Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events

Toxicology and Applied Pharmacology

Volumn 275, Issue 3, 2014, Pages 244-256

  Zeng, Ke Wu ^a   Wang, Shu ^a,b   Dong, Xin ^a   Jiang, Yong ^a   Jin, Hong Wei ^a   Tu, Peng Fei ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Microglia; Neuroinflammation; Non receptor tyrosine kinase; Sesquiterpene dimmer

Indexed keywords

ANTIINFLAMMATORY AGENT; DSF 27; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; SESQUITERPENE DERIVATIVE; SESQUITERPENE DIMMER; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MICROGLIA; NERVE CELL INHIBITION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SPLEEN;

MICROGLIA; NEUROINFLAMMATION; NON-RECEPTOR TYROSINE KINASE; SESQUITERPENE DIMMER;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTEMISIA; CELL LINE; COCULTURE TECHNIQUES; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; INFLAMMATION MEDIATORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN INHIBITORS OF ACTIVATED STAT; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SESQUITERPENES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSFECTION;

EID: 84896707884     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.01.014     Document Type: Article

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