메뉴 건너뛰기




Volumn 7, Issue 4, 2015, Pages 473-491

AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: An overview of recent patent applications

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; NEUROLEPTIC AGENT;

EID: 84928105897     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.15.4     Document Type: Review
Times cited : (25)

References (112)
  • 1
    • 17744387125 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor structure and pharmacology
    • Kew JN, Kemp JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl.) 179(1), 4-26 (2005).
    • (2005) Psychopharmacology (Berl.) , vol.179 , Issue.1 , pp. 4-26
    • Kew, J.N.1    Kemp, J.A.2
  • 3
    • 33646588654 scopus 로고    scopus 로고
    • Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors
    • Chen PE, Wyllie DJ. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br. J. Pharmacol. 147, 839-853 (2006).
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 839-853
    • Chen, P.E.1    Wyllie, D.J.2
  • 4
    • 0025088156 scopus 로고
    • Molecular cloning and functional expression of glutamate receptor subunit genes
    • Boulter J, Hollmann M, O'shea-Greenfield A et al. Molecular cloning and functional expression of glutamate receptor subunit genes. Science 249(4972), 1033-1037 (1990).
    • (1990) Science , vol.249 , Issue.4972 , pp. 1033-1037
    • Boulter, J.1    Hollmann, M.2    O'Shea-Greenfield, A.3
  • 5
    • 0025150414 scopus 로고
    • A family of AMPA-selective glutamate receptors
    • Keinanen K, Wisden W, Sommer B et al. A family of AMPA-selective glutamate receptors. Science 249(4968), 556-560 (1990).
    • (1990) Science , vol.249 , Issue.4968 , pp. 556-560
    • Keinanen, K.1    Wisden, W.2    Sommer, B.3
  • 6
    • 0346156112 scopus 로고    scopus 로고
    • Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain
    • Beneyto M, Meador-Woodruff JH. Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain. J. Comp. Neurol. 468(4), 530-554 (2004).
    • (2004) J. Comp. Neurol. , vol.468 , Issue.4 , pp. 530-554
    • Beneyto, M.1    Meador-Woodruff, J.H.2
  • 7
    • 77249102565 scopus 로고    scopus 로고
    • Contribution of the global subunit structure and stargazin on the maturation of AMPA receptors
    • Shanks NF, Maruo T, Farina AN, Ellisman MH, Nakagawa T. Contribution of the global subunit structure and stargazin on the maturation of AMPA receptors. J. Neurosci. 30(7), 2728-2740 (2010).
    • (2010) J. Neurosci. , vol.30 , Issue.7 , pp. 2728-2740
    • Shanks, N.F.1    Maruo, T.2    Farina, A.N.3    Ellisman, M.H.4    Nakagawa, T.5
  • 8
    • 79955673392 scopus 로고    scopus 로고
    • Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
    • Mayer ML. Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation. Curr. Opin. Neurobiol. 21(2), 283-290 (2011).
    • (2011) Curr. Opin. Neurobiol. , vol.21 , Issue.2 , pp. 283-290
    • Mayer, M.L.1
  • 9
    • 72049124287 scopus 로고    scopus 로고
    • X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
    • Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462(7274), 745-756 (2009).
    • (2009) Nature , vol.462 , Issue.7274 , pp. 745-756
    • Sobolevsky, A.I.1    Rosconi, M.P.2    Gouaux, E.3
  • 10
    • 80054065551 scopus 로고    scopus 로고
    • Emerging models of glutamate receptor ion channel structure and function
    • Mayer ML. Emerging models of glutamate receptor ion channel structure and function. Structure 19(10), 1370-1380 (2011).
    • (2011) Structure , vol.19 , Issue.10 , pp. 1370-1380
    • Mayer, M.L.1
  • 11
    • 78651076694 scopus 로고    scopus 로고
    • Integration of lead optimization with crystallography for a membrane-bound ion channel target: Discovery of a new class of AMPA receptor positive allosteric modulators
    • Ward SE, Harries M, Aldegheri L et al. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. J. Med. Chem. 54(1), 78-94 (2011).
    • (2011) J. Med. Chem. , vol.54 , Issue.1 , pp. 78-94
    • Ward, S.E.1    Harries, M.2    Aldegheri, L.3
  • 12
    • 78149497587 scopus 로고    scopus 로고
    • Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators
    • Pohlsgaard J, Frydenvang K, Madsen U, Kastrup JS. Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. Neuropharmacology 60(1), 135-150 (2011).
