α-Lipoic Acid Reduces Infarct Size and Preserves Cardiac Function in Rat Myocardial Ischemia/Reperfusion Injury through Activation of PI3K/Akt/Nrf2 Pathway

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Deng, Chao ^a   Sun, Zhongchan ^a   Tong, Guang ^a   Yi, Wei ^a   Ma, Li ^b   Zhao, Bijun ^a   Cheng, Liang ^a   Zhang, Jinzhou ^a   Cao, Feng ^a   Yi, Dinghua ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NAVY GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GENETIC TRANSCRIPTION; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEME OXYGENASE 1 GENE; IN VIVO STUDY; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN LOCALIZATION; RAT; REPERFUSION INJURY; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CELL NUCLEUS; CREATINE KINASE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NEUTROPHILS; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; THIOCTIC ACID; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR FUNCTION, LEFT;

EID: 84874678796     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058371     Document Type: Article

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