Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1

International Immunopharmacology

Volumn 18, Issue 1, 2014, Pages 203-211

  Dilshara, Matharage Gayani ^a   Lee, Kyoung Tae ^b   Jayasooriya, Rajapaksha Gedara Prasad Tharanga ^a   Kang, Chang Hee ^a   Park, Sang Rul ^a   Choi, Yung Hyun ^c   Choi, Il Whan ^d   Hyun, Jin Won ^e   Chang, Weon Young ^e   Kim, Yeon Su ^f   Lee, Hak Ju ^b   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Korea Forest Research Institute   (South Korea)

^c Dong Eui University   (South Korea)

^d Inje University   (South Korea)

^e Jeju National University School of Medicine   (South Korea)

^f Korea Securities Depository   (South Korea)

Author keywords

Heme oxgenase 1; Nitric oxide; Nuclear factor erythroid 2 related factor 2; Nuclear factor B; Prostaglandin E2; Trans isoferulic acid

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOFERULIC ACID; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN KINASE B; PYRROLIDINE DITHIOCARBAMATE; TRANSCRIPTION FACTOR NRF2; ANTIINFLAMMATORY AGENT; CINNAMIC ACID DERIVATIVE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; ONCOPROTEIN; PTGS2 PROTEIN, MOUSE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLEMATIS; CLEMATIS MANDSHURICA; CONTROLLED STUDY; CYTOTOXICITY; DEPHOSPHORYLATION; DOWN REGULATION; DRUG ISOLATION; ENZYME REPRESSION; GENE EXPRESSION; IN VITRO STUDY; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; REGULATOR GENE; TRANSCRIPTION INITIATION; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; GENETICS; HEME OXGENASE-1; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; NUCLEAR FACTOR-ΚB; PLANT ROOT; PROSTAGLANDIN E(2); TRANS-ISOFERULIC ACID;

HEME OXGENASE-1; NITRIC OXIDE; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; NUCLEAR FACTOR-ΚB; PROSTAGLANDIN E(2); TRANS-ISOFERULIC ACID;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CINNAMATES; CLEMATIS; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICROGLIA; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT ROOTS;

EID: 84889999553     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.11.020     Document Type: Article

References (35)