    • (2011) Neuropharmacology , vol.60 , Issue.1 , pp. 135-150
    • Pohlsgaard, J.1    Frydenvang, K.2    Madsen, U.3    Kastrup, J.S.4
  • 13
    • 84902162292 scopus 로고    scopus 로고
    • Functional insight into development of positive allosteric modulators of AMPA receptors
    • Weeks AM, Harms JE, Partin KM, Benveniste M. Functional insight into development of positive allosteric modulators of AMPA receptors, Neuropharmacology 85, 57-66 (2014).
    • (2014) Neuropharmacology , vol.85 , pp. 57-66
    • Weeks, A.M.1    Harms, J.E.2    Partin, K.M.3    Benveniste, M.4
  • 14
    • 0442279279 scopus 로고    scopus 로고
    • Structure and function of AMPA receptors
    • Gouaux E. Structure and function of AMPA receptors. J. Physiol. 554, 249-253 (2004).
    • (2004) J. Physiol. , vol.554 , pp. 249-253
    • Gouaux, E.1
  • 16
    • 62149115142 scopus 로고    scopus 로고
    • Neuroscience. More AMPAR garnish
    • Tigaret C, Choquet D. Neuroscience. More AMPAR garnish. Science 323(5919), 1295-1296 (2009).
    • (2009) Science , vol.323 , Issue.5919 , pp. 1295-1296
    • Tigaret, C.1    Choquet, D.2
  • 17
    • 62149085091 scopus 로고    scopus 로고
    • Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    • Schwenk J, Harmel N, Zolles G et al. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323(5919), 1313-1319 (2009).
    • (2009) Science , vol.323 , Issue.5919 , pp. 1313-1319
    • Schwenk, J.1    Harmel, N.2    Zolles, G.3
  • 18
    • 42749091755 scopus 로고    scopus 로고
    • The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases
    • Zarate Jr. CA, Manji HK. The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases. Exp. Neurol. 211(1), 7-10 (2008).
    • (2008) Exp. Neurol. , vol.211 , Issue.1 , pp. 7-10
    • Zarate, C.A.1    Manji, H.K.2
  • 22
    • 0031783831 scopus 로고    scopus 로고
    • The glutamate hypothesis of schizophrenia
    • Akhondzadeh S. The glutamate hypothesis of schizophrenia. J. Clin. Pharm. Ther. 23(4), 243-246 (1998).
    • (1998) J. Clin. Pharm. Ther. , vol.23 , Issue.4 , pp. 243-246
    • Akhondzadeh, S.1
  • 23
    • 84893682532 scopus 로고    scopus 로고
    • Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice
    • Vignisse J, Steinbusch HW, Grigoriev V et al. Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice, Eur. Neuropsychopharmacol. 24(2), 309-20 (2014).
    • (2014) Eur. Neuropsychopharmacol. , vol.24 , Issue.2 , pp. 309-320
    • Vignisse, J.1    Steinbusch, H.W.2    Grigoriev, V.3
  • 24
    • 77957947835 scopus 로고    scopus 로고
    • Recent advances in the discovery of selective AMPA receptor positive allosteric modulators
    • Ward SE, Harries M. Recent advances in the discovery of selective AMPA receptor positive allosteric modulators. Curr. Med. Chem. 17(30), 3503-3513 (2010).
    • (2010) Curr. Med. Chem. , vol.17 , Issue.30 , pp. 3503-3513
    • Ward, S.E.1    Harries, M.2
  • 25
    • 77951694715 scopus 로고    scopus 로고
    • Challenges for and current status of research into positive modulators of AMPA receptors
    • Ward SE, Bax BD, Harries M. Challenges for and current status of research into positive modulators of AMPA receptors. Br. J. Pharmacol. 160(2), 181-190 (2010).
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.2 , pp. 181-190
    • Ward, S.E.1    Bax, B.D.2    Harries, M.3
  • 26
    • 0030601751 scopus 로고    scopus 로고
    • Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics
    • Arai A, Kessler M, Ambros-Ingerson J et al. Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics. Neuroscience 75(2), 573-585 (1996).
    • (1996) Neuroscience , vol.75 , Issue.2 , pp. 573-585
    • Arai, A.1    Kessler, M.2    Ambros-Ingerson, J.3
  • 27
    • 0036828992 scopus 로고    scopus 로고
    • Memory enhancement: The search for mechanism-based drugs
    • Lynch G. Memory enhancement: the search for mechanism-based drugs. Nat. Neurosci. 5(Suppl.), 1035-1038 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 1035-1038
    • Lynch, G.1
  • 28
    • 59449092174 scopus 로고    scopus 로고
    • Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat
    • Woolley ML, Waters KA, Gartlon JE et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl.) 202(1-3), 343-354 (2009).
