메뉴 건너뛰기




Volumn 127, Issue 2, 2009, Pages 206-215

Interleukin 21 up-regulates perforin-mediated cytotoxic activity of human intra-epithelial lymphocytes

Author keywords

Cytotoxicity; Fas ligand; Interleukin 21; Intra epithelial lymphocytes; Perforin; Tumour necrosis factor

Indexed keywords

ANTIGEN; CD3 ANTIGEN; CD45RO ANTIGEN; CD94 ANTIGEN; FAS LIGAND; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; MITOGEN ACTIVATED PROTEIN KINASE; PERFORIN; PHOSPHOTRANSFERASE; SERINE PROTEINASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; SYNAPTOPHYSIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 65449174258     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.02941.x     Document Type: Article
Times cited : (29)

References (39)
  • 1
    • 33846837450 scopus 로고    scopus 로고
    • + intraepithelial lymphocytes: A unique model to study the regulation of effector cytotoxic T lymphocytes in tissue
    • DOI 10.1111/j.1600-065X.2006.00481.x
    • + intraepithelial lymphocytes: a unique model to study the regulation of effector cytotoxic T lymphocytes in tissue. Immunol Rev 2007 215 : 202 14. (Pubitemid 46212241)
    • (2007) Immunological Reviews , vol.215 , Issue.1 , pp. 202-214
    • Jabri, B.1    Ebert, E.2
  • 2
    • 0024237293 scopus 로고
    • Same peculiar subset of HML1+ lymphocytes present within normal intestinal epithelium is associated with tumoral epithelium of gastrointestinal carcinomas
    • + lymphocytes present within normal intestinal epithelium of gastrointestinal carcinomas. Gut 1988 29 : 1632 8. (Pubitemid 19035101)
    • (1988) Gut , vol.29 , Issue.12 , pp. 1632-1638
    • Jarry, A.1    Cerf-Bensussan, N.2    Brousse, N.3    Guy-Grand, D.4    Muzeau, F.5    Potet, F.6
  • 3
    • 0028345061 scopus 로고
    • Human colorectal tumour infiltrating lymphocytes express activation markers and the CD45RO molecule, showing a primed population of lymphocytes in the tumour area
    • Ostenstad B, Lea T, Schlichting E, Harboe M. Human colorectal tumour infiltrating lymphocytes express activation markers and the CD45RO molecule, showing a primed population of lymphocytes in the tumour area. Gut 1994 35 : 382 7. (Pubitemid 24092911)
    • (1994) Gut , vol.35 , Issue.3 , pp. 382-387
    • Ostenstad, B.1    Lea, T.2    Schlichting, E.3    Harboe, M.4
  • 4
    • 0026571296 scopus 로고
    • Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors
    • Taunk J, Roberts AI, Ebert EC. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology 1992 102 : 69 75.
    • (1992) Gastroenterology , vol.102 , pp. 69-75
    • Taunk, J.1    Roberts, A.I.2    Ebert, E.C.3
  • 5
    • 0031788011 scopus 로고    scopus 로고
    • Interleukin 15 is a potent stimulant of intraepithelial lymphocytes
    • Ebert EC. Interleukin 15 is a potent stimulant of intraepithelial lymphocytes. Gastroenterology 1998 115 : 1439 45. (Pubitemid 28545994)
    • (1998) Gastroenterology , vol.115 , Issue.6 , pp. 1439-1445
    • Ebert, E.C.1
  • 6
    • 42149143633 scopus 로고    scopus 로고
    • Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through fas ligand
    • Ebert EC, Groh V. Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through fas ligand. Immunology 2008 124 : 33 41.
    • (2008) Immunology , vol.124 , pp. 33-41
    • Ebert, E.C.1    Groh, V.2
  • 7
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • DOI 10.1182/blood.V97.1.14
    • Fehniger TA, Caligiuri MA. Interleukin 15: biology and relevance to human disease. Blood 2001 97 : 14 32. (Pubitemid 32061238)
    • (2001) Blood , vol.97 , Issue.1 , pp. 14-32
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 8
    • 8144221014 scopus 로고    scopus 로고
    • Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes
    • DOI 10.1111/j.1365-2249.2004.02614.x
    • Ebert EC. Interleukin-12 upregulates perforin- and fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes. Clin Exp Immunol 2004 138 : 259 65. (Pubitemid 39472442)
    • (2004) Clinical and Experimental Immunology , vol.138 , Issue.2 , pp. 259-265
    • Ebert, E.C.1
  • 9
    • 0035889934 scopus 로고    scopus 로고
    • NKG2D receptors induced by IL15 costimulate CD28-negative effector CTL in the tissue microenvironment
    • Roberts AI, Lee L, Schwarz E, Groh V, Spies T, Ebert EC, Jabri B. NKG2D receptors induced by IL15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol 2001 167 : 5527 30.
    • (2001) J Immunol , vol.167 , pp. 5527-30
