Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death

Annals of Anatomy

Volumn 193, Issue 2, 2011, Pages 156-162

  Loreto, Carla ^a   Musumeci, Giuseppe ^a   Castorina, Alessandro ^a   Loreto, Corrado ^b   Martinez, Giuseppa ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b Suzzara Hospital   (Italy)

Author keywords

Apoptosis; IVD herniation; MMP 9; Oxytalan fibers; Vimentin

Indexed keywords

GELATINASE B; PROTEIN BAX; PROTEIN BCL 2; VIMENTIN;

ADULT; AGED; ANNULUS FIBROSUS; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DEATH; CLINICAL ARTICLE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA FRAGMENTATION; ELASTIC FIBER; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; MALE; NICK END LABELING; NUCLEUS PULPOSUS; OXYTALAN FIBER; PATHOGENESIS; PROTEIN EXPRESSION; UPREGULATION;

ADULT; AGED; APOPTOSIS; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MIDDLE AGED; TISSUE DISTRIBUTION; VIMENTIN;

EID: 79952100061     PISSN: 09409602     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aanat.2010.12.001     Document Type: Article

References (54)

1. Alenzi F.Q. Apoptosis and diseases: regulation and clinical relevance. Saudi Med. J. 2005, 26:1679-1690.
2. Andersson G.B.J., An H.S., Oegema T.R.J., Setton L.A. Intervertebral disc degeneration. J. Bone Joint Surg. Am. 2006, 88:895-899.
3. Ariga K., Miyamoto S., Nakase T., Okuda S., Meng W., Yonenobu K., Yoshikawa H. The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine 2001, 26:2414-2420.
4. Barros E.M., Rodrigues C.J., Rodrigues N.R., Oliveira R.P., Barros T.E., Rodrigues A.J. Aging of the elastic and collagen fibers in the human cervical interspinous ligaments. Spine J. 2002, 2:57-62.
5. Bernick S., Caillet R. Vertebral end-plate changes with aging of human vertebrae. Spine 1982, 7:97-102.
6. Bertram H., Nerlich A., Omlor G., Geiger F., Zimmermann G., Fellenberg J. Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks. Mod. Pathol. 2009, 22:895-905.
7. Buckwalter J.A., Cooper R.R., Maynard J.A. Elastic fibers in human intervertebral disc. J. Bone Joint Surg. 1976, 58:73-76.
8. Buckwalter J.A. Aging and degeneration of the human intervertebral disc. Spine 1995, 20:1307-1314.
9. Budihardjo I., Oliver H., Lutter M., Luo X., Wang X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell. Dev. Biol. 1999, 15:269-290.
10. Caltabiano M., Carnazza M.L., Caltabiano C., Martinez G., Leonardi R. Demonstration of oxytalan fibers in human temporomandibular joint. Pathophysiology of Head and Neck Musculoskeletal Disorders. Frontiers of Oral Physiology 1990, vol. 7:150-153. Karger, Basel.
11. Carmicael G.G., Fullmer H.M. The fine structure of the oxytalan fiber. J. Cell Biol. 1966, 28:33-36.
12. Chen B., Ma B., Yang S., Xing X., Gu R., Hu Y. DR5 and DcR2 are expressed in human lumbar intervertebral discs. Spine 2009, 19:E677-E681.
13. Cotta-Pereira G., Guerra Rodrigo F., Bittencourt-Sampaio S. Oxytalan, elaunin, and elastic fibers in the human skin. J. Invest. Dermatol. 1976, 66:143-148.
14. Cotta-Pereira G., Del-Caro M.L., Montes G.S. Distribution of Elastic System Fibers in hyaline and fibrous cartilages of the rat. Acta Anat. 1984, 119:80-85.
15. Court C., Colliou O.K., Chin J., Liebenberg E., Bradford D.S., Lotz J.C. The effect of static in vivo bending on the murine intervertebral disc. Spine 2001, 1:239-245.
16. Crean J.K., Roberts S., Jaffray D.C., Eisenstein S.M., Duance V.C. Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis. Spine 1997, 22:2877-2884.
17. Cuervo L.A., Pita J., Howell D.S. Inhibition of calcium phosphate mineral growth by proteoglycan aggregate fractions in a synthetic lymph. Calcif. Tissue 1973, 13:1-10.
18. Davis E.C. Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta. J. Cell Sci. 1994, 107:727-736.
19. Fesik S.W. Insights into programmed cell death through structural biology. Cell 2000, 103:273-282.
20. Fullmer H.M. A comparative histochemical study of elastic, pre-elastic and oxytalan connective tissue fibers. J. Histochem. Cytochem. 1960, 8:290-295.
21. Gruber H.E., Hanley E.N. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine 1998, 23:751-757.
22. Heyde C.E., Tschoeke S.K., Hellmuth M., Hostmann A., Ertel W., Oberholzer A. Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC Clin. Pathol. 2006, 6:5.
23. Howell D.S., Pita J., Marquez J.F., Gatter R.A. Demonstration of macromolecular inhibitors of calcification and nucleational factors in fluid from calcifying sites in cartilage. J. Clin. Invest. 1969, 48:630-641.
24. Johnson E.F., Chetty C., Moore I.M., Stewart A., Jones W. The distribution and arrangement of elastic fibers in the intervertebral disc of the adult human. J. Anat. 1982, 135:301-309.
