Inducible nitric oxide synthase mediates MG132 lethality in leukemic cells through mitochondrial depolarization

Free Radical Biology and Medicine

Volumn 74, Issue , 2014, Pages 175-187

  Chao, Tung Hui ^a   Chang, Meng Ya ^a,b   Su, Shu Jem ^c   Su, Shu Hui ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c FOOYIN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Free radicals; Mitochondrial depolarization; Nitric oxide synthase; Proteasome inhibitor; Reactive oxygen nitrogen species

Indexed keywords

AMINOGUANIDINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; SUPEROXIDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYCLIC GMP; CYSTEINE PROTEINASE INHIBITOR; LEUPEPTIN; PROTEASOME; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOSTASIS; DEPOLARIZATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; K562 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; UPREGULATION; DRUG EFFECTS; ENZYMOLOGY; LEUKEMIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASES; CYCLIC GMP; CYSTEINE PROTEINASE INHIBITORS; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; K562 CELLS; LEUKEMIA; LEUPEPTINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84905048829     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.023     Document Type: Article

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