The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Skibska, Beata ^a   Goraca, Anna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CARDIOLOGY; CARDIOVASCULAR SYSTEM; DISEASES; MOBILE SECURITY; OXIDATIVE STRESS;

ANTI-AGING PROPERTIES; ANTIOXIDANT DEFENSE; CARDIO-VASCULAR DISEASE; CELLULAR SENESCENCE; ENDOTHELIAL DYSFUNCTION; ISCHEMIC HEART DISEASE; NATURAL ANTIOXIDANTS; REACTIVE OXYGEN SPECIES;

PATHOLOGY;

THIOCTIC ACID; CARDIOTONIC AGENT;

AGING; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL DEATH; ENDOTHELIAL DYSFUNCTION; EXTRACELLULAR MATRIX; HEART FAILURE; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HYPERTENSION; INCIDENCE; ISCHEMIC HEART DISEASE; NONHUMAN; OXIDATIVE STRESS; REVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; CARDIOVASCULAR DISEASES; DRUG EFFECTS; PATHOLOGY;

AGING; ANIMALS; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; HUMANS; OXIDATIVE STRESS; THIOCTIC ACID;

EID: 84928472943     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/313021     Document Type: Review

References (125)

1. T. M. Paravicini and R. M. Touyz, "NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities, " Diabetes care, vol. 31, no. 2, pp. 170-180, 2008.
2. A. Karavidas, G. Lazaros, D. Tsiachris, and V. Pyrgakis, "Aging and the cardiovascular system, " Hellenic Journal of Cardiology, vol. 51, no. 5, pp. 421-427, 2010.
3. Y. Mei, M. D. Thompson, R. A. Cohen, and X. Tong, "Autophagy and oxidative stress in cardiovascular diseases, " Biochimica et Biophysica Acta, vol. 1852, no. 2, pp. 243-251, 2015.
4. D. Harman, "Aging: a theory based on free radical and radiation chemistry, " Journal of Gerontology, vol. 11, no. 3, pp. 298-300, 1956.
5. G. Bartosz, "Reactive oxygen species: destroyers or messengers?" Biochemical Pharmacology, vol. 77, no. 8, pp. 1303-1315, 2009.
6. L. J. Reed, "The chemistry and functionof lipoic acid, " Advances in Enzymology and Related Subjects of Biochemistry, vol. 18, pp. 319-347, 1957.
7. M. Dudek, A. Bilska-Wilkosz, J. Knutelska et al., "Are antiinflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?" Pharmacological Reports, vol. 65, no. 4, pp. 1018-1024, 2013.
8. L. Packer, E. H. Witt, and H. J. Tritschler, "Alpha-lipoic acid as a biological antioxidant, " Free Radical Biology and Medicine, vol. 19, no. 2, pp. 227-250, 1995.
9. F. Navari-Izzo, M. F. Quartacci, and C. Sgherri, "Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species, " Plant Physiology and Biochemistry, vol. 40, no. 6-8, pp. 463-470, 2002.
10. S. Ghibu, C. Richard, C. Vergely, M. Zeller, Y. Cottin, and L. Rochette, "Antioxidant properties of an endogenous thiol: alpha-lipoic acid, useful in the prevention of cardiovascular diseases, " Journal of Cardiovascular Pharmacology, vol. 54, no. 5, pp. 391-398, 2009.
11. L. Rochette, S. Ghibu, C. Richard, M. Zeller, Y. Cottin, and C. Vergely, "Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential, " Molecular Nutrition and Food Research, vol. 57, no. 1, pp. 114-125, 2013.
12. A. Bilska and L. Włodek, "Lipoic acid-the drug of the future?" Pharmacological Reports, vol. 57, no. 5, pp. 570-577, 2005.
13. C. Steyers and F. Miller, "Endothelial dysfunction in chronic inflammatory diseases, " International Journal of Molecular Sciences, vol. 15, no. 7, pp. 11324-11349, 2014.
14. N. R. Madamanchi and M. S. Runge, "Redox signaling in cardiovascular health and disease, " Free Radical Biology and Medicine, vol. 61, pp. 473-501, 2013.
