The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 23, 2009, Pages 1509-1519

  Gwinn, Maureen R ^a   Leonard, Stephen S ^a   Sargent, Linda M ^a   Lowry, David T ^a   McKinstry, Kimberly ^a   Meighan, Terry ^a   Reynolds, Steve H ^a   Kashon, Michael ^a   Castranova, Vince ^a   Vallyathan, Val ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN BAX; PROTEIN BCL 6; PROTEIN MDM2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RNA; SILICON DIOXIDE;

ANEUPLOIDY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER SUSCEPTIBILITY; CELL CYCLE REGULATION; CHEMICAL CARCINOGENESIS; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA DAMAGE; ENDOREDUPLICATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

APOPTOSIS; CARCINOGENICITY TESTS; CELL LINE; CYTOGENETIC ANALYSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 75149188803     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390903129291     Document Type: Article

References (33)

1. Allen, R. G., and Tresini, M. 2000. Oxidative stress and gene regulation. Free Radical Biol. Med. 1:(28):463-499.
2. Castranova, V. 2004. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: Role of reactive oxygen/nitrogen species. Free Radical Biol. Med. 37:916-925.
3. Checkoway, H., Hughes, J. M., Weill, H., Seixas, N. S., and Demers, P. A. 1999. Silica, silicosis and lung cancer: Results from a cohort study in the stone and quarry industry. Int. Arch. Occup. Environ. Health 54:56-59.
4. Daniel, L. N., Mao, Y., Williams, A. O., and Saffiotti, U. 1995. Direct interaction between crystalline silica and DNA-A proposed model for silica carcinogenesis. Scand. J. Work Environ. Health 21(suppl. 2):22-26.
5. Ding, M., Shi, X., Dong Chen, F., Lu, Y., Castranova, V., and Vallyathan, V. 1999. Freshly fractured crystalline silica induces activator protein-1 activation through ERKs and p38 MAPK. J. Biol. Chem. 274:30611-30616.
6. Ding, M., Shi, X., Lu, Y., Huang, C., Leonard, S., Roberts, J., Antonini, J., Castranova, V., and Vallyathan, V. 2001. Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells. J. Biol. Chem. 276: 9108-9114.
7. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. 1994. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878.
8. Gwinn, M. R., Whipkey, D. L., Tennant, L. B., and Weston, A. 2005. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Environ. Health Perspect. 113:1046-1051.
9. Hamilton, R. F., Iyer, L. L., and Holian, A. 1996. Asbestos induces apoptosis in human alveolar macrophages. Am. J. Physiol. Cell Mol. Physiol. 271:L813-L819.
10. Hessel, P. A., Gamble, J. F., Gee, J. B., Gibbs, G., Green, F. H. Y., Morgan, W. K. C., and Mossman, B. T. 2000. Silica, silicosis, and lung cancer: A response to a recent working group report. J. Occup. Environ. Med. 42:704-720.
11. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 1996. Silica, some silicates, coal dust and para-aramid fibrils. IARC Monogr. Eval. Carcinogen. Risks Hum. 68:1-475.
12. ILSI Risk Science Institute Workshop. 2000. The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report. Inhal. Toxicol. 12:1-17.
13. Iyer, R., Hamilton, R.F., Li, L., and Holian, A. 1996. Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol. Appl. Pharmacol. 141:84-92.
14. Janssen, Y. M. W., Soultanakis, R., Steece, K., Heerdt, E., Singh, R. J., Joseph, J., and Kalyanaraman, B.1998. Depletion of nitric oxide causes cell cycle alteration, apoptosis, and oxidative stress in pulmonary cells. Am. J. Physiol. Cell Mol. Physiol. 275:L1100-L1109.
15. Kang, J. L., Go, Y. H., Hur, K. C., and Castranova, V. 2000. Silica-induced nuclear factor-kappaB activation: Involvement of reactive oxygen species and protein tyrosine kinase activation. J. Toxicol. Environ. Health A 60:27-46.
