Complementary Cholesterol-Lowering Response of a Phytosterol/α-Lipoic Acid Combination in Obese Zucker Rats

Journal of Dietary Supplements

Volumn 13, Issue 3, 2016, Pages 283-299

  Rideout, Todd C ^a   Carrier, Bradley ^a   Wen, Shin ^a   Raslawsky, Amy ^a   Browne, Richard W ^b   Harding, Scott V ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alpha lipoic acid; high fat diet; lipids; lipoproteins; phytosterols

Indexed keywords

3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; ACYL COENZYME A; ANTIOXIDANT; BILE ACID; CHOLESTEROL; FAT INTAKE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PCSK9 PROTEIN, RAT; PHYTOSTEROL; PROPROTEIN CONVERTASE 9; SERINE PROTEINASE; THIOCTIC ACID;

ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; COMPLICATION; DIETARY SUPPLEMENT; DRUG EFFECTS; DRUG POTENTIATION; FAT INTAKE; GENETICS; HYPERCHOLESTEROLEMIA; INTESTINE ABSORPTION; LIPID DIET; LIVER; MALE; METABOLISM; OBESITY; ZUCKER RAT;

ACYL COENZYME A; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET, HIGH-FAT; DIETARY FATS; DIETARY SUPPLEMENTS; DRUG SYNERGISM; HYPERCHOLESTEROLEMIA; INTESTINAL ABSORPTION; LIVER; MALE; OBESITY; PHYTOSTEROLS; PROPROTEIN CONVERTASE 9; RATS, ZUCKER; RNA, MESSENGER; SERINE ENDOPEPTIDASES; THIOCTIC ACID;

EID: 84948579821     PISSN: 19390211     EISSN: 1939022X     Source Type: Journal    
DOI: 10.3109/19390211.2015.1008616     Document Type: Article

References (49)