15. M. E. Rubio-Ruiz, I. Pérez-Torres, M. E. Soto, G. Pastelín, and V. Guarner-Lans, "Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly, " Ageing Research Reviews, vol. 18, pp. 132-147, 2014.
16. M. Monti, R. Solito, L. Puccetti et al., "Protective effects of novel metal-nonoates on the cellular components of the vascular system, " Journal of Pharmacology and Experimental Therapeutics, vol. 351, no. 3, pp. 500-509, 2014.
17. M. El Assar, J. Angulo, S. Vallejo, C. Peiró, C. F. Sánchez-Ferrer, and L. Rodríguez-Mañas, "Mechanisms involved in the aginginduced vascular dysfunction, " Frontiers in Physiology, vol. 3, article 132, Article ID Article 132, pp. 1-13, 2012.
18. R. Oakley and B. Tharakan, "Vascular hyperpermeability and aging, " Aging and Disease, vol. 5, no. 2, pp. 114-125, 2014.
19. A. Csiszar, Z. Ungvari, J. G. Edwards et al., "Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function, " Circulation Research, vol. 90, no. 11, pp. 1159-1166, 2002.
20. P. Pacher, J. S. Beckman, and L. Liaudet, "Nitric oxide and peroxynitrite in health and disease, " Physiological Reviews, vol. 87, no. 1, pp. 315-424, 2007.
21. Y. Zhang, S. Zhao, Y. Gu, D. F. Lewis, J. S. Alexander, and Y. Wang, "Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia, " Journal of the Society for Gynecologic Investigation, vol. 12, no. 8, pp. 586-592, 2005.
22. H. J. Yoon, S. W. Cho, B. W. Ahn, and S. Y. Yang, "Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells, " Mechanisms of Ageing and Development, vol. 131, no. 2, pp. 119-123, 2010.
23. A. Csiszar, Z. Ungvari, A. Koller, J. G. Edwards, and G. Kaley, "Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging, " Physiological Genomics, vol. 17, pp. 21-30, 2004.
24. A. Csiszar, N. Labinskyy, Z. Orosz, Z. Xiangmin, R. Buffenstein, and Z. Ungvari, "Vascular aging in the longest-living rodent, the nakedmole rat, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 293, no. 2, pp. H919-H927, 2007.
25. A. Csiszar, M. Wang, E. G. Lakatta, and Z. Ungvari, "Inflammation and endothelial dysfunction during aging: role of NFkappaB, " Journal of Applied Physiology, vol. 105, no. 4, pp. 1333-1341, 2008.
26. H. Cai and D. G. Harrison, "Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress, " Circulation Research, vol. 87, no. 10, pp. 840-844, 2000.
27. Y. Saito, M. Kurabayashi, T. Nakamura, and R. Nagai, "Klotho gene and endothelial function, "NihonRonenIgakkai Zasshi, vol. 43, no. 3, pp. 342-344, 2006.
28. V. Cavieres, K. Valdes, B. Moreno, R. Moore-Carrasco, and D. R. Gonzalez, "Vascular hypercontractility and endothelial dysfunction before development of atherosclerosis in moderate dyslipidemia: role for nitric oxide and interleukin-6, " American Journal of Cardiovascular Disease, vol. 4, no. 3, pp. 114-122, 2014.
29. G. M. Chisolm and D. Steinberg, "The oxidative modification hypothesis of atherogenesis: an overview, " Free Radical Biology and Medicine, vol. 28, no. 12, pp. 1815-1826, 2000.
30. H. Mangge, K. Becker, D. Fuchs, and J. M. Gostner, "Antioxidants, inflammation and cardiovascular disease, " World Journal of Cardiology, vol. 6, no. 6, pp. 462-477, 2014.
31. C. Meisinger, J. Baumert, N. Khuseyinova, H. Loewel, and W. Koenig, "Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population, " Circulation, vol. 112, no. 5, pp. 651-657, 2005.
32. A. H. Sprague and R. A. Khalil, "Inflammatory cytokines in vascular dysfunction and vascular disease, " Biochemical Pharmacology, vol. 78, no. 6, pp. 539-552, 2009.
