메뉴 건너뛰기




Volumn 16, Issue 3, 2012, Pages 123-132

Myocardial ischemia reperfusion injury: From basic science to clinical bedside

Author keywords

heart; ischemic reperfusion injury; myocardial infarction; reperfusion injury; therapeutic impact

Indexed keywords

MITOCHONDRIAL PERMEABILITY TRANSITION PORE; RANOLAZINE; TRIMETAZIDINE;

EID: 84871806998     PISSN: 10892532     EISSN: 19405596     Source Type: Journal    
DOI: 10.1177/1089253211436350     Document Type: Review
Times cited : (418)

References (75)
  • 1
    • 77955444881 scopus 로고    scopus 로고
    • Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
    • Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol. 2010 ; 106: 360-368
    • (2010) Am J Cardiol , vol.106 , pp. 360-368
    • Turer, A.T.1    Hill, J.A.2
  • 2
    • 79955527497 scopus 로고
    • Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog
    • Jennings RB, Sommers HM, Smyth GA, Flack HA, Linn H. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol. 1960 ; 70: 68-78
    • (1960) Arch Pathol , vol.70 , pp. 68-78
    • Jennings, R.B.1    Sommers, H.M.2    Smyth, G.A.3    Flack, H.A.4    Linn, H.5
  • 3
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 ; 74: 1124-1136
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 4
    • 0032510660 scopus 로고    scopus 로고
    • Medical and cellular implications of stunning, hibernation, and preconditioning: An NHLBI workshop
    • Kloner RA, Bolli R, Marban E, Reinlib L, Braunwald E. Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI workshop. Circulation ; 1998 ; 1998. 1848.
    • Circulation
    • Kloner, R.A.1    Bolli, R.2    Marban, E.3    Reinlib, L.4    Braunwald, E.5
  • 5
    • 0025810599 scopus 로고
    • The cell biology of acute myocardial ischemia
    • Jennings RB, Reimer KA. The cell biology of acute myocardial ischemia. Annu Rev Med. 1991 ; 42: 225-246
    • (1991) Annu Rev Med , vol.42 , pp. 225-246
    • Jennings, R.B.1    Reimer, K.A.2
  • 6
    • 0035909985 scopus 로고    scopus 로고
    • Consequences of brief ischemia: Stunning, preconditioning, and their clinical implications: Part 2
    • Kloner RA, Jennings RB. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2. Circulation. 2001 ; 104: 3158-3167
    • (2001) Circulation , vol.104 , pp. 3158-3167
    • Kloner, R.A.1    Jennings, R.B.2
  • 7
    • 0035846605 scopus 로고    scopus 로고
    • Consequences of brief ischemia: Stunning, preconditioning, and their clinical implications: Part 1
    • Kloner RA, Jennings RB. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation. 2001 ; 104: 2981-2989
    • (2001) Circulation , vol.104 , pp. 2981-2989
    • Kloner, R.A.1    Jennings, R.B.2
  • 8
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007 ; 357: 1121-1135
    • (2007) N Engl J Med , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 9
    • 79957937929 scopus 로고    scopus 로고
    • Targeting fatty acid and carbohydrate oxidation: A novel therapeutic intervention in the ischemic and failing heart
    • Jaswal JS, Keung W, Wang W, Ussher JR, Lopaschuk GD. Targeting fatty acid and carbohydrate oxidation: a novel therapeutic intervention in the ischemic and failing heart. Biochim Biophys Acta. 2011 ; 1813: 1333-1350
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1333-1350
    • Jaswal, J.S.1    Keung, W.2    Wang, W.3    Ussher, J.R.4    Lopaschuk, G.D.5
  • 10
    • 50049086740 scopus 로고    scopus 로고
    • AMP-activated protein kinase control of energy metabolism in the ischemic heart
    • Lopaschuk GD. AMP-activated protein kinase control of energy metabolism in the ischemic heart. Int J Obes (Lond). 2008 ; 32 (suppl 4). S29 - S35
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 4
    • Lopaschuk, G.D.1
  • 11
    • 33846447778 scopus 로고    scopus 로고
    • Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease
