Mechanism of arctigenin-induced specific cytotoxicity against human hepatocellular carcinoma cell lines: Hep G2 and SMMC7721

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Lu, Zheng ^a   Cao, Shengbo ^a   Zhou, Hongbo ^a   Hua, Ling ^b   Zhang, Shishuo ^a   Cao, Jiyue ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b SOUTHWEST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARCTIGENIN; CASPASE 3; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; FAS PROTEIN, HUMAN; FASLG PROTEIN, HUMAN; FURAN DERIVATIVE; LIGNAN; TUMOR NECROSIS FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL LOSS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SMMC7721 CELL LINE; UPREGULATION; AGONISTS; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; FAS LIGAND PROTEIN; FURANS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIGNANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; ORGAN SPECIFICITY; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84928776796     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125727     Document Type: Article

References (63)

1. Bruix J, Boix L, Sala M, Llovet JM. Focus on hepatocellular carcinoma. Cancer Cell. 2004; 5: 215-219. PMID: 15050913
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global Cancer Statistics. Ca-a Cancer Journal for Clinicians. 2011; 61: 69-90. doi: 10.3322/caac.20107 PMID: 21296855
3. El-Serag HB, Rudolph L. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 2007; 132: 2557-2576. PMID: 17570226
4. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nature reviews Cancer. 2006; 6: 674-687. PMID: 16929323
5. Cotter TG. Apoptosis and cancer: the genesis of a research field. Nature Reviews Cancer. 2009; 9: 501-507. doi: 10.1038/nrc2663 PMID: 19550425
6. Marsoni S, Damia G. Molecular targeting: new therapeutic strategies to improve tumour apoptosis. Annals of Oncology. 2004; 15: 229-231.
7. Hengartner MO. The biochemistry of apoptosis. Nature. 2000; 407: 770-776. PMID: 11048727
8. Tait SW, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 2010; 11: 621-632. doi: 10.1038/nrm2952 PMID: 20683470
9. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med. 2000; 6: 513-519. PMID: 10802706
10. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology. 2008; 9: 47-59. PMID: 18097445
11. Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011; 21: 92-101. doi: 10.1016/j.devcel.2011.06.017 PMID: 21763611
12. Chipuk JE, Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends in Cell Biology. 2008; 18: 157-164. doi: 10.1016/j.tcb.2008.01.007 PMID: 18314333
13. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995; 14: 5579-5588. PMID: 8521815
14. Fesik SW. Promoting apoptosis as a strategy for cancer drug discovery. Nature Reviews Cancer. 2005; 5: 876-885. PMID: 16239906
15. Moritani S, Nomura M, Takeda Y, Miyamoto K. Cytotoxic components of bardanae fructus (goboshi). Biol Pharm Bull. 1996; 19: 1515-1517. PMID: 8951177
16. Umehara K, Nakamura M, Miyase T, Kuroyanagi M, Ueno A. Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2). Chem Pharm Bull (Tokyo). 1996; 44: 2300-2304. PMID: 8996860
17. Swarup V, Ghosh J, Mishra MK, Basu A. Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan. Journal of Antimicrobial Chemotherapy. 2008; 61: 679-688. doi: 10.1093/jac/dkm503 PMID: 18230688
18. Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, et al. Arctigenin Blocks the Unfolded Protein Response and Shows Therapeutic Antitumor Activity. Journal of Cellular Physiology. 2010; 224: 33-40. doi: 10.1002/jcp.22085 PMID: 20232300
19. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Research. 2006; 66: 1751-1757. PMID: 16452235
20. Cho MK, Jang YP, Kim YC, Kim SG. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. International Immunopharmacology. 2004; 4: 1419-1429. PMID: 15313439
21. Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. Journal of Ethnopharmacology. 2009; 122: 457-462. doi: 10.1016/j.jep.2009.01.038 PMID: 19429312
22. Gu Y, Qi CT, Sun XX, Ma XQ, Zhang HH, Hu LH, et al. Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochemical Pharmacology. 2012; 84: 468-476. doi: 10.1016/j.bcp.2012.06.002 PMID: 22687625
23. Susanti S, Iwasaki H, Inafuku M, Taira N, Oku H. Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines. Phytomedicine. 2013; 21: 39-46. doi: 10.1016/j.phymed.2013.08.003 PMID: 24021157
24. Jeong JB, Hong SC, Jeong HJ, Koo JS. Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells. International Immunopharmacology. 2011; 11: 1573-1577. doi: 10.1016/j.intimp.2011.05.016 PMID: 21621647
25. Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. Free Radical Biology and Medicine. 2014; 67: 159-170. doi: 10.1016/j.freeradbiomed.2013.10.004 PMID: 24140706
26. Gross A, Jockel J, Wei MC, Korsmeyer SJ. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 1998; 17: 3878-3885. PMID: 9670005
27. Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, et al. Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis. Science. 1997; 275: 983-986. PMID: 9020082
