Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2 h -1,2,4-benzothiadiazine 1,1-dioxide scaffold

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8736-8745

  Nørholm, Ann Beth ^a   Francotte, Pierre ^b   Olsen, Lars ^a   Krintel, Christian ^a   Frydenvang, Karla ^a   Goffin, Eric ^b   Challal, Sylvie ^c   Danober, Laurence ^c   Botez Pop, Iuliana ^c   Lestage, Pierre ^c   Pirotte, Bernard ^b   Kastrup, Jette S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 CYCLOPROPYL 7 FLUORO 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; BENZOTHIADIAZINE DERIVATIVE; IONOTROPIC RECEPTOR; METHIONINE; PHENYLALANINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; RAT; RECEPTOR DOWN REGULATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANIMALS; BENZOTHIADIAZINES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURONS; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84887911519     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4012092     Document Type: Article

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