Peroxynitrite-mediated glyoxalase i epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB

Free Radical Biology and Medicine

Volumn 84, Issue , 2015, Pages 128-141

  Antognelli, Cinzia ^a   Gambelunghe, Angela ^b   Muzi, Giacomo ^b   Talesa, Vincenzo Nicola ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Apoptosis; Argpyrimidine modified Hsp70; Crystalline silicaMin U Sil5; ERK1 2 MAPK; Freeradicals; GlyoxalaseI; Human bronchialBEAS 2Bcells; JNK; MiR 101; NF B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ADVANCED GLYCATION END PRODUCT; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOYLGLUTATHIONE LYASE; MICRORNA 101; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXYNITRITE; PROTEIN BAX; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; STRESS ACTIVATED PROTEIN KINASE; GLO1 PROTEIN, HUMAN; MICRORNA; MIRN101 MICRORNA, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXYNITROUS ACID; POLLUTANT;

ANTIBODY AFFINITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DNA FRAGMENTATION ASSAY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; EPIGENETICS; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNODETECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; SPECTROPHOTOMETRY; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; CELL LINE; DRUG EFFECTS; ENZYME REPRESSION; ENZYMOLOGY; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY; POLLUTANT; RESPIRATORY TRACT MUCOSA; TOXICITY;

APOPTOSIS; CELL LINE; ENVIRONMENTAL POLLUTANTS; ENZYME REPRESSION; EPIGENESIS, GENETIC; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOSYLATION END PRODUCTS, ADVANCED; HSP70 HEAT-SHOCK PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTOYLGLUTATHIONE LYASE; MICRORNAS; NF-KAPPA B; OXIDATIVE STRESS; PEROXYNITROUS ACID; RESPIRATORY MUCOSA; SILICON DIOXIDE;

EID: 84928790709     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.03.026     Document Type: Article

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