Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15

Blood

Volumn 93, Issue 10, 1999, Pages 3531-3539

  Musso, Tiziana ^a   Calosso, Liliana ^b   Zucca, Mario ^b   Millesimo, Maura ^b   Ravarino, Daniela ^b   Giovarelli, Mirella ^b   Malavasi, Fabio ^b   Negro Ponzi, Alessandro ^b   Paus, Ralf ^b   Bulfone Paus, Silvia ^b  

^a Institute of Microbiology   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15;

ARTICLE; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CELL SURFACE; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MEMBRANE BINDING; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

CELLS, CULTURED; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-15; INTERLEUKIN-4; JURKAT CELLS; LIPOPOLYSACCHARIDES; MONOCYTES; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 0033562382     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Cloning of a T cell growth factor that interacts with the β-chain of the interleukin-2 receptor. Science 264:965, 1994
2. Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91:4935, 1994
3. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255, 1995
4. McInnes IB, Al-Mughales J, Field M, Leung BP, Huang F, Dixon R, Sturrock RD, Wilkinson PC, Liew FY: The role of IL-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 2:175, 1996
5. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro. J Clin Invest 96:2578, 1995
6. Armitage RJ, Macduff BM, Eisenmann J, Paxton R, Grabstein KH: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154:483, 1995
7. Badolato R, Negro Ponzi A, Millesimo M, Notarangelo LD, Musso T: Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein I production in human monocytes. Blood 90:2804, 1997
8. Alleva DG, Kaser SB, Monroy MA, Fenton MJ, Beller DI: IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production. Evidence for differential receptor subunit utilization associated with stimulation or inhibition. J Immunol 159: 2941, 1997
9. Girard D, Paquet M, Faquin R, Beaulieu AD: Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: Modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15. Blood 88:3176, 1996
10. Musso T, Calosso L, Zucca M, Millesimo M, Puliti M, Bulfone-Paus S, Merlino C, Savoia D, Cavallo R, Negro Ponzi A, Badolato R: Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells. Infect Immun 66:2640, 1998
11. Vasquez N, Walsh TJ, Friedman D, Chanock SJ, Lyman CA: Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. Infect Immun 66:145, 1998
12. Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: The interleukin (IL)-2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that simulates T cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91:4940, 1994
13. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson DM: Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13:2822, 1994
14. Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisnmann J, Grabstein K, Caligiuri MA: Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395, 1994
15. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NJ, Gilbert DJ, Jenkins NA, Valentine V, Shapiro DN, Morris SW, Park LS, Cosman D: Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL-15RA and IL2RA genes. J Biol Chem 270:29862, 1995
16. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM: Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J 14:3654, 1995
17. Doherty TM, Seder RA, Sher A: Induction and regulation of IL-15 expression in murine macrophages. J Immunol 156:735, 1996
18. Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y: IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J Immunol 156:663, 1996
19. Bamford RN, Battiata AP, Burton JD, Sharma H, Waldmann TA: Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc Natl Acad Sci USA 93:2897, 1996
20. Flamand L, Stefanescu I, Menezes J: Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J Clin Invest 97:1373, 1996
21. Agostini C, Trentin L, Facco M, Sancetta R, Cerutti A, Tassinari C, Cimarosto L, Adami F, Cipriani A, Zambello R, Semenzato G: Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol 157:910, 1996
22. Onu A, Pohl T, Krause H, Bulfone-Paus S: Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol 158:255, 1997
23. Tagaya Y, Kurys G, Thies TA, Losi JM, Azimi N, Hanover JA, Bamford RN, Waldmann TA: Generation of secretable and non secretable interleukin 15 isoforms through alternate usage of signal peptides. Proc Natl Acad Sci USA 94:14444, 1997
24. Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y: Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol 160:936, 1998
25. Meazza R, Verdiani S, Biassoni R, Coppolecchia M, Gaggero A, Orengo AM, Colombo MP, Azzarone B, Ferrini S: Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. Oncogene 12:2187, 1996
26. Ziegle-Heitbrock HW, Thiel E, Futterer A, Hergoz V, Wirtz A, Riethmuller G: Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int J Cancer 41:456, 1988
