메뉴 건너뛰기




Volumn 114, Issue 6, 2006, Pages 898-904

PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract

Author keywords

Aroclor 1254; DES; Diethylstilbestrol; Endocrine disruptor; Female reproductive tract; PCBs; Polychlorinated biphenyls; Wnt7a

Indexed keywords

AROCLOR 1254; BIOLOGICAL MARKER; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; ENVIRONMENTAL CHEMICAL; ESTROGEN DERIVATIVE; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT7A PROTEIN;

EID: 33745011578     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8748     Document Type: Article
Times cited : (55)

References (54)
  • 2
    • 0029591725 scopus 로고
    • Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: An assessment of the biological and epidemiological evidence
    • Ahlborg UG, Lipworth L, Titus-Ernstoff L, Hsieh CC, Hanberg A, Baron J, et al. 1995. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit Rev Toxicol 25:463-531.
    • (1995) Crit Rev Toxicol , vol.25 , pp. 463-531
    • Ahlborg, U.G.1    Lipworth, L.2    Titus-Ernstoff, L.3    Hsieh, C.C.4    Hanberg, A.5    Baron, J.6
  • 4
    • 0034832175 scopus 로고    scopus 로고
    • Endocrine disrupters - Testing strategies to assess human hazard
    • Baker VA. 2001. Endocrine disrupters - testing strategies to assess human hazard. Toxicol In Vitro 15:413-419.
    • (2001) Toxicol In Vitro , vol.15 , pp. 413-419
    • Baker, V.A.1
  • 5
    • 0027982201 scopus 로고
    • Review of the safety assessment of polychlorinated biphenyls (PCBs) with particular reference to reproductive toxicity
    • Battershill JM. 1994. Review of the safety assessment of polychlorinated biphenyls (PCBs) with particular reference to reproductive toxicity. Hum Exp Toxicol 13:581-597.
    • (1994) Hum Exp Toxicol , vol.13 , pp. 581-597
    • Battershill, J.M.1
  • 6
    • 0032878082 scopus 로고    scopus 로고
    • Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs
    • Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J, et al. 1999. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ Health Perspect 107(suppl 4):639-649.
    • (1999) Environ Health Perspect , vol.107 , Issue.SUPPL. 4 , pp. 639-649
    • Brouwer, A.1    Longnecker, M.P.2    Birnbaum, L.S.3    Cogliano, J.4    Kostyniak, P.5    Moore, J.6
  • 7
    • 0029116150 scopus 로고
    • Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat
    • Brown NM, Lamartiniere CA. 1995. Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. Environ Health Perspect 103:708-713.
    • (1995) Environ Health Perspect , vol.103 , pp. 708-713
    • Brown, N.M.1    Lamartiniere, C.A.2
  • 8
    • 3242775503 scopus 로고    scopus 로고
    • Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth
    • Carta L, Sassoon D. 2004. Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth. Biol Reprod 71:444-454.
    • (2004) Biol Reprod , vol.71 , pp. 444-454
    • Carta, L.1    Sassoon, D.2
  • 9
    • 0029692377 scopus 로고    scopus 로고
    • Epidemiological analysis of persistent organochlorine contaminants in cetaceans
    • Colborn T, Smolen MJ. 1996. Epidemiological analysis of persistent organochlorine contaminants in cetaceans. Rev Environ Contam Toxicol 146:91-172.
    • (1996) Rev Environ Contam Toxicol , vol.146 , pp. 91-172
    • Colborn, T.1    Smolen, M.J.2
  • 10
    • 5444266190 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract
    • Couse JF, Korach KS. 2004. Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205:55-63.
    • (2004) Toxicology , vol.205 , pp. 55-63
    • Couse, J.F.1    Korach, K.S.2
  • 11
    • 0031762212 scopus 로고    scopus 로고
    • Environmental estrogens and breast cancer risk
    • Davidson NE. 1998. Environmental estrogens and breast cancer risk. Curr Opin Oncol 10:475-478.
    • (1998) Curr Opin Oncol , vol.10 , pp. 475-478
    • Davidson, N.E.1
  • 12
    • 0029969771 scopus 로고    scopus 로고
    • Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
    • Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, et al. 1996. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 137:4796-4805.
