Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7455-7459

  Mueller, Rudolf ^a   Rachwal, Stanislaw ^a   Varney, Mark A ^a   Johnson, Steven A ^a   Alisala, Kashinatham ^a   Zhong, Sheng ^a   Li, Yong Xin ^a   Haroldsen, Peter ^a   Herbst, Todd ^a   Street, Leslie J ^a  

^a Cortex Pharmaceuticals Inc ^*  (United States)

Author keywords

AMPA; CNS; Positive allosteric modulator; Triazinone

Indexed keywords

AMPA RECEPTOR; BENZOBISPYRIMIDINONE DERIVATIVE; BENZOBISTRIAZINONE DERIVATIVE; HETEROCYCLIC KETONE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; HETEROCYCLIC COMPOUNDS; RATS; RECEPTORS, AMPA; TRIAZINES;

RATTUS;

EID: 81255127895     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.132     Document Type: Article

References (36)

1. J.A. Morrow, J.K.F. Maclean, and C. Jamieson Curr. Opin. Drug Discov. Devel. 19 2006 571
2. R. Jin, S. Clark, A.M. Weeks, J.T. Dudman, E. Gouaux, and K.M. Partin J. Neurosci. 25 2005 9027
3. A.C. Arai, and M. Kessler Curr. Drug Targets 8 2007 583
4. K. Harpsøe, T. Liljefors, and T. Balle J. Mol. Graph. Model. 26 2008 874
5. K. Harpsøe, T. Varming, A.H. Gouliaev, D. Peters, and T. Liljefors J. Mol. Graph. Model. 26 2007 213
6. Y. Sun, R. Olson, M. Horning, N. Armstrong, M. Mayer, and E. Gouaux Nature 417 2002 245
7. A.C. Arai, Y.-F. Xia, G. Rogers, G. Lynch, and M. Kessler J. Pharmacol. Exp. Ther. 303 2002 1075
8. S. Marenco, and D.R.C.N.S. Weinberger Drugs 20 2006 173
9. A. Alt, E.S. Nisenbaum, D. Bleakman, and J.M. Witkin Biochem. Pharmacol. 77 2006 1273
10. P.M. Kanju, K. Parameshwaran, C. Sims, B.A. Bahr, B.C. Shonesy, and V. Suppiramaniam Exp. Neurol. 214 2008 55
11. M.J. O'Neill, D. Bleakman, D.M. Zimmerman, and E.S. Nisenbaum Curr. Drug Targets CNS Neurol. Disord. 3 2004 181
12. G. Sanacora, C.A. Zarate, J.H. Krystal, and H.K. Manji Nat. Rev. 7 2008 426
13. K. Hashimoto Brain Res. Rev. 61 2009 105
14. E.B. Bloss, R.G. Hunter, E.M. Waters, C. Munoz, K. Bernard, and B.S. McEwen Exp. Neurol. 210 2008 109
15. T.K. Murray, K. Whalley, C.S. Robinson, M.A. Ward, C.A. Hicks, D. Lodge, J.L. Vandergriff, P. Baumbarger, E. Siuda, M. Gates, A.M. Ogden, P. Skolnick, D.M. Zimmerman, E.S. Nisenbaum, D. Bleakman, and M.J. O'Neill Pharmacol. Exp Ther. 306 2003 752
16. J.C. Lauterborn, G. Lynch, P. Vanderklish, A. Arai, and C.M. Gall J. Neurosci. 2000 8
17. J.C. Lauterborn, E. Pineda, L.Y. Chen, E.A. Ramirez, G. Lynch, and C.M. Gall Neuroscience 159 2009 283
18. J.C. Lauterborn, G. Troung, M. Baudry, X. Bi, G. Lynch, and C. Gall J. Pharmacol. Exp. Ther. 307 2003 297
19. A.N. Clarkson, J.J. Overman, S. Zhong, R. Mueller, G. Lynch, and S.T. Carmichael J. Neurosci. 31 2011 3766
20. Rogers, G. A.; Allan, M.; Harris, C.; Huang, J.; Marrs, C. M.; Mueller, R.; Rachwal, S. US7799913, 2010.
21. R. Mueller, Y.X. Li, A. Hampson, S. Zhong, C. Harris, C. Marrs, S. Rachwal, J. Ulas, L. Nielsson, and G. Rogers Bioorg. Med. Chem. Lett. 21 2011 3923
22. R. Mueller, S. Rachwal, M.E. Tedder, Y.X. Li, S. Zhong, A. Hampson, J. Ulas, M. Varney, L. Nielsson, and G. Rogers Bioorg. Med. Chem. Lett. 21 2011 3927
23. R. Mueller, S. Rachwal, S. Lee, S. Zhong, Y.X. Li, P. Haroldsen, T. Herbst, S. Tanimura, M. Varney, S. Johnson, G. Rogers, and L.J. Street Bioorg. Med. Chem. Lett. 21 2011 6170
24. G. Lynch Curr. Opin. Pharmacol. 4 2004 4
25. G. Lynch, and C.M. Gall Trends Neurosci. 29 2006 554
26. M.J. O'Neill, and S. Dix IDrugs 10 2007 185
27. A. Arai, M. Kessler, G. Rogers, and G. Lynch J. Pharmacol. Exp. Ther 278 1996 627
28. U. Staubli, G. Rogers, and G. Lynch Proc. Natl. Acad. Sci. 91 1994 777
29. C.R. Raymond Trends Neurosci. 30 2007 167
30. R. Lamprecht, and J. LeDoux Nat. Rev. Neurosci. 5 2004 45
31. M.A. Lynch Physiol. Rev. 84 2004 87
32. I. Zivcovic, D.M. Thompson, M. Bertolino, D. Uzunov, M. Dibella, E. Costa, and A. Guidotti Pharmacol. Exp. Ther. 272 2009 300
33. E.B. Skibo, and J.H. Gilchrist J. Org. Chem. 53 1988 4209
34. E.B. Skibo, X. Huang, R. Martinez, R.H. Lemus, and W.A. Craigo J. Med. Chem. 45 2002 5543
35. Mueller, R.; Street, L. J.; Rachwal, S.; Alisala, K. US2010/0267728 A1, 2010.
36. Mueller, R.; Lee, S. O'Hare, S.; Rogers, G.; Rachwal, S.; Street, L. US2010/0041647 A1, 2010.