33. A. R. Weseler and A. Bast, "Oxidative stress and vascular function: implications for pharmacologic treatments, " Current Hypertension Reports, vol. 12, no. 3, pp. 154-161, 2010.
34. T. Watson, P. K. Y. Goon, and G. Y. H. Lip, "Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension, " Antioxidants and Redox Signaling, vol. 10, no. 6, pp. 1079-1088, 2008.
35. M. D. Herrera, C. Mingorance, R. Rodríguez-Rodríguez, and M. Alvarez de Sotomayor, "Endothelial dysfunction and aging: an update, " Ageing Research Reviews, vol. 9, no. 2, pp. 142-152, 2010.
36. M. Kajiya, M. Hirota, Y. Inai et al., "Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats, " The American Journal of Physiology-Heart and Circulatory Physiology, vol. 292, no. 6, pp. H2737-H2744, 2007.
37. A. Piechota, A. Polanczyk, and A. Goraca, "Role of endothelin-1 receptor blockers on hemodynamic parameters and oxidative stress, " Pharmacological Reports, vol. 62, no. 1, pp. 28-34, 2010.
38. D. Versari, E. Daghini, A. Virdis, L. Ghiadoni, and S. Taddei, "Endothelium-dependent contractions and endothelial dysfunction in human hypertension, " British Journal of Pharmacology, vol. 157, no. 4, pp. 527-536, 2009.
39. A. Kowalczyk, P. Kleniewska, M. Kolodziejczyk, B. Skibska, and A. Goraca, "The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis, " Archivum Immunologiae et Therapiae Experimentalis, vol. 63, no. 1, pp. 41-52, 2015.
40. T. Kumazaki, "Modulation of gene expression during aging of human vascular endothelial cells, " Hiroshima Journal ofMedical Sciences, vol. 42, no. 2, pp. 97-100, 1993.
41. R. P. Brandes, I. Fleming, and R. Busse, "Endothelial aging, " Cardiovascular Research, vol. 66, no. 2, pp. 286-294, 2005.
42. T. G. Canty Jr., E. M. Boyle Jr., A. Farr, E. N. Morgan, E. D. Verrier, and T. H. Pohlman, "Oxidative stress induces NF-κB nuclear translocationwithout degradation of IκBα, " Circulation, vol. 100, no. 19, pp. 361-364, 1999.
43. P. Kleniewska, A. Piechota-Polanczyk, L. Michalski et al., "Influence of block of NF-kappa B signaling pathway on oxidative stress in the liver homogenates, " Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 308358, 8 pages, 2013.
44. S. R. Bhatt, M. F. Lokhandwala, and A. A. Banday, "Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B, " Clinical and Experimental Hypertension, vol. 36, no. 6, pp. 367-373, 2014.
45. D. Versari, E. Daghini, A. Virdis, L. Ghiadoni, and S. Taddei, "Endothelial dysfunction as a target for prevention of cardiovascular disease, " Diabetes Care, vol. 32, no. 2, pp. 314-321, 2009.
46. O. Yildiz, "Vascular smooth muscle and endothelial functions in aging, " Annals of the New York Academy of Sciences, vol. 1100, pp. 353-360, 2007.
47. D. E. Kohan, E. W. Inscho, D. Wesson, and D. M. Pollock, "Physiology of endothelin and the kidney, " Comprehensive Physiology, vol. 1, no. 2, pp. 883-919, 2011.
48. G. R. Drummond, S. Selemidis, K. K. Griendling, and C. G. Sobey, "Combating oxidative stress in vascular disease:NADPH oxidases as therapeutic targets, " Nature Reviews Drug Discovery, vol. 10, no. 6, pp. 453-471, 2011.
49. P. N. Seshiah, D. S. Weber, P. Rocic, L. Valppu, Y. Taniyama, and K. K. Griendling, "Angiotensin II stimulation of NAD(P)H oxidase activity: upstreammediators, " Circulation Research, vol. 91, no. 5, pp. 406-413, 2002.
50. T. M. Paravicini, S. Chrissobolis, G. R. Drummond, and C. G. Sobey, "Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo, " Stroke, vol. 35, no. 2, pp. 584-589, 2004.
51. R. M. Touyz, "Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension. What is the clinical significance?" Hypertension, vol. 44, no. 3, pp. 248-252, 2004.