1. Amir Shaghaghi M, Abumweis SS, Jones PJ. Cholesterol-lowering efficacy of plant sterols/stanols provided in capsule and tablet formats: results of a systematic review and meta-analysis. J Acad Nutr Diet. 2013; 113: 1494-1503.
2. Amom Z, Zakaria Z, Mohamed J, Azlan A, Bahari H, et al. Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis. J Clin Biochem Nutr. 2008; 43: 88-94.
3. Awaisheh SS, Khalifeh MS, Al-Ruwaili MA, Khalil OM, Al-Ameri OH, et al. Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. J Dairy Sci. 2013; 96: 9-15.
4. Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, et al. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. J Hepatol. 2011; 54: 1214-1223.
5. Butler JA, Hagen TM, Moreau R. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Arch Biochem Biophys. 2009; 485: 63-71.
6. Campos H, Blijlevens E, McNamara JR, Ordovas JM, Posner BM, et al. LDL particle size distribution. Results from the Framingham Offspring Study. Arterioscler Thromb. 1992; 12: 1410-1419.
7. Cao A, Wu M, Li H, Liu J. Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells. J Lipid Res. 2011; 52: 518-530.
8. Carrier B, Rideout TC. Anti-obesity and lipid-lowering properties of alpha-lipoic acid. J Human Nutr Food Sci. 2013; 1: 1002.
9. Carrier B, Wen S, Zigouras S, Browne RW, Li Z, et al. (2014) Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese zucker rats. PLoS One. 2009; 9: e90863.
10. Castellanos-Jankiewicz A, Del Bosque-Plata L, Tejero ME. Combined effect of plant sterols and dietary fiber for the treatment of hypercholesterolemia. Plant Foods Hum Nutr. 2014; 69: 93-100.
11. Chen WL, Kang CH, Wang SG, Lee HM. alpha-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. Diabetologia. 2012; 55: 1824-1835.
12. Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, et al. Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr. 2008; 87: 817-823.
13. Csont T, Sarkozy M, Szucs G, Szucs C, Barkanyi J, et al. Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet. Lipids Health Dis. 2013; 12: 138.
14. De Castro-Oros I, Pampin S, Cofan M, Mozas P, Pinto X, et al. Promoter variant-204A > C of the cholesterol 7alpha-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clin Nutr. 2011; 30: 239-246.
15. De Smet E, Mensink RP, Plat J. Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present. Mol Nutr Food Res. 2012; 56: 1058-1072.
16. Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, et al. R-alpha-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. Am J Physiol Regul Integr Comp Physiol. 2012; 302: R587-597.
17. Graner E, Tang D, Rossi S, Baron A, Migita T, et al. The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004; 5: 253-261.
18. Gylling H, Plat J, Turley S, Ginsberg HN, Ellegard L, et al. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis. 2014; 232: 346-360.
19. Hansel B, Courie R, Bayet Y, Delestre F, Bruckert E. [Phytosterols and atherosclerosis]. Rev Med Interne. 2011; 32: 124-129.
20. El Harchaoui K, Arsenault BJ, Franssen R, Despres JP, Hovingh GK, et al. High-density lipoprotein particle size and concentration and coronary risk. Ann Intern Med. 2009; 150: 84-93.
21. Harding SV, Rideout TC, Jones PJ. Hepatic nuclear sterol regulatory binding element protein 2 abundance is decreased and that of ABCG5 increased in male hamsters fed plant sterols. J Nutr. 2010; 140: 1249-1254.
22. Hoekstra M, Kruijt JK, Van Eck M, Van Berkel TJ. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J Biol Chem. 2003; 278: 25448-25453.
23. Jeyarajah EJ, Cromwell WC, Otvos JD. Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy. Clin Lab Med. 2006; 26: 847-870.
24. Keith D, Finlay L, Butler J, Gomez L, Smith E, et al. Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. Biochem Biophys Res Commun. 2014.
25. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004; 10: 727-733.
26. Kuehl RO. Design of Experiments: Statistical Principles of Research Design Analysis, 2nd ed. Brooks/Cole Publishing Company, 2000.
27. Kumar SA, Sudhahar V, Varalakshmi P. Attenuation of serum lipid abnormalities and cardiac oxidative stress by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental hypercholesterolemia. Clin Chim Acta. 2005; 355: 197-204.
28. Langheim S, Yu L, von Bergmann K, Lutjohann D, Xu F, et al. ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile. J Lipid Res. 2005; 46: 1732-1738.
29. Lin X, Racette SB, Lefevre M, Ma L, Spearie CA, et al. Combined effects of ezetimibe and phytosterols on cholesterol metabolism: a randomized, controlled feeding study in humans. Circulation. 2011; 124: 596-601.
30. Moghadasian MH, Nguyen LB, Shefer S, Salen G, Batta AK, et al. Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment. Metabolism. 2001; 50: 708-714.
31. Mora S, Glynn RJ, Ridker PM. High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation. 2013; 128: 1189-1197.
32. Muntner P, Levitan EB, Brown TM, Sharma P, Zhao H, et al. Trends in the prevalence, awareness, treatment and control of high low density lipoprotein-cholesterol among United States adults from 1999-2000 through 2009-2010. Am J Cardiol. 2013; 112: 664-670.
33. Park KG, Min AK, Koh EH, Kim HS, Kim MO, et al. Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology. 2008; 48: 1477-1486.
34. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001; 29: e45.
35. Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br J Nutr. 2014; 112: 214-219.
36. Rideout TC, Harding SV, Jones PJ. Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. Mol Nutr Food Res. 2010; 54 (Suppl 1): S7-13.
37. Rideout TC, Harding SV, Marinangeli CP, Jones PJ. Combination drug-diet therapies for dyslipidemia. Transl Res 2010; 155: 220-227.
38. Rideout TC, Yuan Z, Bakovic M, Liu Q, Li RK, et al. Guar gum consumption increases hepatic nuclear SREBP2 and LDL receptor expression in pigs fed an atherogenic diet. J Nutr. 2007; 137: 568-572.
39. Scholle JM, Baker WL, Talati R, Coleman CI. The effect of adding plant sterols or stanols to statin therapy in hypercholesterolemic patients: systematic review and meta-analysis. J Am Coll Nutr. 2009; 28: 517-524.
40. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009; 1790: 1149-1160.
41. Shrestha S, Ehlers SJ, Lee JY, Fernandez ML, Koo SI. Dietary green tea extract lowers plasma and hepatic triglycerides and decreases the expression of sterol regulatory element-binding protein-1c mRNA and its responsive genes in fructose-fed, ovariectomized rats. J Nutr. 2009; 139: 640-645.
42. Thirunavukkarasu V, Anitha Nandhini AT, Anuradha CV. Effect of alpha-lipoic acid on lipid profile in rats fed a high-fructose diet. Exp Diabesity Res. 2004; 5: 195-200.
43. Trautwein EA, Schulz C, Rieckhoff D, Kunath-Rau A, Erbersdobler HF, et al. Effect of esterified 4-desmethylsterols and-stanols or 4,4-dimethylsterols on cholesterol and bile acid metabolism in hamsters. Br J Nutr. 2002; 87: 227-237.
44. van der Vusse GJ, Roemen TH, Reneman RS. The content of non-esterified fatty acids in rat myocardial tissue. A comparison between the Dole and Folch extraction procedures. J Mol Cell Cardiol. 1985; 17: 527-531.
45. Varady KA, St-Pierre AC, Lamarche B, Jones PJ. Effect of plant sterols and endurance training on LDL particle size and distribution in previously sedentary hypercholesterolemic adults. Eur J Clin Nutr. 2005; 59: 518-525.
46. Weingartner O, Bohm M, Laufs U. Controversial role of plant sterol esters in the management of hypercholesterolaemia. Eur Heart J. 2009; 30: 404-409.
47. Yi X, Pashaj A, Xia M, Moreau R. Reversal of obesity-induced hypertriglyceridemia by (R)-alpha-lipoic acid in ZDF (fa/fa) rats. Biochem Biophys Res Commun. 2013.
48. Ying Z, Kherada N, Farrar B, Kampfrath T, Chung Y, et al. Lipoic acid effects on established atherosclerosis. Life Sci. 2010; 86: 95-102.
49. Zhou Y, Zhang X, Chen L, Wu J, Dang H, et al. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am J Physiol Renal Physiol. 2008; 295: F662-671.