Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling

Toxicology and Applied Pharmacology

Volumn 279, Issue 1, 2014, Pages 76-86

  Skuland, Tonje ^a   Øvrevik, Johan ^a   Låg, Marit ^a   Schwarze, Per ^a   Refsnes, Magne ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

BEAS 2B; Cytokines; Intracellular signalling; Particles

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NANOPARTICLE; SILICON DIOXIDE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME ACTIVATION; HYDRODYNAMICS; LUNG ALVEOLUS EPITHELIUM; PARTICLE SIZE; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURFACE PROPERTY; ZETA POTENTIAL;

BEAS-2B; CYTOKINES; INTRACELLULAR SIGNALLING; PARTICLES;

ADAM PROTEINS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CYTOKINES; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-5; INTERLEUKIN-8; LUNG; NANOPARTICLES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SILICON DIOXIDE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 84902278798     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.05.006     Document Type: Article

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