Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women

Environmental Health Perspectives

Volumn 114, Issue 5, 2006, Pages 740-745

  Wang, Shu Li ^a,b   Chang, Yu Chen ^a   Chao, How Ran ^a,c   Li, Chien Ming ^a   Li, Lih Ann ^a   Lin, Long Yau ^d   Päpke, Olaf ^e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e ERGO Research Laboratory   (Germany)

Author keywords

Breast neoplasm; Carcinogenic marker; Estrogen catabolism; Estrogen metabolism; Polychlorinated biphenyls; Polychlorinated dibenzodioxins; Polychlorinated dibenzofurans

Indexed keywords

2 HYDROXYESTRADIOL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 HYDROXYESTRADIOL; ANDROSTENEDIONE; DIOXIN; ESTRADIOL; ESTRIOL; ESTRONE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; PROGESTERONE; TUMOR MARKER;

ADULT; ARTICLE; BLOOD SAMPLING; BODY BURDEN; BREAST CANCER; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENVIRONMENTAL EXPOSURE; ESTROGEN METABOLISM; FEMALE; FETUS; GAS CHROMATOGRAPHY; HIGH RISK POPULATION; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; LINEAR REGRESSION ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATERNAL BLOOD; MOTHER FETUS RELATIONSHIP; PLACENTA; PLASMA HALF LIFE; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; TAIWAN; TANDEM MASS SPECTROMETRY; THIRD TRIMESTER PREGNANCY;

BENZOFURANS; BODY BURDEN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTROGENS; FEMALE; HUMANS; POLYCHLORINATED BIPHENYLS; POLYMERS; PREGNANCY; TETRACHLORODIBENZODIOXIN;

EID: 33646368663     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8809     Document Type: Article

References (43)