16. Knudson, A. G. 1996. Hereditary cancer: Two hits revisited. J. Cancer Res. Clin. Oncol. 122:135-140.
17. Kurosu, T., Fukuda, T., Miki, T., and Miura, O. 2003. BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells. Oncogene 22:4459-4468.
18. MacCorkle, R. A., Slattery, S. D., Nash, D. R., and Brinkley, B. R. 2006. Intracellular protein binding to asbestos induces aneuploidy in human lung fibroblasts. Cell Motil. Cytoskeleton 63:646-657
19. Pfeifer, G. P., Denissenko, M. F., Olivier, M., Tretyakova, N., Hecht, S. S., and Hainaut, P. 2002. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene 21:7435-7451.
20. Robles, A. I., Linke, S. P., and Harris, C. C. 2002. The p53 network in lung carcinogenesis. Oncogene 21:6898-6907.
21. Saffiotti, U., Williams, A. O., David, L. N., Kaighn, M., Mao, Y., and Shi, X. 1996. Carcinogenesis by crystalline silica: Animal, cellular and molecular studies. In Silica and silica-induced lung diseases, ed. V. Casatranova, pp. 345-381. Boca Raton, FL: CRC Press.
22. Sargent, L. M., Senft, J. R., Lowry, D. T., Jefferson, A. M., Tyson, F. L., Malkinson, A. M., Coleman, A. F., and Reynolds, S. H. 2002. Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: A comparison with human lung adenocarcinoma. Cancer Res. 62:1152-1157.
23. Sargent, L. M., Dragan, Y. P., Babcock, K., Klaunig, J. E., Wiley, J. E., and Pitot, H. C. 1996. Correlation of an early, consistent chromosomal alteration with insulin-like growth factor II expression in three at liver epithelial cell lines. Cancer Res. 56:2992-2997.
24. Shi, X., Castranova, V., Halliwell, B., and Vallyathan, V. 1998. Reactive oxygen species and silica-induced carcinogenesis. J. Toxicol. Environ. Health B 1:181-197. (Pubitemid 128693558)
25. Shi, X. L., Dalal, N. S., and Vallyathan, V. 1988. ESR evidence for the hydroxyl radical formation in aqueous suspension of quartz particles and its possible significance to lipid peroxidation in silicosis. J. Toxicol. Environ. Health 25:237-245.
26. Shi, X., Ding, M., Chen, F., Vallyathan, V., and Castranova, V. 2001. Reactive oxygen species and molecular mechanism of silica-induced lung injury. J. Environ. Pathol. Toxicol. Oncol. 20(suppl. 1):85-93.
27. Shi, X., Mao, Y., Daniel, L. N., Saffiotti, U., Dalal, N. S., and Vallyathan, V. 1994. Silica radical-induced DNA damage and lipid peroxidation. Environ. Health Perspect. 102(suppl. 10):149-154.
28. Vallyathan, V., Castranova, V., Pack, D., Leonard, S., Shumaker, J., Hubbs, A. F., Shoemaker, D. A., Ramsey, D. M., Pretty, J. R., McLaurin, J. L., Khan, A., and Teass, A. 1995. Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Am. J. Respir. Crit. Care Med. 152:1003-1009.
29. Vallyathan, V., Shi, X., and Castranova, V. 1998. Reactive oxygen species: Their relation to pneumoconiosis and carcinogenesis. Environ. Health Perspect. 106(suppl. 5):1151-1155. (Pubitemid 28554520)
30. Vallyathan, V., Shi, X. L., Dalal, N. S., et al. 1988. Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury. Am. Rev. Respir. Dis. 138:1213-1219.
31. Wang, X., Wang, Y., Kim, H. P., Nakahira, K., Ryter, S. W., and Choi, A. M. 2007. Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting oxygen species formation. J. Biol. Chem. 282: 1718-1726.
32. Xiao, G., Chicas, A., Olivier, M., Taya, Y., Tyagi, S., Kramer, F. R., and Bargonetti, J. 2000. A DNA damage signal is required for p53 to activate gadd45. Cancer Res. 60:1711-1719.
33. Zeidler, P. C., Roberts, J. R., Castranova, V., Chen, F., Butterworth, L., Andrew, M. E., Robinson, V. A., and Porter, D. W. 2003. Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure. J. Toxicol. Environ. Health A 66:995-1013.