Klotho gene and endothelial function

Japanese Journal of Geriatrics

Volumn 43, Issue 3, 2006, Pages 342-344

  Saito, Yuichiro ^a   Kurabayashi, Masahiko ^a   Nakamura, Tetsuya ^b   Nagai, Ryozo ^c  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Aging; Arteriosclerosis; Endothelial function; Nitric oxide; Oxidative stress

Indexed keywords

EID: 33745746128     PISSN: 03009173     EISSN: None     Source Type: Journal    
DOI: 10.3143/geriatrics.43.342     Document Type: Conference Paper

References (8)

1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al.: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51.
2. Shiraki-Iida T, Iida A, Nabeshima Y, Anazawa H, Nishikawa S, Noda M, et al.: Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. J Gene Med 2000; 2: 233-242.
3. Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y: Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 1998; 242: 626-630.
4. Shiraki-Iida T, Aizawa H, Matsumura Y, Sekine S, Iida A, Anazawa H, et al.: Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett 1998; 424: 6-10.
5. Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, et al.: Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun 1998; 248: 324-329.
6. Nakamura T, Saito Y, Ohyama Y, Masuda H, Sumino H, Kuro-o M, et al.: Production of nitric oxide, but not prostacyclin, is reduced in klotho mice. Jpn J Pharmacol 2002; 89: 149-156.
7. Nagai T, Yamada K, Kim HC, Kim YS, Noda Y, Imura A, et al.: Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J 2003; 17: 50-52.
8. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, et al.: In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002; 39: 838-843.