    • (1996) Endocrinology , vol.137 , pp. 4796-4805
    • Eddy, E.M.1    Washburn, T.F.2    Bunch, D.O.3    Goulding, E.H.4    Gladen, B.C.5    Lubahn, D.B.6
  • 13
    • 0031440187 scopus 로고    scopus 로고
    • Examination of the estrogenicity of 2,4,6,2′,6′-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2′,6′-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2′,4′,6′-hexachlorobiphenyl (PCB 155)
    • Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. 1997. Examination of the estrogenicity of 2,4,6,2′,6′-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2′,6′-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2′,4′,6′-hexachlorobiphenyl (PCB 155). Environ Health Perspect 105:1238-1248.
    • (1997) Environ Health Perspect , vol.105 , pp. 1238-1248
    • Fielden, M.R.1    Chen, I.2    Chittim, B.3    Safe, S.H.4    Zacharewski, T.R.5
  • 15
    • 21644453932 scopus 로고    scopus 로고
    • Use of the laboratory rat as a model in endocrine disruptor screening and testing
    • Gray LE Jr, Wilson V, Noriega N, Lambright C, Furr J, Stoker TE, et al. 2004. Use of the laboratory rat as a model in endocrine disruptor screening and testing. ILAR J 45:425-437.
    • (2004) ILAR J , vol.45 , pp. 425-437
    • Gray Jr., L.E.1    Wilson, V.2    Noriega, N.3    Lambright, C.4    Furr, J.5    Stoker, T.E.6
  • 16
    • 0033180529 scopus 로고    scopus 로고
    • Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: Effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior
    • Hany J, Lilienthal H, Sarasin A, Roth-Harer A, Fastabend A, Dunemann L, et al. 1999. Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior. Toxicol Appl Pharmacol 158:231-243.
    • (1999) Toxicol Appl Pharmacol , vol.158 , pp. 231-243
    • Hany, J.1    Lilienthal, H.2    Sarasin, A.3    Roth-Harer, A.4    Fastabend, A.5    Dunemann, L.6
  • 17
    • 0006645425 scopus 로고    scopus 로고
    • Incidence of squamous neoplasia of the cervix and vagina in DES-exposed daughters
    • Hatch E, Herbst A, Hoover R, Noller K, Adam E, Kaufman R, et al. 2000. Incidence of squamous neoplasia of the cervix and vagina in DES-exposed daughters. Ann Epidemiol 10:467.
    • (2000) Ann Epidemiol , vol.10 , pp. 467
    • Hatch, E.1    Herbst, A.2    Hoover, R.3    Noller, K.4    Adam, E.5    Kaufman, R.6
  • 19
    • 0027597736 scopus 로고
    • Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies
    • Jansen HT, Cooke PS, Porcelli J, Liu TC, Hansen LG. 1993. Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies. Reprod Toxicol 7:237-248.
    • (1993) Reprod Toxicol , vol.7 , pp. 237-248
    • Jansen, H.T.1    Cooke, P.S.2    Porcelli, J.3    Liu, T.C.4    Hansen, L.G.5
  • 20
    • 0028535243 scopus 로고
    • Reproductive toxicity of Aroclor-1254: Effects on oocyte, spermatozoa, in vitro fertilization, and embryo development in the mouse
    • Kholkute SD, Rodriguez J, Dukelow WR. 1994. Reproductive toxicity of Aroclor-1254: effects on oocyte, spermatozoa, in vitro fertilization, and embryo development in the mouse. Reprod Toxicol 8:487-493.
    • (1994) Reprod Toxicol , vol.8 , pp. 487-493
    • Kholkute, S.D.1    Rodriguez, J.2    Dukelow, W.R.3
  • 21
    • 0033780112 scopus 로고    scopus 로고
    • The emergence of molecular gynecology: Homeobox and Wntgenes in the female reproductive tract
    • Kitajewski J, Sassoon D. 2000. The emergence of molecular gynecology: homeobox and Wntgenes in the female reproductive tract. Bioessays 22:902-910.