1. L.J. Lawson, V.H. Perry, and S. Gordon Turnover of resident microglia in the normal adult mouse brain Neuroscience 4 1992 405 415
2. F. González-Scarano, and G. Baltuch Microglia as mediators of inflammatory degenerative diseases Annu Rev Neurosci 22 1999 219 240
3. M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: uncovering the molecular mechanism Nat Rev Neurosci 8 2007 57 69
4. K.M. Boje, and P.K. Arora Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death Brain Res 587 1992 250 256
5. M.E. Lull, and M.L. Block Microglial activation and chronic neurodegeneration Neurotherapeutics 7 2010 354 365
6. S. Wang, Z. Liu, L. Wang, and X. Zhang NF-κB signaling pathway, inflammation and colorectal cancer Cell Mol Immunol 6 2009 327 334
7. Y. Chen, S. Vallee, J. Wu, D. Vu, J. Sondek, and G. Ghosh Inhibition of NF-κB activity by IκBβ in association with κB-Ras Mol Cell Biol 24 2004 3048 3056
8. Y. Yamamoto, and R.B. Gaynor Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer J Clin Invest 107 2001 135 142
9. Y.J. Surh, K.S. Chun, H.H. Cha, S.S. Han, Y.S. Keum, and K.K. Park Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation Mutat Res 480-1 2001 243 268
10. A.Y. Kotsiuba, and M. Chertok The distribution of heme oxygenase-2 in the brainstem nuclei of rats Morfologiia 142 2012 15 19
11. A.A. Elmarakby, J. Faulkner, B. Baban, M.A. Saleh, and J.C. Sullivan Induction of hemeoxigenase-1 reduces glomerular injury and apoptosis in diabetic spontaneously hypertensive rats Am J Physiol Renal Physiol 302 2012 791 800
12. I. Pérez-de-Puig, A. Martín, R. Gorina, X. de la Rosa, E. Martinez, and A.M. Planas Induction of hemeoxigenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice Neuroscience 243 2013 22 32
13. A. Jazwa, and A. Cuadrado Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative disease Curr Drug Targets 11 2010 1517 1531
14. A. Paine, B. Eiz-Vesper, R. Blasczyk, and S. Immenschuh Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential Biochem Pharmacol 80 2010 1895 1903
15. M.D. Maines Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications FASEB J 2 1988 2557 2568
16. Y.J. Surh, J.K. Kundu, M.H. Li, H.K. Na, and Y.N. Cha Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress Arch Pharm Res 32 2009 1163 1176
17. T. Nguyen, P.J. Sherratt, and C.B. Pickett Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu Rev Pharmacol Toxicol 43 2003 233 260
18. J.H. Shin, S.W. Kim, Y. Jin, I.D. Kim, and J.K. Lee Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms Neurochem Int 61 2012 89 99
19. Y.C. Zhang, F.F. Gan, S.B. Shelar, K.Y. Ng, and E.H. Chew Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury Food Chem Toxicol 59 2013 272 280
20. E.K. Kim, M.Y. Song, T.O. Hwang, H.J. Kim, W.S. Moon, and D.G. Ryu Radix clematidis extract protects against cytokine-and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway Int J Mol Med 22 2008 349 356
21. Y.R. Lee, E.M. Noh, K.B. Kwon, Y.S. Lee, J.P. Chu, and E.J. Kim Radix clematidis extract inhibits UVB-induced MMP expression by suppressing the NF-κB pathway in human dermal fibroblasts Int J Mol Med 23 2009 679 684
22. E.M. Noh, Y.R. Lee, H. Hur, and J.S. Kim Radix clematidis extract inhibits TPA-induced MMP-9 expression by suppressing NF-κB activation in MCF-7 human breast cancer cells Mol Med Rep 4 2011 879 883
23. I.M. Liu, W.C. Chen, and J.T. Cheng Mediation of β-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats J Pharmacol Exp Ther 307 2003 1196 1204
24. I.M. Liu, T.C. Chi, F.L. Hsu, C.F. Chen, and J.T. Cheng Isoferulic acid as active principle from the rhizome of Cimicifuga dahurica to lower plasma glucose in diabetic rats Plant Med 65 1999 712 714
25. S. Prachayasittikul, S. Suphapong, A. Worachartcheewan, R. Lawung, S. Ruchirawat, and V. Prachayasittikul Bioactive metabolites from Spilanthes acmella Murr Molecules 14 2009 850 867
26. R.N. Saha, and K. Pahan Regulation of inducible nitric oxide synthase gene in glial cells Antioxid Redox Signal 8 2006 929 947
27. D.J. Wadleigh, S.T. Reddy, E. Kopp, S. Ghosh, and H.R. Herschman Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages J Biol Chem 27 2000 6259 6266
28. P. Singh, and A. Mittal Current status of COX-2 inhibitors Mini Rev Med Chem 8 2008 73 90
29. P. Teismann COX-2 in the neurodegenerative process of Parkinson's disease Biofactors 38 2012 395 397
30. A. Murakami, H. Ohigashi, A. Murakami, and H. Ohigashi Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals Int J Cancer 121 2007 2357 2363
31. P. Viatour, M.P. Merville, V. Bours, and A. Chariot Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation Trend Biochem Sci 30 2005 43 52
32. S. O'Connor, S. Shumway, and S. Miyamoto Inhibition of IκBα nuclear export as an approach to abrogate nuclear factor-κB-dependent cancer cell survival Mole Cancer Res 3 2005 42 49
33. M. Ojaniemi, V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages Eur J Immunol 33 2003 597 605
34. T. Jarmi, and A. Agarwal Heme oxygenase and renal disease Curr Hypertens Rep 11 2009 56 62
35. J. Wang, and S. Doré Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage Brain 130 2007 1643 1652