Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells

International Immunopharmacology

Volumn 11, Issue 10, 2011, Pages 1573-1577

  Jeong, Jin Boo ^a   Hong, Se Chul ^a   Jeong, Hyung Jin ^a   Koo, Jin Suk ^a  

^a Andong National University   (South Korea)

Author keywords

Antitumor; Apoptosis; Arctigenin; Cell cycle arrest; Gastric cancer

Indexed keywords

ARCTIGENIN; BAG 1 PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN E; PROTEIN BAX; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; FURANS; HUMANS; LIGNANS; PHOSPHORYLATION; PLANTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINOBLASTOMA PROTEIN; STOMACH NEOPLASMS;

EID: 80053241183     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.05.016     Document Type: Article

References (30)

1. M.E. Quasney, L.C. Carte, C. Oxford, S.M. Watkins, M.E. Gershwin, and J.B. German Inhibition of proliferation and induction of apoptosis in SNU-1 human gastric cancer cells by the plant sulfolipid, sulfoquinovosyldiacylglycerol J Nutr Biochem 12 2001 310 315 (Pubitemid 32520846)
2. J.K. Bastos, J.C. Carvalho, G.H. De Souza, A.H. Pedrazzi, and S.J. Sarti Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb J Ethnopharmacol 75 2001 279 282 (Pubitemid 32297745)
3. T. Midori, K. Takao, K. Katsuko, T. Harukuni, and N. Hoyoku Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa Cancer Lett 158 2000 53 59
4. Y.P. Jang, S.R. Kim, Y.H. Choi, J. Kim, S.G. Kim, and G.J. Markelonis Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor J Neurosci Res 68 2002 233 240 (Pubitemid 34275016)
5. Y.P. Jang, S.R. Kim, and Y.C. Kim Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera Planta Med 67 2001 470 472
6. S. Moritani, M. Nomura, Y. Takeda, and K. Miyamoto Cytotoxic components of Bardanae fructus (goboshi) Biol Pharm Bull 19 1996 1515 1517 (Pubitemid 26403265)
7. K. Umehara, M. Nakamura, T. Miyase, M. Kuroyanagi, and A. Ueno Studies on differentiation inducers: VI. Lignan derivatives from Arctium fructus. (2). Chem Pharm Bull 44 1996 2300 2304
8. S. Awale, J. Lu, S.K. Kalauni, Y. Kurashima, Y. Tezuka, and S. Kadota Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation Cancer Res 66 2006 1751 1757 (Pubitemid 43259960)
9. M.K. Cho, Y.P. Jang, Y.C. Kim, and S.G. Kim Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-α inhibition Int Immunopharmacol 4 2004 1419 1429 (Pubitemid 39094415)
10. T. Matsumoto, K. Hosono-Nishiyama, and H. Yamada Anti-proliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells Planta Med 72 2006 276 278
11. T. Miyashita, S. Krajewski, M. Krajewska, H.G. Wang, H.K. Lin, and D.A. Liebermann Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo Oncogene 9 1994 1799 1805 (Pubitemid 24163411)
12. A.L. Murphree, and W.F. Benedict Retinoblastoma: clues to human oncogenesis Science 223 1984 1028 1033 (Pubitemid 14193283)
13. M. Vietri, M. Bianchi, J.W. Ludlow, S. Mittnacht, and E. Villa-Moruzzi Direct interaction between the catalytic subunit of protein phosphatase 1 and pRb Cancer Cell Int 6 2006 3
14. T. Moroy, C. Geisen, and E. Cyclin Int J Biochem Cell Biol 36 2004 1424 1439
15. J.R. Alt, J.L. Cleveland, M. Hannink, and J.A. Diehl Phosphorylation- dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation Genes Dev 14 2000 3102 3114 (Pubitemid 32015129)
16. E. Lees Cyclin dependent kinase regulation Curr Opin Cell Biol 7 1995 773 780
17. A.L. Gartel, and S.K. Radhakrishnan Lost in transcription: p21 repression, mechanisms, and consequences Cancer Res 65 2006 3980 3985 (Pubitemid 40775632)
18. J. Lukas, J. Bartkova, and J. Bartek Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint Mol Cell Biol 16 1996 6917 6925 (Pubitemid 26389751)
19. A.I. Neugut, M. Hayek, and G. Howe Epidemiology of gastric cancer Semin Oncol 3 1996 281 291 (Pubitemid 26187728)
20. Y. Chang, L. Li, C. Wu, T. Liu, W. Lui, and F. P'eng Paclitaxel induced apoptosis in human gastric carcinoma cell lines Cancer 77 1996 14 18 (Pubitemid 26002731)
21. P. Correa, and V.W. Chen Gastric cancer Cancer Surv 19-20 1994 55 76 (Pubitemid 24289379)
22. B.A. Jones, and G.J. Gores Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine Am J Physiol 273 1997 G1174 G1188
23. R.M. Kluck, E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1997 1132 1136 (Pubitemid 27097313)
24. M.K. Manion, and D.M. Hockenbery Targeting BCL-2 related protein in cancer therapy Cancer Biol Ther 2 2003 S105 S114
25. P.P. Trivedi, P.C. Roberts, N.A. Wolf, and R.H. Swanborg NK cells inhibit T cell proliferation via p21-mediated cell cycle arrest J Immunol 174 2005 4590 4597
26. C.J. Sherr G1 phase progression: cycling on cue Cell 79 1994 551 555 (Pubitemid 24363798)
27. R.D. Kornberg, and Y. Lorch Twenty-five years of the nucleosome, fundamental particle of the eukaryotic chromosome Cell 98 1999 285 294 (Pubitemid 29380564)
28. A.J. Hume, J.S. Finkel, J.P. Kamil, D.M. Coen, M.R. Culbertson, and R.F. Kalejta Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function Science 320 2008 797 799 (Pubitemid 351929629)
29. C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev 13 1999 1501 1512 (Pubitemid 29297917)
30. S. Awale, J. Lu, S.K. Kalauni, Y. Kurashima, Y. Tezuka, and S. Kadota Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation Cancer Res 3 2006 1571 1577