Anti-neuroinflammatory effect of MC13, a novel coumarin compound from condiment murraya, through inhibiting lipopolysaccharide-induced TRAF6-TAK1-NF-κB, P38/ERK MAPKS and Jak2-Stat1/Stat3 pathways

Journal of Cellular Biochemistry

Volumn 116, Issue 7, 2015, Pages 1286-1299

  Zeng, Ke Wu ^a   Yu, Qian ^b   Liao, Li Xi ^a   Song, Fang Jiao ^b   Lv, Hai Ning ^a   Jiang, Yong ^a   Tu, Peng Fei ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

COUMARIN; JAK STAT; MAPK; MICROGLIA; NEUROINFLAMMATION; NF B

Indexed keywords

CASPASE 3; COUMARIN DERIVATIVE; CYCLOOXYGENASE 2; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MC 13; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS ASSAY; ARTICLE; CELL LOSS; CELL STRUCTURE; CELL VIABILITY; CELL VIABILITY ASSAY; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; MICROGLIA; MICROGLIAL CELL CULTURE; MOUSE; MTT ASSAY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; APOPTOSIS; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; MURRAYA; SPRAGUE DAWLEY RAT;

MURRAYA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; COUMARINS; GENE EXPRESSION REGULATION; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MURRAYA; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84929118873     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25084     Document Type: Article

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