Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κb and JAK2/STAT3 transcription factors in adjuvant induced arthritis

European Journal of Pharmaceutical Sciences

Volumn 56, Issue 1, 2014, Pages 70-86

  Saravanan, S ^a   Hairul Islam, V I ^a,b   Prakash Babu, N ^a   Pandikumar, P ^a   Thirugnanasambantham, K ^b   Chellappandian, M ^a   Simon Durai Raj, C ^c   Gabriel Paulraj, M ^a   Ignacimuthu, S ^a,d  

^a LOYOLA COLLEGE   (India)

^b Pondicherry Centre for Biological Sciences Jawahar Nagar   (India)

^c SRI RAMACHANDRA UNIVERSITY   (India)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Adjuvant induced animals; Antiarthritic activity; JAK2 STAT3; NF B I B; Proinflammatory cytokines; Swertiamarin

Indexed keywords

ANTIRHEUMATIC AGENT; AUTACOID; CYCLOOXYGENASE 2; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE 2; LYSOSOME ENZYME; MATRIX METALLOPROTEINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; STAT3 PROTEIN; SWERTIAMARIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; CYTOKINE; GELATINASE B; IRIDOID; JAK2 PROTEIN, RAT; MMP9 PROTEIN, RAT; NOS2 PROTEIN, RAT; PLASMA PROTEIN; PTGS2 PROTEIN, RAT; PYRONE DERIVATIVE; STAT3 PROTEIN, RAT;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DESTRUCTION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RHEUMATOID ARTHRITIS; ANIMAL; ARTHRITIS, EXPERIMENTAL; BLOOD; CARBOHYDRATE METABOLISM; CELL LINE; FOOT; GENETICS; METABOLISM; MOUSE; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BLOOD PROTEINS; CARBOHYDRATE METABOLISM; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; FEMALE; FOOT; I-KAPPA B PROTEINS; IRIDOID GLUCOSIDES; JANUS KINASE 2; MATRIX METALLOPROTEINASE 9; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PPAR GAMMA; PYRONES; RATS, SPRAGUE-DAWLEY; STAT3 TRANSCRIPTION FACTOR;

EID: 84896524588     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.02.005     Document Type: Article

References (75)