25. Johnson W.E.B., Roberts S. Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. J. Anat. 2003, 203:605-612.
26. Johnson E.F., Caldwell R.W., Berryman H.E., Miller A., Chetty K. Elastic fibers in the annulus fibrosus of the dog intervertebral disc. Acta Anat. 1984, 118:238-242.
27. Karppinen J., Paakko E., Raina S., Tervonen O., Kurunlahti M., Nieminen P., Ala-Kokko L., Malmivaara A., Vanharanta H. Magnetic imaging resonance findings in relation to the COL9A2 tryptophan allele among patients with sciatica. Spine 2002, 27:78-83.
28. Kielty C.M., Sherratt M.J., Shuttleworth C.A. Elastic fibers. J. Cell Sci. 2002, 15:2817-2828.
29. Leonardi R., Loreto C. Temporomandibular joint disc: a proposed histopathological degeneration grading score system. Histol. Histopathol. 2010, 25:1117-1122.
30. Leonardi R., Almeida E., Trevillatto P., Loreto C. Occurrence and regional distribution of trail and dr5 on temporo-mandibular joint discs. A comparison on disc " derangement" with and without reduction. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2010, 109:244-251.
31. Maroudas A., Stockwall R.A., Nachemson A., et al. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J. Anat. 1975, 120:113-117.
32. Martinez G., Carnazza M.L., Caltabiano C. Le fiber ossitalaniche nel derma fetale umano. Quad. Anat. Prat. S XLV 1989, 1-4:125-134.
33. Martinez G., Caltabiano C., Avondo S. Considerazioni morfologico-strutturali sul disco intervertebrale umano. Quad. Anat. Prat. XLVII-N 1991, 1-4.
34. Mollica Q., Russo T.C., Martinez G., Avondo S., Pavone V. Calcification and fibroblasts in human lumbar disc hernation. Ital. J. Orthop. Traumatol. 1996, 22:49-55.
35. Oegema T.R.J. Biochemistry of the intervertebral disc. Clin. Sports Med. 1993, 12:419-439.
36. Park J.B., Chang H., Kim K.W. Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue. Spine 2001, 26:618-621.
37. Peng B., Hou S., Shi Q., Jia L. The relationship between cartilage end-plate calcification and disc degeneration: and experimental study. Chin. Med. J. 2001, 114:308-312.
38. Roberts S., Menage J., Urban J.P.G. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine 1989, 14:166-174.
39. Roberts S., Caterson B., Menage J., Evans E.H., Jaffray D.C., Eisenstein S.M. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine 2000, 25:3005-3013.
40. Rodrigo F.G., Cotta-Pereira G., David-Ferreira J.F. The fine structure of the elastic tendons in the human arrector pili muscle. Br. J. Dermatol. 1975, 93:631-637.
41. Ross R., Bornstein P. The elastic fiber. I. The separation and partial characterization of its macromolecular components. J. Cell Biol. 1969, 40:366-381.
42. Rannou F., Richette P., Benallaoua M., Francois M., Genries V., Korwin-Zmijowska C., Reyel M., et al. Cyclic tensile stretch modulates proteoglycans production by intervertebral disc annulus fibrosus cells through production of nitrite oxide. J. Cell Biochem. 2003, 90:148-157.
43. Rannou F., Lee T.S., Zhou R.H., et al. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am. J. Pathol. 2004, 164:915-924.
44. Saunders J., Inman V. Pathology of the intervertebral disc. Arch. Surg. Chicago 1940, 40:384-416.
45. Serigano K., Sakai D., Hiyama A., Tamura F., Tanaka M., Mochida J. Effect of cell number on mesenchymal stem cell transplantation in a canine disc de generation model. J. Orthop. Res. 2010, 28:1267-1275.
46. Setton L.A., Chen J. Mechanobiology of the intervertebral disc and relevance to disc degeneration. J. Bone Joint. Surg. Am. 2006, 88:52-57.
47. Sitte I., Kathrein A., Pfaller K., Pedross F., Roberts S. Intervertebral disc cell death in the porcine and human injured cervical spine after trauma. Spine 2009, 34:131-140.
48. Smith L., Fazzalari N. The elastic fiber network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration. Eur. Spine J. 2009, 18:439-448.
49. Sudo H., Minami A. Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression. J. Orthop. Res. 2010, 28:1608-1613.
50. Tatsuo U. Collagen fibers, reticular fibers and elastic fibers. A comprehensive understanding from a morphological viewpoint. Arch. Histol. Cytol. 2002, 65:109-126.
51. Trout J.J., Buckwalter J.A., Moore K.C. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat. Rec. 1982, 204:307-314.
52. Tschoeke S.K., Hellmuth M., Hostmann A., Robinson Y., Ertel W., Oberholzer A., Heyde C.E. Apoptosis of human intervertebral discs after trauma compares to degenerated discs involving both receptor-mediated and mitochondrial-dependent pathways. J. Orthop. Res. 2008, 26:999-1006.
53. Weiler C., Nerlich A.G., Zipperer J., et al. 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur. Spine J. 2002, 11:308-320.
54. Yu J.C., Peter S., Roberts J.P.G. Urban. Elastic fiber organization in the intervertebral discs of the bovine tail. J. Anat. 2002, 201:465-475.