52. Q. N. Dinh, G. R. Drummond, C. G. Sobey, and S. Chrissobolis, "Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension, " BioMed Research International, vol. 2014, pp. 1-11, 2014.
53. M. M. Govender and A. Nadar, "A subpressor dose of angiotensin II elevates blood pressure in a normotensive rat model by oxidative stress, " Physiological Research. In press.
54. M. P. Ocaranza, J. Moya, V. Barrientos et al., "Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis, " Journal of Hypertension, vol. 32, no. 4, pp. 771-783, 2014.
55. S.-J. Lee and S.-H. Park, "Arterial ageing, " Korean Circulation Journal, vol. 43, no. 2, pp. 73-79, 2013.
56. M. Pacurari, R. Kafoury, P. B. Tchounwou, and K. Ndebele, "The renin-angiotensin-aldosterone system in vascular inflammation and remodeling, " International Journal of Inflammation, vol. 2014, Article ID689360, 13 pages, 2014.
57. D. F. Dai, Y. A. Chiao, D. J. Marcinek, H. H. Szeto, and P. S. Rabinovitch, "Mitochondrial oxidative stress in aging and healthspan, " Longevity and Healthspan, vol. 3, article 6, 2014.
58. E. J. Lesnefsky, S. Moghaddas, B. Tandler, J. Kerner, and C. L. Hoppel, "Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure, " Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. 1065-1089, 2001.
59. S. Pepe, "Mitochondrial function in ischaemia and reperfusion of the ageing heart, " Clinical and Experimental Pharmacology and Physiology, vol. 27, no. 9, pp. 745-750, 2000.
60. S. Khurana, K. Venkataraman, A. Hollingsworth, M. Piche, and T. C. Tai, "Polyphenols: benefits to the cardiovascular system in health and in aging, " Nutrients, vol. 5, no. 10, pp. 3779-3827, 2013.
61. T. Yamamoto and J. Sadoshima, "Protection of the heart against ischemia/reperfusion by silent information regulator 1, " Trends in Cardiovascular Medicine, vol. 21, no. 1, pp. 27-32, 2011.
62. A. Jahangir, S. Sagar, and A. Terzic, "Aging and cardioprotection, " Journal of Applied Physiology, vol. 103, no. 6, pp. 2120-2128, 2007.
63. F. Di Lisa and P. Bernardi, "Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition, " Cardiovascular Research, vol. 66, no. 2, pp. 222-232, 2005.
64. M. Avkiran and M. S. Marber, "Na+/H+ exchange inhibitors for cardioprotective therapy: progress, problems and prospects, " Journal of the American College of Cardiology, vol. 39, no. 5, pp. 747-753, 2002.
65. N. Gonzaga, G. E. Callera, A. Yogi et al., "Acute ethanol intake induces mitogen-activated protein kinase activation, platelet-derived growth factor receptor phosphorylation, and oxidative stress in resistance arteries, " Journal of Physiology and Biochemistry, vol. 70, no. 2, pp. 509-523, 2014.
66. T. Finkel and N. J. Holbrook, "Oxidants, oxidative stress and the biology of ageing, " Nature, vol. 408, no. 6809, pp. 239-247, 2000.
67. R. Rodrigo, M. Libuy, F. Feliú, and D. Hasson, "Oxidative stressrelated biomarkers in essential hypertension and ischemiareperfusion myocardial damage, " Disease Markers, vol. 35, no. 6, pp. 773-790, 2013.
68. P. Ferdinandy, R. Schulz, and G. F. Baxter, "Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning, " Pharmacological Reviews, vol. 59, no. 4, pp. 418-458, 2007.
69. S. K. Maulik and S. Kumar, "Oxidative stress and cardiac hypertrophy: a review, " Toxicology Mechanisms and Methods, vol. 22, no. 5, pp. 359-366, 2012.
70. T. A. Ajith, "Mitochondria-targeted agents: fture perspectives of mitochondrial pharmaceutics in cardiovascular diseases, " World Journal of Cardiology, vol. 6, no. 10, pp. 1091-1099, 2014.