    • Lopaschuk GD, Stanley WC. Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease. Cardiovasc Drugs Ther. 2006 ; 20: 433-439
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 433-439
    • Lopaschuk, G.D.1    Stanley, W.C.2
  • 12
    • 77950348533 scopus 로고    scopus 로고
    • Inhibition of mitochondrial permeability transition pore opening: The Holy Grail of cardioprotection
    • Heusch G, Boengler K, Schulz R. Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol. 2010 ; 105: 151-154
    • (2010) Basic Res Cardiol , vol.105 , pp. 151-154
    • Heusch, G.1    Boengler, K.2    Schulz, R.3
  • 13
    • 68649090703 scopus 로고    scopus 로고
    • The role of the mitochondrial permeability transition pore in heart disease
    • Halestrap AP, Pasdois P. The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta. 2009 ; 1787: 1402-1415
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1402-1415
    • Halestrap, A.P.1    Pasdois, P.2
  • 14
    • 77956605222 scopus 로고    scopus 로고
    • Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease
    • Cadenas S, Aragones J, Landazuri MO. Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease. Cardiovasc Res. 2010 ; 88: 219-228
    • (2010) Cardiovasc Res , vol.88 , pp. 219-228
    • Cadenas, S.1    Aragones, J.2    Landazuri, M.O.3
  • 15
    • 0032805207 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function
    • Cain BS, Meldrum DR, Dinarello CA, et al. Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit Care Med. 1999 ; 27: 1309-1318
    • (1999) Crit Care Med , vol.27 , pp. 1309-1318
    • Cain, B.S.1    Meldrum, D.R.2    Dinarello, C.A.3
  • 16
    • 78650971588 scopus 로고    scopus 로고
    • TNFalpha in myocardial ischemia/reperfusion, remodeling and heart failure
    • Kleinbongard P, Schulz R, Heusch G. TNFalpha in myocardial ischemia/reperfusion, remodeling and heart failure. Heart Fail Rev. 2011 ; 16: 49-69
    • (2011) Heart Fail Rev , vol.16 , pp. 49-69
    • Kleinbongard, P.1    Schulz, R.2    Heusch, G.3
  • 17
    • 79951679204 scopus 로고    scopus 로고
    • Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury
    • Kawaguchi M, Takahashi M, Hata T, et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation. 2011 ; 123: 594-604
    • (2011) Circulation , vol.123 , pp. 594-604
    • Kawaguchi, M.1    Takahashi, M.2    Hata, T.3
  • 19
    • 80052180144 scopus 로고    scopus 로고
    • Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure
    • Fragasso G, Salerno A, Lattuada G, et al. Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure. Heart. 2011 ; 97: 1495-1500
    • (2011) Heart , vol.97 , pp. 1495-1500
    • Fragasso, G.1    Salerno, A.2    Lattuada, G.3
  • 21
    • 79551469280 scopus 로고    scopus 로고
    • Trimetazidine: A meta-analysis of randomised controlled trials in heart failure
    • Gao D, Ning N, Niu X, Hao G, Meng Z. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart. 2011 ; 97: 278-286
    • (2011) Heart , vol.97 , pp. 278-286
    • Gao, D.1    Ning, N.2    Niu, X.3    Hao, G.4    Meng, Z.5
  • 22
    • 79551494641 scopus 로고    scopus 로고
    • Metabolic modulation in heart failure: High time for a definitive clinical trial
    • Ashrafian H, Neubauer S. Metabolic modulation in heart failure: high time for a definitive clinical trial. Heart. 2011 ; 97: 267-268
    • (2011) Heart , vol.97 , pp. 267-268
    • Ashrafian, H.1    Neubauer, S.2
  • 23
    • 70350560556 scopus 로고    scopus 로고
    • Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart
    • Ko HJ, Zhang Z, Jung DY, et al. Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes. 2009 ; 58: 2536-2546
    • (2009) Diabetes , vol.58 , pp. 2536-2546
    • Ko, H.J.1    Zhang, Z.2    Jung, D.Y.3
  • 24
    • 0036153778 scopus 로고    scopus 로고