    • (2000) Bioessays , vol.22 , pp. 902-910
    • Kitajewski, J.1    Sassoon, D.2
  • 22
    • 0032972581 scopus 로고    scopus 로고
    • Effects of the antiestrogenic environmental pollutant 3,3′,4,4′,5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: Diverging effects in ovariectomized and intact animals
    • Lind PM, Eriksen EF, Sahlin L, Edlund M, Orberg J. 1999. Effects of the antiestrogenic environmental pollutant 3,3′,4,4′,5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Toxicol Appl Pharmacol 154:236-244.
    • (1999) Toxicol Appl Pharmacol , vol.154 , pp. 236-244
    • Lind, P.M.1    Eriksen, E.F.2    Sahlin, L.3    Edlund, M.4    Orberg, J.5
  • 25
    • 0021893087 scopus 로고
    • Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta)
    • McNulty WP. 1985. Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta). Environ Health Perspect 60:77-88.
    • (1985) Environ Health Perspect , vol.60 , pp. 77-88
    • McNulty, W.P.1
  • 26
    • 16444376498 scopus 로고    scopus 로고
    • Diethylstilbestrol exposure in utero: A paradigm for mechanisms leading to adult disease
    • Mericskay M, Carta L, Sassoon D. 2005. Diethylstilbestrol exposure in utero: a paradigm for mechanisms leading to adult disease. Birth Defects Res A Clin Mol Teratol 73:133-135.
    • (2005) Birth Defects Res A Clin Mol Teratol , vol.73 , pp. 133-135
    • Mericskay, M.1    Carta, L.2    Sassoon, D.3
  • 27
    • 2542557308 scopus 로고    scopus 로고
    • Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus
    • Mericskay M, Kitajewski J, Sassoon D. 2004. Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development 131:2061-2072.
    • (2004) Development , vol.131 , pp. 2061-2072
    • Mericskay, M.1    Kitajewski, J.2    Sassoon, D.3
  • 28
    • 0031791874 scopus 로고    scopus 로고
    • Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis
    • Miller C, Degenhardt K, Sassoon DA. 1998a. Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis. Nat Genet 20:228-230.
    • (1998) Nat Genet , vol.20 , pp. 228-230
    • Miller, C.1    Degenhardt, K.2    Sassoon, D.A.3
  • 29
    • 0032144172 scopus 로고    scopus 로고
    • Differential expression patterns of Wntgenes in the murine female reproductive tract during development and the estrous cycle
    • Miller C, Pavlova A, Sassoon DA. 1998b. Differential expression patterns of Wntgenes in the murine female reproductive tract during development and the estrous cycle. Mech Dev 76:91-99.
    • (1998) Mech Dev , vol.76 , pp. 91-99
    • Miller, C.1    Pavlova, A.2    Sassoon, D.A.3
  • 30
    • 0031690260 scopus 로고    scopus 로고
    • Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract
    • Miller C, Sassoon DA. 1998. Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development 125:3201-3211.
    • (1998) Development , vol.125 , pp. 3201-3211
    • Miller, C.1    Sassoon, D.A.2
  • 32
    • 0029758425 scopus 로고    scopus 로고
    • 3,4,3′,4′-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo
    • Nesaretnam K, Corcoran D, Dils RR, Darbre P. 1996. 3,4,3′,4′-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo. Mol Endocrinol 10:923-936.
    • (1996) Mol Endocrinol , vol.10 , pp. 923-936
    • Nesaretnam, K.1    Corcoran, D.2    Dils, R.R.3    Darbre, P.4
  • 33
    • 0035360280 scopus 로고    scopus 로고
    • Uterine adenocarcinoma in mice treated neonatally with genistein
    • Newbold RR, Banks EP, Bullock B, Jefferson WN. 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61:4325-4328.
    • (2001) Cancer Res , vol.61 , pp. 4325-4328
    • Newbold, R.R.1    Banks, E.P.2    Bullock, B.3    Jefferson, W.N.4
  • 34
    • 0035017358 scopus 로고    scopus 로고
    • The impact of endocrine disrupters on the female reproductive system
    • Nicolopoulou-Stamati P, Pitsos MA. 2001. The impact of endocrine disrupters on the female reproductive system. Hum Reprod Update 7:323-330.