28. Desagher S, Martinou J-C. Mitochondria as the central control point of apoptosis. Trends in Cell Biology. 2000; 10: 369-377. PMID: 10932094
29. Galluzzi L, Larochette N, Zamzami N, Kroemer G. Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene. 2006; 25: 4812-4830. PMID: 16892093
30. Ahmad N, Gupta S, Mukhtar H. Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys. 2000; 376: 338-346. PMID: 10775421
31. Kalra N, Seth K, Prasad S, Singh M, Pant AB, Shukla Y. Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life Sciences. 2007; 80: 2137-2146. PMID: 17499812
32. Kruse JP, Gu W. Modes of p53 Regulation. Cell. 2009; 137: 609-622. doi: 10.1016/j.cell.2009.04.050 PMID: 19450511
33. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000; 288: 1053-1058. PMID: 10807576
34. Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004; 6: 443-450. PMID: 15077116
35. Harris CC. p53 tumor suppressor gene: from the basic research laboratory to the clinic - an abridged historical perspective. Carcinogenesis. 1996; 17: 1187-1198. PMID: 8681432
36. Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Letters. 2014; 344: 174-179. doi: 10.1016/j.canlet.2013.11.019 PMID: 24333738
37. Makin G, Hickman JA. Apoptosis and cancer chemotherapy. Cell Tissue Res. 2000; 301: 143-152. PMID: 10928287
38. Lu JH, Quearry B, Harada H. p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells. Febs Letters. 2006; 580: 3539-3544. PMID: 16730715
39. Cosentino K, García-Sáez AJ. Mitochondrial alterations in apoptosis. Chemistry and Physics of Lipids. 2014; 181: 62-75. doi: 10.1016/j.chemphyslip.2014.04.001 PMID: 24732580
40. Huttemann M, Pecina P, Rainbolt M, Sanderson TH, Kagan VE, Samavati L, et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 2011; 11: 369-381. doi: 10.1016/j.mito.2011.01.010 PMID: 21296189
41. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999; 13: 1899-1911. PMID: 10444588
42. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001; 15: 2922-2933. PMID: 11711427
43. Peter ME, Krammer PH. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 2003; 10: 26-35. PMID: 12655293
44. Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer. 2002; 2: 420-430. PMID: 12189384
45. Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999; 17: 331-367. PMID: 10358762
46. Chao X, Zao J, Xiao-Yi G, Li-Jun M, Tao S. Blocking of PI3K/AKT induces apoptosis by its effect on NF-κB activity in gastric carcinoma cell line SGC7901. Biomedicine & Pharmacotherapy. 2010; 64: 600-604.
47. Sun Y, Gao C, Luo M, Wang W, Gu C, Zu Y, et al. Aspidin PB, a phloroglucinol derivative, induces apoptosis in human hepatocarcinoma HepG2 cells by modulating PI3K/Akt/GSK3β pathway. Chemico-Biological Interactions. 2013; 201: 1-8. doi: 10.1016/j.cbi.2012.11.005 PMID: 23178381
48. Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem. 1999; 68: 965-1014. PMID: 10872470
49. Jeong S-J, Dasgupta A, Jung K-J, Um J-H, Burke A, Park HU, et al. PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology. 2008; 370: 264-272. PMID: 17931677
50. Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends in Biochemical Sciences. 2001; 26: 657-664. PMID: 11701324
51. Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cellular Signalling. 2002; 14: 381-395. PMID: 11882383
52. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994; 9: 1799-1805. PMID: 8183579
53. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Molecular Cell. 2003; 11: 577-590. PMID: 12667443
54. Bragado P, Armesilla A, Silva A, Porras A. Apoptosis by cisplatin requires p53 mediated p38 alpha MAPK activation through ROS generation. Apoptosis. 2007; 12: 1733-1742. PMID: 17505786
55. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer D, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004; 303: 1010-1014. PMID: 14963330
56. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998; 281: 1680-1683. PMID: 9733516
57. Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J. NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol. 2001; 21: 5299-5305. PMID: 11463813
58. Penolazzi L, Lambertini E, Borgatti M, Piva R, Cozzani M, Giovannini I, et al. Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclasts. Biochem Pharmacol. 2003; 66: 1189-1198. PMID: 14505798
59. Wahl C, Maier S, Marre R, Essig A. Chlamydia pneumoniae induces the expression of inhibitor of apoptosis 2 (c-IAP2) in a human monocytic cell line by an NF-kappaB-dependent pathway. Int J Med Microbiol. 2003; 293: 377-381. PMID: 14695066
60. Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett. 2007; 246: 201-209. PMID: 16563612
61. Dai Y, Liu ML, Tang WH, Li YM, Lian JQ, Lawrence TS, et al. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. Bmc Cancer. 2009; 9.
62. Chiao PJ, Na R, Niu J, Sclabas GM, Dong Q, Curley SA. Role of Rel/NF-κB transcription factors in apoptosis of human hepatocellular carcinoma cells. Cancer. 2002; 95: 1696-1705. PMID: 12365017
63. Li X, Huang Q, Ong C-N, Yang X-F, Shen H-M. Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB. Cancer Letters. 2010; 293: 109-116. doi: 10.1016/j.canlet.2010.01.002 PMID: 20133051