Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 51-59

  Kumar, Ashutosh ^a   Chen, Shih Heng ^a   Kadiiska, Maria B ^a   Hong, Jau Shyong ^a   Zielonka, Jacek ^b   Kalyanaraman, Balaraman ^b   Mason, Ronald P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b FREE RADICAL RESEARCH CENTER   (United States)

Author keywords

Free radicals; Inducible nitric oxide synthase; Lipopolysaccharide; Microglia; Nitrone adducts; Parkinson disease; Peroxynitrite; Protein radical

Indexed keywords

APOCYNIN; BORONIC ACID DERIVATIVE; COUMARIN 7 BORONIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; PEROXYNITRITE; PYRROLIDINE DITHIOCARBAMATE; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; TYROSINE; UNCLASSIFIED DRUG; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; 5,10,15,20-TETRAKIS(4-SULFONATOPHENYL)PORPHYRINATO IRON(III) CHLORIDE; ACETOPHENONE DERIVATIVE; AMIDINE; ANTIOXIDANT; BENZYLAMINE DERIVATIVE; COUMARIN DERIVATIVE; ENZYME INHIBITOR; FREE RADICAL; IMIDAZOLE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METALLOPORPHYRIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; PEROXYNITROUS ACID; PROLINE; PROLINEDITHIOCARBAMATE; PYRIDINE DERIVATIVE; THIOCARBAMIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CATALYST; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; GENE SILENCING; MICROGLIA; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DEGENERATIVE DISEASE; GENETICS; METABOLISM; MOUSE; SPIN TRAPPING; TRANSFORMED CELL LINE;

ACETOPHENONES; AMIDINES; ANIMALS; ANTIOXIDANTS; BENZYLAMINES; BORONIC ACIDS; CELL LINE, TRANSFORMED; COUMARINS; ENZYME INHIBITORS; FREE RADICALS; IMIDAZOLES; LIPOPOLYSACCHARIDES; METALLOPORPHYRINS; MICE; MICROGLIA; NEURODEGENERATIVE DISEASES; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXYNITROUS ACID; PROLINE; PYRIDINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPIN TRAPPING; THIOCARBAMATES;

EID: 84901763503     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.014     Document Type: Article

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