71. S. Zhou, W. Sun, Z. Zhang, and Y. Zheng, "The role of Nrf2-mediated pathway in cardiac remodeling and heart failure, " OxidativeMedicine and Cellular Longevity, vol. 2014, Article ID 260429, 16 pages, 2014.
72. T. Doenst, T. D. Nguyen, and E. D. Abel, "Cardiacmetabolismin heart failure: implications beyond atp production, " Circulation Research, vol. 113, no. 6, pp. 709-724, 2013.
73. V. A. Cameron, T. J. Mocatta, A. P. Pilbrow et al., "Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure, " Hypertension, vol. 47, no. 6, pp. 1155-1161, 2006.
74. C. Wojciechowska, E. Romuk, A. Tomasik et al., "Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy, " Mediators of Inflammation, vol. 2014, Article ID147040, 10pages, 2014.
75. B. Douglas and M. D. Sawyer, "Oxidative stress in heart failure: what are wemissing?"American Journal of theMedical Sciences, vol. 342, no. 2, pp. 120-124, 2011.
76. M. M. Elahi, Y. X. Kong, and B. M. Matata, "Oxidative stress as a mediator of cardiovascular disease, " Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 259-269, 2009.
77. K. Venkataraman, S. Khurana, and T. C. Tai, "Oxidative stress in aging-matters of the heart and mind, " International Journal of Molecular Sciences, vol. 14, no. 9, pp. 17897-17925, 2013.
78. J. Peng, B. Liu, Q. L. Ma, and X. J. Luo, "Dysfunctional endothelial progenitor cells in cardiovascular diseases: role of NADPH oxidase, " Journal of Cardiovascular Pharmacology, vol. 65, no. 1, pp. 80-87, 2015.
79. A. D. Hafstad, A. A. Nabeebaccus, and A. M. Shah, "Novel aspects of ROS signalling in heart failure, " Basic Research in Cardiology, vol. 108, no. 4, article 359, 2013.
80. A. Gorąca, H. Huk-Kolega, A. Piechota, P. Kleniewska, E. Ciejka, and B. Skibska, "Lipoic acid-biological activity and therapeutic potential, " Pharmacological Reports, vol. 63, no. 4, pp. 849-858, 2011.
81. G. K. Glantzounis, W. Yang, R. S. Koti, D. P. Mikhailidis, A. M. Seifalian, and B. R. Davidson, "The role of thiols in liver ischemia-reperfusion injury, " Current Pharmaceutical Design, vol. 12, no. 23, pp. 2891-2901, 2006.
82. U. Singh and I. Jialal, "Alpha-lipoic acid supplementation and diabetes, " Nutrition Reviews, vol. 66, no. 11, pp. 646-657, 2008.
83. A. Segall, M. Sosa, A. Alami et al., "Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application, " Journal of Cosmetic Science, vol. 55, no. 5, pp. 449-461, 2004.
84. S. D. Wollin and P. J. H. Jones, "Alpha-lipoic acid and cardiovascular disease, " Journal ofNutrition, vol. 133, no. 11, pp. 3327-3330, 2003.
85. A. L. Catapano, F. M. Maggi, and E. Tragni, "Low density lipoprotein oxidation, antioxidants, and atherosclerosis, " Current Opinion in Cardiology, vol. 15, no. 5, pp. 355-363, 2000.
86. I. Sadowska-Bartosz and G. Bartosz, "Effect of antioxidants supplementation on aging and longevity, " BioMed Research International, vol. 2014, Article ID 404680, 17 pages, 2014.
87. S. Sola, M. Q. S. Mir, F. A. Cheema et al., "Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study, " Circulation, vol. 111, no. 3, pp. 343-348, 2005.
88. L. Packer, K. Kraemer, and G. Rimbach, "Molecular aspects of lipoic acid in the prevention of diabetes complications, " Nutrition, vol. 17, no. 10, pp. 888-895, 2001.
89. T. C. Rideout, B. Carrier, S. Wen, A. Raslawsky, R. W. Browne, and S. V. Harding, "Complementary cholesterol-lowering response of a phytosterol/alpha-Lipoic acid combination in obese zucker rats, " Journal of Dietary Supplements, 2015.