    • (2009) Psychopharmacology (Berl.) , vol.202 , Issue.1-3 , pp. 343-354
    • Woolley, M.L.1    Waters, K.A.2    Gartlon, J.E.3
  • 29
    • 84891526412 scopus 로고    scopus 로고
    • Are AMPA receptor positive allosteric modulators potential pharmacotherapeutics for addiction?
    • Watterson LR, Olive, MF. Are AMPA receptor positive allosteric modulators potential pharmacotherapeutics for addiction? Pharmaceuticals 7(1), 29-45, (2014).
    • (2014) Pharmaceuticals , vol.7 , Issue.1 , pp. 29-45
    • Watterson, L.R.1    Olive, M.F.2
  • 30
    • 60349093590 scopus 로고    scopus 로고
    • Ampakines cause sustained increases in BDNF signaling at excitatory synapses without changes in AMPA receptor subunit expression
    • Lauterborn JC, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM. Ampakines cause sustained increases in BDNF signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience 159(1), 283-295 (2009).
    • (2009) Neuroscience , vol.159 , Issue.1 , pp. 283-295
    • Lauterborn, J.C.1    Pineda, E.2    Chen, L.Y.3    Ramirez, E.A.4    Lynch, G.5    Gall, C.M.6
  • 31
    • 84868211415 scopus 로고    scopus 로고
    • A Translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator Org 26576 in adult attention-deficit/hyperactivity disorder
    • Adler LA, Kroon RA, Stein M et al. A Translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator Org 26576 in adult attention-deficit/hyperactivity disorder. Biol. Psychiatry 72(11), 971-977 (2012).
    • (2012) Biol. Psychiatry , vol.72 , Issue.11 , pp. 971-977
    • Adler, L.A.1    Kroon, R.A.2    Stein, M.3
  • 33
    • 84892581500 scopus 로고    scopus 로고
    • 1-(1,3-Benzodioxol-5-yl-carbonyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice
    • Fan W, Wu X, Pan Y et al. 1-(1,3-Benzodioxol-5-yl-carbonyl) piperidine, a modulator of α - amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice Biol. Pharm. Bull. 37(1), 13-17 (2014).
    • (2014) Biol. Pharm. Bull. , vol.37 , Issue.1 , pp. 13-17
    • Fan, W.1    Wu, X.2    Pan, Y.3
  • 34
    • 0031214027 scopus 로고    scopus 로고
    • Enhancement by an ampakine of memory encoding in humans
    • Ingvar M, Ambros-Ingerson J, Davis M et al. Enhancement by an ampakine of memory encoding in humans. Exp. Neurol. 146(2), 553-559 (1997).
    • (1997) Exp. Neurol. , vol.146 , Issue.2 , pp. 553-559
    • Ingvar, M.1    Ambros-Ingerson, J.2    Davis, M.3
  • 35
    • 0031148706 scopus 로고    scopus 로고
    • Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans
    • Lynch G, Granger R, Ambros-Ingerson J, Davis CM, Kessler M, Schehr R. Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Exp. Neurol. 145(1), 89-92 (1997).
    • (1997) Exp. Neurol. , vol.145 , Issue.1 , pp. 89-92
    • Lynch, G.1    Granger, R.2    Ambros-Ingerson, J.3    Davis, C.M.4    Kessler, M.5    Schehr, R.6
  • 36
    • 0034796599 scopus 로고    scopus 로고
    • A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia
    • Goff DC, Leahy L, Berman I et al. A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. J. Clin. Psychopharmacol. 21(5), 484-487 (2001).
    • (2001) J. Clin. Psychopharmacol. , vol.21 , Issue.5 , pp. 484-487
    • Goff, D.C.1    Leahy, L.2    Berman, I.3
  • 38
    • 33750962399 scopus 로고    scopus 로고
    • Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: A controlled trial
    • Berry-Kravis E, Krause SE, Block SS et al. Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. J. Child Adolesc. Psychopharmacol. 16(5), 525-40 (2006).