1. W.P. Arend, and J.M. Dayer Inhibition of the production and effects of interleukin-1 and tumor necrosis factor in rheumatoid arthritis Arthritis Rheum. 38 1995 151 160
2. K. Aupperle, B. Bennett, and Z. Han et al. NF-κB regulation by IκB kinase-2 in rheumatoid arthritis synoviocytes J. Immunol. 166 2001 2705 2711
3. N.P. Babu, P. Pandikumar, and S. Ignacimuthu Anti-inflammatory activity of Albizia lebbeck Benth., an ethnomedicinal plant, in acute and chronic animal models of inflammation J. Ethnopharmacol. 125 2009 356 360
4. T. Bitter, and H.M. Muir Modified uronic acid-carbazole reaction Ann. Biochem. 4 1962 330 334
5. 2: protein structure prediction server Nucl. Acids Res. 34 2006 W152 W157
6. J.Y. Choe, K.Y. Park, and S.H. Park et al. Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes Arthritis Res. Ther. 15 2013 26
7. L.G. Darlington, and T.W. Stone Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders Brit. J. Nr. 85 2001 251 252
8. K. Davis, E. Martin, and I. Turko et al. Novel effects of nitric oxide Ann. Rev. Pharmacol. Toxicol. 41 2001 203 236
9. E. Delvin, and R. Gianetto The purification of lysosomal rat liver β-glucuronidase Biochem. Biophys. Acta 220 1970 93 100
10. G.-M. Deng, and M. Lenardo The role of immune cells and cytokines in the pathogenesis of rheumatoid arthritis Drug Discov. Today Dis. Mech. 3 2006 163 168
11. Golan, D.E., Tashjian, H.A., Armstrong, E.J., et al., 2007. Principles of Pharmacology: The Pathophysiologic Basis of, Drug Therapy. 704p.
12. L.O. Hanson, and L. Lindquist C-reactive protein: its role in the diagnosis and follow-up of infectious diseases Curr. Opin. Infect. Dis. 10 1997 196 201
13. W. Heng, F. Yongfei, and W. Yong et al. Inhibitory effect of curcumol on Jak2-STAT signal pathway molecules of fibroblast-like synoviocytes in patients with rheumatoid arthritis Evid. Based Complement Altern. Med. 2012 2012 1 8 DOI: 1155/2012/746426
14. J.-E. Huh, J.-M. Hong, and Y.-H. Baek et al. Anti-inflammatory and anti-nociceptive effect of Betula platyphylla var. japonica in human interleukin-1β-stimulated fibroblast-like synoviocytes and in experimental animal models J. Ethnopharmacol. 135 2011 126 134
15. D. Hwang, B.C. Jang, and G. Yu et al. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen activated protein kinase and NF-κB signaling pathways in macrophages Biochem. Pharmacol. 54 1997 87 96
16. V. Jaishree, and S. Badami Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats J. Ethnopharmacol. 130 2010 103 106
17. V. Jaishree, S. Badami, and M. Rupesh Kumar et al. Antinociceptive activity of swertiamarin isolated from Enicostemma axillare Phytomedicine 16 2009 227 232
18. H.W. Jung, R. Mahesh, J.H. Park, Y.C. Boo, K.M. Park, and Y.K. Park Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory meditors by down-regulation of NF-kappaB and ERK MAPkinase activity in LPS stimulated RAW 264.7 cells Int. Immunopharmacol. 10 2010 155 162
19. Y. Kawahito, M. Kondo, Y. Tsubouchi, A. Hashiramoto, D. Bishop-Bailey, K. Inoue, M. Kohno, R. Yamada, T. Hla, and H. Sano 15-Deoxy-delta (12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats J. Clin. Invest. 106 2 2000 189 197
20. Y. Kimura, and M. Sumiyoshi Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice Fitoterapia 82 2011 827 833
21. J. King In practical clinical enzymology D. Van, 1965 Nostrand Company Limited London 91 208
22. A.E. Koch Angiogenesis as a target in rheumatoid arthritis Ann. Rheum. Dis. 62 2003 S ii60-7
23. A.E. Koch, Z. Szekanecz, and J. Friedman et al. Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis Clin. Immunol. Immunopathol. 86 1998 199 208
24. R.A. Laskowski, M.W. MacArthur, and D.S. Moss et al. PROCHECK - a program to check the stereochemical quality of protein structures J. Appl. Crystallogr. 26 1993 283 291
25. A.T. Laurie, and R.M. Jackson Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites Bioinformatics 21 2005 1908 1916
26. A.A. Leach Notes on a modification of the Neuman and Logan method for the determination of hydroxyproline Biochem. J. 74 1960 70
27. K.M. Lee Overview of drug product development Curr. Prot. Pharmacol. 7 2001 1 10
28. J.I. Lee, and G.J. Burckart Nuclear factor kappa B: important transcription factor and therapeutic target J. Clin. Pharmacol. 38 1998 981 993
29. S.-J. Lee, W.-D. Nam, and H.-J. Na et al. CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-κB activation Biochem. Pharmacol. 76 2008 79 90
30. H. Lempert Determination of plasma protein H. Varley, Practical Clinical Biochemistry 1969 CBS Publishers New Delhi 233
31. T method Methods 25 2001 402 408
32. H.B. Magora, M.M. Rahman, and A.I. Gray et al. Swertiamarin from Enicostemma axillere subsp. axillere (Gentianaceae) Biochem. Syst. Ecol. 31 2003 553 555
33. S.S. Makarov NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction Arthritis Res. 3 2001 200 206
34. N. Maruotti, F.P. Cantatore, and E. Crivellato et al. Angiogenesis in rheumatoid arthritis Histol. Histopathol. 21 2006 557 566
35. J.M. Mbuyi, J. Dequeker, and M. Teblick et al. Relevance of urinary excretion of alcian blue-glycosaminoglycans complexes and hydroxyproline to disease activity in rheumatoid arthritis J. Rheumatol. 9 1982 579 583
36. J. Morel, and F. Berenbaum Signal transduction pathways: new targets for treating rheumatoid arthritis Joint Bone Spine 71 2004 503 510
37. A.G. Mowat Anaemia in rheumatoid arthritis Mod. Trends. Rheumatol. 2 1971 106 116
38. Mudaliar, K.S.M., 2002. Siddha Materia Medica - Vol. II plant kingdom (6th reprint). Department of Indian Medicine and Homeopathy, Chennai, pp. 843-844.