    • Roberts, A.I.1    Lee, L.2    Schwarz, E.3    Groh, V.4    Spies, T.5    Ebert, E.C.6    Jabri, B.7
  • 12
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000 408 : 57 63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 14
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin 21 enhances T-helper cell type 1 signaling and interferon-γ production in Crohn's disease
    • Monteleone G, Monteleone I, Fina D et al. Interleukin 21 enhances T-helper cell type 1 signaling and interferon-γ production in Crohn's disease. Gastroenterology 2005 128 : 687 94.
    • (2005) Gastroenterology , vol.128 , pp. 687-94
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 15
    • 40749123066 scopus 로고    scopus 로고
    • Autocrine regulation of IL-21 production in human T lymphocytes
    • Caprioli F, Sarra M, Caruso R et al. Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol 2008 180 : 1800 7.
    • (2008) J Immunol , vol.180 , pp. 1800-7
    • Caprioli, F.1    Sarra, M.2    Caruso, R.3
  • 17
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • DOI 10.1038/nri1688, PII NRI1688
    • Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005 5 : 688 98. (Pubitemid 43086171)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.9 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 20
    • 23444445913 scopus 로고    scopus 로고
    • IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
    • Li Y, Bleakley M, Yee C. IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response. J Immunol 2005 175 : 2261 9. (Pubitemid 41113833)
    • (2005) Journal of Immunology , vol.175 , Issue.4 , pp. 2261-2269
    • Li, Y.1    Bleakley, M.2    Yee, C.3
  • 22
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 Induces the Functional Maturation of Murine NK Cells
    • Brady J, Hayakawa Y, Smyth MJ, Nutt SL. IL-21 induces the functional maturation of murine NK cells. J Immunol 2004 172 : 22048 58. (Pubitemid 38182350)
    • (2004) Journal of Immunology , vol.172 , Issue.4 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 26
  • 27
    • 34250173393 scopus 로고    scopus 로고
    • IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
    • Casey KA, Meschere MF. IL-21 promotes differentiation of naïve CD8 T cells to a unique effector phenotype. J Immunol 2007 178 : 7640 8. (Pubitemid 46898034)
    • (2007) Journal of Immunology , vol.178 , Issue.12 , pp. 7640-7648
    • Casey, K.A.1    Mescher, M.F.2
  • 29
    • 39549101010 scopus 로고    scopus 로고
    • Interleukin-21 activates human natural killer cells and modulates their surface receptor expression
    • Skak K, Frederiksen KS, Lundsgaard D. Interleukin-21 activates human natural killer cells and modulates their surface receptor expression. Immunol 2008 123 : 575 83.
    • (2008) Immunol , vol.123 , pp. 575-83
    • Skak, K.1    Frederiksen, K.S.2    Lundsgaard, D.3
  • 30
    • 23844501960 scopus 로고    scopus 로고
    • Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells
    • Gays F, Martin K, Kenefeck R, aust JG, Brooks CG. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J Immunol 2005 175 : 2938 47. (Pubitemid 41170511)
    • (2005) Journal of Immunology , vol.175 , Issue.5 , pp. 2938-2947
    • Gays, F.1    Martin, K.2    Kenefeck, R.3    Aust, J.G.4    Brooks, C.G.5
  • 31
    • 35848937653 scopus 로고    scopus 로고
    • Interleukin-21 differentially affects human natural killer cell subsets
    • DOI 10.1111/j.1365-2567.2007.02675.x
    • Wendt K, Wilk E, Buyny S, Schmidt RE, Jacobs R. Interleukin-21 differentially affects human natural killer cell subsets. Immunol 2007 122 : 486 95. (Pubitemid 350075955)
    • (2007) Immunology , vol.122 , Issue.4 , pp. 486-495
    • Wendt, K.1    Wilk, E.2    Buyny, S.3    Schmidt, R.E.4    Jacobs, R.5
  • 32
    • 0024331733 scopus 로고
    • Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli
    • Ebert EC. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 1989 97 : 1372 81. (Pubitemid 20004160)
    • (1989) Gastroenterology , vol.97 , Issue.6 , pp. 1372-1381
    • Ebert, E.C.1
  • 39
    • 10344238050 scopus 로고    scopus 로고
    • In vivo and in vitro roles of IL-21 in inflammation
    • Pelletier M, Bouchard A, Girard D. In vivo and in vitro roles of IL-21 in inflammation. J Immunol 2004 173 : 7521 30. (Pubitemid 39628193)
    • (2004) Journal of Immunology , vol.173 , Issue.12 , pp. 7521-7530
    • Pelletier, M.1    Bouchard, A.2    Girard, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.