    • Warm up phenomenon and preconditioning in clinical practice
    • Tomai F. Warm up phenomenon and preconditioning in clinical practice. Heart. 2002 ; 87: 99-100
    • (2002) Heart , vol.87 , pp. 99-100
    • Tomai, F.1
  • 25
    • 56449100005 scopus 로고    scopus 로고
    • Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury-A review
    • Tapuria N, Kumar Y, Habib MM, Abu Amara M, Seifalian AM, Davidson BR. Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury-a review. J Surg Res. 2008 ; 150: 304-330
    • (2008) J Surg Res , vol.150 , pp. 304-330
    • Tapuria, N.1    Kumar, Y.2    Habib, M.M.3    Abu Amara, M.4    Seifalian, A.M.5    Davidson, B.R.6
  • 27
    • 79953775326 scopus 로고    scopus 로고
    • Playing with cardiac "redox switches": The "hNO way" to modulate cardiac function
    • Tocchetti CG, Stanley BA, Murray CI, et al. Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function. Antioxid Redox Signal. 2011 ; 14: 1687-1698
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1687-1698
    • Tocchetti, C.G.1    Stanley, B.A.2    Murray, C.I.3
  • 28
    • 51249093667 scopus 로고    scopus 로고
    • Myocardial protection by nitrite: Evidence that this reperfusion therapeutic will not be lost in translation
    • Sinha SS, Shiva S, Gladwin MT. Myocardial protection by nitrite: evidence that this reperfusion therapeutic will not be lost in translation. Trends Cardiovasc Med. 2008 ; 18: 163-172
    • (2008) Trends Cardiovasc Med , vol.18 , pp. 163-172
    • Sinha, S.S.1    Shiva, S.2    Gladwin, M.T.3
  • 29
    • 0037623908 scopus 로고    scopus 로고
    • Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning
    • Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003 ; 285: H579 - H588
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Zhao, Z.Q.1    Corvera, J.S.2    Halkos, M.E.3
  • 30
    • 40749130846 scopus 로고    scopus 로고
    • Long-term benefit of postconditioning
    • Thibault H, Piot C, Staat P, et al. Long-term benefit of postconditioning. Circulation. 2008 ; 117: 1037-1044
    • (2008) Circulation , vol.117 , pp. 1037-1044
    • Thibault, H.1    Piot, C.2    Staat, P.3
  • 31
    • 77954910444 scopus 로고    scopus 로고
    • Postconditioning the human heart in percutaneous coronary intervention
    • Xue F, Yang X, Zhang B, et al. Postconditioning the human heart in percutaneous coronary intervention. Clin Cardiol. 2010 ; 33: 439-444
    • (2010) Clin Cardiol , vol.33 , pp. 439-444
    • Xue, F.1    Yang, X.2    Zhang, B.3
  • 32
    • 34249026375 scopus 로고    scopus 로고
    • Postconditioning the human heart with adenosine in heart valve replacement surgery
    • Jin ZX, Zhou JJ, Xin M, et al. Postconditioning the human heart with adenosine in heart valve replacement surgery. Ann Thorac Surg. 2007 ; 83: 2066-2072
    • (2007) Ann Thorac Surg , vol.83 , pp. 2066-2072
    • Jin, Z.X.1    Zhou, J.J.2    Xin, M.3
  • 33
    • 34147093239 scopus 로고    scopus 로고
    • "Postconditioning" the human heart: Multiple balloon inflations during primary angioplasty may confer cardioprotection
    • Darling CE, Solari PB, Smith CS, Furman MI, Przyklenk K. "Postconditioning" the human heart: multiple balloon inflations during primary angioplasty may confer cardioprotection. Basic Res Cardiol. 2007 ; 102: 274-278
    • (2007) Basic Res Cardiol , vol.102 , pp. 274-278
    • Darling, C.E.1    Solari, P.B.2    Smith, C.S.3    Furman, M.I.4    Przyklenk, K.5
  • 34
    • 26944445765 scopus 로고    scopus 로고
    • Postconditioning the human heart
    • Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005 ; 112: 2143-2148
    • (2005) Circulation , vol.112 , pp. 2143-2148
    • Staat, P.1    Rioufol, G.2    Piot, C.3
  • 35
    • 74049107874 scopus 로고    scopus 로고
    • Post-conditioning for cardioprotection during reperfusion therapy: Too good to be true?