39. K.D. Muirden Lysosomal enzymes in synovial membrane in rheumatoid arthritis Ann. rheum. Dis. 31 1972 265
40. U. Muller-Ladner, C. Ospelt, S. Gay, O. Distler, and T. Pap Cells of the synovium in rheumatoid arthritis Arthritis Res. Ther. 9 2007 223
41. M. Murakami, and N. Nishimoto Osteoimmunology-basic principles and clinical applications-inflammatory cytokines in rheumatoid arthritis Clin. Calcium 22 2012 1737 1746
42. R.E. Neuman, and M.A. Logan The determination of collagen and elastin in tissues J. Biol. Chem. 186 1950 549 556
43. B.B. Newbould Suppression of adjuvant-induced arthritis in rats with 2-butoxy carbonyl methylene-4-oxothiazolidine Br. J. Pharmacol. Chemother. 24 1965 632 640
44. P. Niebes Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects Clin. Chim. Acta 42 1972 399 408
45. H. Okamoto, T. Iwamoto, S. Kotake, S. Momohara, H. Yamanaka, and N. Kamatani Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis Clin. Exp. Rheumatol. 23 3 2005 323 330
46. H.C. Oliveira, M.P. Dos Santos, and R. Grigulo et al. Antidiabetic activity of Vatairea macrocarpa extract in rats J. Ethnopharmacol. 115 2008 515 519
47. J.A. Owen, T.B. Iggo, and F.J. Scandrett et al. Determination of creatinine in plasma or serum and in urine, a critical examination Biochem. J. 58 1954 426 437
48. R. Pan, Y. Dai, and X. Gao et al. Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis Int. Immunopharmacol. 9 2009 859 869
49. K.S. Park, B.H. Kim, and I.M. Chang Inhibitory potencies of several iridoids on cyclooxygenase-1, cyclooxygnase-2 enzymes activities, tumor necrosis factor-α and nitric oxide production in vitro Evid. Based Complement Altern. Med. 7 2010 41 45
50. C.M. Pearson, and F.D. Wood Studies of polyarthritis and other lesions induced in rats given adjuvants Arthritis Rheumatol. 2 1959 440 445
51. V.R. Ramprasath, P. Shanthi, and P. Sachdanandam Effect of Semecarpus Anacardium Linn. Nut milk extract on rat neutrophil functions in adjuvant arthritis Cell Biochem. Funct. 24 2006 333 340
52. J.A. Ravin Improved colorimetric enzymatic assay of ceruloplasmin J. Lab. Clin. Med. 58 1961 161 168
53. Rosenblit, P.D., Metzyer, P.P., Wick, A.N., 1974. In: Proceedings of the Society for Experimental Biology and Medicine 145, pp. 244-247.
54. S. Roux, E. Sable, and R.D. Porsolt Primary observation (Irwin) test in Rodents for assessing acute toxicity of a test agent and its effect on behavior and physiological function Curr. Prot. Pharmacol. 10 2004 1 23
55. M.F. Sanner Python: a programming language for software integration and development J. Mol. Graph. Model. 17 1999 57 61
56. A.I. Sapolsky, R.D. Altman, and D.S. Howell Cathepsin-D activity in normal and osteoarthritic human cartilage Federation Proc. 32 1973 1489 1493
57. S. Saravanan, N. Prakash Babu, and P. Pandikumar et al. Therapeutic effect of Saraca asoca (Roxb.) wilde on lysosomal enzymes and collagen metabolism in adjuvant induced arthritis Inflammopharmacology 19 2011 317 325
58. S. Saravanan, N. Prakash Babu, and P. Pandikumar et al. Immunomodulatory potential of Enicostema axillare (Lam.) A. Raynal, a traditional medicinal Plant J. Ethnopharmacol. 140 2012 239 246
59. K. Seibert, Y. Zhang, and K. Leahy et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase-2 in inflammation and pain Proc. Natl. Acad. Sci. USA 91 1994 12013 12017
60. J. Vaijanathappa, and S. Badami Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare Planta Med. 75 2009 12 17
61. J. Van Roon, S. Wijngaarden, and F.P. Lafeber et al. Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immune complex stimulation J. Rheumatol. 30 2003 648 665
62. J. Van Snick Interleukin-6: an overview Ann. Rev. Immunol. 8 1990 253 278
63. A. Verstraeten, and J. Dequeker Mineral metabolism in postmenopausal women with active rheumatoid arthritis J. Rheumatol. 13 1986 43 46
64. W.D. Wagner More sensitive assay discriminating galactosamine and glucosamine in mixtures Ann. Biochem. 94 1979 394 397
65. L. Warren The thiobarbituric acid assay of sialic acid J. Biol. Chem. 234 1959 1971 1975
66. P.K. Warrier, V.P. Nambiar, and C. Ramankutty Indian Medicinal Plants - A Compendium of 500 Species 1995 Orient Longman Publishers Chennai 600 002, India 374 378
67. S. Wei, G. Chen, and W. He et al. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils Phytother. Res. 26 2012 168 173
68. A.F. Wells Anticytokine therapies in rheumatoid arthritis: from the pipette to the patient Drug Discov. Today Ther. Strateg. 1 2004 293 297
69. P. Whiteman The quantitative measurement of Alcian blue - glycosaminoglycan complexes Biochem. J. 131 1973 343 350
70. J.F. Woessner The determination of hydroxyproline in tissue and protein samples containing small portions of this aminoacid Arch. Biochem. Biophys. 93 1961 440 447
71. J. Yamahara, M. Kobayashi, and H. Matsuda et al. Anticholinergic action of Swertia japonica and an active constituent J. Ethnopharmacol. 33 1991 31 35
72. X.O. Yang, A.D. Panopoulos, R. Nurieva, S.H. Chang, D. Wang, S.S. Watowich, and C. Dong STAT3 regulates cytokine-mediated generation of inflammatory helper T cells J. Biol. Chem. 282 2007 9358 9363
73. M. Yang, C. Xia, and Q. Wu et al. Anti-inflammatory effect of Sanshuibaihu decoction may be associated with nuclear factor-κB and p38 MAPKα in collagen-induced arthritis in rat J. Ethnopharmacol. 127 2010 264 273
74. E. Yelin, and L.A. Wanke An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline Arthritis Rheum. 42 1999 1209 1218
75. A. Yoshimura, H. Nishinakamura, and Y. Matsumura et al. Negative regulation of cytokine signaling and immune responses by SOCS proteins Arthritis Res. Ther. 7 2005 100 110