H.C., Kwon, U.H., Seol, N.H., Kim, H.J., Park, J.O., Chun, H.J., Kwon, I.K., and Lee, H.M. (2009). Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. Spine (Phila Pa 1976). 34: 1834-1838.
24. Huang, J., Ballou, L.R., and Hasty, K.A. (2007). Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondrocytes. Gene. 404: 101-109.
25. Overbergh, L., Valckx, D., Waer, M., and Mathieu, C. (1999). Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine. 11: 305-312.
26. Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R., and Mathieu, C. (2001). An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods. 25: 386-401.
27. Masuda, K., and An, H.S. (2004). Growth factors and the intervertebral disc. Spine J. 4: 330S-340S.
28. Antoniou, J., Steffen, T., Nelson, F., Winterbottom, N., Hollander, A.P., Poole, R.A., Aebi, M., and Alini, M. (1996). The human lumbar intervertebral disc: Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J. Clin. Invest. 98: 996-1003.
29. Cho, H., Park, S.H., Lee, S., Kang, M., Hasty, K.A., and Kim, S.J. (2011). Snapshot of degenerative aging of porcine intervertebral disc: A model to unravel the molecular mechanisms. Exp. Mol. Med. 43: 334-340.
30. Tow, B.P., Hsu, W.K., and Wang, J.C. (2007). Disc regeneration: A glimpse of the future. Clin. Neurosurg. 54: 122-128.
31. Murakami, H., Yoon, S.T., Attallah-Wasif, E.S., Tsai, K.J., Fei, Q., and Hutton, W.C. (2006). The expression of anabolic cytokines in intervertebral discs in age-related degeneration. Spine (Phila Pa 1976). 31: 1770-1774.
32. Sobajima, S., Kim, J.S., Gilbertson, L.G., and Kang, J.D. (2004). Gene therapy for degenerative disc disease. Gene. Ther. 11: 390-401.
33. Evans, C. (2006). Potential biologic therapies for the intervertebral disc. J. Bone Joint Surg. Am. 88(Suppl 2): 95-98.
34. Thompson, J.P., Oegema, T.R., and Bradford, D.S. (1991). Stimulation of mature canine intervertebral disc by growth factors. Spine (Phila Pa 1976). 16: 253-260.
35. Longo, U.G., Petrillo, S., Franceschetti, E., Maffulli, N., and Denaro, V. (2012). Growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration. Stem Cells Int. 2012: 1-12.
36. Matsunaga, S., Nagano, S., Onishi, T., Morimoto, N., Suzuki, S., and Komiya, S. (2003). Age-related changes in expression of transforming growth factor-? and receptors in cells of intervertebral discs. J. Neurosurg. 98(1): 63-67.
37. Specchia, N., Pagnotta, A., Toesca, A., and Greco, F. (2002). Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur. Spine J. 11(2): 145-151.