Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

Journal of Experimental Medicine

Volumn 209, Issue 13, 2012, Pages 2395-2408

  Junker, Yvonne ^a,b   Zeissig, Sebastian ^b   Kim, Seong Jun ^a   Barisani, Donatella ^a,c   Wieser, Herbert ^d,e   Leffler, Daniel A ^a   Zevallos, Victor ^f   Libermann, Towia A ^a   Dillon, Simon ^a   Freitag, Tobias L ^a,g   Kelly, Ciaran P ^a   Schuppan, Detlef ^a,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

^e Hans Dieter Belitz Institute for Cereal Grain Research   (Germany)

^f JOHANNES GUTENBERG UNIVERSITY   (Germany)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE INHIBITOR; CD14 ANTIGEN; CM 0.19; CM 3; CYTOKINE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELIAC DISEASE; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFICACY; ENTERITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTESTINE BIOPSY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WHEAT;

AMINO ACID SEQUENCE; ANIMALS; CELIAC DISEASE; CELL LINE; GLIADIN; HEK293 CELLS; HORDEUM; HUMANS; IMMUNITY, INNATE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; PLANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRITICUM; TRYPSIN INHIBITORS; U937 CELLS;

EID: 84871885592     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20102660     Document Type: Article

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