T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease

Gastroenterology

Volumn 142, Issue 3, 2012, Pages 552-561

  Bodd, Michael ^a   Kim, Chuyoung ^b   Lundin, Knut E A ^a   Sollid, Ludvig M ^a,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

DQ2.2 glut L 1; Genetics; Immune Response; Inflammatory Reaction

Indexed keywords

GLUTEN; HLA DQ2 ANTIGEN;

ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; DNA POLYMORPHISM; GEL FILTRATION; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE;

EID: 84857634950     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.11.021     Document Type: Article

References (29)

1. B. Jabri, L.M. Sollid Tissue-mediated control of immunopathology in coeliac disease Nat Rev Immunol 9 2009 858 870
2. Ø. Molberg, K. Kett, H. Scott Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls Scand J Immunol 46 1997 103 108
3. K.E. Lundin, H. Scott, T. Hansen Gliadin-specific, HLA-DQ(alfa1 (*)0501,beta1 (*)0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients J Exp Med 178 1993 187 196
4. K.E. Lundin, H. Scott, O. Fausa T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8 Hum Immunol 41 1994 285 291
5. L.M. Sollid, G. Markussen, J. Ek Evidence for a primary association of celiac disease to a particular HLA-DQ alfa/beta heterodimer J Exp Med 169 1989 345 350
6. K. Karell, A.S. Louka, S.J. Moodie HLA types in celiac disease patients not carrying the DQA1 (*)05-DQB1 (*)02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease Hum Immunol 64 2003 469 477
7. S.W. Qiao, E. Bergseng, Ø. Molberg Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation J Immunol 175 2005 254 261
8. W. Vader, D. Stepniak, Y. Kooy The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses Proc Natl Acad Sci U S A 100 2003 12390 12395
9. L.E. Fallang, E. Bergseng, K. Hotta Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation Nat Immunol 10 2009 1096 1101
10. W. Vader, Y. Kooy, P.A. van Veelen The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides Gastroenterology 122 2002 1729 1737
11. S. Tollefsen, H. Arentz-Hansen, B. Fleckenstein HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease J Clin Invest 116 2006 2226 2236
12. J.A. Tye-Din, J.A. Stewart, J.A. Dromey Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease Sci Transl Med 2 2010 41ra51
13. H. Arentz-Hansen, R. Korner, Ø. Molberg The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase J Exp Med 191 2000 603 612
14. Y. van de Wal, Y.M. Kooy, P.A. van Veelen Glutenin is involved in the gluten-driven mucosal T cell response Eur J Immunol 29 1999 3133 3139
15. K.N. Henderson, J.A. Tye-Din, H.H. Reid A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease Immunity 27 2007 23 34
16. AGA Institute AGA Institute medical position statement on the diagnosis and management of celiac disease Gastroenterology 131 2006 1977 1980
17. Ø. Molberg, S.N. McAdam, K.E. Lundin Studies of gliadin-specific T cells in celiac disease M.N. Marsh, Celiac disease Methods and protocols 2000 Humana Totowa, NJ 105 124
18. C. Combet, C. Blanchet, C. Geourjon NPS: network protein sequence analysis Trends Biochem Sci 25 2000 147 150
19. U. Jse, M. Arntzen, P. Højrup Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach Bioorg Med Chem 19 2011 2470 2477
20. W.F. van Gunsteren, S.R. Billeter, A.A. Eising et al. Biomolecular simulation: the GROMOS96 manual and user guide 1996 vdf Hochschulverlag AG an der ETH Zrich Zrich, Groningen 1042
21. N. Guex, M.C. Peitsch SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling Electrophoresis 18 1997 2714 2723
22. L.W. Vader, D.T. Stepniak, E.M. Bunnik Characterization of cereal toxicity for celiac disease patients based on protein homology in grains Gastroenterology 125 2003 1105 1113
23. S.W. Qiao, L.M. Sollid, R.S. Blumberg Antigen presentation in celiac disease Curr Opin Immunol 21 2009 111 117
24. Y. van de Wal, Y.M. Kooy, J.W. Drijfhout Unique peptide binding characteristics of the disease-associated DQ(alpha1 (*)0501, beta1 (*)0201) vs the non-disease-associated DQ(alpha1 (*)0201, beta1 (*)0202) molecule Immunogenetics 46 1997 484 492
25. S.E. Henrickson, T.R. Mempel, I.B. Mazo T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation Nat Immunol 9 2008 282 291
26. A. Polvi, E. Arranz, M. Fernandez-Arquero HLA-DQ2-negative celiac disease in Finland and Spain Hum Immunol 59 1998 169 175
27. M. Fernandez-Arquero, M.A. Figueredo, C. Maluenda HLA-linked genes acting as additive susceptibility factors in celiac disease Hum Immunol 42 1995 295 300
28. J.M. Tjon, J. van Bergen, F. Koning Celiac disease: how complicated can it get? Immunogenetics 62 2010 641 651
29. M. Bodd, M. Raki, S. Tollefsen HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22 Mucosal Immunol 3 2010 594 601