    • (2006) J. Child Adolesc. Psychopharmacol. , vol.16 , Issue.5 , pp. 525-540
    • Berry-Kravis, E.1    Krause, S.E.2    Block, S.S.3
  • 43
    • 34848906857 scopus 로고    scopus 로고
    • Ampakine (CX717) effects on performance and alertness during simulated night shift work
    • Wesensten NJ, Reichardt RM, Balkin TJ. Ampakine (CX717) effects on performance and alertness during simulated night shift work. Aviat. Space Environ. Med. 78(10), 937-943 (2007).
    • (2007) Aviat. Space Environ. Med. , vol.78 , Issue.10 , pp. 937-943
    • Wesensten, N.J.1    Reichardt, R.M.2    Balkin, T.J.3
  • 44
    • 57649121628 scopus 로고    scopus 로고
    • Targeting AMPA and kainate receptors in neurological disease: Therapies on the horizon?
    • Swanson GT. Targeting AMPA and kainate receptors in neurological disease: therapies on the horizon? Neuropsychopharmacology 34, 249-250 (2009).
    • (2009) Neuropsychopharmacology , vol.34 , pp. 249-250
    • Swanson, G.T.1
  • 45
    • 75749140468 scopus 로고    scopus 로고
    • Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia
    • Oertel BG, Felden L, Tran PV et al. Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia. Clin. Pharmacol. Ther. 87(2), 204-211 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , Issue.2 , pp. 204-211
    • Oertel, B.G.1    Felden, L.2    Tran, P.V.3
  • 48
    • 84870427621 scopus 로고    scopus 로고
    • Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: An exploratory, randomized, double-blind, placebo-controlled trial
    • Nations KR, Dogterom P, Bursi R et al. Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial. J. Psychopharmacol. 26(12), 1525-1539 (2012).
    • (2012) J. Psychopharmacol. , vol.26 , Issue.12 , pp. 1525-1539
    • Nations, K.R.1    Dogterom, P.2    Bursi, R.3
  • 49
    • 84868211415 scopus 로고    scopus 로고
    • A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder
    • Adler LA, Kroon RA, Stein M, Shahid M, Tarazi FI. A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder. Biol. Psychiatry 72(11), 971-977 (2012)49.
    • (2012) Biol. Psychiatry , vol.72 , Issue.11 , pp. 971-977
    • Adler, L.A.1    Kroon, R.A.2    Stein, M.3    Shahid, M.4    Tarazi, F.I.5
  • 50
    • 34147116283 scopus 로고    scopus 로고
    • AMPA potentiator treatment of cognitive deficits in Alzheimer disease
    • Chapell AS. AMPA potentiator treatment of cognitive deficits in Alzheimer disease, Neurology 68(13), 1008 (2007)
    • (2007) Neurology , vol.68 , Issue.13 , pp. 1008
    • Chapell, A.S.1
  • 51
    • 84875475732 scopus 로고    scopus 로고
    • Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease
    • Trzepacz PT, Cummings J, Konechnik T et al. Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease. Int. Psychogeriatr. 25(5), 707-719 (2013).
    • (2013) Int. Psychogeriatr. , vol.25 , Issue.5 , pp. 707-719
    • Trzepacz, P.T.1    Cummings, J.2    Konechnik, T.3
  • 54
    • 77955368627 scopus 로고    scopus 로고
    • Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator
    • Ward SE, Harries M, Aldegheri L et al. Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J. Med. Chem. 53(15), 5801-5812 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.15 , pp. 5801-5812
    • Ward, S.E.1    Harries, M.2    Aldegheri, L.3
  • 55
    • 85119161760 scopus 로고    scopus 로고
    • PF-4958242: A novel AMPA positive allosteric modulator (PAM) for the treatment of cognitive deficits associated with schizophrenia
    • MEDI 27
    • nd ACS Natl Meet. Abst. MEDI 27 (2011).
    • (2011) nd ACS Natl Meet. Abst.
    • O'Donnell, C.J.1
  • 57
    • 77958509938 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Bradley DM, Chan WN, Thewlis KM, Ward SE. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2008053031A1 (2008).
    • (2008)
    • Bradley, D.M.1    Chan, W.N.2    Thewlis, K.M.3    Ward, S.E.4
  • 58
    • 77958509938 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Bertheleme N, Bradley DM, Cardullo F et al. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2008113795A1 (2008).
    • (2008)
    • Bertheleme, N.1    Bradley, D.M.2    Cardullo, F.3
  • 59
    • 77958509938 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Bradley DM, Chan WN, Harrison SA, Thewlis KM, Ward SE. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2008110566A1 (2008).