    • Prasad A. Post-conditioning for cardioprotection during reperfusion therapy: too good to be true?. JACC Cardiovasc Interv. 2010 ; 3: 56-57
    • (2010) JACC Cardiovasc Interv , vol.3 , pp. 56-57
    • Prasad, A.1
  • 36
    • 78650168192 scopus 로고    scopus 로고
    • ST-segment resolution and clinical outcome with ischemic postconditioning and comparison to magnetic resonance
    • Lonborg J, Holmvang L, Kelbaek H, et al. ST-segment resolution and clinical outcome with ischemic postconditioning and comparison to magnetic resonance. Am Heart J. 2010 ; 160: 1085-1091
    • (2010) Am Heart J , vol.160 , pp. 1085-1091
    • Lonborg, J.1    Holmvang, L.2    Kelbaek, H.3
  • 37
    • 81255195550 scopus 로고    scopus 로고
    • Ischemia and reperfusion: From mechanism to translation
    • Eltzschig HK, Eckle T. Ischemia and reperfusion: from mechanism to translation. Nat Med. 2011 ; 17: 1391-1401
    • (2011) Nat Med , vol.17 , pp. 1391-1401
    • Eltzschig, H.K.1    Eckle, T.2
  • 38
    • 79952039647 scopus 로고    scopus 로고
    • Toll-like receptor signaling during myocardial ischemia
    • Eckle T, Eltzschig HK. Toll-like receptor signaling during myocardial ischemia. Anesthesiology. 2011 ; 114: 490-492
    • (2011) Anesthesiology , vol.114 , pp. 490-492
    • Eckle, T.1    Eltzschig, H.K.2
  • 39
    • 80051721082 scopus 로고    scopus 로고
    • Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model
    • Wang RP, Yao Q, Xiao YB, et al. Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model. Stress. 2011 ; 14: 567-575
    • (2011) Stress , vol.14 , pp. 567-575
    • Wang, R.P.1    Yao, Q.2    Xiao, Y.B.3
  • 40
    • 67650102620 scopus 로고    scopus 로고
    • Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: Mediating KC and MCP-1 expression induced by extracellular HSC70
    • Ao L, Zou N, Cleveland JC, Fullerton DA, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol. 2009 ; 297: H21 - H28
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Ao, L.1    Zou, N.2    Cleveland, J.C.3    Fullerton, D.A.4    Meng, X.5
  • 41
    • 58149500135 scopus 로고    scopus 로고
    • Toll-like receptor signaling: A critical modulator of cell survival and ischemic injury in the heart
    • Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol. 2009 ; 296: H1 - H12
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Chao, W.1
  • 42
    • 79952535561 scopus 로고    scopus 로고
    • Endotoxin release in cardiac surgery with cardiopulmonary bypass: Pathophysiology and possible therapeutic strategies-an update
    • Kats S, Schonberger JP, Brands R, Seinen W, van Oeveren W. Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies-an update. Eur J Cardiothorac Surg. 2011 ; 39: 451-458
    • (2011) Eur J Cardiothorac Surg , vol.39 , pp. 451-458
    • Kats, S.1    Schonberger, J.P.2    Brands, R.3    Seinen, W.4    Van Oeveren, W.5
  • 43
    • 0037010009 scopus 로고    scopus 로고
    • The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: The results of the HALT-MI study
    • Faxon DP, Gibbons RJ, Chronos NA, Gurbel PA, Sheehan F. The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study. J Am Coll Cardiol. 2002 ; 40: 1199-204
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1199-1204
    • Faxon, D.P.1    Gibbons, R.J.2    Chronos, N.A.3    Gurbel, P.A.4    Sheehan, F.5
  • 44
    • 70349658872 scopus 로고    scopus 로고
    • Adenosine: An old drug newly discovered
    • Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009 ; 111: 904-915
    • (2009) Anesthesiology , vol.111 , pp. 904-915
    • Eltzschig, H.K.1
  • 45
    • 79251625729 scopus 로고    scopus 로고
    • Targeting hypoxia-induced Inflammation
    • Eltzschig HK. Targeting hypoxia-induced Inflammation. Anesthesiology. 2011 ; 114: 239-242
    • (2011) Anesthesiology , vol.114 , pp. 239-242
    • Eltzschig, H.K.1
  • 47
    • 11244261365 scopus 로고    scopus 로고
    • Vascular ischaemia and reperfusion injury
    • Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. Br Med Bull. 2004 ; 70: 71-86
    • (2004) Br Med Bull , vol.70 , pp. 71-86
    • Eltzschig, H.K.1    Collard, C.D.2
  • 48
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Hasko G, Linden J, Cronstein B, Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov. 2008 ; 7: 759-770
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 759-770
    • Hasko, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 49
    • 34247343418 scopus 로고    scopus 로고
    • Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors
    • Eckle T, Krahn T, Grenz A, et al. Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 ; 115: 1581-1590
    • (2007) Circulation , vol.115 , pp. 1581-1590
    • Eckle, T.1    Krahn, T.2    Grenz, A.3
  • 50
    • 33646031836 scopus 로고    scopus 로고
    • Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade
    • Philipp S, Yang XM, Cui L, Davis AM, Downey JM, Cohen MV. Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res. 2006 ; 70: 308-314
    • (2006) Cardiovasc Res , vol.70 , pp. 308-314
    • Philipp, S.1    Yang, X.M.2    Cui, L.3    Davis, A.M.4    Downey, J.M.5    Cohen, M.V.6
  • 51
    • 0031024750 scopus 로고    scopus 로고
    • Glucose metabolism in the ischemic heart
    • Lopaschuk GD, Stanley WC. Glucose metabolism in the ischemic heart. Circulation. 1997 ; 95: 313-315
    • (1997) Circulation , vol.95 , pp. 313-315
    • Lopaschuk, G.D.1    Stanley, W.C.2
  • 52
    • 0024385671 scopus 로고
    • Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir
    • Lopaschuk GD, McNeil GF, McVeigh JJ. Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir. Mol Cell Biochem. 1989 ; 88: 175-179
    • (1989) Mol Cell Biochem , vol.88 , pp. 175-179
    • Lopaschuk, G.D.1    McNeil, G.F.2    McVeigh, J.J.3
  • 53
    • 2942512039 scopus 로고    scopus 로고
    • Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: A double-blind placebo-controlled study
    • Rosano GM, Vitale C, Sposato B, Mercuro G, Fini M. Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study. Cardiovasc Diabetol. 2003 ; 2: 16
    • (2003) Cardiovasc Diabetol , vol.2 , pp. 16
    • Rosano, G.M.1    Vitale, C.2    Sposato, B.3    Mercuro, G.4    Fini, M.5
  • 54
    • 55249098908 scopus 로고    scopus 로고
    • The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease
    • Grabczewska Z, Bialoszynski T, Szymanski P, et al. The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease. Cardiol J. 2008 ; 15: 344-350
    • (2008) Cardiol J , vol.15 , pp. 344-350
    • Grabczewska, Z.1    Bialoszynski, T.2    Szymanski, P.3
  • 55
    • 4944222848 scopus 로고    scopus 로고
    • Efficacy and safety of a metabolic modulator drug in chronic stable angina: Review of evidence from clinical trials
    • Chaitman BR. Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials. J Cardiovasc Pharmacol Ther. 2004 ; 9 (suppl 1). S47 - S64
    • (2004) J Cardiovasc Pharmacol Ther , vol.9 , Issue.SUPPL. 1