90. D. C. Kim, D. W. Jun, E. C. Jang et al., "Lipoic acid prevents the changes of intracellular lipid partitioning by free fatty acid, " Gut and Liver, vol. 7, no. 2, pp. 221-227, 2013.
91. B. Carrier, S. Wen, S. Zigouras et al., "Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese zucker rats, " PLoS ONE, vol. 9, no. 3, Article ID e90863, 2014.
92. Y. Zhang, P. Han, N. Wu et al., "Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and antiinflammatory effects, " Obesity, vol. 19, no. 8, pp. 1647-1653, 2011.
93. Z. Ying, N. Kherada, B. Farrar et al., "Lipoic acid effects on established atherosclerosis, " Life Sciences, vol. 86, no. 3-4, pp. 95-102, 2010.
94. S. V. Harding, T. C. Rideout, and P. J. H. Jones, "Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk, " Journal of Dietary Supplements, vol. 9, no. 2, pp. 116-127, 2012.
95. W.-J. Zhang, K. E. Bird, T. S. McMillen, R. C. LeBoeuf, T. M. Hagen, and B. Frei, "Dietary α-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice, " Circulation, vol. 117, no. 3, pp. 421-428, 2008.
96. Z. Amom, Z. Zakaria, J. Mohamed et al., "Lipid lowering effect of antioxidant alpha-lipoic acid in experimental atherosclerosis, " Journal of Clinical Biochemistry and Nutrition, vol. 43, no. 2, pp. 88-94, 2008.
97. S. Vasdev, J. Stuckless, and V. Richardson, "Role of the immune system in hypertension: modulation by dietary antioxidants, " International Journal of Angiology, vol. 20, no. 4, pp. 189-212, 2011.
98. J. Leong, S. Pepe, J. Van der Merwe et al., "Preoperative metabolic therapy improves cardiac surgical outcomes: a prospective randomized clinical trial, " Heart, Lung and Circulation, vol. 16, supplement 2, p. S178, 2007.
99. S. R. Lee, M. H. Jeong, S. Y. Limet al., "The effect of alpha lipoic acid (Thioctacid HR) on endothelial function in diabetic and hypertensive patients, " Korean Circulation Journal, vol. 36, no. 8, pp. 559-564, 2006.
100. M. Takaoka, Y. Kobayashi, M. Yuba, M. Ohkita, and Y. Matsumura, "Effects of α-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats, " European Journal of Pharmacology, vol. 424, no. 2, pp. 121-129, 2001.
101. T. Heitzer, B. Finckh, S. Albers, K. Krohn, A. Kohlschütter, and T. Meinertz, "Beneficial effects of α-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress, " Free Radical Biology andMedicine, vol. 31, no. 1, pp. 53-61, 2001.
102. C. M. Sena, E. Nunes, T. Louro et al., "Effects of α-lipoic acid on endothelial function in aged diabetic and high-fat fed rats, " British Journal of Pharmacology, vol. 153, no. 5, pp. 894-906, 2008.
103. W.-J. Zhang and B. Frei, "α-Lipoic acid inhibits TNF-α-induced NF-κB activation and adhesion molecule expression in human aortic endothelial cells, " The FASEB Journal, vol. 15, no. 13, pp. 2423-2432, 2001.
104. M. B. Gomes and C. A. Negrato, "Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases, " Diabetology and Metabolic Syndrome, vol. 6, no. 1, p. 80, 2014.
105. S. Vasdev, C. A. Ford, S. Parai, L. Longerich, and V. Gadag, "Dietary α-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats, " Journal of Hypertension, vol. 18, no. 5, pp. 567-573, 2000.
106. K. P. Shay, R. F. Moreau, E. J. Smith, A. R. Smith, and T. M. Hagen, "Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential, " Biochimica et Biophysica Acta, vol. 1790, no. 10, pp. 1149-1160, 2009.
107. T. J. Kizhakekuttu and M. E. Widlansky, "Natural antioxidants and hypertension: promise and challenges, " Cardiovascular Therapeutics, vol. 28, no. 4, pp. e20-e32, 2010.
108. C. J. McMackin, M. E. Widlansky, N. M. Hamburg et al., "Effect of combined treatment with α-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease, "The Journal of Clinical Hypertension, vol. 9, no. 4, pp. 249-255, 2007.