27. Kazula B, Betzl G, Shao H, Diamantstein T, Weidle UH: A general method for chimerization of monoclonal antibodies by inverse polymerase chain reaction conserving authentic N-terminal sequences. Gene 122:321, 1993
28. Bulfone-Paus S, Ungureanu D, Pohl T, Lindner G, Krause H, Paus R, Kunzendorf U: Interleukin-15 protects from lethal apoptotic cell death in mice. Nat Med 3:1124, 1997
29. Rückert R, Herz U, Ungureanu D, Pohl T, Renz H, Bulfone-Paus S: IL-15-IgG2b fusion protein accelerates and enhances aTh2 but not a ThI immune response in vivo, while IL-2-IgG2b fusion protein inhibits both. Eur J Immunol 28:3312, 1998
30. Mohamadzadeh M, Takashima A, Dougherty, Knop J, Bergstresser PR, Cruz PD Jr: Ultraviolet B radiation up-regulates the expression of IL-15 in human skin. J Immunol 155:4492, 1995
31. Fleming SD, Campbell PA: Macrophages have cell surface IL-10 that regulates macrophage bactericidal activity. J Immunol 156:1143, 1996
32. Matsushima K, Taguchi M, Kovacs EJ, Young HA, Oppenheim JJ: Intracellular localization of human monocyte associated interleukin 1 (IL-1) activity and release of biologically active IL-1 from monocytes by trypsin and plasmin. J Immunol 136:2883, 1986
33. Espinoza-Delgado I, Ortaldo JR, Winkler-Pickett R, Sugamura K, Varesio L, Longo DL: Expression and role of p75 interleukin 2 receptor on human monocytes. J Exp Med 171:1821, 1990
34. Bosco MC, Espinoza-Delgado I, Schwabe M, Russel SM, Leonard WJ, Longo DL, Varesio L: The gamma subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon gamma, and transforming growth factor beta 1. Blood 83:3462, 1994
35. Luettig B, Decker T, Lohmann-Matthes M: Evidence for the existence of two forms of membrane tumor necrosis factor: An integral protein and a molecule attached to its receptor. J Immunol 143:4034, 1989
36. te Velde AA, Huijbens RJ, Heije K, de Vries JE, Figdor CG: Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes. Blood 76:1392, 1990
37. Standiford TJ, Strieter RM, Chensue SW, Westwick J, Kasahara K, Kunkel SL: IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J Immunol 145:1435, 1990
38. de Waal Malefyt R, Figdor CG, Huijbens R, Mohan-Peterson S, Bennet B, Culpepper J, Dang W, Zurawski G, de Vries JE: Effects of IL-13 on phenotype, cytokine production, and cytotoxic function on human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol 151:6370, 1993
39. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A: IL-10 inhibits cytokine production by activated macrophages. J Immunol 147:3815, 1991
40. Musso T, Gusella GL, Brooks A, Longo DL, Varesio L: Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes. Blood 83:1408, 1994
41. Willheim M, Gessl A, Berger R, Schedle A, Luger T, Foster O, Boltz-Nitulescu G: IL-6 augments Fc IgE receptor (Fc epsilon RII/ CD23) expression on human monoblastic/monocytic cell lines U937, THP-1, and Mono-Mac-6 but not on blood monocytes. Regulatory effects of IL-4 and IFN-γ. J Immunol 147:1837, 1991
42. Bulfone-Paus S, Dürkop H, Paus R, Krause H, Pohl T, Onu A: Differential regulation of human T lymphoblast functions by IL-2 and IL-15. Cytokine 9:507, 1997
43. Agostini C, Trentin L, Sancetta R, Facco M, Tassinari C, Cerutti A, Bortolin M, Milani A, Siviero M, Zambello R, Semenzato G: Interleukin-15 triggers activation and growth of the CD8 T-cell pool in extravascular tissues of patients with acquired immunodeficiency syndrome. Blood 90:1115, 1997
44. Frankenberger M, Pechumer H, Ziegler-Heitbrock HW: Interleukin-10 is upregulated in LPS tolerance. J Inflamm 45:56, 1995
45. Grass HJ, Brach MA, Schumann RR, Herrmann F: Regulation of MCP-1/JE gene expression during monocytic differentiation. J Immunol 153:4907, 1994
46. Varesio L, Cox GW, Pulkki K, Musso T, Latham PS, Gusella GL, Espinoza-Delgado I: Activation of macrophages and monocytes by interferon-gamma and interleukin-2, in Klostergaard J, Lopez-Berestein G (eds): Mononuclear Phagocytes in Cell Biology, Boca Raton, FL, CRC, 1993, p 119
47. Lindner G, Rücken R, Bulfone-Paus S, Paus R: Inhibition of chemotherapy-induced keratinocyte apoptosis in vivo by an interleukin-15-IgG fusion protein. J Invest Dermatol 110:457, 1998
48. Kurt-Jones EA, Beller DI, Mizel SB, Unanue ER: Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci USA 82:1204, 1985
49. Kaplanski G, Farnarier C, Kaplanski S, Porat R, Shapiro L, Bongrand P, Dinarello CA: Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism. Blood 84:4242, 1994
50. Perez C, Albert I, DeFay K, Zachariades N, Gooding L, Kriegler M: A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact. Cell 63:251, 1990
51. Wong ST, Winchell LF, McCune BK, Earp HS, Teixidò J, Massagué J, Herman B, Lee DC: The TGF-a precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 56:495, 1989
52. Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA: An essential role for ectodomain shedding in mammalian development. Science 282:1281, 1998