    • Chaitman, B.R.1
  • 56
    • 20844432056 scopus 로고    scopus 로고
    • Effects of glucose-insulin-potassium solution added to reperfusion treatment in acute myocardial infarction
    • Türel B, Gemici K, Baran I, et al. Effects of glucose-insulin- potassium solution added to reperfusion treatment in acute myocardial infarction. Anadolu Kardiyol Derg. 2005 ; 5: 90-94
    • (2005) Anadolu Kardiyol Derg , vol.5 , pp. 90-94
    • Türel, B.1    Gemici, K.2    Baran, I.3
  • 57
    • 43449089513 scopus 로고    scopus 로고
    • Glucose-insulin-potassium for acute myocardial infarction: Continuing controversy over cardioprotection
    • Kloner RA, Nesto RW. Glucose-insulin-potassium for acute myocardial infarction: continuing controversy over cardioprotection. Circulation. 2008 ; 117: 2523-2533
    • (2008) Circulation , vol.117 , pp. 2523-2533
    • Kloner, R.A.1    Nesto, R.W.2
  • 58
    • 18844445117 scopus 로고    scopus 로고
    • A challenge to the metabolic approach to myocardial ischaemia
    • Apstein CS, Opie LH. A challenge to the metabolic approach to myocardial ischaemia. Eur Heart J. 2005 ; 26: 956-959
    • (2005) Eur Heart J , vol.26 , pp. 956-959
    • Apstein, C.S.1    Opie, L.H.2
  • 59
    • 17744399714 scopus 로고    scopus 로고
    • Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart
    • Wang P, Lloyd SG, Chatham JC. Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart. Circulation. 2005 ; 111: 2066-2072
    • (2005) Circulation , vol.111 , pp. 2066-2072
    • Wang, P.1    Lloyd, S.G.2    Chatham, J.C.3
  • 60
    • 65649101870 scopus 로고    scopus 로고
    • The metabolic treatment of patients with coronary artery disease: Effects on quality of life and effort angina
    • Cesar LA, Gowdak LH, Mansur AP. The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina. Curr Pharm Des. 2009 ; 15: 841-849
    • (2009) Curr Pharm des , vol.15 , pp. 841-849
    • Cesar, L.A.1    Gowdak, L.H.2    Mansur, A.P.3
  • 61
    • 77949343027 scopus 로고    scopus 로고
    • The cardiomyocyte circadian clock: Emerging roles in health and disease
    • Durgan DJ, Young ME. The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res. 2010 ; 106: 647-658
    • (2010) Circ Res , vol.106 , pp. 647-658
    • Durgan, D.J.1    Young, M.E.2
  • 62
    • 42549165229 scopus 로고    scopus 로고
    • Linking the cardiomyocyte circadian clock to myocardial metabolism
    • Durgan DJ, Young ME. Linking the cardiomyocyte circadian clock to myocardial metabolism. Cardiovasc Drugs Ther. 2008 ; 22: 115-124
    • (2008) Cardiovasc Drugs Ther , vol.22 , pp. 115-124
    • Durgan, D.J.1    Young, M.E.2
  • 63
    • 79953666149 scopus 로고    scopus 로고
    • Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice
    • Durgan DJ, Tsai JY, Grenett MH, et al. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011 ; 28: 187-203
    • (2011) Chronobiol Int , vol.28 , pp. 187-203
    • Durgan, D.J.1    Tsai, J.Y.2    Grenett, M.H.3
  • 64
    • 33747662966 scopus 로고    scopus 로고
    • The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids
    • Durgan DJ, Trexler NA, Egbejimi O, et al. The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J Biol Chem. 2006 ; 281: 24254-24269
    • (2006) J Biol Chem , vol.281 , pp. 24254-24269
    • Durgan, D.J.1    Trexler, N.A.2    Egbejimi, O.3
  • 65
    • 77649094910 scopus 로고    scopus 로고
