Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells

Gastroenterology

Volumn 141, Issue 2, 2011, Pages

  Du Pré, M Fleur ^a   Kozijn, Anne E ^a   Van Berkel, Lisette A ^a   Ter Borg, Mariëtte N D ^a   Lindenberghkortleve, Dicky ^a   Jensen, Lise Torp ^b   Kooywinkelaar, Yvonne ^c   Koning, Frits ^c   Boon, Louis ^d   Nieuwenhuis, Edward E S ^f   Sollid, Ludvig M ^e   Fugger, Lars ^b,g   Samsom, Janneke N ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d BIOCEROS   (Netherlands)

^e UNIVERSITY OF OSLO   (Norway)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Food Allergy; Immune Regulation; Mucosal Tolerance Induction; Treg Cells

Indexed keywords

GAMMA INTERFERON; GLIADIN; GLUTEN; INTERLEUKIN 10; OVALBUMIN; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL TRANSFER; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; T LYMPHOCYTE;

EID: 80051535925     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.04.048     Document Type: Article

References (26)

1. K.E. Lundin, H. Scott, and T. Hansen Gliadin-specific, HLA-DQ(alpha 1 (*)0501,beta 1 (*)0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients J Exp Med 178 1993 187 196 (Pubitemid 23173254)
2. E.M. Nilsen, K.E. Lundin, and P. Krajci Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma Gut 37 1995 766 776
3. S. Tollefsen, H. Arentz-Hansen, and B. Fleckenstein HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease J Clin Invest 116 2006 2226 2236 (Pubitemid 44162332)
4. O. Molberg, S.N. McAdam, and R. Korner Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Nat Med 4 1998 713 717 (Pubitemid 28274673)
5. Y. van de Wal, Y. Kooy, and P. van Veelen Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity J Immunol 161 1998 1585 1588 (Pubitemid 28387571)
6. F. Broere, M.F. du Pre, and L.A. van Berkel Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4 Mucosal Immunol 2 2009 254 264
7. J.L. Coombes, K.R. Siddiqui, and C.V. Arancibia-Carcamo A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism J Exp Med 204 2007 1757 1764 (Pubitemid 47236314)
8. F. Hauet-Broere, W.W. Unger, and J. Garssen Functional CD25- and CD25+ mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application Eur J Immunol 33 2003 2801 2810 (Pubitemid 37337146)
9. T. Worbs, U. Bode, and S. Yan Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells J Exp Med 203 2006 519 527
10. H. Sjostrom, K.E. Lundin, and O. Molberg Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition Scand J Immunol 48 1998 111 115 (Pubitemid 28365999)
11. V. Kouskoff, K. Signorelli, and C. Benoist Cassette vectors directing expression of T cell receptor genes in transgenic mice J Immunol Methods 180 1995 273 280
12. L. Madsen, N. Labrecque, and J. Engberg Mice lacking all conventional MHC class II genes Proc Natl Acad Sci U S A 96 1999 10338 10343 (Pubitemid 29422559)
13. W.W. Unger, F. Hauet-Broere, and W. Jansen Early events in peripheral regulatory T cell induction via the nasal mucosa J Immunol 171 2003 4592 4603 (Pubitemid 37310575)
14. M.F. du Pré, L.A. van Berkel, and M. Ráki CD62L(neg)CD38(+) expression on circulating CD4(+) T Cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls Am J Gastroenterol 106 2011 1147 1159
15. M. Siegel, P. Strnad, and R.E. Watts Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury PLoS One 3 2008 e1861
16. C. Gianfrani, M.K. Levings, and C. Sartirana Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells J Immunol 177 2006 4178 4186 (Pubitemid 44359953)
17. H. Groux, A. O'Garra, and M. Bigler A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature 389 1997 737 742 (Pubitemid 27458961)
18. M. Saraiva, J.R. Christensen, and M. Veldhoen Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose Immunity 31 2009 209 219
19. K.E. Black, J.A. Murray, and C.S. David HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice J Immunol 169 2002 5595 5600 (Pubitemid 35291659)
20. A.L. de Kauwe, Z. Chen, and R.P. Anderson Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells J Immunol 182 2009 7440 7450
21. B.A. de Koning, J.M. van Dieren, and D.J. Lindenbergh-Kortleve Contributions of mucosal immune cells to methotrexate-induced mucositis Int Immunol 18 2006 941 949 (Pubitemid 43983289)
22. G. Kraal, J.N. Samsom, and R.E. Mebius The importance of regional lymph nodes for mucosal tolerance Immunol Rev 213 2006 119 130 (Pubitemid 44401497)
23. L. Shan, O. Molberg, and I. Parrot Structural basis for gluten intolerance in celiac sprue Science 297 2002 2275 2279
24. M. Raki, S. Tollefsen, and O. Molberg A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells Gastroenterology 131 2006 428 438 (Pubitemid 44142462)
25. T.L. Freitag, S. Rietdijk, and Y. Junker Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice Gut 58 2009 1597 1605
26. G. Forsberg, O. Hernell, and S. Melgar Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease Gastroenterology 123 2002 667 678 (Pubitemid 34977072)