STAT1 Mediates Oroxylin A Inhibition of iNOS and Pro-Inflammatory Cytokines Expression in Microglial BV-2 Cells

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Liu, Po Wen ^a   Chen, Mei Fang ^a,b,c   Tsai, Andy Po Yi ^a   Lee, Tony J F ^a,d  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^d SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OROXYLIN A; STAT1 PROTEIN; SYNAPTOTAGMIN I;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; ENZYME DEGRADATION; GENE EXPRESSION; MICROGLIA; MOLECULAR MECHANICS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEINASE INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 84870802638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050363     Document Type: Article

References (40)

1. Gao HM, Liu B, Zhang W, Hong JS, (2003) Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. FASEB J 17: 1957-1959.
2. Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE, (2000) Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 20: 558-567.
3. Sapp E, Kegel KB, Aronin N, Hashikawa T, Uchiyama Y, et al. (2001) Early and progressive accumulation of reactive microglia in the Huntington disease brain. J Neuropathol Exp Neurol 60: 161-172.
4. Takeuchi H, Wang J, Kawanokuchi J, Mitsuma N, Mizuno T, et al. (2006) Interferon-gamma induces microglial-activation-induced cell death: a hypothetical mechanism of relapse and remission in multiple sclerosis. Neurobiol Dis 22: 33-39.
5. Block ML, Hong JS, (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76: 77-98.
6. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH, (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140: 918-934.
7. Neumann H, Kotter MR, Franklin RJ, (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132: 288-295.
8. Block ML, Zecca L, Hong JS, (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69.
9. Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, et al. (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5: 1403-1409.
10. Mander P, Brown GC, (2005) Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration. J Neuroinflammation 2: 20.
11. Pearson VL, Rothwell NJ, Toulmond S, (1999) Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 25: 311-323.
12. Mizuno T, Kurotani T, Komatsu Y, Kawanokuchi J, Kato H, et al. (2004) Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology 46: 404-411.
13. Barnes PJ, Karin M, (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071.
14. Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, et al. (2002) TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 3: 392-398.
15. Jacobs AT, Ignarro LJ, (2001) Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem 276: 47950-47957.
16. Kim HP, Son KH, Chang HW, Kang SS, (2004) Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 96: 229-245.
17. Tedeschi E, Menegazzi M, Yao Y, Suzuki H, Forstermann U, et al. (2004) Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation. Mol Pharmacol 65: 111-120.
18. Ichikawa T, Li J, Nagarkatti P, Nagarkatti M, Hofseth LJ, et al. (2009) American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages. J Ethnopharmacol 125: 145-150.
19. Chen Y, Yang L, Lee TJ, (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol 59: 1445-1457.
20. Pham TA, Che H, Phan PT, Lee JW, Kim SS, et al. (2012) Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. Bioorg Med Chem Lett 22: 2534-2535.
21. Kim DH, Jeon SJ, Son KH, Jung JW, Lee S, et al. (2006) Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced memory impairment in mice. Pharmacol Biochem Behav 85: 658-668.
22. Kim DH, Kim S, Jeon SJ, Son KH, Lee S, et al. (2008) The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Neuropharmacology 55: 639-647.
23. Wang MJ, Huang HY, Chen WF, Chang HF, Kuo JS, (2010) Glycogen synthase kinase-3beta inactivation inhibits tumor necrosis factor-alpha production in microglia by modulating nuclear factor kappaB and MLK3/JNK signaling cascades. J Neuroinflammation 7: 99.
24. Boje KM, Arora PK, (1992) Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587: 250-256.
25. Possel H, Noack H, Putzke J, Wolf G, Sies H, (2000) Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32: 51-59.
26. Salonen T, Sareila O, Jalonen U, Kankaanranta H, Tuominen R, et al. (2006) Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages. Br J Pharmacol 147: 790-799.
27. Sareila O, Hamalainen M, Nissinen E, Kankaanranta H, Moilanen E, (2008) Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli. J Pharmacol Exp Ther 324: 858-866.
28. Chang LC, Tsao LT, Chang CS, Chen CJ, Huang LJ, et al. (2008) Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia. Biochem Pharmacol 76: 507-519.
29. Pautz A, Linker K, Altenhofer S, Heil S, Schmidt N, et al. (2009) Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem 284: 2755-2766.
30. Lahti A, Jalonen U, Kankaanranta H, Moilanen E, (2003) c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. Mol Pharmacol 64: 308-315.
31. Hammermann R, Dreissig MD, Mossner J, Fuhrmann M, Berrino L, et al. (2000) Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and Up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages. Mol Pharmacol 58: 1294-1302.
32. Beck KF, Sterzel RB, (1996) Cloning and sequencing of the proximal promoter of the rat iNOS gene: activation of NFkappaB is not sufficient for transcription of the iNOS gene in rat mesangial cells. FEBS Lett 394: 263-267.
33. Guillemin GJ, Brew BJ, (2004) Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 75: 388-397.
34. Won JS, Im YB, Singh AK, Singh I, (2004) Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability. Free Radic Biol Med 37: 1834-1844.
35. Petrova TV, Akama KT, Van Eldik LJ, (1999) Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proc Natl Acad Sci U S A 96: 4668-4673.
36. Straus DS, Pascual G, Li M, Welch JS, Ricote M, et al. (2000) 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A 97: 4844-4849.
37. Ghosh CC, Ramaswami S, Juvekar A, Vu HY, Galdieri L, et al. (2010) Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IkappaBalpha. J Immunol 185: 3685-3693.
38. Okugawa S, Ota Y, Kitazawa T, Nakayama K, Yanagimoto S, et al. (2003) Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages. Am J Physiol Cell Physiol 285: C399-408.
39. Prele CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, et al. (2008) SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages. J Immunol 181: 8018-8026.
40. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F, (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27: 229-237.