    • Short communication: Ischemia/reperfusion tolerance is time-of-day-dependent: Mediation by the cardiomyocyte circadian clock
    • Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, et al. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010 ; 106: 546-550
    • (2010) Circ Res , vol.106 , pp. 546-550
    • Durgan, D.J.1    Pulinilkunnil, T.2    Villegas-Montoya, C.3
  • 67
    • 39149108483 scopus 로고    scopus 로고
    • Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
    • Bray MS, Shaw CA, Moore MW, et al. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol. 2008 ; 294: H1036 - H1047
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Bray, M.S.1    Shaw, C.A.2    Moore, M.W.3
  • 68
    • 21344470923 scopus 로고    scopus 로고
    • Circadian rhythms from multiple oscillators: Lessons from diverse organisms
    • Bell-Pedersen D, Cassone VM, Earnest DJ, et al. Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet. 2005 ; 6: 544-556
    • (2005) Nat Rev Genet , vol.6 , pp. 544-556
    • Bell-Pedersen, D.1    Cassone, V.M.2    Earnest, D.J.3
  • 69
    • 1442333357 scopus 로고    scopus 로고
    • Central and peripheral circadian oscillators in Drosophila
    • Hardin PE, Krishnan B, Houl JH, et al. Central and peripheral circadian oscillators in Drosophila. Novartis Found Symp. 2003 ; 253: 140-150
    • (2003) Novartis Found Symp , vol.253 , pp. 140-150
    • Hardin, P.E.1    Krishnan, B.2    Houl, J.H.3
  • 70
    • 33751250489 scopus 로고    scopus 로고
    • Essential and expendable features of the circadian timekeeping mechanism
    • Hardin PE. Essential and expendable features of the circadian timekeeping mechanism. Curr Opin Neurobiol. 2006 ; 16: 686-692
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 686-692
    • Hardin, P.E.1
  • 71
    • 24044444531 scopus 로고    scopus 로고
    • The circadian timekeeping system of Drosophila
    • Hardin PE. The circadian timekeeping system of Drosophila. Curr Biol. 2005 ; 15: R714 - R722
    • (2005) Curr Biol , vol.15
    • Hardin, P.E.1
  • 72
    • 78649687209 scopus 로고    scopus 로고
    • Circadian integration of metabolism and energetics
    • Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010 ; 330: 1349-1354
    • (2010) Science , vol.330 , pp. 1349-1354
    • Bass, J.1    Takahashi, J.S.2
  • 73
    • 77954848215 scopus 로고    scopus 로고
    • Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    • Marcheva B, Ramsey KM, Buhr ED, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 ; 466: 627-631
    • (2010) Nature , vol.466 , pp. 627-631
    • Marcheva, B.1    Ramsey, K.M.2    Buhr, E.D.3
  • 74
    • 79959843192 scopus 로고    scopus 로고
    • Genomic convergence among ERRalpha, PROX1, and BMAL1 in the control of metabolic clock outputs
    • Dufour CR, Levasseur MP, Pham NH, et al. Genomic convergence among ERRalpha, PROX1, and BMAL1 in the control of metabolic clock outputs. PLoS Genet. 2011 ; 7: e1002143
    • (2011) PLoS Genet , vol.7 , pp. 1002143
    • Dufour, C.R.1    Levasseur, M.P.2    Pham, N.H.3
  • 75
    • 80052966107 scopus 로고    scopus 로고
    • Low-power light and isolated rat hearts after ischemia of myocardium
    • Monich V, Drugova O, Lazukin V, Bavrina A. Low-power light and isolated rat hearts after ischemia of myocardium. J Photochem Photobiol B. 2011 ; 105: 21-24
    • (2011) J Photochem Photobiol B , vol.105 , pp. 21-24
    • Monich, V.1    Drugova, O.2    Lazukin, V.3    Bavrina, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.