A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6072-6075

  Jamieson, Craig ^a,b   Campbell, Robert A ^a   Cumming, Iain A ^a   Gillen, Kevin J ^a   Gillespie, Jonathan ^a   Kazemier, Bert ^a   Kiczun, Michael ^a   Lamont, Yvonne ^a   Lyons, Amanda J ^a   MacLean, John K F ^a   Martin, Frederic ^a   Moir, Elizabeth M ^a   Morrow, John A ^a   Pantling, John ^a   Rankovic, Zoran ^a   Smith, Lynn ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

AMPA receptor; Ion channels; Positive allosteric modulators; SBDD

Indexed keywords

AMPA RECEPTOR; ION CHANNEL; LEAD;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CHEMICAL STRUCTURE; ELECTROPHYSIOLOGY; MOLECULAR WEIGHT; NONHUMAN; RAT; REACTOR OPTIMIZATION; SYNTHESIS; WISTAR RAT;

ALLOSTERIC REGULATION; AMINES; ANIMALS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956906200     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.063     Document Type: Article

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