    • (2008)
    • Bradley, D.M.1    Chan, W.N.2    Harrison, S.A.3    Thewlis, K.M.4    Ward, S.E.5
  • 60
    • 77958509938 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Bradley DM, Thewlis KM, Ward SE. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2008148832A1 (2008).
    • (2008)
    • Bradley, D.M.1    Thewlis, K.M.2    Ward, S.E.3
  • 61
    • 77958509938 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Bradley DM, Chan WN, Ward SE. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2008148836A1 (2008).
    • (2008)
    • Bradley, D.M.1    Chan, W.N.2    Ward, S.E.3
  • 63
    • 84876580734 scopus 로고    scopus 로고
    • Thiazoles which potentiate ampa receptor and medicinal uses thereof
    • WO
    • Chan WN, Thewlis KM, Ward SE. Thiazoles which potentiate ampa receptor and medicinal uses thereof: WO 2009053449A1 (2009).
    • (2009)
    • Chan, W.N.1    Thewlis, K.M.2    Ward, S.E.3
  • 64
    • 84876571294 scopus 로고    scopus 로고
    • Compounds which potentiate the AMPA receptor and uses thereof in medicine
    • WO
    • Bertheleme N, Chan WN, Scott JS, Ward SE. Compounds which potentiate the AMPA receptor and uses thereof in medicine: WO 2009080637A1 (2009).
    • (2009)
    • Bertheleme, N.1    Chan, W.N.2    Scott, J.S.3    Ward, S.E.4
  • 65
    • 84928110506 scopus 로고    scopus 로고
    • Compounds which potentiate the AMPA receptor and uses thereof in medicine
    • WO
    • Thewlis KM, Ward SE. Compounds which potentiate the AMPA receptor and uses thereof in medicine: WO 2009092712A1 (2009).
    • (2009)
    • Thewlis, K.M.1    Ward, S.E.2
  • 66
    • 84928110506 scopus 로고    scopus 로고
    • Compounds which potentiate the AMPA receptor and uses thereof in medicine
    • WO
    • Thewlis KM, Ward SE. Compounds which potentiate the AMPA receptor and uses thereof in medicine: WO 2009092713A1 (2009).
    • (2009)
    • Thewlis, K.M.1    Ward, S.E.2
  • 67
    • 84928127412 scopus 로고    scopus 로고
    • Compounds which potentiate AMPA receptor and uses thereof in medicine
    • WO
    • Ward SE, Bertheleme N. Compounds which potentiate AMPA receptor and uses thereof in medicine: WO 2010037760A1 (2010).
    • (2010)
    • Ward, S.E.1    Bertheleme, N.2
  • 69
    • 84928156261 scopus 로고    scopus 로고
    • Heterocyclic compound
    • WO
    • Mochizuki M, Miura S. Heterocyclic compound: WO 2009119088A1 (2009).
    • (2009)
    • Mochizuki, M.1    Miura, S.2
  • 70
    • 84876542915 scopus 로고    scopus 로고
    • Heterocyclic compound
    • WO
    • Mochizuki M, Imaeda T. Heterocyclic compound: WO 2010140339A1 (2010).
    • (2010)
    • Mochizuki, M.1    Imaeda, T.2
  • 71
  • 73
    • 84928122642 scopus 로고    scopus 로고
    • Heterocyclic compound and use thereof
    • WO
    • Kori M, Imaeda T, Nakamura S et al. Heterocyclic compound and use thereof: WO 2012020848A1 (2012).
    • (2012)
    • Kori, M.1    Imaeda, T.2    Nakamura, S.3
  • 74
    • 84928153740 scopus 로고    scopus 로고
    • Sulfonamide derivative and use thereof
    • WO
    • Fukumoto S, Ujikawa O, Morimoto S et al. Sulfonamide derivative and use thereof: WO 2012137982A2 (2012).
    • (2012)
    • Fukumoto, S.1    Ujikawa, O.2    Morimoto, S.3
  • 75
    • 84884634313 scopus 로고    scopus 로고
    • Positive allosteric modulation of AMPA receptors from efficacy to toxicity: The interspecies exposure-response continuum of the novel potentiator PF-4778574
    • Shaffer C L, Hurst R S, Scialis R J et al. Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574. J. Pharmacol. Exp. Ther. 347, 212-224 (2013).
