Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease

Gut

Volumn 44, Issue 1, 1999, Pages 17-25

  Daum, S ^a   Bauer, U ^a   Foss, H D ^b   Schuppan, D ^a   Stein, H ^b   Riecken, E O ^a   Ullrich, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b NONE

Author keywords

Coeliac disease; Collagen I; Extracellular matrix; Matrix metalloproteinases; TIMP 1; Villus atrophy

Indexed keywords

COLLAGENASE; GLUTEN; MESSENGER RNA; PROCOLLAGEN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; AGED; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DUODENUM BIOPSY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; GENE EXPRESSION; GLUTEN FREE DIET; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; MACROPHAGE; MALE; PRIORITY JOURNAL;

EID: 0033034038     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.44.1.17     Document Type: Article

References (40)

1. 1 Marsh MN. The morphology and immunopathology of the jejunal lesion in gluten-sensitivity. Eur J Gastroenterol Hepatol 1991;3:163-8.
2. 2 Halstensen TS, Brandtzaeg P. Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ α/β cells in the lamina propria but proliferation (Ki-67) of α/β and γ/δ cells in the epithelium. Eur J Immunol 1993;23:505-10.
3. 3 Lundin KEA, Scott H, Hansen T, et al. Gliadin-specific, HLA-DQ(α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96.
4. 4 MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 1988;167:1341-9.
5. 5 Garside P, Felstein V, Green EA, et al. The role of interferon α/β in the induction of intestinal pathology in mice. Immunology 1991;74:279-83.
6. 6 Mowat AM. Antibodies to IFN-γ prevent immunologically mediated intestinal damage in murine graft versus host reaction. Immunology 1989;68:18-23.
7. 7 Mowat AM, Hutton AK, Garside P, et al. A role for interleukin-1α in immunologically mediated intestinal pathology. Immunology 1993;80:110-15.
8. 8 Piguet P-F, Grau GE, Allet B, et al. Tumor necrosis factor/ cachectin is an effector of skin and gut lesions of the acut phase of graft-vs.-host disease. J Exp Med 1987;166:1280-9.
9. 9 Kontakou M, Przemioslo RT, Sturgess RP, et al. Cytokine mRNA expression in the mucosa of treated coeliac patients after wheat peptide challenge. Gut 1995;37:52-7.
10. 10 Przemioslo RT, Kontakou M, Nobili V, et al. Raised proinflammatory cytokines interleukin 6 and tumour necrosis factor a in coeliac disease mucosa detected by immunohistochemistry. Gut 1994;35:1398-403.
11. 11 Nilsen EM, Lundin KEA, Krajci P, et al. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon γ. Gut 1995;37:766-76.
12. 12 Marsh MN, Loft D, Garner V, et al. Time/dose responses of coeliac mucosae to graded oral challenges with Frazer's fraction III of gliadin. Eur J Gastroenterol Hepatol 1992;4: 667-73.
13. 13 Pender SL, Tickle SP, Docherty AJ, et al. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997;158:1582-90.
14. 14 Pender SLF, Fell JME, Chamow SM, et al. A p55 receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production. J Immunol 1998;160:4098-103
15. 15 Mauviel A. Cytokine regulation of metalloproteinase gene expression. J Cell Biochem 1993;53:288-95.
16. 16 Graham M, Willey A, Adams J, et al. Interleukin-1β down-regulates collagen and augments collagenase expression in human intestinal smooth muscle cells. Gastroenterology 1996;110:344-50.
17. 17 Dayer JM, Beutler B, Cerami A. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 1985;162:2163-8.
18. 18 DeClerck Y, Draper V, Parkman R. Clonal analysis of murine graft-vs-host disease. II. Leukokines that stimulate fibroblast proliferation and collagen synthesis in graft-vs.-host disease. J Immunol 1986;136:3549-52.
19. 19 Bossart R, Henry K, Booth CC, et al. Subepithelial collagen in intestinal malabsorption. Gut 1975;16:18-22.
20. 20 Hein J, Hahn E, Riecken EO. Kollagentypen und mononukleäre Zellen in der Dünndarmschleimhaut: Lokalisation bei Gesunden und Patienten mit Sprue. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin 1977;83:452-5.
21. 21 Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 1995;7:728-35.
22. 22 Woessner JF. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-54.
23. 23 Matthes H, Stallmach A, Matthes B, et al. Hinweise für einen differenten Kollagenmetabolismus bei Morbus Crohn und Colitis ulcerosa. Med Klin 1993;88:185-92.
24. 24 Saarialho-Kere UK, Vaalamo M, Puolakkainen P, et al. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 1997; 148:519-26.
25. 25 Graham M, Diegelmann R, Elson C, et al. Collagen content and types in the intestinal strictures of Crohn's disease. Gastroenterology 1988;94:257-65.
26. 26 Matthes H, Herbst H, Schuppan D, et al. Cellular localization of procollagen gene transcripts in inflammatory bowel diseases. Gastroenterology 1992;102:431-42.
27. 27 Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 1990;6:121-5.
28. 28 Goldberg GI Marmer BL, Grant GA, et al. Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2. Proc Natl Acad Sci USA 1989;86:8207-11.
29. 29 Walker-Smith JA, Guandalini S, Schmitz J, et al. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990;65:909-11.
30. 30 Herbst H, Wege T, Milani S, et al. Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 1997;150:1647-59.
31. 31 Matrisian LM, Glaichenhaus N, Gesnel MC, et al. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J 1985;4:1435-40.
32. 32 Milani S, Herbst H, Schuppan D, et al. In situ hybridization for collagen types I, III and IV mRXN in normal and fibrotic rat liver. Evidence for predominant expression in non-parenchymal liver cells. Hepatology 1989;10:84-92.
33. 33 Schuppan D, Riecken EO. Molecules of the extracellular matrix: potential role of collagens and glycoproteins in intestinal adaptation. Digestion 1990;46 (suppl):2-11.
34. 34 Hahn U, Stallmach A, Hahn EG, et al. Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro. Gastroenterology 1990;98:322-5.
35. 35 Pender SLF, Breese E, Günther U, et al. Suppression of T cell mediated injury in human gut by interleukin-10: role of matrix metalloprotenases. Gastroenterology 1998;115: 573-83.
36. 36 Gifford GE, Flick DA. Tumour necrosis factor. Microbiol Sci 1988;5:104-7.
37. 37 Whitelock JM, Paine ML, Gibbins JR, et al. Multiple levels of post-transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line. Immunol Cell Biol 1993;71:39-47.
38. 38 Milani S, Herbst H, Schuppan D, et al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994;144:528-37.
39. 39 Murphy G, Reynolds HH, Werb Z. Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. J Biol Chem 1985;260:3079-83.
40. 40 Colombel JF, Hallgren R, Engstrom-Laurent A, et al. Hyaluronic acid and type II procollagen peptide in jejunal perfusion fluid as markers of connective tissue turnover. Gastroenterology 1989;96:68-73.