Discovery of N -[(2 s)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1 H -inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5801-5812

  Ward, Simon E ^a   Harries, Mark ^a   Aldegheri, Laura ^b   Andreotti, Daniele ^b   Ballantine, Stuart ^a   Bax, Benjamin D ^a   Harris, Andrew J ^a   Harker, Andy J ^a   Lund, Jesper ^b   Melarange, Rosemary ^a   Mingardi, Anna ^b   Mookherjee, Claudette ^a   Mosley, Julie ^a   Neve, Marta ^b   Oliosi, Beatrice ^b   Profeta, Roberto ^b   Smith, Kathrine J ^a   Smith, Paul W ^a   Spada, Simone ^b   Thewlis, Kevin M ^a   Yusaf, Shahnaz P ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR AGONIST; N [5 (6 FLUORO 3 PYRIDINYL) 2,3 DIHYDRO 1H INDEN 2 YL] 2 PROPANESULFONAMIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; AMPA RECEPTOR; INDENE DERIVATIVE; N (5 (6 FLUORO 3 PYRIDINYL) 2,3 DIHYDRO 1H INDEN 2 YL) 2 PROPANESULFONAMIDE; N-(5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL)-2-PROPANESULFONAMIDE; PLASMA PROTEIN; SULFONAMIDE;

ALLOSTERISM; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG TOLERABILITY; HUMAN; HUMAN CELL; NONHUMAN; ANIMAL; BIOAVAILABILITY; BLOOD BRAIN BARRIER; CELL LINE; CHEMICAL STRUCTURE; CLINICAL TRIAL; DOG; LIVER MICROSOME; MACACA; MALE; MARMOSET; METABOLISM; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; CALLITHRIX; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DOGS; HUMANS; INDENES; MACACA FASCICULARIS; MALE; MICROSOMES, LIVER; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SPECIES SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77955368627     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1005429     Document Type: Article

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