109. S. Ozbal, B. U. Ergur, G. Erbil, I. Tekmen, A. Bagryank, and Z. Cavdar, "The effects of α-lipoic acid against testicular ischemiareperfusion injury in rats, " The Scientific World Journal, vol. 2012, Article ID 489248, 8 pages, 2012.
110. A. Frank, M. Bonney, S. Bonney, L. Weitzel, M. Koeppen, and T. Eckle, "Myocardial ischemia reperfusion injury: from basic science to clinical bedside, " Seminars in Cardiothoracic and Vascular Anesthesia, vol. 16, no. 3, pp. 123-132, 2012.
111. E. A. Aiello, R. I. Jabr, and W. C. Cole, "Arrhythmia and delayed recovery of cardiac action potential during reperfusion after ischemia: role of oxygen radical-induced no-reflow phenomenon, " Circulation Research, vol. 77, no. 1, pp. 153-162, 1995.
112. M. Dudek, J. Knutelska, M. Bednarski et al., "Alpha lipoic acid protects the heart againstmyocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts, " Pharmacological Reports, vol. 66, no. 3, pp. 499-504, 2014.
113. C. Deng, Z. Sun, G. Tong et al., "α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway, " PLoS ONE, vol. 8, no. 3, Article ID e58371, 2013.
114. Y.-F. Tian, C.-T. He, Y.-T. Chen, and P.-S. Hsieh, "Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats, " World Journal of Gastroenterology, vol. 19, no. 18, pp. 2761-2771, 2013.
115. M. Gomes and C. Negrato, "Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases, " Diabetology and Metabolic Syndrome, vol. 6, article 80, 2014.
116. M. Bayeva, M. Gheorghiade, and H. Ardehali, "Mitochondria as a therapeutic target in heart failure, " Journal of the American College of Cardiology, vol. 61, no. 6, pp. 599-610, 2013.
117. H. Ardehali, H. N. Sabbah, M. A. Burke et al., "Targeting myocardial substrate metabolism in heart failure: potential for new therapies, " European Journal of Heart Failure, vol. 14, no. 2, pp. 120-129, 2012.
118. D. B. Sawyer, "Oxidative stress in heart failure: what are we missing?"TheAmericanJournal of theMedical Sciences, vol. 342, no. 2, pp. 120-124, 2011.
119. C.-J. Li, L. Lv, H. Li, and D.-M. Yu, "Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid, " Cardiovascular Diabetology, vol. 11, article 73, 2012.
120. L. Packer and E. Cadenas, "Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling, " Journal of Clinical Biochemistry and Nutrition, vol. 48, no. 1, pp. 26-32, 2011.
121. I. Padmalayam, "Targeting mitochondrial oxidative stress through Lipoic acid synthase: a novel strategy to manage diabetic cardiovascular disease, " Cardiovascular andHematological Agents in Medicinal Chemistry, vol. 10, no. 3, pp. 223-233, 2012.
122. S. Subramanian, B. Kalyanaraman, and R. Q. Migrino, "Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases, " Recent Patents on Cardiovascular Drug Discovery, vol. 5, no. 1, pp. 54-65, 2010.
123. C.-J. Li, Q.-M. Zhang, M.-Z. Li, J.-Y. Zhang, P. Yu, and D.-M. Yu, "Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression ofmitochondrial oxidative stress to reduce diabetic cardiomyopathy, " ChineseMedical Journal, vol. 122, no. 21, pp. 2580-2586, 2009.
124. Z. Cao, M. Tsang, H. Zhao, and Y. Li, "Induction of endogenous antioxidants and phase 2 enzymes by α-lipoic acid in rat cardiac H9C2 cells: protection against oxidative injury, " Biochemical and Biophysical Research Communications, vol. 310, no. 3, pp. 979-985, 2003.
125. H. Huk-Kolega, B. Skibska, P. Kleniewska, A. Piechota,. Michalski, and A. Gorąca, "Role of lipoic acld in health and disease, " PolskiMerkuriusz Lekarski, vol. 31, no. 183, pp. 183-185, 2011.