Local communication among mucosal immune cells in patients with celiac disease

Gastroenterology

Volumn 148, Issue 6, 2015, Pages 1187-1194

  Van Bergen, Jeroen ^a   Mulder, Chris J ^b   Mearin, M Luisa ^a   Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD4; Celiac Disease; HLA; Immunology; Intestinal Epithelial Cell; Intraepithelial Lymphocyte; T Cell

Indexed keywords

GLUTEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; INTERLEUKIN 15; AUTOANTIBODY; HLA DQ ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TISSUE TRANSGLUTAMINASE 2, HUMAN;

ADAPTIVE IMMUNITY; B LYMPHOCYTE; BASEMENT MEMBRANE; CD4+ T LYMPHOCYTE; CELIAC DISEASE; DISEASE PREDISPOSITION; DUODENUM; ENVIRONMENTAL FACTOR; EPITHELIUM CELL; GENE CONTROL; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; JEJUNUM; LAMINA PROPRIA; LYMPHOCYTE; MASS COMMUNICATION; MOLECULAR PATHOLOGY; MUCOSAL IMMUNITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ANIMAL; BLOOD; CELL COMMUNICATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION;

ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELIAC DISEASE; CELL COMMUNICATION; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ ANTIGENS; HUMANS; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSGLUTAMINASES;

EID: 84928409543     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.01.030     Document Type: Article

References (68)

