GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease

Brain, Behavior, and Immunity

Volumn 46, Issue , 2015, Pages 112-120

  Audoy Rémus, Julie ^a   Bozoyan, Lusine ^a   Dumas, Aline ^a   Filali, Mohammed ^a   Lecours, Cynthia ^a   Lacroix, Steve ^a,b   Rivest, Serge ^a,b   Tremblay, Marie Eve ^a,b   Vallières, Luc ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Chemotaxis; Endotoxemia; G protein coupled receptor 84; Lipopolysaccharide; Microglial cells; Multiple sclerosis; Neurodegeneration; Neuroinflammation; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 84; KI 67 ANTIGEN; MESSENGER RNA; PRESENILIN 1; UNCLASSIFIED DRUG; GPR84 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITIC CELL; DENTATE GYRUS; DISEASE COURSE; ENDOPLASMIC RETICULUM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GLIOSIS; HIPPOCAMPAL CA1 REGION; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SEPTIC SHOCK; STATISTICAL SIGNIFICANCE; STRATUM RADIATUM; UPREGULATION; ANIMAL; DENDRITE; DISEASE MODEL; GENETICS; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION DISORDERS; DENDRITES; DISEASE MODELS, ANIMAL; GLIOSIS; HIPPOCAMPUS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NERVE DEGENERATION; RECEPTORS, G-PROTEIN-COUPLED; UP-REGULATION;

EID: 84928824304     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.01.010     Document Type: Article

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