1. Augustowska K, Gregoraszczuk EE, Grochowalski A, Milewicz T, Mika M, Krzysiek J, et al. 2003. Comparison of accumulation and altered steroid secretion by placental tissue treated with TCDD and natural mixture of PCDDs-PCDFs. Reproduction 126:681-687.
2. Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, et al. 2002. Immunologic effects of dioxin: new results from Seveso and comparison with other studies. Environ Health Perspect 110:1169-1173.
3. Badawi AF, Cavalieri EL, Rogan EG. 2001. Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. Metabolism 50:1001-1003.
4. Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J, et al. 1999. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ Health Perspect 107(suppl 4):639-649.
5. Cavalieri EL, Kumar S, Todorovic R, Higginbotham S, Badawi AF, Rogan EG. 2001. Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol: implications for estrogen-induced initiation of renal tumors. Chem Res Toxicol 14:1041-1050.
6. Chao HR, Wang SL, Lee CC, Yu HY, Lu YK, Papke O. 2004. Level of polychlorinated dibenzo- p-dioxins, dibenzofurans and biphenyls (PCDD/ Fs, PCBs) in human milk and the input to infant body burden. Food Chem Toxicol 42:1299-1308.
7. Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, et al. 2004. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis 25:2005-2013.
8. Cheng SH, Tsou MH, Liu MC, Jian JJ, Cheng JC, Leu SY, et al. 2000. Unique features of breast cancer in Taiwan. Breast Cancer Res Treat 63:213-223.
9. Clemons M, Goss P. 2001. Estrogen and the risk of breast cancer. N Engl J Med 344:276-285.
10. Dohr O, Vogel C, Abel J. 1995. Different response of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells. Arch Biochem Biophys 321:405-412.
11. Guo YL, Hsu PC, Hsu CC, Lambert GH. 2000. Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 356:1240-1241.
12. Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 1996. 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 93:9776-9781.
13. Jacobson JL, Jacobson SW. 1996. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 335:783-789.
14. Jacobson JL, Jacobson SW. 2002. Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. J Toxicol Clin Toxicol 40:467-475.
15. Kerlan V, Dreano Y, Bercovici JP, Beaune PH, Floch HH, Berthou F. 1992. Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes. Biochem Pharmacol 44:1745-1756.
16. Kogevinas M. 2001. Human health effects of dioxins: cancer, reproductive and endocrine system effects. Hum Reprod Update 7:331-339.
17. Kress S, Greenlee WF. 1997. Cell-specific regulation of human CYP1A1 and CYP1B1 genes. Cancer Res 57:1264-1269.
18. Liehr JG. 1999. 4-Hydroxylation of oestrogens as a marker for mammary tumours. Biochem Soc Trans 27:318-323.
19. Liehr JG, Ricci MJ, Jefcoate CR, Hannigan EV, Hokanson JA, Zhu BT. 1995. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci USA 92:9220-9224.
20. Mitamura K, Yatera M, Shimada K. 2000. Studies on neurosteroids. Part XIII. Characterization of catechol estrogens in rat brains using liquid chromatography-mass spectrometrymass spectrometry. Analyst 125:811-814.
21. Mitrunen K, Hirvonen A. 2003. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 544:9-41.
22. Nebert DW, Russell DW. 2002. Clinical importance of the cytochromes P450. Lancet 360:1155-1162.
23. NIPH. 2001. International Comparison on Dioxins in Food. Final Report 4. Folkehelsa, Norway:National Institute of Public Health.
24. Oeltmann T, Carson R, Shannon JR, Ketch T, Robertson D. 2004. Assessment of O-methylated catecholamine levels in plasma and urine for diagnosis of autonomic disorders. Auton Neurosci 116:1-10.
25. Palter SF, Olive DL. 1996. Reproductive physiology. In: Novak's Gynecology (Berek JS, Adashi EY, Hillard PA, eds). Baltimore, MD:Williams & Wilkins, 149-172.
26. Päpke O. 1998. PCDD/PCDF: human background data for Germany, a 10-year experience. Environ Health Perspect 106(suppl 2):723-731.
27. Russo J, Hasan Lareef M, Balogh G, Guo S, Russo IH. 2003. Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol 87:1-25.
28. Safe S. 2001. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 120:1-7.
29. Schecter A, Kassis I, Papke O. 1998. Partitioning of dioxins, dibenzofurans, and coplanar PCBS in blood, milk, adipose tissue, placenta and cord blood from five American women. Chemosphere 37:1817-1823.
30. Schecter A, Olson JR. 1997. Cancer risk assessment using blood dioxin levels and daily dietary TEQ intake in general populations of industrial and non-industrial countries. Chemosphere 34:1569-1577.
31. Schecter A, Startin J, Wright C, Papke O, Ball M, Lis A. 1996. Concentrations of polychlorinated dibenzo- p-dioxins and dibenzofurans in human placental and fetal tissues from the U.S. and in placentas from Yu-Cheng exposed mothers. Chemosphere 32:551-557.
32. Schwarz M, Appel KE. 2005. Carcinogenic risks of dioxin: mechanistic considerations. Regul Toxicol Pharmacol 43:19-34.
33. SPSS. 2000. SPSS for Windows, Release 10.0.7. User's Guide. Chicago, IL:SPSS Inc.
34. Steenland K, Bertazzi P, Baccarelli A, Kogevinas M. 2004. Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ Health Perspect 112:1265-1268.
35. Suzuki G, Nakano M, Nakano S. 2005. Distribution of PCDDs/PCDFs and Co-PCBs in human maternal blood, cord blood, placenta, milk, and adipose tissue: dioxins showing high toxic equivalency factor accumulate in the placenta. Biosci Biotechnol Biochem 69:1836-1847.
36. Van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P, Feeley M, et al. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775-792.
37. van Duursen MB, Sanderson JT, van der Bruggen M, van der Linden J, van den Berg M. 2003. Effects of several dioxinlike compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. Toxicol Appl Pharmacol 190:241-250.
38. Wang SL, Lin CY, Guo YL, Lin LY, Chou WL, Chang LW. 2004. Infant exposure to polychlorinated dibenzo- p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs)-correlation between prenatal and postnatal exposure. Chemosphere 54:1459-1473.
39. Wang SL, Su PH, Jong SB, Guo YL, Chou WL, Papke O. 2005. In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. Environ Health Perspect 113:1645-1650.
40. Warner M, Eskenazi B, Mocarelli P, Gerthoux PM, Samuels S, Needham L, et al. 2002. Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study. Environ Health Perspect 110:625-628.
41. World Medical Association. 2000. Declaration of Helsinki: ethical principles for medical research involving human subjects. Bull Med Ethics 162:8-11.
42. Yager JD. 2000. Endogenous estrogens as carcinogens through metabolic activation. J Natl Cancer Inst Monogr 27:67-73.
43. Zhu BT, Conney AH. 1998. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19:1-27.