Identification of a potential physiological precursor of aberrant cells in Refractory coeliac disease type II

Gut

Volumn 62, Issue 4, 2013, Pages 509-519

  Schmitz, Frederike ^a   Tjon, Jennifer M L ^a   Lai, Yuching ^a   Thompson, Allan ^a   Kooy Winkelaar, Yvonne ^a   Lemmers, Richard J L F ^a   Verspaget, Hein W ^a   Mearin, M Luisa ^a   Staal, Frank J ^a   Schreurs, Marco W ^b   Cupedo, Tom ^b   Langerak, Anton W ^b   Mulder, Chris J ^c   Bergen, Jeroen Van ^a   Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD7 ANTIGEN; GRANULYSIN; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 7 RECEPTOR; LYMPHOTOXIN BETA; NATURAL KILLER CELL RECEPTOR; PHOSPHOLIPASE C GAMMA2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELIAC DISEASE; CELL EXPANSION; CELL ISOLATION; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; DUODENUM BIOPSY; EFFECTOR CELL; FETUS; FLOW CYTOMETRY; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INTRAEPITHELIAL LYMPHOCYTE; LYMPHOCYTE; MEMORY CELL; MICROARRAY ANALYSIS; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REFRACTORY CELIAC DISEASE TYPE II; STEM CELL; T LYMPHOCYTE;

ANTIGENS, CD; BIOLOGICAL MARKERS; BIOPSY; CELIAC DISEASE; CELL LINE; CELLS, CULTURED; DUODENUM; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-15; INTESTINAL MUCOSA; KILLER CELLS, NATURAL; LYMPHOCYTES; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; TISSUE ARRAY ANALYSIS;

EID: 84874601654     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-302265     Document Type: Article

References (50)

