Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

Free Radical Biology and Medicine

Volumn 76, Issue , 2014, Pages 173-184

  Zanetti, Filippo ^a,b   Giacomello, Marta ^c   Donati, Yves ^a,b   Carnesecchi, Stephanie ^a,b   Frieden, Maud ^b   Barazzone Argiroffo, Constance ^a,b  

^a Children's Hospital of Geneva   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

Alveolar epithelial type II cells; Apoptosis; Bcl 2; Free radicals; Nicotine; NOX1; Oxidative stress

Indexed keywords

CALCIUM; CASPASE 3; NICOTINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SHORT HAIRPIN RNA; NICOTINIC AGENT; OXIDOREDUCTASE; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPEROXIA; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; LUNG; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; NICOTINE; NICOTINIC AGONISTS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 84907197113     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.08.002     Document Type: Article

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