    • (2013) J. Pharmacol. Exp. Ther. , vol.347 , pp. 212-224
    • Shaffer, C.L.1    Hurst, R.S.2    Scialis, R.J.3
  • 76
    • 84889254433 scopus 로고    scopus 로고
    • Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators
    • Patel N C, Schwarz J, Hou X J et al. Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators. J. Med. Chem. 56, 9180-9191 (2013).
    • (2013) J. Med. Chem. , vol.56 , pp. 9180-9191
    • Patel, N.C.1    Schwarz, J.2    Hou, X.3
  • 77
    • 77957605595 scopus 로고    scopus 로고
    • A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies
    • Jamieson C, Basten S, Campbell R A et al. A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies Bioorg. Med. Chem. Lett. (20), 5753-5756 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , Issue.20 , pp. 5753-5756
    • Jamieson, C.1    Basten, S.2    Campbell, R.A.3
  • 78
    • 77956906200 scopus 로고    scopus 로고
    • A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization
    • Jamieson C, Basten S, Campbell R A et al. A novel series of positive modulators of the AMPA receptor: structure-based lead optimization Bioorg. Med. Chem. Lett. (20) 6072-6075 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , Issue.20 , pp. 6072-6075
    • Jamieson, C.1    Basten, S.2    Campbell, R.A.3
  • 79
    • 79960285866 scopus 로고    scopus 로고
    • Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation
    • Timm D E, Benveniste M, Weeks AM et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol. Pharmacol. 80, 267-280 (2011).
    • (2011) Mol. Pharmacol. , vol.80 , pp. 267-280
    • Timm, D.E.1    Benveniste, M.2
  • 80
    • 79958735578 scopus 로고    scopus 로고
    • Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I
    • Mueller R, Zhong S, Hampson A et al. Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I Bioorg. Med. Chem. Lett. (21), 3923-3926 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , Issue.21 , pp. 3923-3926
    • Mueller, R.1    Zhong, S.2    Hampson, A.3
  • 81
    • 79958720426 scopus 로고    scopus 로고
    • Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part 2
    • Mueller R, Zhong S, Hampson A et al. Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part 2 Bioorg. Med. Chem. Lett. (21), 3927-3930 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , Issue.21 , pp. 3927-3930
    • Mueller, R.1    Zhong, S.2    Hampson, A.3
  • 82
    • 80052926555 scopus 로고    scopus 로고
    • Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators
    • Mueller R, Rachwal S, Lee S et al. Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators Bioorg. Med. Chem. Lett. (21), 6170-6175 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , Issue.21 , pp. 6170-6175
    • Mueller, R.1    Rachwal, S.2    Lee, S.3
  • 83
    • 81255127895 scopus 로고    scopus 로고
    • Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators
    • Mueller R, Rachwal S, Varney M A et al. Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators Bioorg. Med. Chem. Lett. (21), 7455-7459 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , Issue.21 , pp. 7455-7459
    • Mueller, R.1    Rachwal, S.2    Varney, M.A.3
  • 84
    • 77956418461 scopus 로고    scopus 로고
    • DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer
    • Bernard K, Danober L, Thomas JY et al. DRUG FOCUS: S 18986: a positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer. CNS Neurosci. Ther. 16(5):e193-21 (2010).
    • (2010) CNS Neurosci. Ther. , vol.16 , Issue.5 , pp. e193-e221
    • Bernard, K.1    Danober, L.2    Thomas, J.Y.3
  • 85
    • 84887911519 scopus 로고    scopus 로고
    • Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold
    • Norholm A-B, Francotte P, Olsen L et al. Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. J. Med. Chem. 56, 8736-8745 (2013).
    • (2013) J. Med. Chem. , vol.56 , pp. 8736-8745
    • Norholm, A.-B.1    Francotte, P.2    Olsen, L.3
  • 86
    • 79959242809 scopus 로고    scopus 로고
    • New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors
    • Dintilhac G, Arslan D, Dilly S et al. New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Med. Chem. Commun., 2, 509-523 (2011).
    • (2011) Med. Chem. Commun. , vol.2 , pp. 509-523
    • Dintilhac, G.1    Arslan, D.2    Dilly, S.3
  • 87
    • 84855902830 scopus 로고    scopus 로고
    • 5-Arylbenzothiadiazine type compounds as positive allosteric modulators of AMPA/kainate receptors
    • Battisti U M, Ozwiak K, Cannazza G et al. 5-Arylbenzothiadiazine type compounds as positive allosteric modulators of AMPA/kainate receptors. ACS Med. Chem. Lett. 3(1), 25-29 (2012).