1. P.C. Dubois, G. Trynka, and L. Franke Multiple common variants for celiac disease influencing immune gene expression Nat Genet 42 2010 295 302
2. K.A. Hunt, A. Zhernakova, and G. Turner Newly identified genetic risk variants for celiac disease related to the immune response Nat Genet 40 2008 395 402
3. G. Trynka, K.A. Hunt, and N.A. Bockett Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease Nat Genet 43 2011 1193 1201
4. D.A. van Heel, L. Franke, and K.A. Hunt A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Nat Genet 39 2007 827 829
5. M.L. Mearin, J. Bouquet, and N. Mourad HLA-DR antigens and phenotypes in Dutch coeliac children and their families Clin Genet 27 1985 45 50
6. L.M. Sollid, G. Markussen, and J. Ek Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer J Exp Med 169 1989 345 350
7. M. Bodd, C.Y. Kim, and K.E. Lundin T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease Gastroenterology 142 2012 552 561
8. L.E. Fallang, E. Bergseng, and K. Hotta Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation Nat Immunol 10 2009 1096 1101
9. V. Kumar, J. Gutierrez-Achury, and K. Kanduri Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon gamma levels Hum Mol Genet 24 2015 397 409
10. O. Molberg, K. Kett, and H. Scott Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls Scand J Immunol 46 1997 103 109
11. Y. van de Wal, Y.M. Kooy, and P.A. van Veelen Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin Proc Natl Acad Sci U S A 95 1998 10050 10054
12. L.M. Sollid, S.W. Qiao, and R.P. Anderson Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules Immunogenetics 64 2012 455 460
13. Y. van de Wal, Y. Kooy, and P. van Veelen Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity J Immunol 161 1998 1585 1588
14. O. Molberg, S.N. McAdam, and R. Korner Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Nat Med 4 1998 713 717
15. S. Tollefsen, H. Rentz-Hansen, and B. Fleckenstein HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease J Clin Invest 116 2006 2226 2236
16. M. Bodd, M. Raki, and S. Tollefsen HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22 Mucosal Immunol 3 2010 594 601
17. E.M. Nilsen, F.L. Jahnsen, and K.E. Lundin Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease Gastroenterology 115 1998 551 563
18. M.A. van Leeuwen, D.J. Lindenbergh-Kortleve, and H.C. Raatgeep Increased production of interleukin-21, but not interleukin-17A, in the small intestine characterizes pediatric celiac disease Mucosal Immunol 6 2013 1202 1213
19. S.L. Vriezinga, R. Auricchio, and E. Bravi Randomized Feeding Intervention in Infants at High Risk for Celiac Disease N Engl J Med 371 2014 1304 1315
20. R. Di Niro, L. Mesin, and N.Y. Zheng High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions Nat Med 18 2012 441 445
21. O. Steinsbo, C.J. Henry Dunand, and M. Huang Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells Nat Commun 5 2014 4041
22. W. Dieterich, E. Laag, and H. Schopper Autoantibodies to tissue transglutaminase as predictors of celiac disease Gastroenterology 115 1998 1317 1321
23. W. Dieterich, T. Ehnis, and M. Bauer Identification of tissue transglutaminase as the autoantigen of celiac disease Nat Med 3 1997 797 801
24. A. Rostom, C. Dube, and A. Cranney The diagnostic accuracy of serologic tests for celiac disease: a systematic review Gastroenterology 128 Suppl 2005 S38 S46
25. S. Husby, S. Koletzko, and I.R. Korponay-Szabo European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease J Pediatr Gastroenterol Nutr 54 2012 136 160
26. S. Bjorck, C. Brundin, and E. Lorinc Screening detects a high proportion of celiac disease in young HLA-genotyped children J Pediatr Gastroenterol Nutr 50 2010 49 53
27. S.W. Qiao, A. Christophersen, and K.E. Lundin Biased usage and preferred pairing of alpha- and beta-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease Int Immunol 26 2014 13 19
28. S.W. Qiao, M. Raki, and K.S. Gunnarsen Posttranslational modification of gluten shapes TCR usage in celiac disease J Immunol 187 2011 3064 3071
29. S.E. Broughton, J. Petersen, and A. Theodossis Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease Immunity 37 2012 611 621
30. J. Petersen, V. Montserrat, and J.R. Mujico T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease Nat Struct Mol Biol 21 2014 480 488
31. J.J. Mention, A.M. Ben, and B. Begue Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease Gastroenterology 125 2003 730 745
32. A. Di Sabatino, R. Ciccocioppo, and F. Cupelli Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease Gut 55 2006 469 477
33. L. Maiuri, C. Ciacci, and I. Ricciardelli Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease Lancet 362 2003 30 37
34. S. Hue, J.J. Mention, and R.C. Monteiro A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease Immunity 21 2004 367 377
35. A. Luciani, V.R. Villella, and A. Vasaturo Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa Gut 59 2010 311 319
36. Y. Junker, S. Zeissig, and S.J. Kim Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 J Exp Med 209 2012 2395 2408
37. E. Furrie, S. Macfarlane, and G. Thomson Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria Immunology 115 2005 565 574
38. B. Meresse, Z. Chen, and C. Ciszewski Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease Immunity 21 2004 357 366
39. B. Meresse, S.A. Curran, and C. Ciszewski Reprogramming of CTLs into natural killer-like cells in celiac disease J Exp Med 203 2006 1343 1355
40. J. Spencer, P.G. Isaacson, and J.A. Walker-Smith Heterogeneity in intraepithelial lymphocyte subpopulations in fetal and postnatal human small intestine J Pediatr Gastroenterol Nutr 9 1989 173 177
41. F. Schmitz, J.M. Tjon, and Y. Lai Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II Gut 62 2013 509 519
42. G.R. Sander, and B.C. Powell Expression of Notch receptors and ligands in the adult gut J Histochem Cytochem 52 2004 509 516
43. M. Watanabe, Y. Ueno, and T. Yajima Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes J Clin Invest 95 1995 2945 2953
44. A. Okazawa, T. Kanai, and K. Nakamaru Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes Clin Exp Immunol 136 2004 269 276
45. C.S. Klose, M. Flach, and L. Mohle Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages Cell 157 2014 340 356
46. J.H. Bernink, C.P. Peters, and M. Munneke Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues Nat Immunol 14 2013 221 229
47. G. Malamut, M.R. El, and N. Montcuquet IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis J Clin Invest 120 2010 2131 2143
48. J.M. Tjon, Y.M. Kooy-Winkelaar, and G.J. Tack DNAM-1 mediates epithelial cell-specific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease type II patients J Immunol 186 2011 6304 6312
49. R. Timpl Macromolecular organization of basement membranes Curr Opin Cell Biol 8 1996 618 624
50. S. Verbeke, M. Gotteland, and M. Fernandez Basement membrane and connective tissue proteins in intestinal mucosa of patients with coeliac disease J Clin Pathol 55 2002 440 445
51. J.H. Niess, S. Brand, and X. Gu CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance Science 307 2005 254 258
52. R.L. Deem, F. Shanahan, and S.R. Targan Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells Clin Exp Immunol 83 1991 79 84
53. R.T. Przemioslo, K.E. Lundin, and L.M. Sollid Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody Gut 36 1995 874 879
54. J.R. Muller, T.A. Waldmann, and M.J. Kruhlak Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Ralpha in human monocytes and dendritic cells J Biol Chem 287 2012 40328 40338
55. T. Musso, L. Calosso, and M. Zucca Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15 Blood 93 1999 3531 3539
56. H.C. Reinecker, R.P. MacDermott, and S. Mirau Intestinal epithelial cells both express and respond to interleukin 15 Gastroenterology 111 1996 1706 1713
57. R. Caruso, D. Fina, and I. Peluso A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells Gastroenterology 132 2007 166 175
58. G. Monteleone, R. Caruso, and D. Fina Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21 Gut 55 2006 1774 1780
59. R. Ciccocioppo, S.A. Di, and M. Bauer Matrix metalloproteinase pattern in celiac duodenal mucosa Lab Invest 85 2005 397 407
60. M.T. Salmela, T.T. MacDonald, and D. Black Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation Gut 51 2002 540 547
61. S. Daum, U. Bauer, and H.D. Foss Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease Gut 44 1999 17 25
62. E.C. Ebert Interleukin 21 up-regulates perforin-mediated cytotoxic activity of human intra-epithelial lymphocytes Immunology 127 2009 206 215
63. W. Vader, D. Stepniak, and Y. Kooy The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses Proc Natl Acad Sci U S A 100 2003 12390 12395
64. G. Monteleone, S.L. Pender, and E. Alstead Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease Gut 48 2001 425 429
65. M.T. Bardella, R. Marino, and P.L. Meroni Celiac disease during interferon treatment Ann Intern Med 131 1999 157 158
66. A. Di Sabatino, K.M. Pickard, and J.N. Gordon Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease Gastroenterology 133 2007 1175 1187
67. M.F. Du Pre, A.E. Kozijn, and L.A. van Berkel Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells Gastroenterology 141 2011 610 620 620
68. R.W. DePaolo, V. Abadie, and F. Tang Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens Nature 471 2011 220 224