    • (2001) Hum Reprod Update , vol.7 , pp. 323-330
    • Nicolopoulou-Stamati, P.1    Pitsos, M.A.2
  • 35
    • 0033607207 scopus 로고    scopus 로고
    • Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice
    • Ogawa S, Chan J, Chester AE, Gustafsson JA, Korach KS, Pfaff DW. 1999. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Proc Natl Acad Sci USA 96:12887-12892.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12887-12892
    • Ogawa, S.1    Chan, J.2    Chester, A.E.3    Gustafsson, J.A.4    Korach, K.S.5    Pfaff, D.W.6
  • 37
    • 0028951117 scopus 로고
    • Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb
    • Parr BA, McMahon AP. 1995. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374:350-353.
    • (1995) Nature , vol.374 , pp. 350-353
    • Parr, B.A.1    McMahon, A.P.2
  • 38
    • 0032531820 scopus 로고    scopus 로고
    • Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a
    • Parr BA, McMahon AP. 1998. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395:707-710.
    • (1998) Nature , vol.395 , pp. 707-710
    • Parr, B.A.1    McMahon, A.P.2
  • 39
    • 0030704659 scopus 로고    scopus 로고
    • Additive estrogenic activities of a binary mixture of 2′,4′,6′-trichloro- and 2′,3′,4′,5′-tetrachloro-4-biphenylol
    • Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, et al. 1997. Additive estrogenic activities of a binary mixture of 2′,4′,6′-trichloro- and 2′,3′,4′,5′-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol 147:93-100.
    • (1997) Toxicol Appl Pharmacol , vol.147 , pp. 93-100
    • Ramamoorthy, K.1    Vyhlidal, C.2    Wang, F.3    Chen, I.4    Safe, S.5    McDonnell, D.P.6
  • 40
    • 0032985901 scopus 로고    scopus 로고
    • Sex ratio after exposure to dioxin-like chemicals in Taiwan
    • Rogan WJ, Gladen BC, Guo YL, Hsu CC. 1999. Sex ratio after exposure to dioxin-like chemicals in Taiwan. Lancet 353:206-207.
    • (1999) Lancet , vol.353 , pp. 206-207
    • Rogan, W.J.1    Gladen, B.C.2    Guo, Y.L.3    Hsu, C.C.4
  • 41
    • 0030925236 scopus 로고    scopus 로고
    • Is there an association between exposure to environmental estrogens and breast cancer?
    • Safe SH. 1997. Is there an association between exposure to environmental estrogens and breast cancer? Environ Health Perspect 105(suppl 3):675-678.
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 3 , pp. 675-678
    • Safe, S.H.1
  • 42
    • 0030637651 scopus 로고    scopus 로고
    • Organochlorine exposure and risk for breast cancer
    • Safe SH, Zacharewski T. 1997. Organochlorine exposure and risk for breast cancer. Prog Clin Biol Res 396:133-145.
    • (1997) Prog Clin Biol Res , vol.396 , pp. 133-145
    • Safe, S.H.1    Zacharewski, T.2
  • 43
    • 0032722717 scopus 로고    scopus 로고
    • Wnt genes and endocrine disruption of the female reproductive tract: A genetic approach
    • Sassoon D. 1999. Wnt genes and endocrine disruption of the female reproductive tract: a genetic approach. Mol Cell Endocrinol 158:1-5.
    • (1999) Mol Cell Endocrinol , vol.158 , pp. 1-5
    • Sassoon, D.1
  • 44
    • 0027501673 scopus 로고
    • Detection of messenger RNA by in situ hybridization
    • Sassoon D, Rosenthal N. 1993. Detection of messenger RNA by in situ hybridization. Methods Enzymol 225:384-404.
    • (1993) Methods Enzymol , vol.225 , pp. 384-404
    • Sassoon, D.1    Rosenthal, N.2
  • 45
    • 0023863018 scopus 로고
    • Physical and psychological problems associated with exposure to diethylstilbestrol (DES)
    • Saunders EJ. 1988. Physical and psychological problems associated with exposure to diethylstilbestrol (DES). Hosp Community Psychiatry 39:73-77.
    • (1988) Hosp Community Psychiatry , vol.39 , pp. 73-77
    • Saunders, E.J.1
  • 46
    • 0027940553 scopus 로고
    • Effects of persistent chlorinated hydrocarbons on fertility and embryonic development in the rabbit
    • Seiler P, Fischer B, Lindenau A, Beier HM. 1994. Effects of persistent chlorinated hydrocarbons on fertility and embryonic development in the rabbit. Hum Reprod 9:1920-1926.
