Estrogen receptor-hijacking by dioxin-like 3,3'4,4',5-pentachlorobiphenyl (PCB126) in salmon hepatocytes involves both receptor activation and receptor protein stability

Aquatic Toxicology

Volumn 124-125, Issue , 2012, Pages 197-208

  Gjernes, Martine H ^a   Schlenk, Daniel ^b   Arukwe, Augustine ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AhR; Estrogen receptor; Inhibitors; Interactions; PCB126

Indexed keywords

3',4' DIMETHOXYFLAVONE; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; AROMATIC HYDROCARBON RECEPTOR 2; CYCLOHEXIMIDE; CYTOCHROME P450 1A1; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AHR; TRANSCRIPTION FACTOR ARNT; TRANSCRIPTION FACTOR PER; TRANSCRIPTION FACTOR SIM; UNCLASSIFIED DRUG; VITELLOGENIN;

BIOCHEMISTRY; ESTROGENIC COMPOUND; GENE EXPRESSION; INHIBITOR; PROTEIN; SALMONID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SALMON; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; GENE EXPRESSION REGULATION; HEPATOCYTES; POLYCHLORINATED BIPHENYLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; RECEPTORS, ESTROGEN; SALMON; SIGNAL TRANSDUCTION; WATER POLLUTANTS, CHEMICAL;

MAMMALIA; PISCES; VERTEBRATA;

EID: 84865853572     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2012.08.015     Document Type: Article

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