Role of Rel/NF-κB transcription factors in apoptosis of human hepatocellular carcinoma cells

Cancer

Volumn 95, Issue 8, 2002, Pages 1696-1705

  Chiao, Paul J ^a   Na, Ren ^a   Niu, Jiangong ^a   Sclabas, Guido M ^a   Dong, Qianggang ^a   Curley, Steven A ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; HBV x gene; Hepatocellular carcinoma; NF B

Indexed keywords

BORTEZOMIB; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL XL; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE OVEREXPRESSION; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PHOSPHORYLATION; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; DOXORUBICIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0037108089     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10829     Document Type: Article

References (49)

1. Verma IM, Stevenson JK, Schwarz EM, Antwerp DV, Miyamoto S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 1995;9:2723-2735.
2. Gilmore TD. NF-κB. Oncogene. 1999.;4:1367-1378.
3. Baldwin A Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:694-781.
4. Bacuerle PA, Baltimore D. I kappa B: a specific inhibitor of the NF-kappa transcription factor. Science. 1988;42:540-546.
5. Chiao PJ, Miyamoto S, Verma IM. Autoregulation of IκBα activity. Proc Natl Acad Sci USA. 1994;91:28-33.
6. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of IκBαproteolysis by site-specific, signal-induced phosphorylation. Science. 1995;267:1485-1488.
7. Didonato JA, Mercurio F, Karin M. Phosphorylation of IκBαprecedes but is not sufficient for its dissociation from NF-κB. Mol Cell Biol. 1995;15:1302-1311.
8. Chen ZJ, Hagler J, Palombella VJ, et al. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 1995;9:1586-1597.
9. Mercurio F, Zhu H, Murray BW, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases are essential for NF-kappaB activation. Science. 1997;278:860-866.
10. Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science. 1997;278:866-869.
11. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin MA. Cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997;388:548-554.
12. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an IkappaB kinase. Cell. 1997;90:373-383.
13. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997;91:243-252.
14. Hirano M, Osada S, Aoki T, et al. MEK kinase is involved in tumor necrosis factor a-induced NF-κB activation and degradation of IκBα. J Biol Chem. 1996;271:13234-13238.
15. Lee FS, Hagler J, Chen Z, Maniatis T. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 1997;88:213-222.
16. Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K. NAK is an IkappaB kinase-activating kinase. Nature. 2000;404:778-782.
17. Watkins KT, Curley SA. Liver and bile ducts. In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, editors. Clinical oncology, 2nd ed. New York: Churchill Livingstone, 2000:1681-1748.
18. Tai DI, Tsai SL, Chang YH, et al. Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. Cancer. 2000;89:2274-2281.
19. Tay N, Chan SH, Ren EC. Detection of integrated hepatitis B virus DNA in hepatocellular carcinoma cell lines by nonradioactive in situ hybridization. J Med Virol. 1990;30: 266-271.
20. Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 1991;19:2499.
21. waf1 expression and growth inhibition by transforming growth factor-β is mediated by tumor suppressor gene, DPC4, in human pancreatic adenocarcinoma cells. Cancer Res. 1997; 57:3929-3934.
22. Van Antwerp D, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 1996;274:787-789.
23. Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-κB in p53-mediated programmed cell death. Nature. 2000;404:892-897.
24. Gilmore TD, Koedood M, Piffat KA, White D. Rel/NF-κB/IκB proteins and cancer. Oncogene. 1997;14:1367-1378.
25. Moore BE, Bose HR. Transformation of avian lymphoid cells by reticuloendotheliosis virus. Mutat Res. 1988;195:9-80.
26. Moore BE, Bose HRJ. Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts. Virology. 1988;162:377-387.
27. Sylla BS, Temin HM. Activation of oncogenicity of the c-rel proto-oncogene. Mol Cell Biol. 1986;6:4709-4716.
28. Kitajima I, Shinohara T, Bilakovics JDAB, Xu X, Nerenberg M. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science. 1992;258:1792-1795.
29. Yin MJ, Christerson LB, Yamamoto Y, et al. HTLV-1 Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation. Cell. 1998;93:875-884.
30. Twu JS, Chu K, Robinson WS. Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus I. Proc Natl Acad Sci USA. 1989;86:5168-5172.
31. Mahe Y, Mukaida N, Kuno K, et al. Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor KB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem. 1991;266:13759-13763.
32. Lucito R, Schneider RJ. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J Virol. 1992;66:983-991.
33. Su F, Schneider RJ. Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J Virol. 1996;70:4558-4566.
34. Luque I, Gelinas C. Rel/NF-κB and IκB factors in oncogenesis. Cancer Biol. 1997;8:103-112.
35. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res. 1999;5:119-127.
36. Beg AA, Sha WC, Bronson RT, Ghosh G, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature. 1996;376:167-170.
37. Beg AA, Baltimore D. An essential role of NF-κB in preventing TNF-α-induced cell death. Science. 1996;274:782-784.
38. Wang CY, Mayo MW, Baldwin A Jr. TNF-α and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science. 1996;274:784-787.
39. Mayo MW, Wang CY, Cogswell PC, et al. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science. 1997;278:1812-1815.
40. Jung M, Zhang Y, Lee S, Dritschilo A. Correction of radiation sensitivity in ataxia telengiectasia by a truncated IκBα. Science. 1995;268:1619-1621.
41. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA. 1997;94:1441-1446.
42. Glasgow JN, Wood T, Perez-Polo JR. Identification and characterization of nuclear factor κB binding sites in the murine bcl-xl promoter. J Neurochem. 2000;75:1377-1389.
43. Chen C, Edelstein LC, Gelinas C. The Rel/NF-κB family directly activates expression of the apoptosis inhibitor bclxl. Mol Cell Biol. 2000;20:2687-2695.
44. Stroka DM, Badrichani AZ, Bach FH, Ferran C. Overexpression of A1, an NF-κB-inducible anti-apoptotic bcl gene, inhibits endothelial cell activation. Blood. 1999;93:3803-3810.
45. Bui NT, Livolsi A, Peyron JF, Prehn JHM. Activation of nuclear factor κB and bcl-xl survival gene expression by nerve growth factor requires tyrosine phosphorylation of Iκbα. J Cell Biol. 2000;152:753-763.
46. Tsukahara T, Kannagi M, Ohashi T, et al. Induction of Bcl-xl expression by human T-cell leukemia virus type 1 tax through NF-κB in apoptosis-resistant T-cell transfectants with Tax. J Virol. 1999;73:7981-7987.
47. Weil R, Sirma H, Giannini C, et al. Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Mol Cell Biol. 1999;9: 6345-6354.
48. Cusack JC Jr., Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 2001;61-3535-3540.
49. Farshid M, Tabor E. Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines. J Med Virol. 1992;38:177-178.