    • (2012) ACS Med. Chem. Lett. , vol.3 , Issue.1 , pp. 25-29
    • Battisti, U.M.1    Ozwiak, K.2    Cannazza, G.3
  • 88
    • 59649085514 scopus 로고    scopus 로고
    • A novel class of allosteric modulators of AMPA/Kainate receptors
    • Cannazza G, Jozwiak K, Parenti C et al. A novel class of allosteric modulators of AMPA/Kainate receptors. Bioorg. Med, Chem. Lett. 19, 1254-1257 (2009).
    • (2009) Bioorg. Med, Chem. Lett. , vol.19 , pp. 1254-1257
    • Cannazza, G.1    Jozwiak, K.2    Parenti, C.3
  • 89
    • 84873873454 scopus 로고    scopus 로고
    • A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents
    • Chen H, Wang C Z, Ding C et al. A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents. Chem. Med. Chem. 8, 226-230 (2013).
    • (2013) Chem. Med. Chem. , vol.8 , pp. 226-230
    • Chen, H.1    Wang, C.Z.2
  • 91
    • 84876512963 scopus 로고    scopus 로고
    • Tetrahydrofuranyl sulfonamides for use as AMPA modulators in the treatment of CNS disorders
    • WO
    • Estep KG, O'donnell CJ, Xie L. Tetrahydrofuranyl sulfonamides for use as AMPA modulators in the treatment of CNS disorders: WO 2010041162A1 (2010).
    • (2010)
    • Estep, K.G.1    O'Donnell, C.J.2    Xie, L.3
  • 93
    • 77958485151 scopus 로고    scopus 로고
    • Sulfonamides and pharmaceutical compositions thereof
    • WO
    • Estep KG, Fliri AFJ, O'donnell CJ. Sulfonamides and pharmaceutical compositions thereof: WO 2008120093A1 (2008).
    • (2008)
    • Estep, K.G.1    Fliri, A.F.J.2    O'Donnell, C.J.3
  • 98
    • 77957942304 scopus 로고    scopus 로고
    • Benzotriazinone derivatives as AMPA receptor enhancers and their preparation, pharmaceutical compositions and use in the treatment of diseases
    • Mueller R, Lee S, O'hare S, Rogers G, Rachwal S, Street L. Benzotriazinone derivatives as AMPA receptor enhancers and their preparation, pharmaceutical compositions and use in the treatment of diseases: WO2008085505A1 (2008).
    • (2008)
    • Mueller, R.1    Lee, S.2    O'Hare, S.3    Rogers, G.4    Rachwal, S.5    Street, L.6
  • 99
    • 77957961535 scopus 로고    scopus 로고
    • 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
    • WO
    • Cordi A, Rogers G. 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses: WO 2008085506A1 (2008).
    • (2008)
    • Cordi, A.1    Rogers, G.2
  • 100
    • 77957939229 scopus 로고    scopus 로고
    • Preparation of substituted triazinone derivatives and analogs as glutamatergic synaptic response enhancers
    • Mueller R, Street LJ, Rachwal S, Alisala K. Preparation of substituted triazinone derivatives and analogs as glutamatergic synaptic response enhancers: WO2009038752A2 (2009).
    • (2009)
    • Mueller, R.1    Street, L.J.2    Rachwal, S.3    Alisala, K.4
  • 101
    • 84876581724 scopus 로고    scopus 로고
    • Benzothiadiazepine derivatives used as AMPA and NMDA receptor modulators
    • WO
    • Cordi A, Desos P, Lestage P, Danober L. Benzothiadiazepine derivatives used as AMPA and NMDA receptor modulators: WO 2010106249A1 (2010).
    • (2010)
    • Cordi, A.1    Desos, P.2    Lestage, P.3    Danober, L.4
  • 102
    • 84876578011 scopus 로고    scopus 로고
    • New cycloalkylated benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them
    • WO
    • Francotte P, De Tullio P, Pirotte B, Danober L, Lestage P, Caignard D-H. New cycloalkylated benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them: WO 2010004139A1 (2010).
    • (2010)
    • Francotte, P.1    De Tullio, P.2    Pirotte, B.3    Danober, L.4    Lestage, P.5    Caignard, D.-H.6
  • 103
    • 84876534415 scopus 로고    scopus 로고
    • Novel derivatives of cyclopropylated benzothiadiazines, method for preparing same and pharmaceutical compositions containing same
    • WO
    • De Tullio P, Pirotte B, Botez L, Danober L, Lestage P. Novel derivatives of cyclopropylated benzothiadiazines, method for preparing same and pharmaceutical compositions containing same: WO 2011083265A1 (2011).