1. *0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96. (Pubitemid 23173254)
2. Kutlu T, Brousse N, Rambaud C, et al. Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut 1993;34:208-14. (Pubitemid 23049114)
3. Mention JJ, Ben AM, Begue B, et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003;125:730-45. (Pubitemid 37070691)
4. Di Sabatino A, Ciccocioppo R, Cupelli F, et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 2006;55:469-77.
5. Al-Toma A, Verbeek WH, Hadithi M, et al. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 2007;56:1373-8. (Pubitemid 47517830)
6. Verbeek WH, Goerres MS, von Blomberg BM, et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in refractory celiac disease. Clin Immunol 2008;126:48-56. (Pubitemid 350266454)
7. Cellier C, Patey N, Mauvieux L, et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology 1998;114:471-81. (Pubitemid 28141192)
8. Malamut G, Afchain P, Verkarre V, et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 2009;136:81-90.
9. Tjon JM, Verbeek WH, Kooy-Winkelaar YM, et al. Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma. Blood 2008;112:5103-10.
10. Lanier LL, Chang C, Spits H, et al. Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. J Immunol 1992;149:1876-80.
11. De Smedt M, Taghon T, Van de Walle I, et al. Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells. Blood 2007;110:2696-703. (Pubitemid 47523197)
12. Spencer J, MacDonald TT, Diss TC, et al. Changes in intraepithelial lymphocyte subpopulations in celiac-disease and enteropathy associated T-cell lymphoma (malignant histiocytosis of the intestine). Gut 1989;30:339-46. (Pubitemid 19091160)
13. Eiras P, Leon F, Camarero C, et al. Intestinal intraepithelial lymphocytes contain a CD3 (-) CD7 (+) subset expressing natural killer markers and a singular pattern of adhesion molecules. Scand J Immunol 2000;52:1-6. (Pubitemid 30435978)
14. Gunther U, Holloway JA, Gordon JN, et al. Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells. J Immunol 2005;174:5414-22. (Pubitemid 40593181)
15. Jarry A, Cerf-Bensussan N, Brousse N, et al. Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3e lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 1990;20:1097-103. (Pubitemid 20206064)
16. Lundqvist C, Baranov V, Hammarstrom S, et al. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 1995;7:1473-87.
17. Leon F, Roldan E, Sanchez L, et al. Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology 2003;125:345-56. (Pubitemid 36929414)
18. Williams AM, Bland PW, Phillips AC, et al. Intestinal alpha beta T cells differentiate and rearrange antigen receptor genes in situ in the human infant. J Immunol 2004;173:7190-9. (Pubitemid 39628154)
19. Dik WA, Pike-Overzet K, Weerkamp F, et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 2005;201:1715-23. (Pubitemid 41002890)
20. Van Damme N, Baeten D, De Vos M, et al. Chemical agents and enzymes used for the extraction of gut lymphocytes influence flow cytometric detection of T cell surface markers. J Immunol Methods 2000;236:27-35. (Pubitemid 30107906)
21. David G, Morvan M, Gagne K, et al. Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies. Immunology 2009;128:172-84.
22. Pende D, Biassoni R, Cantoni C, et al. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J Exp Med 1996;184:505-18. (Pubitemid 26324104)
23. Estefania E, Flores R, Gomez-Lozano N, et al. Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. J Immunol 2007;178:4402-10. (Pubitemid 46492391)
24. Dunning MJ, Smith ML, Ritchie ME, et al. beadarray: R classes and methods for Illumina bead-based data. Bioinformatics 2007;23:2183-4. (Pubitemid 47394121)
25. Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3:Article3.
26. Caraux A, Kim N, Bell SE, et al. Phospholipase C-gamma 2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood 2006;107:994-1002. (Pubitemid 43156297)
27. Morra M, Lu J, Poy F, et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J 2001;20:5840-52. (Pubitemid 33049260)
28. Betser-Cohen G, Mizrahi S, Elboim M, et al. The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells. J Immunol 2010;184:2761-8.
29. Tack GJ, van Wanrooij RLJ, Langerak AW, et al. Origin and immunophenotype of aberrant IEL in RCDII patients. Mol Immunol 2012;50:262-70.
30. Hue S, Mention JJ, Monteiro RC, et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004;21:367-77. (Pubitemid 39208338)
31. Meresse B, Curran SA, Ciszewski C, et al. Reprogramming of CTLs into natural killerlike cells in celiac disease. J Exp Med 2006;203:1343-55. (Pubitemid 43736602)
32. Tjon JM, Kooy-Winkelaar YM, Tack GJ, et al. DNAM-1 mediates epithelial cellspecific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease type II patients. J Immunol 2011;186:6304-12.
33. Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol 2006;24:287-320.
34. Freud AG, Caligiuri MA. Human natural killer cell development. Immunol Rev 2006;214:56-72. (Pubitemid 44707902)
35. Cupedo T, Crellin NK, Papazian N, et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol 2009;10:66-74.
36. Vivier E, Spits H, Cupedo T. Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol 2009;9:229-34.
37. Cellier C, Delabesse E, Helmer C, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 2000;356:203-8. (Pubitemid 30446975)
38. Malamut G, El MR, Montcuquet N, et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 2010;120:2131-43.
39. Spencer J, Isaacson PG, Macdonald TT, et al. Gamma-delta T-cells and the diagnosis of celiac-disease. Clin Exp Immunol 1991;85:109-13.
40. Spencer J, Isaacson PG, Diss TC, et al. Expression of disulfide-linked and nondisulfide-linked forms of the T-cell receptor-gamma-delta heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 1989;19:1335-8. (Pubitemid 19196916)
41. Holmes GKT, Asquith P, Stokes PL, et al. Cellular infiltrate of jejunal biopsies in adult celiac-disease in relation to gluten withdrawal. Gut 1974;15:278-83.
42. Salmi TT, Collin P, Reunala T, et al. Diagnostic methods beyond conventional histology in coeliac disease diagnosis. Dig Liver Dis 2010;42:28-32.
43. Gorfu G, Rivera-Nieves J, Ley K. Role of beta (7) integrins in intestinal lymphocyte homing and retention. Curr Mol Med 2009;9:836-50.
44. Camarero C, Eiras P, Asensio A, et al. Intraepithelial lymphocytes and coeliac disease: permanent changes in CD3e/CD7+ and T cell receptor gammadelta subsets studied by flow cytometry. Acta Paediatr 2000;89:285-90. (Pubitemid 30625352)
45. Lynch S, Kelleher D, Mcmanus R, et al. Rag1 and Rag2 expression in human intestinal epitheliumdevidence of extrathymic T-cell differentiation. Eur J Immunol 1995;25:1143-7.
46. Howie D, Spencer J, De Lord D, et al. Extrathymic T cell differentiation in the human intestine early in life. J Immunol 1998;161:5862-72. (Pubitemid 28535952)
47. Bas A, Hammarstrom SG, Hammarstrom ML. Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression. J Immunol 2003;171:3359-71. (Pubitemid 37254535)
48. Meresse B, Chen ZG, Ciszewski C, et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 2004;21:357-66. (Pubitemid 39208337)
49. Jabri B, De Serre NPM, Cellier C, et al. Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease. Gastroenterology 2000;118:867-79. (Pubitemid 30243750)
50. Deleeuw RJ, Zettl A, Klinker E, et al. Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes. Gastroenterology 2007;132:1902-11. PAGE fraction trail=10.5 (Pubitemid 46677947)