    • (1994) Hum Reprod , vol.9 , pp. 1920-1926
    • Seiler, P.1    Fischer, B.2    Lindenau, A.3    Beier, H.M.4
  • 47
    • 0030692641 scopus 로고    scopus 로고
    • Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines
    • Shekhar PV, Werdell J, Basrur VS. 1997a. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst 89:1774-1782.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1774-1782
    • Shekhar, P.V.1    Werdell, J.2    Basrur, V.S.3
  • 48
    • 0030692641 scopus 로고    scopus 로고
    • Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines
    • Shekhar PV, Werdell J, Basrur VS. 1997b. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst 89:1774-1782.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1774-1782
    • Shekhar, P.V.1    Werdell, J.2    Basrur, V.S.3
  • 49
    • 0031710442 scopus 로고    scopus 로고
    • Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 3. Estrogen receptor and progesterone receptor concentrations, and potential correlation with dietary PCB consumption
    • Shipp EB, Restum JC, Bursian SJ, Aulerich RJ, Helferich WG. 1998. Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 3. Estrogen receptor and progesterone receptor concentrations, and potential correlation with dietary PCB consumption. J Toxicol Environ Health A 54:403-420.
    • (1998) J Toxicol Environ Health A , vol.54 , pp. 403-420
    • Shipp, E.B.1    Restum, J.C.2    Bursian, S.J.3    Aulerich, R.J.4    Helferich, W.G.5
  • 50
    • 0035005854 scopus 로고    scopus 로고
    • Reassessment of models used to test xenobiotics for oestrogenic potency is overdue
    • Spearow JL, Barkley M. 2001. Reassessment of models used to test xenobiotics for oestrogenic potency is overdue. Hum Reprod 16:1027-1029.
    • (2001) Hum Reprod , vol.16 , pp. 1027-1029
    • Spearow, J.L.1    Barkley, M.2
  • 51
    • 0031411001 scopus 로고    scopus 로고
    • Empirical modeling of an in vitroactivity of polychlorinated biphenyl congeners and mixtures
    • Svendsgaard DJ, Ward TR, Tilson HA, Kodavanti PR. 1997. Empirical modeling of an in vitroactivity of polychlorinated biphenyl congeners and mixtures. Environ Health Perspect 105:1106-1115.
    • (1997) Environ Health Perspect , vol.105 , pp. 1106-1115
    • Svendsgaard, D.J.1    Ward, T.R.2    Tilson, H.A.3    Kodavanti, P.R.4
  • 52
    • 0028920516 scopus 로고
    • Human exposure to polychlorinated biphenyls (PCBs): A critical assessment of the evidence for adverse health effects
    • Swanson GM, Ratcliffe HE, Fischer LJ. 1995. Human exposure to polychlorinated biphenyls (PCBs): a critical assessment of the evidence for adverse health effects. Regul Toxicol Pharmacol 21:136-150.
    • (1995) Regul Toxicol Pharmacol , vol.21 , pp. 136-150
    • Swanson, G.M.1    Ratcliffe, H.E.2    Fischer, L.J.3
  • 53
    • 0030983932 scopus 로고    scopus 로고
    • Neurochemical effects of polychlorinated biphenyls: An overview and identification of research needs
    • Tilson HA, Kodavanti PR. 1997. Neurochemical effects of polychlorinated biphenyls: an overview and identification of research needs. Neurotoxicology 18:727-743.
    • (1997) Neurotoxicology , vol.18 , pp. 727-743
    • Tilson, H.A.1    Kodavanti, P.R.2
  • 54
    • 25144460682 scopus 로고    scopus 로고
    • The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs
    • Yang CY, Yu ML, Guo HR, Lai TJ, Hsu CC, Lambert G, et al. 2005. The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs. Chemosphere 61:355-360.
    • (2005) Chemosphere , vol.61 , pp. 355-360
    • Yang, C.Y.1    Yu, M.L.2    Guo, H.R.3    Lai, T.J.4    Hsu, C.C.5    Lambert, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.