    • (2011)
    • De Tullio, P.1    Pirotte, B.2    Botez, L.3    Danober, L.4    Lestage, P.5
  • 104
    • 84928121220 scopus 로고    scopus 로고
    • Thiochroman derivatives, method for preparing same and pharmaceutical compositions containing same
    • WO
    • Francotte P, De Tullio P, Pirotte B, Botez I, Danober L, Lestage P. Thiochroman derivatives, method for preparing same and pharmaceutical compositions containing same: WO 2011083264A1.
    • Francotte, P.1    De Tullio, P.2    Pirotte, B.3    Botez, I.4    Danober, L.5    Lestage, P.6
  • 105
    • 84928105477 scopus 로고    scopus 로고
    • Dihydrobenzoxathiazepine derivatives, preparation thereof, pharmaceutical compositions and use as ampa receptor modulators
    • WO
    • Cordi A, Desos P, Lestage P, Laurence D. Dihydrobenzoxathiazepine derivatives, preparation thereof, pharmaceutical compositions and use as ampa receptor modulators: WO 2012035216A1 (2012).
    • (2012)
    • Cordi, A.1    Desos, P.2    Lestage, P.3    Laurence, D.4
  • 106
    • 84928161845 scopus 로고    scopus 로고
    • 1,2,4-Benzothiadiazine dioxide derivatives as allosteric modulators of AMPA receptor and their preparation and use for treatment of mnemocognitive disorders
    • Battisti U, Cannazza G, Puja G et al. 1,2,4-Benzothiadiazine dioxide derivatives as allosteric modulators of AMPA receptor and their preparation and use for treatment of mnemocognitive disorders: EP2457906A1 (2012).
    • (2012)
    • Battisti, U.1    Cannazza, G.2    Puja, G.3
  • 107
    • 84928105721 scopus 로고    scopus 로고
    • Bivalent AMPA receptor positive allosteric modulators
    • WO
    • Zhou, J, Chen Haijun, Johnson, K, Wang C. Bivalent AMPA receptor positive allosteric modulators: WO 2013130501A1 (2013).
    • (2013)
    • Zhou, J.1    Haijun, C.2    Johnson, K.3    Wang, C.4
  • 109
    • 84928127408 scopus 로고    scopus 로고
    • 4,4′-Biphenylamide derivatives having a pharmacological activity, and medicaments based thereon
    • WO
    • Zapolsky ME, Zefirov NS, Palyulin VA et al. 4,4′-Biphenylamide derivatives having a pharmacological activity, and medicaments based thereon: WO 2012138254A2 (2012).
    • (2012)
    • Zapolsky, M.E.1    Zefirov, N.S.2    Palyulin, V.A.3
  • 110
    • 84928127407 scopus 로고    scopus 로고
    • Pharmacologically active alicyclic N,N′-substituted 3,7-diazabicyclo[3. 3. 1]nonane derivatives and drugs based thereon
    • WO
    • Zapolsky ME, Zefirov NS, Palyulin VA, Lavrov MI. Pharmacologically active alicyclic N,N′-substituted 3,7-diazabicyclo[3. 3. 1]nonane derivatives and drugs based thereon: WO 2012148308A1 (2012).
    • (2012)
    • Zapolsky, M.E.1    Zefirov, N.S.2    Palyulin, V.A.3    Lavrov, M.I.4
  • 111
    • 77958468790 scopus 로고    scopus 로고
    • Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
    • Grove S J A, Jamieson C, Maclean J F K, Morrow J A, Rankovic Z. Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. J. Med. Chem. 53(20) 7271-7279 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.20 , pp. 7271-7279
    • Grove, S.J.A.1    Jamieson, C.2    Maclean, J.F.K.3    Morrow, J.A.4    Rankovic, Z.5
  • 112
    • 84876720539 scopus 로고    scopus 로고
    • Allosteric modulators for the treatment of schizophrenia: Targeting glutamatergic networks
    • Menniti F S, Lindsley C W, Conn P J et al. Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks. Curr. Top. Med. Chem. 13(1), 26-54 (2014).
    • (2014) Curr. Top. Med. Chem. , vol.13 , Issue.1 , pp. 26-54
    • Menniti, F.S.1    Lindsley, C.W.2    Conn, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.